azathioprine has been researched along with Osteoporosis in 30 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) with ursodeoxycholic acid (UDCA) has been in common use since 1985." | 4.81 | Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis. ( Holtmeier, J; Leuschner, U, 2001) |
| "We report a rare case of ulcerative colitis (UC) associated with methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa infections in multiple organs, and with compressive fracture from osteoporosis after the administration of high-dose prednisolone and azathioprine." | 3.70 | Severe complications of ulcerative colitis after high-dose prednisolone and azathioprine treatment. ( Abo, Y; Kawamura, YJ; Masaki, T; Matsuda, K; Muto, T; Uchida, H; Watanabe, T, 1999) |
| "Ulcerative colitis is a chronic inflammatory bowel disease." | 2.42 | [Management of ulcerative colitis]. ( Kullak-Ublick, GA; Rammert, Ch, 2003) |
| "There is a high prevalence of low bone mineral density (BMD) among patients with inflammatory bowel disease (IBD) although there is a lack of clinical data on the impact of IBD specific medications and recommended vitamin D (VD) and calcium (Ca) supplements on it." | 1.40 | Combination therapy with an immunomodulator and anti-TNFα agent improves bone mineral density in IBD patients. ( Cierny, D; Hlavaty, T; Huorka, M; Killinger, Z; Koller, T; Krajcovicova, A; Letkovsky, J; Miznerova, E; Nevidanska, M; Payer, J; Toth, J; Zelinkova, Z, 2014) |
| "Osteoporosis, osteopenia, and osteonecrosis are common in renal transplant recipients." | 1.36 | Bone disease in renal transplantation and pleotropic effects of vitamin D therapy. ( Balal, M; Binokay, F; Demir, E; Erken, U; Kurt, C; Paydas, S; Sertdemir, Y; Sikgenc, MM, 2010) |
| "The subgroups with ulcerative colitis and Crohn's disease and the effect of taking azathioprine were compared." | 1.32 | Bone density improves with disease remission in patients with inflammatory bowel disease. ( Jugdaohsingh, R; Meenan, J; Powell, JJ; Reffitt, DM; Sanderson, JD; Thompson, RP, 2003) |
| "Zoledronic acid is a new intravenous bisphosphonate that has been approved by the US FDA for use with hypercalcemia of malignancies and might be an effective treatment for postmenopausal osteoporosis." | 1.32 | The effect of intravenous zoledronic acid on glucocorticoid-induced multiple vertebral fractures in juvenile systemic lupus erythematosus. ( Borges, CT; Jorgetti, V; Pereira, RM; Souza, SC, 2004) |
| "Hypogonadism has been established as a cause of osteoporosis in males, and in this case would explain the occurrence of fractures in the absence of other major risk factors." | 1.31 | Osteoporosis with underlying connective tissue disease: an unusual case. ( De Silva, M; Prasad, R, 2002) |
| "Two paediatric patients with systemic lupus erythematosus were treated with immunoglobulin G (IgG)." | 1.27 | IgG therapy in systemic lupus erythematosus--two case reports. ( Dopfer, R; Gaedicke, G; Kohne, E; Niethammer, D; Teller, WM, 1984) |
| "The diagnosis of Crohn's disease with extensive involvement of small intestine and colon was first made in a 12 3/4-year-old girl, now 15 1/2 years old." | 1.27 | [Crohn disease: initial experiences with cyclosporin A in an adolescent girl]. ( Dannecker, G; Malchow, H; Niessen, KH; Ranke, MB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (40.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 13 (43.33) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krajcovicova, A | 1 |
| Hlavaty, T | 1 |
| Killinger, Z | 1 |
| Miznerova, E | 1 |
| Toth, J | 1 |
| Letkovsky, J | 1 |
| Nevidanska, M | 1 |
| Cierny, D | 1 |
| Koller, T | 1 |
| Zelinkova, Z | 1 |
| Huorka, M | 1 |
| Payer, J | 1 |
| Sikgenc, MM | 1 |
| Paydas, S | 1 |
| Balal, M | 1 |
| Demir, E | 1 |
| Kurt, C | 1 |
| Sertdemir, Y | 1 |
| Binokay, F | 1 |
| Erken, U | 1 |
| Prasad, R | 1 |
| De Silva, M | 1 |
| Rammert, Ch | 1 |
| Kullak-Ublick, GA | 1 |
| Beglinger, Ch | 1 |
| Verkasalo, M | 1 |
| Reffitt, DM | 1 |
| Meenan, J | 1 |
| Sanderson, JD | 1 |
| Jugdaohsingh, R | 1 |
| Powell, JJ | 1 |
| Thompson, RP | 1 |
| Stief, J | 1 |
| Sohn, HY | 1 |
| Alt, A | 1 |
| Uberfuhr, P | 1 |
| Theisen, K | 1 |
| Stempfle, HU | 1 |
| Souza, SC | 1 |
| Borges, CT | 1 |
| Jorgetti, V | 1 |
| Pereira, RM | 1 |
| Gaedicke, G | 1 |
| Teller, WM | 1 |
| Kohne, E | 1 |
| Dopfer, R | 1 |
| Niethammer, D | 1 |
| Oka, K | 1 |
| Shimodaira, H | 1 |
| Hirano, T | 1 |
| Sakurai, E | 1 |
| Tamaki, T | 1 |
| Kozaki, M | 1 |
| Tałałaj, M | 1 |
| Gradowska, L | 1 |
| Marcinowska-Suchowierska, E | 1 |
| Durlik, M | 1 |
| Gaciong, Z | 1 |
| Lao, M | 1 |
| Matsuda, K | 1 |
| Watanabe, T | 1 |
| Abo, Y | 1 |
| Uchida, H | 1 |
| Kawamura, YJ | 1 |
| Masaki, T | 1 |
| Muto, T | 1 |
| Seidman, EG | 1 |
| Hamburg, SM | 1 |
| Piers, DA | 1 |
| van den Berg, AP | 1 |
| Slooff, MJ | 1 |
| Haagsma, EB | 1 |
| Monegal, A | 1 |
| Navasa, M | 1 |
| Guañabens, N | 1 |
| Peris, P | 1 |
| Pons, F | 1 |
| Martínez de Osaba, MJ | 1 |
| Rimola, A | 1 |
| Rodés, J | 1 |
| Muñoz-Gómez, J | 1 |
| Ponticelli, C | 1 |
| Aroldi, A | 1 |
| Holtmeier, J | 1 |
| Leuschner, U | 1 |
| Loddenkemper, K | 1 |
| Perka, C | 1 |
| Burmester, GR | 1 |
| Buttgereit, F | 1 |
| Brunner, G | 1 |
| Dannecker, G | 1 |
| Malchow, H | 1 |
| Niessen, KH | 1 |
| Ranke, MB | 1 |
| Warnes, TW | 1 |
| Formgren, H | 1 |
| Tolentino, P | 1 |
| Strohmeyer, G | 1 |
| Spuck, W | 1 |
| Martini, GA | 1 |
| Nichols, G | 1 |
| Flanagan, B | 1 |
| van der Sluys Veer, J | 1 |
| Johnson, JW | 1 |
| Hampers, CL | 1 |
| Merrill, JP | 1 |
| Hulme, B | 1 |
| Kenyon, JR | 1 |
| Owen, K | 1 |
| Snell, M | 1 |
| Mowbray, JF | 1 |
| Porter, KA | 1 |
| Starkie, SJ | 1 |
| Muras, H | 1 |
| Peart, WS | 1 |
| van Dijk, TJ | 1 |
| van Velde, JL | 1 |
| Ginn, HE | 1 |
| Brown, CH | 1 |
| Turner-Warwick, M | 1 |
7 reviews available for azathioprine and Osteoporosis
| Article | Year |
|---|---|
[Management of ulcerative colitis].
Topics: Administration, Oral; Adrenal Cortex Hormones; Aminosalicylic Acids; Anemia; Anti-Inflammatory Agent | 2003 |
[Treatment of Crohn's disease].
Topics: Acute Disease; Adjuvants, Immunologic; Adrenal Cortex Hormones; Algorithms; Aminosalicylic Acids; An | 2003 |
[Drug therapy and nutrition therapy of a young patient with Crohn disease].
Topics: Adjuvants, Immunologic; Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal | 2003 |
Recent advances in the diagnosis and treatment of pediatric inflammatory bowel disease.
Topics: Adolescent; Azathioprine; Biomarkers; Child; Humans; Immunosuppressive Agents; Inflammatory Bowel Di | 2000 |
Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis.
Topics: Azathioprine; Celiac Disease; Cholagogues and Choleretics; Cholangitis, Sclerosing; Drug Therapy, Co | 2001 |
Treatment of primary biliary cirrhosis.
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cholelithiasis; Colchicine | 1985 |
Late medical complications of renal transplantation.
Topics: Adrenal Cortex Hormones; Adult; Allopurinol; Autoimmune Diseases; Azathioprine; Bone Diseases; Diabe | 1969 |
3 trials available for azathioprine and Osteoporosis
| Article | Year |
|---|---|
[Effect of immunosuppression-induced hypogonadism on bone metabolism after heart transplantation].
Topics: Absorptiometry, Photon; Azathioprine; Bone Density; Calcitriol; Calcium; Calcium Channel Agonists; C | 2004 |
Efficiency of preventive treatment of glucocorticoid-induced osteoporosis with 25-hydroxyvitamin D3 and calcium in kidney transplant patients.
Topics: Adolescent; Adult; Azathioprine; Bone Density; Calcitriol; Calcium; Calcium Carbonate; Cyclosporine; | 1996 |
Osteoporosis after organ transplantation.
Topics: Absorptiometry, Photon; Azathioprine; Bone Density; Cyclosporine; Dose-Response Relationship, Drug; | 2001 |
20 other studies available for azathioprine and Osteoporosis
| Article | Year |
|---|---|
Combination therapy with an immunomodulator and anti-TNFα agent improves bone mineral density in IBD patients.
Topics: Absorptiometry, Photon; Adalimumab; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; A | 2014 |
Bone disease in renal transplantation and pleotropic effects of vitamin D therapy.
Topics: Azathioprine; Bone Density; Bone Diseases; Bone Diseases, Metabolic; Creatinine; Female; Humans; Kid | 2010 |
Osteoporosis with underlying connective tissue disease: an unusual case.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Accidental Falls; Adult; Anti-Ulcer Agents; Antibodies, Ant | 2002 |
Bone density improves with disease remission in patients with inflammatory bowel disease.
Topics: Adult; Aged; Azathioprine; Bone Density; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies | 2003 |
The effect of intravenous zoledronic acid on glucocorticoid-induced multiple vertebral fractures in juvenile systemic lupus erythematosus.
Topics: Adolescent; Azathioprine; Bone Density; Bone Density Conservation Agents; Cervical Vertebrae; Diphos | 2004 |
IgG therapy in systemic lupus erythematosus--two case reports.
Topics: Azathioprine; Child; Cushing Syndrome; Female; Humans; Immunoglobulin G; Lupus Erythematosus, System | 1984 |
Comparison of adrenal functions in kidney transplant recipients with different long-term immunosuppressive treatments--prednisolone and azathioprine versus prednisolone and cyclosporine.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Azathioprine; Cyclosporine; Dose-Response Relati | 1993 |
Severe complications of ulcerative colitis after high-dose prednisolone and azathioprine treatment.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Colonoscopy; Dose-Response Relat | 1999 |
Bone mineral density in the long term after liver transplantation.
Topics: Absorptiometry, Photon; Adolescent; Adult; Anti-Inflammatory Agents; Antimetabolites; Azathioprine; | 2000 |
Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A.
Topics: Absorptiometry, Photon; Azathioprine; Bone Density; Cyclosporine; Drug Therapy, Combination; Femur N | 2001 |
Coincidence of asymptomatic avascular necrosis and fracture of the femoral neck: a rare combination of glucocorticoid induced side effects.
Topics: Azathioprine; Bone Density; Female; Femoral Neck Fractures; Femur Head Necrosis; Humans; Immunosuppr | 2002 |
[Therapy of the chronic destructive, non-purulent cholangitis (primary biliary cirrhosis)].
Topics: Azathioprine; Calcium; Cholangitis; Cholestyramine Resin; Clofibrate; Humans; Hypercholesterolemia; | 1976 |
[Crohn disease: initial experiences with cyclosporin A in an adolescent girl].
Topics: Adolescent; Azathioprine; Crohn Disease; Cyclosporins; Female; Humans; Lymphoma; Osteoporosis; Predn | 1985 |
Immunosuppressive treatment of bronchial asthma.
Topics: Adrenocorticotropic Hormone; Aged; Asthma; Azathioprine; Blood Platelets; Bronchial Diseases; Eosino | 1970 |
[Chronic viral hepatitis in childhood. 24 cases including 5 sibling pairs].
Topics: Adolescent; Agammaglobulinemia; Age Factors; Autoantibodies; Azathioprine; Biopsy; Child; Child, Pre | 1973 |
[What is guaranteed in the therapy of chronic hepatitis?].
Topics: Acne Vulgaris; Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Diabetes Mellitus; Gastrointe | 1973 |
Metabolic studies of bone in uremia before and after treatment.
Topics: Adult; Azathioprine; Bone and Bones; Bone Resorption; Carbon Isotopes; Chronic Kidney Disease-Minera | 1972 |
Renal transplantation in children. Analysis of 25 consecutive transplants in 19 recipients.
Topics: Adolescent; Azathioprine; Child; Female; Graft Rejection; Histocompatibility Testing; Humans; Immuno | 1972 |
Treatment of pemphigus and pemphigoid with azathioprine.
Topics: Aged; Azathioprine; Candidiasis, Cutaneous; Drug Therapy, Combination; Female; Follow-Up Studies; Hu | 1973 |
The treatment of cryptogenic fibrosing alveolitis with immunosuppressant drugs.
Topics: Adult; Agglutination Tests; Antibodies, Antinuclear; Azathioprine; Chlorambucil; Complement Fixation | 1971 |