azathioprine has been researched along with Nervous System Diseases in 27 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to prevent exacerbations of multiple sclerosis, immunoglobulin therapy was combined with azathioprine (AZA)." | 7.70 | Combined immunoglobulin and azathioprine in multiple sclerosis. ( Kalanie, H; Tabatabai, SS, 1998) |
| "Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health." | 3.75 | Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. ( Fauci, AS; Haynes, BF; Katz, P; Wolff, SM, 1983) |
| "In an attempt to prevent exacerbations of multiple sclerosis, immunoglobulin therapy was combined with azathioprine (AZA)." | 3.70 | Combined immunoglobulin and azathioprine in multiple sclerosis. ( Kalanie, H; Tabatabai, SS, 1998) |
| "Prednisone dosage was successfully tapered to 10 to 20 mg/d without worsening symptoms in 10 (38%) of the 26 patients studied." | 2.68 | Therapeutic considerations in patients with refractory neurosarcoidosis. ( Agbogu, BN; Sewell, C; Stern, BJ; Yang, G, 1995) |
| "Because autoimmune neurologic disorders are so diverse, evidence from randomized controlled trials is limited for most of the immunotherapies used in neurology." | 2.48 | Immunotherapies in neurologic disorders. ( Graves, D; Vernino, S, 2012) |
| "CINCA syndrome is a genetic disorder characterized by early onset of recurrent fever, rash, progressive articular and neurological involvement." | 1.34 | CINCA Syndrome. ( Khemani, C; Khubchandani, R, 2007) |
| " We evaluate TPMT genotyping and TPMT enzyme activity as predictive tests for developing azathioprine-related adverse events." | 1.33 | Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events. ( Heckmann, JM; Lambson, EM; Little, F; Owen, EP, 2005) |
| "Progressive multiple sclerosis has been held to be irreversible." | 1.31 | Partial and significant reversal of progressive visual and neurological deficits in multiple sclerosis: a possible therapeutic effect. ( Milder, DG, 2002) |
| "Neurosarcoidosis is a rare, but well-recognized cause of hypopituitarism with a predilection for the hypothalamus." | 1.31 | Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion. ( Bouloux, PM; Chamoun, V; Davison, R; Randeva, HS, 2002) |
| "The tremor was coarse, irregular, and unrelated to proprioception loss, muscle weakness, or fatigue; it appeared to represent disease activity or an early sign of a new relapse." | 1.27 | Tremor as a feature of chronic relapsing and dysgammaglobulinemic polyneuropathies. Incidence and management. ( Dalakas, MC; Engel, WK; Teräväinen, H, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (48.15) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| McWilliam, M | 1 |
| Khan, U | 1 |
| Senol, S | 1 |
| Ucar, M | 1 |
| İmamoğlu, H | 1 |
| Yildirim, A | 1 |
| Pareja-Esteban, J | 1 |
| Gutiérrez-Solana, S | 1 |
| Cedazo, M | 1 |
| Sánchez-Cordón, B | 1 |
| Gamo-Gallego, M | 1 |
| Teus, MA | 1 |
| Graves, D | 1 |
| Vernino, S | 1 |
| Milder, DG | 1 |
| Gertner, E | 1 |
| Heckmann, JM | 1 |
| Lambson, EM | 1 |
| Little, F | 1 |
| Owen, EP | 1 |
| Khemani, C | 1 |
| Khubchandani, R | 1 |
| Fauci, AS | 2 |
| Haynes, BF | 1 |
| Katz, P | 1 |
| Wolff, SM | 2 |
| Cordonnier, M | 1 |
| Robin, M | 1 |
| Cornette, M | 1 |
| Brassinne, A | 1 |
| Pirotte, J | 1 |
| Dalakas, MC | 1 |
| Teräväinen, H | 1 |
| Engel, WK | 1 |
| Maas, AI | 1 |
| Busch, HF | 1 |
| van der Heul, C | 1 |
| Agbogu, BN | 1 |
| Stern, BJ | 1 |
| Sewell, C | 1 |
| Yang, G | 1 |
| Gruessner, RW | 1 |
| Kalanie, H | 1 |
| Tabatabai, SS | 1 |
| García-Tortosa, C | 1 |
| Amrani, Y | 1 |
| Casado, A | 1 |
| Muñoz, FJ | 1 |
| Vázquez, J | 1 |
| Randeva, HS | 1 |
| Davison, R | 1 |
| Chamoun, V | 1 |
| Bouloux, PM | 1 |
| Cendrowski, W | 1 |
| Brandt, LJ | 1 |
| Oh, SJ | 1 |
| Joy, JL | 1 |
| Sunwoo, I | 1 |
| Kuruoglu, R | 1 |
| Sabouraud, O | 1 |
| Kahan, BD | 1 |
| Flechner, SM | 1 |
| Lorber, MI | 1 |
| Golden, D | 1 |
| Conley, S | 1 |
| Van Buren, CT | 1 |
| Bryant, GL | 1 |
| Weinblatt, ME | 1 |
| Rumbaugh, C | 1 |
| Coblyn, JS | 1 |
| Dyck, PJ | 1 |
| O'Brien, P | 1 |
| Swanson, C | 1 |
| Low, P | 1 |
| Daube, J | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Horn, RG | 1 |
| Dale, DC | 1 |
| Thomson, TJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II Trial of TNFR:Fc (Etanercept) in Patients With Wegener's Granulomatosis[NCT00001901] | Phase 2 | 60 participants | Interventional | 1999-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for azathioprine and Nervous System Diseases
| Article | Year |
|---|---|
Azathioprine and the neurologist.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Methyltransferases; Nervous System Diseases; Neurolo | 2020 |
Immunotherapies in neurologic disorders.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Antibodies, Mono | 2012 |
Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.
Topics: Adolescent; Adult; Aged; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Administrati | 1983 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
Advances in gastroenterology.
Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Colitis, Ulcerative; Diet; Disaccharides; Du | 1972 |
4 trials available for azathioprine and Nervous System Diseases
| Article | Year |
|---|---|
Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.
Topics: Adolescent; Adult; Aged; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Administrati | 1983 |
Therapeutic considerations in patients with refractory neurosarcoidosis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Female; Humans; Immunosuppressive | 1995 |
Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Bone Marrow Transplantation; Case-Control Studies; Cy | 1997 |
Combined azathioprine and prednisone in chronic inflammatory-demyelinating polyneuropathy.
Topics: Adult; Aged; Azathioprine; Demyelinating Diseases; Drug Combinations; Female; Humans; Male; Middle A | 1985 |
19 other studies available for azathioprine and Nervous System Diseases
| Article | Year |
|---|---|
Neuro-Behçet's disease mimicking a cranial tumour.
Topics: Azathioprine; Behcet Syndrome; Diagnosis, Differential; Female; Humans; Immunosuppressive Agents; Ma | 2015 |
[Hypertrophic pachymeningitis and ophthalmological disturbances: description of two case reports].
Topics: Abducens Nerve Diseases; Adrenal Cortex Hormones; Adult; Azathioprine; Cranial Nerves; Dura Mater; F | 2008 |
Partial and significant reversal of progressive visual and neurological deficits in multiple sclerosis: a possible therapeutic effect.
Topics: Adult; Azathioprine; Disease Progression; Drug Therapy, Combination; Female; Glatiramer Acetate; Hum | 2002 |
Severe recurrent neurological disease in the MAGIC syndrome.
Topics: Administration, Oral; Adult; Azathioprine; Behcet Syndrome; Genital Diseases, Male; Humans; Immunosu | 2004 |
Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events.
Topics: Adult; Analysis of Variance; Azathioprine; Black People; Evaluation Studies as Topic; Female; Gene F | 2005 |
CINCA Syndrome.
Topics: Age Factors; Arthritis; Azathioprine; Carrier Proteins; Child; Chronic Disease; Erythema; Female; Fe | 2007 |
[Neurologic complications of celiac disease in adults. Apropos of a case].
Topics: Aged; Azathioprine; Celiac Disease; Combined Modality Therapy; Female; Humans; Methylprednisolone; N | 1983 |
Tremor as a feature of chronic relapsing and dysgammaglobulinemic polyneuropathies. Incidence and management.
Topics: Adolescent; Adult; Azathioprine; Chronic Disease; Dysgammaglobulinemia; Humans; Hypergammaglobulinem | 1984 |
Plasma infusion and plasma exchange in chronic idiopathic polyneuropathy.
Topics: Azathioprine; Chronic Disease; Humans; Male; Middle Aged; Nervous System Diseases; Plasma; Plasma Ex | 1981 |
Combined immunoglobulin and azathioprine in multiple sclerosis.
Topics: Adolescent; Adult; Azathioprine; Female; Humans; Immunization, Passive; Immunoglobulins, Intravenous | 1998 |
[Blood levels of soluble ICAM-1 in patients with multiple sclerosis].
Topics: Autoimmune Diseases; Azathioprine; Humans; Immunologic Factors; Immunosuppressive Agents; Intercellu | 1998 |
Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion.
Topics: Antimetabolites; Azathioprine; Female; Humans; Leukocyte Count; Liver; Magnetic Resonance Imaging; M | 2002 |
Treatment of polyneuropathy with azathioprine and adrenal steroids.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Female; Humans; Male; Middle Aged; N | 1977 |
Formication and azathioprine therapy.
Topics: Ants; Azathioprine; Drug Hypersensitivity; Female; Humans; Middle Aged; Nervous System Diseases; Sen | 1977 |
A case of chronic sensory demyelinating neuropathy responding to immunotherapies.
Topics: Azathioprine; Demyelinating Diseases; Humans; Immunotherapy; Male; Middle Aged; Nervous System Disea | 1992 |
[Immunodepressive agents in neurology].
Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Cyclophosphamide; Dermatomyositis; Huma | 1986 |
Complications of cyclosporine-prednisone immunosuppression in 402 renal allograft recipients exclusively followed at a single center for from one to five years.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Cyclosporins; Follow-Up Studies; Gra | 1987 |
Cerebral vasculopathy: an analysis of sixteen cases.
Topics: Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Blood Sedimentation; Cerebral Angiography; Cereb | 1986 |
Wegener's granulomatosis.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Diagnosis, Differe | 1974 |