azathioprine has been researched along with Nervous System Disorders in 27 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to prevent exacerbations of multiple sclerosis, immunoglobulin therapy was combined with azathioprine (AZA)." | 7.70 | Combined immunoglobulin and azathioprine in multiple sclerosis. ( Kalanie, H; Tabatabai, SS, 1998) |
| "Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health." | 3.75 | Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. ( Fauci, AS; Haynes, BF; Katz, P; Wolff, SM, 1983) |
| "In an attempt to prevent exacerbations of multiple sclerosis, immunoglobulin therapy was combined with azathioprine (AZA)." | 3.70 | Combined immunoglobulin and azathioprine in multiple sclerosis. ( Kalanie, H; Tabatabai, SS, 1998) |
| "Prednisone dosage was successfully tapered to 10 to 20 mg/d without worsening symptoms in 10 (38%) of the 26 patients studied." | 2.68 | Therapeutic considerations in patients with refractory neurosarcoidosis. ( Agbogu, BN; Sewell, C; Stern, BJ; Yang, G, 1995) |
| "Because autoimmune neurologic disorders are so diverse, evidence from randomized controlled trials is limited for most of the immunotherapies used in neurology." | 2.48 | Immunotherapies in neurologic disorders. ( Graves, D; Vernino, S, 2012) |
| "CINCA syndrome is a genetic disorder characterized by early onset of recurrent fever, rash, progressive articular and neurological involvement." | 1.34 | CINCA Syndrome. ( Khemani, C; Khubchandani, R, 2007) |
| " We evaluate TPMT genotyping and TPMT enzyme activity as predictive tests for developing azathioprine-related adverse events." | 1.33 | Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events. ( Heckmann, JM; Lambson, EM; Little, F; Owen, EP, 2005) |
| "Progressive multiple sclerosis has been held to be irreversible." | 1.31 | Partial and significant reversal of progressive visual and neurological deficits in multiple sclerosis: a possible therapeutic effect. ( Milder, DG, 2002) |
| "Neurosarcoidosis is a rare, but well-recognized cause of hypopituitarism with a predilection for the hypothalamus." | 1.31 | Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion. ( Bouloux, PM; Chamoun, V; Davison, R; Randeva, HS, 2002) |
| "The tremor was coarse, irregular, and unrelated to proprioception loss, muscle weakness, or fatigue; it appeared to represent disease activity or an early sign of a new relapse." | 1.27 | Tremor as a feature of chronic relapsing and dysgammaglobulinemic polyneuropathies. Incidence and management. ( Dalakas, MC; Engel, WK; Teräväinen, H, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (48.15) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| McWilliam, M | 1 |
| Khan, U | 1 |
| Senol, S | 1 |
| Ucar, M | 1 |
| İmamoğlu, H | 1 |
| Yildirim, A | 1 |
| Pareja-Esteban, J | 1 |
| Gutiérrez-Solana, S | 1 |
| Cedazo, M | 1 |
| Sánchez-Cordón, B | 1 |
| Gamo-Gallego, M | 1 |
| Teus, MA | 1 |
| Graves, D | 1 |
| Vernino, S | 1 |
| Milder, DG | 1 |
| Gertner, E | 1 |
| Heckmann, JM | 1 |
| Lambson, EM | 1 |
| Little, F | 1 |
| Owen, EP | 1 |
| Khemani, C | 1 |
| Khubchandani, R | 1 |
| Fauci, AS | 2 |
| Haynes, BF | 1 |
| Katz, P | 1 |
| Wolff, SM | 2 |
| Cordonnier, M | 1 |
| Robin, M | 1 |
| Cornette, M | 1 |
| Brassinne, A | 1 |
| Pirotte, J | 1 |
| Dalakas, MC | 1 |
| Teräväinen, H | 1 |
| Engel, WK | 1 |
| Maas, AI | 1 |
| Busch, HF | 1 |
| van der Heul, C | 1 |
| Agbogu, BN | 1 |
| Stern, BJ | 1 |
| Sewell, C | 1 |
| Yang, G | 1 |
| Gruessner, RW | 1 |
| Kalanie, H | 1 |
| Tabatabai, SS | 1 |
| García-Tortosa, C | 1 |
| Amrani, Y | 1 |
| Casado, A | 1 |
| Muñoz, FJ | 1 |
| Vázquez, J | 1 |
| Randeva, HS | 1 |
| Davison, R | 1 |
| Chamoun, V | 1 |
| Bouloux, PM | 1 |
| Cendrowski, W | 1 |
| Brandt, LJ | 1 |
| Oh, SJ | 1 |
| Joy, JL | 1 |
| Sunwoo, I | 1 |
| Kuruoglu, R | 1 |
| Sabouraud, O | 1 |
| Kahan, BD | 1 |
| Flechner, SM | 1 |
| Lorber, MI | 1 |
| Golden, D | 1 |
| Conley, S | 1 |
| Van Buren, CT | 1 |
| Bryant, GL | 1 |
| Weinblatt, ME | 1 |
| Rumbaugh, C | 1 |
| Coblyn, JS | 1 |
| Dyck, PJ | 1 |
| O'Brien, P | 1 |
| Swanson, C | 1 |
| Low, P | 1 |
| Daube, J | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Horn, RG | 1 |
| Dale, DC | 1 |
| Thomson, TJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II Trial of TNFR:Fc (Etanercept) in Patients With Wegener's Granulomatosis[NCT00001901] | Phase 2 | 60 participants | Interventional | 1999-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for azathioprine and Nervous System Disorders
| Article | Year |
|---|---|
Azathioprine and the neurologist.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Methyltransferases; Nervous System Diseases; Neurolo | 2020 |
Immunotherapies in neurologic disorders.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Antibodies, Mono | 2012 |
Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.
Topics: Adolescent; Adult; Aged; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Administrati | 1983 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
Advances in gastroenterology.
Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Colitis, Ulcerative; Diet; Disaccharides; Du | 1972 |
4 trials available for azathioprine and Nervous System Disorders
| Article | Year |
|---|---|
Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.
Topics: Adolescent; Adult; Aged; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Administrati | 1983 |
Therapeutic considerations in patients with refractory neurosarcoidosis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Female; Humans; Immunosuppressive | 1995 |
Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Bone Marrow Transplantation; Case-Control Studies; Cy | 1997 |
Combined azathioprine and prednisone in chronic inflammatory-demyelinating polyneuropathy.
Topics: Adult; Aged; Azathioprine; Demyelinating Diseases; Drug Combinations; Female; Humans; Male; Middle A | 1985 |
19 other studies available for azathioprine and Nervous System Disorders
| Article | Year |
|---|---|
Neuro-Behçet's disease mimicking a cranial tumour.
Topics: Azathioprine; Behcet Syndrome; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Ma | 2015 |
[Hypertrophic pachymeningitis and ophthalmological disturbances: description of two case reports].
Topics: Abducens Nerve Diseases; Adrenal Cortex Hormones; Adult; Azathioprine; Cranial Nerves; Dura Mater; F | 2008 |
Partial and significant reversal of progressive visual and neurological deficits in multiple sclerosis: a possible therapeutic effect.
Topics: Adult; Azathioprine; Disease Progression; Drug Therapy, Combination; Female; Glatiramer Acetate; Hum | 2002 |
Severe recurrent neurological disease in the MAGIC syndrome.
Topics: Administration, Oral; Adult; Azathioprine; Behcet Syndrome; Genital Diseases, Male; Humans; Immunosu | 2004 |
Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events.
Topics: Adult; Analysis of Variance; Azathioprine; Black People; Evaluation Studies as Topic; Female; Gene F | 2005 |
CINCA Syndrome.
Topics: Age Factors; Arthritis; Azathioprine; Carrier Proteins; Child; Chronic Disease; Erythema; Female; Fe | 2007 |
[Neurologic complications of celiac disease in adults. Apropos of a case].
Topics: Aged; Azathioprine; Celiac Disease; Combined Modality Therapy; Female; Humans; Methylprednisolone; N | 1983 |
Tremor as a feature of chronic relapsing and dysgammaglobulinemic polyneuropathies. Incidence and management.
Topics: Adolescent; Adult; Azathioprine; Chronic Disease; Dysgammaglobulinemia; Humans; Hypergammaglobulinem | 1984 |
Plasma infusion and plasma exchange in chronic idiopathic polyneuropathy.
Topics: Azathioprine; Chronic Disease; Humans; Male; Middle Aged; Nervous System Diseases; Plasma; Plasma Ex | 1981 |
Combined immunoglobulin and azathioprine in multiple sclerosis.
Topics: Adolescent; Adult; Azathioprine; Female; Humans; Immunization, Passive; Immunoglobulins, Intravenous | 1998 |
[Blood levels of soluble ICAM-1 in patients with multiple sclerosis].
Topics: Autoimmune Diseases; Azathioprine; Humans; Immunologic Factors; Immunosuppressive Agents; Intercellu | 1998 |
Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion.
Topics: Antimetabolites; Azathioprine; Female; Humans; Leukocyte Count; Liver; Magnetic Resonance Imaging; M | 2002 |
Treatment of polyneuropathy with azathioprine and adrenal steroids.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Female; Humans; Male; Middle Aged; N | 1977 |
Formication and azathioprine therapy.
Topics: Ants; Azathioprine; Drug Hypersensitivity; Female; Humans; Middle Aged; Nervous System Diseases; Sen | 1977 |
A case of chronic sensory demyelinating neuropathy responding to immunotherapies.
Topics: Azathioprine; Demyelinating Diseases; Humans; Immunotherapy; Male; Middle Aged; Nervous System Disea | 1992 |
[Immunodepressive agents in neurology].
Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Cyclophosphamide; Dermatomyositis; Huma | 1986 |
Complications of cyclosporine-prednisone immunosuppression in 402 renal allograft recipients exclusively followed at a single center for from one to five years.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Cyclosporins; Follow-Up Studies; Gra | 1987 |
Cerebral vasculopathy: an analysis of sixteen cases.
Topics: Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Blood Sedimentation; Cerebral Angiography; Cereb | 1986 |
Wegener's granulomatosis.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Diagnosis, Differe | 1974 |