azathioprine has been researched along with Nausea in 35 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-two patients with severe rheumatoid arthritis (RA) from four Australian centres were randomised to receive cyclosporin A (CSA) (n = 25) or azathioprine (AZA) (n = 27) for six months." | 9.07 | A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis. ( Ahern, MJ; Bayliss, C; Bradley, J; Harrison, W; Hollingsworth, P; Laing, B, 1991) |
| "Sixty-five patients, 33 receiving azathioprine and 32 receiving penicillamine, took part in a one-year, single-blind external-observer trial designed to compare the efficacy and toxicity of these two drugs in the treatment of rheumatoid arthritis." | 9.04 | Azathioprine and penicillamine in treatment of rheumatoid arthritis: a controlled trial. ( Barnes, CG; Berger, LA; Berry, H; Durance, RA; Evans, S; Liyanage, SP, 1976) |
| "To determine whether the presence of thiopurine methyltransferase (TPMT) alleles associated with reduced or absent activity of thiopurine methyltransferase is a major factor for withdrawal of azathioprine (AZA) in rheumatoid arthritis (RA) patients." | 7.72 | Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients? ( Baiget, M; Corominas, H; de Cuevillas, F; Díaz, C; Domènech, M; Geli, C; Gich, I; Laíz, A; Moreno, M; Vázquez, G, 2003) |
| "Our experience with azathioprine in the treatment of rheumatoid arthritis covers ten years, during which 91 rheumatoid patients (66 female and 25 male) received this drug, with a median treatment period of 36 months." | 7.66 | Side-effects of azathioprine treatment in rheumatoid arthritis: analysis of 10 years of experience. ( Boerbooms, AM; Kruijsen, MW; Speerstra, F; van Beusekom, HJ; van de Putte, LB; Vandenbroucke, JP, 1982) |
| "A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease." | 7.66 | Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982) |
| "Azathioprine treatment benefited 19 (66%) out of 29 patients suffering from severe psoriasis." | 7.65 | Treatment of psoriasis with azathioprine. ( Du Vivier, A; Munro, DD; Verbov, J, 1974) |
| "Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases." | 5.51 | Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019) |
| "Azathioprine was administrated to all of them for periods varying from two and a half to six months." | 5.25 | The effect of azathioprine on gastric mucosal histology and acid secretion in chronic gastritis. ( Jorge, AD; Sanchez, D, 1973) |
| "Fifty-two patients with severe rheumatoid arthritis (RA) from four Australian centres were randomised to receive cyclosporin A (CSA) (n = 25) or azathioprine (AZA) (n = 27) for six months." | 5.07 | A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis. ( Ahern, MJ; Bayliss, C; Bradley, J; Harrison, W; Hollingsworth, P; Laing, B, 1991) |
| "Sixty-five patients, 33 receiving azathioprine and 32 receiving penicillamine, took part in a one-year, single-blind external-observer trial designed to compare the efficacy and toxicity of these two drugs in the treatment of rheumatoid arthritis." | 5.04 | Azathioprine and penicillamine in treatment of rheumatoid arthritis: a controlled trial. ( Barnes, CG; Berger, LA; Berry, H; Durance, RA; Evans, S; Liyanage, SP, 1976) |
| " Azathioprine has a significant early adverse reaction (EAR) profile, which includes an acute syndrome of constitutional symptoms, fever, rash, and acute pancreatitis and often requires discontinuation of drug." | 3.73 | Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. ( Bajaj, JS; Binion, DG; Emmons, J; Franco, J; Knox, JF; Levy, M; Podoll, J; Saeian, K; Varma, RR, 2005) |
| "To determine whether the presence of thiopurine methyltransferase (TPMT) alleles associated with reduced or absent activity of thiopurine methyltransferase is a major factor for withdrawal of azathioprine (AZA) in rheumatoid arthritis (RA) patients." | 3.72 | Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients? ( Baiget, M; Corominas, H; de Cuevillas, F; Díaz, C; Domènech, M; Geli, C; Gich, I; Laíz, A; Moreno, M; Vázquez, G, 2003) |
| "Studies on azathioprine (Aza) treatment in Crohn disease have indicated a positive correlation between clinical remission and a concentration in erythrocytes of the metabolites 6-thioguanine nucleotides (E-6-TGN) above 230 pmol/8 x 10(8) RBC." | 3.72 | Pharmacological monitoring of azathioprine therapy. ( Christensen, S; Haaber, A; Johansen, N; Kjeldsen, J; Larsen, B; Larsen, NE; Rasmussen, SN; Reuther, LO; Schmiegelow, K; Sonne, J; Tofteng, F, 2003) |
| "We describe two patients with rheumatic disease who developed nausea, vomiting, fever and diarrhea after a single dose of azathioprine." | 3.67 | Adverse reactions to azathioprine mimicking gastroenteritis. ( Assini, JF; Hamilton, R; Strosberg, JM, 1986) |
| "Our experience with azathioprine in the treatment of rheumatoid arthritis covers ten years, during which 91 rheumatoid patients (66 female and 25 male) received this drug, with a median treatment period of 36 months." | 3.66 | Side-effects of azathioprine treatment in rheumatoid arthritis: analysis of 10 years of experience. ( Boerbooms, AM; Kruijsen, MW; Speerstra, F; van Beusekom, HJ; van de Putte, LB; Vandenbroucke, JP, 1982) |
| "A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease." | 3.66 | Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982) |
| "Azathioprine treatment benefited 19 (66%) out of 29 patients suffering from severe psoriasis." | 3.65 | Treatment of psoriasis with azathioprine. ( Du Vivier, A; Munro, DD; Verbov, J, 1974) |
| "Corticosteroids are the systemic treatment of choice in patients with pemphigus vulgaris, but chronic administration is associated with side effects." | 2.74 | [Prolonged complete clinical remission in patients with severe pemphigus vulgaris after cycles of intravenous cyclophosphamide]. ( Aguado, L; España Alonso, A; Fernández, S; Marquina, M; Panizo, C; Pretel, M; Sánchez-Ibarrola, A, 2009) |
| "Rates of malignancy were within published ranges for transplant recipients." | 2.68 | Mycophenolate mofetil for maintenance therapy in kidney transplantation. ( Gonwa, TA, 1996) |
| " Fortunately, the absolute incidence of serious toxicity remains low, and an improved understanding of how best to minimize risk and the recognition of groups of patients at higher risk of toxicity from thiopurines means that they remain a relatively safe therapy in the majority of patients." | 2.52 | Toxicity and response to thiopurines in patients with inflammatory bowel disease. ( Goldberg, R; Irving, PM, 2015) |
| "Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases." | 1.51 | Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019) |
| " However, nearly 20% of patients discontinue thiopurines due to adverse events." | 1.43 | Genetic Predictors of Azathioprine Toxicity and Clinical Response in Patients with Inflammatory Bowel Disease. ( Al-Judaibi, B; Chande, N; Dresser, GK; Gregor, JC; Huda, N; Kim, RB; Mosli, M; Ponich, T; Schwarz, UI, 2016) |
| " Systemic treatment usually begins with high dosage corticosteroids." | 1.42 | Atypical Cogan's syndrome: a case report and summary of current treatment options. ( Jančatová, D; Komínek, P; Matoušek, P; Zeleník, K, 2015) |
| "Azathioprine was administrated to all of them for periods varying from two and a half to six months." | 1.25 | The effect of azathioprine on gastric mucosal histology and acid secretion in chronic gastritis. ( Jorge, AD; Sanchez, D, 1973) |
| "Azathioprine (Imuran) was administered to seven patients with ulcerative colitis suffering from a relapse which could not be controlled by adrenocortical steroids." | 1.25 | Treatment of ulcerative colitis with azathioprine. ( Gilon, E; Theodor, E; Waks, U, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (40.00) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 10 (28.57) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Stanich, PP | 1 |
| Lujan, G | 1 |
| Hosmer, A | 1 |
| Macaluso, FS | 1 |
| Renna, S | 1 |
| Maida, M | 1 |
| Dimarco, M | 1 |
| Sapienza, C | 1 |
| Affronti, M | 1 |
| Orlando, E | 1 |
| Rizzuto, G | 1 |
| Orlando, R | 1 |
| Ventimiglia, M | 1 |
| Cottone, M | 1 |
| Orlando, A | 1 |
| Zhang, Y | 1 |
| Kou, G | 1 |
| Li, Y | 2 |
| Gisi, K | 1 |
| Ispiroglu, M | 1 |
| Kantarceken, B | 1 |
| Sayar, H | 1 |
| Frapard, T | 1 |
| Amoura, Z | 1 |
| Pineton de Chambrun, M | 1 |
| Jančatová, D | 1 |
| Zeleník, K | 1 |
| Komínek, P | 1 |
| Matoušek, P | 1 |
| Goldberg, R | 1 |
| Irving, PM | 1 |
| Actis, GC | 1 |
| Pellicano, R | 1 |
| Rosina, F | 1 |
| Al-Judaibi, B | 1 |
| Schwarz, UI | 1 |
| Huda, N | 1 |
| Dresser, GK | 1 |
| Gregor, JC | 1 |
| Ponich, T | 1 |
| Chande, N | 1 |
| Mosli, M | 1 |
| Kim, RB | 1 |
| España Alonso, A | 1 |
| Panizo, C | 1 |
| Fernández, S | 1 |
| Marquina, M | 1 |
| Pretel, M | 1 |
| Aguado, L | 1 |
| Sánchez-Ibarrola, A | 1 |
| Meggitt, SJ | 1 |
| Anstey, AV | 1 |
| Mohd Mustapa, MF | 1 |
| Reynolds, NJ | 1 |
| Wakelin, S | 1 |
| Seinen, ML | 1 |
| van Asseldonk, DP | 1 |
| de Boer, NK | 1 |
| Losekoot, N | 1 |
| Smid, K | 1 |
| Mulder, CJ | 1 |
| Bouma, G | 1 |
| Peters, GJ | 1 |
| van Bodegraven, AA | 1 |
| Corominas, H | 1 |
| Domènech, M | 1 |
| Laíz, A | 1 |
| Gich, I | 1 |
| Geli, C | 1 |
| Díaz, C | 1 |
| de Cuevillas, F | 1 |
| Moreno, M | 1 |
| Vázquez, G | 1 |
| Baiget, M | 1 |
| Reuther, LO | 1 |
| Sonne, J | 1 |
| Larsen, NE | 1 |
| Larsen, B | 1 |
| Christensen, S | 1 |
| Rasmussen, SN | 1 |
| Tofteng, F | 1 |
| Haaber, A | 1 |
| Johansen, N | 1 |
| Kjeldsen, J | 1 |
| Schmiegelow, K | 1 |
| Bajaj, JS | 1 |
| Saeian, K | 1 |
| Varma, RR | 1 |
| Franco, J | 1 |
| Knox, JF | 1 |
| Podoll, J | 1 |
| Emmons, J | 1 |
| Levy, M | 1 |
| Binion, DG | 1 |
| Duley, JA | 1 |
| Florin, TH | 1 |
| Speerstra, F | 1 |
| Boerbooms, AM | 1 |
| van de Putte, LB | 1 |
| van Beusekom, HJ | 1 |
| Kruijsen, MW | 1 |
| Vandenbroucke, JP | 1 |
| Whisnant, JK | 1 |
| Pelkey, J | 1 |
| Kanamaru, A | 1 |
| Takemoto, Y | 1 |
| Kakishita, E | 1 |
| Dohy, H | 1 |
| Kodera, Y | 1 |
| Moriyama, Y | 1 |
| Shibata, A | 1 |
| Kasai, M | 1 |
| Katoh, S | 1 |
| Saitoh, H | 1 |
| Gonwa, TA | 1 |
| Lear, JT | 1 |
| English, JS | 1 |
| Jones, P | 1 |
| Smith, AG | 1 |
| Craner, MJ | 1 |
| Zajicek, JP | 1 |
| Berry, H | 1 |
| Liyanage, SP | 1 |
| Durance, RA | 1 |
| Barnes, CG | 1 |
| Berger, LA | 1 |
| Evans, S | 1 |
| Ahern, MJ | 1 |
| Harrison, W | 1 |
| Hollingsworth, P | 1 |
| Bradley, J | 1 |
| Laing, B | 1 |
| Bayliss, C | 1 |
| Assini, JF | 1 |
| Hamilton, R | 1 |
| Strosberg, JM | 1 |
| Brooke, BN | 1 |
| Javett, SL | 1 |
| Davison, OW | 1 |
| Jewell, DP | 1 |
| Truelove, SC | 1 |
| Dale, I | 1 |
| Jorge, AD | 1 |
| Sanchez, D | 1 |
| Du Vivier, A | 1 |
| Munro, DD | 1 |
| Verbov, J | 1 |
| Enderlin, M | 1 |
| Swannell, AJ | 1 |
| Kersley, GD | 1 |
| Kämpfen, P | 1 |
| Hodler, J | 1 |
| Theodor, E | 1 |
| Gilon, E | 1 |
| Waks, U | 1 |
3 reviews available for azathioprine and Nausea
| Article | Year |
|---|---|
Toxicity and response to thiopurines in patients with inflammatory bowel disease.
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Crohn Disease; Humans; Im | 2015 |
6-Mercaptopurine for Azathioprine Intolerant Inflammatory Bowel Disease: Literature Search and Reappraisal of Own Data.
Topics: Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Substi | 2015 |
Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.
Topics: Azathioprine; Drug Monitoring; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Leukopenia; Me | 2005 |
6 trials available for azathioprine and Nausea
| Article | Year |
|---|---|
[Prolonged complete clinical remission in patients with severe pemphigus vulgaris after cycles of intravenous cyclophosphamide].
Topics: Adrenal Cortex Hormones; Adult; Autoantibodies; Autoantigens; Azathioprine; Cyclophosphamide; Desmog | 2009 |
FK506 treatment of graft-versus-host disease developing or exacerbating during prophylaxis and therapy with cyclosporin and/or other immunosuppressants. Japanese FK506 BMT Study Group.
Topics: Acute Disease; Adolescent; Adult; Azathioprine; Bone Marrow Transplantation; Child; Chronic Disease; | 1995 |
Mycophenolate mofetil for maintenance therapy in kidney transplantation.
Topics: Antilymphocyte Serum; Azathioprine; Cytomegalovirus Infections; Diarrhea; Double-Blind Method; Graft | 1996 |
Azathioprine and penicillamine in treatment of rheumatoid arthritis: a controlled trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Blood Sedimentation; Clinical Trials as Topic; Fem | 1976 |
A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Blood Pressure; Creatinine; Cyclosporine; Double-B | 1991 |
Azathioprine in ulcerative colitis: final report on controlled therapeutic trial.
Topics: Acute Disease; Adult; Azathioprine; Biopsy; Colitis, Ulcerative; Diarrhea; Erythema; Female; Humans; | 1974 |
26 other studies available for azathioprine and Nausea
| Article | Year |
|---|---|
Nausea and Diarrhea with Fingernail and Hair Changes.
Topics: Alopecia; Azathioprine; Diarrhea; Drug Tapering; Female; Humans; Immunosuppressive Agents; Intestina | 2021 |
Tolerability profile of thiopurines in inflammatory bowel disease: a prospective experience.
Topics: Adult; Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Italy; K | 2017 |
A woman with intractable nausea and vomiting.
Topics: Adult; Alkalosis; Antiemetics; Azathioprine; Delayed Diagnosis; Female; Functional Neuroimaging; Hum | 2018 |
Severe cholestasis due to azathioprine in Behcet's disease.
Topics: Adult; Azathioprine; Behcet Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; I | 2019 |
Intractable Nausea and Vomiting: Gut Is Not Always the Answer.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Female; Humans; Immunosuppressive Agents; Magnetic Res | 2019 |
Atypical Cogan's syndrome: a case report and summary of current treatment options.
Topics: Adolescent; Azathioprine; Cogan Syndrome; Female; Glucocorticoids; Hearing Loss, Bilateral; Hearing | 2015 |
Genetic Predictors of Azathioprine Toxicity and Clinical Response in Patients with Inflammatory Bowel Disease.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Diarrhea; Female; Follow-Up Studies; Genetic Markers; | 2016 |
British Association of Dermatologists' guidelines for the safe and effective prescribing of azathioprine 2011.
Topics: Abnormalities, Drug-Induced; Adult; Aged; Azathioprine; Bone Marrow Diseases; Chemical and Drug Indu | 2011 |
The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study.
Topics: Adult; Allopurinol; Azathioprine; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; F | 2013 |
Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients?
Topics: 5' Untranslated Regions; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Case-Control Stu | 2003 |
Pharmacological monitoring of azathioprine therapy.
Topics: Adult; Aged; Antimetabolites; Azathioprine; Crohn Disease; Cross-Sectional Studies; Drug Monitoring; | 2003 |
Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Arthralgia; Azathioprine; Crohn Disease; Disease Sus | 2005 |
Side-effects of azathioprine treatment in rheumatoid arthritis: analysis of 10 years of experience.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Bacterial Infections; Bone Marrow; Cardiovascular Disease | 1982 |
Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities.
Topics: Adult; Aged; Anorexia; Arthritis, Rheumatoid; Azathioprine; Bacterial Infections; Chemical and Drug | 1982 |
Retrospective review of the use of azathioprine in severe atopic dermatitis.
Topics: Abdominal Pain; Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Dermatitis, Atopic; | 1996 |
Immunosuppressive treatments in MS--side effects from azathioprine.
Topics: Azathioprine; Drug Hypersensitivity; Humans; Immunosuppressive Agents; Multiple Sclerosis; Nausea; P | 2001 |
Adverse reactions to azathioprine mimicking gastroenteritis.
Topics: Azathioprine; Diarrhea; Female; Fever; Gastrointestinal Diseases; Humans; Middle Aged; Nausea; Vomit | 1986 |
Further experience with azathioprine for Crohn's disease.
Topics: Adolescent; Adult; Azathioprine; Crohn Disease; Female; Humans; Intestinal Fistula; Klebsiella Infec | 1970 |
The treatment of rheumatoid arthritis with azathioprine.
Topics: Adolescent; Arthritis, Juvenile; Azathioprine; Child; Child, Preschool; Female; Humans; Male; Nausea | 1972 |
The effect of azathioprine on gastric mucosal histology and acid secretion in chronic gastritis.
Topics: Adult; Aged; Azathioprine; Biopsy; Female; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Male; M | 1973 |
Azathioprine in Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Intestinal Fistula; Leukopenia; Nausea | 1973 |
Treatment of psoriasis with azathioprine.
Topics: Alcohol Drinking; Anemia; Azathioprine; Biopsy; Blood Cell Count; Chemical and Drug Induced Liver In | 1974 |
[Experiences with antimetabolite therapy of malignant forms of progressive chronic polyarthritis].
Topics: Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Feeding and Eating Disorders; | 1966 |
Preliminary results with azathioprine treatment in rheumatoid arthritis.
Topics: Alkaline Phosphatase; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Drug Synergism; Fem | 1969 |
[Treatment of chronic glomerulonephritis with imuran].
Topics: Adolescent; Adult; Aged; Azathioprine; Biopsy; Blood Sedimentation; Child; Chronic Disease; Colic; D | 1970 |
Treatment of ulcerative colitis with azathioprine.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Colitis, Ulcerative; Female; Humans; Leuko | 1968 |