azathioprine has been researched along with Optic Neuritis in 15 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azathioprine was the treatment prescribed in the four patients with NMOSD." | 1.51 | Inflammatory demyelinating diseases of the central nervous system in Niger. ( Adehossi Omar, É; Assadeck, H; Douma Maiga, D; Hassane Djibo, F; Mamadou, Z; Toudou Daouda, M, 2019) |
| "A new colonoscopy showed moderate ulcerative colitis activity and the patient was declared as a steroid nonresponder." | 1.42 | Irreversible optic neuritis after infliximab treatment in a patient with ulcerative colitis. ( Akrawi, N; Clemmensen, K; Stawowy, M, 2015) |
| "Optic neuritis in Wegener's granulomatosis without signs of orbital involvement is rare and most likely caused by occlusive vasculitis of the vasa nervorum." | 1.39 | Successful remission induction with a combination therapy of rituximab, cyclophosphamide, and steroids in a patient with refractory optic neuritis in Wegener's granulomatosis. ( Holbach, L; Huchzermeyer, C; Mardin, C; Rech, J; Schett, G; Zwerina, J, 2013) |
| "Relapsing polychondritis is a rare disorder of uncertain origin characterized by recurrent inflammation of cartilage." | 1.28 | [Relapsing polychondritis in a patient with myelodysplastic syndrome]. ( Egami, K; Honda, J; Matsuo, K; Naitoh, K; Nakamura, E; Natori, H; Osabe, S; Tanaka, K; Utsunomiya, I; Yoshida, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ssemmanda, S | 1 |
| Musubire, AK | 1 |
| Wong, YYM | 1 |
| Hacohen, Y | 1 |
| Armangue, T | 1 |
| Wassmer, E | 1 |
| Verhelst, H | 1 |
| Hemingway, C | 1 |
| van Pelt, ED | 1 |
| Catsman-Berrevoets, CE | 1 |
| Hintzen, RQ | 1 |
| Deiva, K | 1 |
| Lim, MJ | 1 |
| Rostásy, K | 1 |
| Neuteboom, RF | 1 |
| Assadeck, H | 1 |
| Toudou Daouda, M | 1 |
| Adehossi Omar, É | 1 |
| Mamadou, Z | 1 |
| Hassane Djibo, F | 1 |
| Douma Maiga, D | 1 |
| Alam, M | 1 |
| Haq, MAU | 1 |
| Iqbal, A | 1 |
| Ullah, K | 1 |
| Nabi, D | 1 |
| Clemmensen, K | 1 |
| Akrawi, N | 1 |
| Stawowy, M | 1 |
| Pareja-Esteban, J | 1 |
| Gutiérrez-Solana, S | 1 |
| Cedazo, M | 1 |
| Sánchez-Cordón, B | 1 |
| Gamo-Gallego, M | 1 |
| Teus, MA | 1 |
| Huchzermeyer, C | 1 |
| Mardin, C | 1 |
| Holbach, L | 1 |
| Zwerina, J | 1 |
| Schett, G | 1 |
| Rech, J | 1 |
| García-Gómez, PJ | 1 |
| Belzunce, A | 1 |
| Salinas Alamán, A | 1 |
| Heras, H | 1 |
| Sádaba, LM | 1 |
| Krämer, M | 1 |
| Baumgärtel, MW | 1 |
| Neuen-Jacob, E | 1 |
| Berlit, P | 1 |
| Reder, AT | 1 |
| Antel, JP | 1 |
| Aulhorn, E | 1 |
| Hennerici, M | 1 |
| Kampik, A | 1 |
| Schmidt, D | 1 |
| Schmidt, R | 1 |
| Friedburg, D | 1 |
| Purvin, VA | 1 |
| Chioran, G | 1 |
| García-Tortosa, C | 1 |
| Amrani, Y | 1 |
| Casado, A | 1 |
| Muñoz, FJ | 1 |
| Vázquez, J | 1 |
| Itoyama, Y | 1 |
| Fujihara, K | 1 |
| Nakashima, I | 1 |
| Misu, T | 1 |
| Fujimori, T | 1 |
| Sato, S | 1 |
| Tanaka, K | 1 |
| Nakamura, E | 1 |
| Naitoh, K | 1 |
| Utsunomiya, I | 1 |
| Matsuo, K | 1 |
| Osabe, S | 1 |
| Honda, J | 1 |
| Yoshida, K | 1 |
| Egami, K | 1 |
| Natori, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Continuous Positive Airway Pressure for Fatigue Treatment in Patients With Multiple Sclerosis and Obstructive Sleep Apnea[NCT01563900] | 0 participants (Actual) | Interventional | 2012-02-29 | Withdrawn (stopped due to Was unable to recruit subjects) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for azathioprine and Optic Neuritis
| Article | Year |
|---|---|
[Multiple sclerosis--recent advances in pathogenesis and treatment].
Topics: Autoimmunity; Azathioprine; Cytokines; Glatiramer Acetate; Humans; Immunoglobulins, Intravenous; Imm | 2002 |
14 other studies available for azathioprine and Optic Neuritis
| Article | Year |
|---|---|
Different clinical phenotypes of AQP4-IgG positive NMOSD in two first degree relatives.
Topics: Adult; Autoimmune Diseases; Azathioprine; Female; Gadolinium; HIV Infections; Humans; Immunoglobulin | 2023 |
Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome.
Topics: Adolescent; Autoantibodies; Azathioprine; Child; Child, Preschool; Disease Progression; Encephalomye | 2018 |
Inflammatory demyelinating diseases of the central nervous system in Niger.
Topics: Adult; Aged; Azathioprine; Central Nervous System Diseases; Demyelinating Diseases; Disability Evalu | 2019 |
Sequential Optic Neuritis: A Neuromyelitis Optica Spectrum Disorder.
Topics: Adolescent; Aquaporin 4; Autoantibodies; Azathioprine; Female; Humans; Immunoglobulin G; Neuromyelit | 2019 |
Irreversible optic neuritis after infliximab treatment in a patient with ulcerative colitis.
Topics: Adult; Azathioprine; Blindness; Colitis, Ulcerative; Drug Therapy, Combination; Gastrointestinal Age | 2015 |
[Hypertrophic pachymeningitis and ophthalmological disturbances: description of two case reports].
Topics: Abducens Nerve Diseases; Adrenal Cortex Hormones; Adult; Azathioprine; Cranial Nerves; Dura Mater; F | 2008 |
Successful remission induction with a combination therapy of rituximab, cyclophosphamide, and steroids in a patient with refractory optic neuritis in Wegener's granulomatosis.
Topics: Antibodies, Monoclonal, Murine-Derived; Azathioprine; Cyclophosphamide; Dose-Response Relationship, | 2013 |
[Bilateral recurrent autoimmune optical neuropathy in childhood].
Topics: Autoimmune Diseases; Azathioprine; Child; Female; Humans; Immunosuppressive Agents; Optic Neuritis; | 2006 |
[Myalgia in Neuro-Behçet's disease. Medication side effects or expression of underlying disease].
Topics: Adult; Azathioprine; Behcet Syndrome; Biopsy; Brain Diseases; Cyclosporine; Dose-Response Relationsh | 2008 |
Clinical spectrum of multiple sclerosis.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Age Factors; Azathioprine; Brain Diseas | 1983 |
[Summary of a round table discussion on the therapy of optic nerve neuritis].
Topics: Adrenal Cortex Hormones; Azathioprine; Humans; Multiple Sclerosis; Optic Neuritis | 1983 |
Recurrent neuroretinitis.
Topics: Adult; Azathioprine; Female; Follow-Up Studies; Fundus Oculi; Glucocorticoids; Humans; Male; Optic D | 1994 |
[Blood levels of soluble ICAM-1 in patients with multiple sclerosis].
Topics: Autoimmune Diseases; Azathioprine; Humans; Immunologic Factors; Immunosuppressive Agents; Intercellu | 1998 |
[Relapsing polychondritis in a patient with myelodysplastic syndrome].
Topics: Azathioprine; Dapsone; gamma-Globulins; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Optic | 1990 |