azathioprine has been researched along with Myelodysplastic Syndromes in 26 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 7.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "Azathioprine (Aza) is a widely used immunosuppressive drug in multiple sclerosis (MS) treatment." | 7.73 | Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis. ( Diener, HC; Germing, U; Knipp, S; Limmroth, V; Putzki, N; Ramczykowski, T; Vago, S, 2006) |
| "A woman with relapsing-remitting multiple sclerosis (MS) was treated with oral azathioprine (AZA) for 4 years and subsequently switched to interferon-beta1a." | 7.73 | Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosis. ( Al-Ali, HK; Niederwieser, D; Niklas, A; Schwarz, J; Strauss, A; Then Bergh, F; von Ahsen, N; Wagner, A, 2006) |
| "Azathioprine is widely used in patients with autoimmune diseases and after organ allografting." | 4.86 | Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia. ( Kwong, YL, 2010) |
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 3.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "Azathioprine (Aza) is a widely used immunosuppressive drug in multiple sclerosis (MS) treatment." | 3.73 | Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis. ( Diener, HC; Germing, U; Knipp, S; Limmroth, V; Putzki, N; Ramczykowski, T; Vago, S, 2006) |
| "A woman with relapsing-remitting multiple sclerosis (MS) was treated with oral azathioprine (AZA) for 4 years and subsequently switched to interferon-beta1a." | 3.73 | Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosis. ( Al-Ali, HK; Niederwieser, D; Niklas, A; Schwarz, J; Strauss, A; Then Bergh, F; von Ahsen, N; Wagner, A, 2006) |
| "Treatment with azathioprine may - depending on its cumulative dosage - lead to pancytopenia and subsequent development of myelodysplasia or secondary leukaemia, respectively." | 3.72 | [Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations]. ( Kaiser, U; Schlegelberger, B; Wilkens, L; Willerding-Möllmann, S, 2004) |
| "We describe a case of spontaneously reversible refractory anaemia, a subtype of myelodysplastic syndrome (MDS), with monosomy 7 secondary to chronic treatment with azathioprine (AZA) in a young renal transplant recipient." | 3.69 | Spontaneous remission in a patient with therapy-related myelodysplastic syndrome (t-MDS) with monosomy 7. ( De Mulder, A; Ferster, A; Hansen, V; Heimann, P; Jannsen, F; Renneboog, B, 1996) |
| "A 71-year-old man developed ulcerative colitis (UC) at 48 years of age." | 1.72 | [A case of "colitis-like intestinal Behçet's disease" accompanied by ulcerative colitis after the development of myelodysplastic syndrome]. ( Hara, E; Kamakura, M; Kitabatake, H; Kondo, S; Kunimoto, H; Nakamura, A; Ochi, Y; Saito, H; Seki, A, 2022) |
| "that describes potential risk of acute myeloid leukemia or myeloproliferative disorder among thiopurine therapy." | 1.62 | The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits? ( Ha, C, 2021) |
| "Azathioprine sodium use was observed more frequently in cases (odds ratio [OR], 7." | 1.46 | Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia. ( Al-Kali, A; Castro, J; Dueck, A; Ertz-Archambault, N; Finn, L; Foran, J; Gauthier, S; Kelemen, K; Kosiorek, H; Marino, R; Mesa, RA; Palmer, J; Sproat, LZ; Taylor, GE; Tibes, R, 2017) |
| "Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality." | 1.38 | Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus. ( Besbas, N; Bilginer, Y; Bulus, D; Cetin, M; Gokce, M; Gumruk, F, 2012) |
| " The long-term use of immunodulating agents in patients with CD is not without risks, and early therapy related myelodysplasia might not be easily detected by blood count and morphology assessment alone." | 1.31 | Clonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: a cautionary tale. ( Au, WY; Lai, KC; Ma, SK; Wan, TS; Yuen, MF, 2002) |
| "Relapsing polychondritis is a rare disorder of uncertain origin characterized by recurrent inflammation of cartilage." | 1.28 | [Relapsing polychondritis in a patient with myelodysplastic syndrome]. ( Egami, K; Honda, J; Matsuo, K; Naitoh, K; Nakamura, E; Natori, H; Osabe, S; Tanaka, K; Utsunomiya, I; Yoshida, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Kondo, S | 1 |
| Kamakura, M | 1 |
| Nakamura, A | 1 |
| Saito, H | 1 |
| Kunimoto, H | 1 |
| Kitabatake, H | 1 |
| Seki, A | 1 |
| Ochi, Y | 1 |
| Hara, E | 1 |
| Ha, C | 1 |
| Tibes, R | 2 |
| Ertz-Archambault, N | 2 |
| Kosiorek, H | 2 |
| Meijer, B | 1 |
| de Boer, NKH | 1 |
| Ram, R | 1 |
| Swarnalatha, G | 1 |
| Rao, CS | 1 |
| Adiraju, KP | 1 |
| Dakshinamurty, KV | 1 |
| Lopez, A | 1 |
| Mounier, M | 1 |
| Bouvier, AM | 1 |
| Carrat, F | 1 |
| Maynadié, M | 1 |
| Beaugerie, L | 1 |
| Peyrin-Biroulet, L | 1 |
| Deepak, P | 1 |
| Stobaugh, DJ | 1 |
| Taylor, GE | 1 |
| Kelemen, K | 1 |
| Dueck, A | 1 |
| Castro, J | 1 |
| Marino, R | 1 |
| Gauthier, S | 1 |
| Finn, L | 1 |
| Sproat, LZ | 1 |
| Palmer, J | 1 |
| Mesa, RA | 1 |
| Al-Kali, A | 1 |
| Foran, J | 1 |
| Tabata, R | 1 |
| Tabata, C | 1 |
| Okamoto, T | 1 |
| Omori, K | 1 |
| Terada, M | 1 |
| Nagai, T | 1 |
| Kwong, YL | 2 |
| Heredia, F | 1 |
| Sousa, J | 1 |
| Magalhães, S | 1 |
| Pinheiro, R | 1 |
| Chihara, D | 1 |
| Takeoka, T | 1 |
| Shirase, T | 1 |
| Kishimoto, W | 1 |
| Arimoto-Miyamoto, K | 1 |
| Tsuji, M | 1 |
| Ohno, T | 1 |
| Gokce, M | 1 |
| Bulus, D | 1 |
| Bilginer, Y | 1 |
| Gumruk, F | 1 |
| Besbas, N | 1 |
| Cetin, M | 1 |
| Au, WY | 2 |
| Yuen, MF | 1 |
| Lai, KC | 1 |
| Wan, TS | 2 |
| Ma, SK | 1 |
| Roy-Peaud, F | 1 |
| Paccalin, M | 1 |
| Le Moal, G | 1 |
| Landron, C | 1 |
| Juhel, L | 1 |
| Roblot, P | 1 |
| Becq-Giraudon, B | 1 |
| Offman, J | 1 |
| Opelz, G | 1 |
| Doehler, B | 1 |
| Cummins, D | 1 |
| Halil, O | 1 |
| Banner, NR | 1 |
| Burke, MM | 1 |
| Sullivan, D | 1 |
| Macpherson, P | 1 |
| Karran, P | 1 |
| Willerding-Möllmann, S | 1 |
| Wilkens, L | 1 |
| Schlegelberger, B | 1 |
| Kaiser, U | 1 |
| Knipp, S | 2 |
| Hildebrandt, B | 1 |
| Richter, J | 1 |
| Haas, R | 1 |
| Germing, U | 2 |
| Gattermann, N | 1 |
| Pang, A | 1 |
| Ma, ES | 1 |
| Cheng, LC | 1 |
| Putzki, N | 1 |
| Ramczykowski, T | 1 |
| Vago, S | 1 |
| Diener, HC | 1 |
| Limmroth, V | 1 |
| Then Bergh, F | 1 |
| Niklas, A | 1 |
| Strauss, A | 1 |
| von Ahsen, N | 1 |
| Niederwieser, D | 1 |
| Schwarz, J | 1 |
| Wagner, A | 1 |
| Al-Ali, HK | 1 |
| Aoki, M | 1 |
| Miura, A | 1 |
| Sato, I | 1 |
| Suzuki, C | 1 |
| Renneboog, B | 1 |
| Hansen, V | 1 |
| Heimann, P | 1 |
| De Mulder, A | 1 |
| Jannsen, F | 1 |
| Ferster, A | 1 |
| Tanaka, K | 1 |
| Nakamura, E | 1 |
| Naitoh, K | 1 |
| Utsunomiya, I | 1 |
| Matsuo, K | 1 |
| Osabe, S | 1 |
| Honda, J | 1 |
| Yoshida, K | 1 |
| Egami, K | 1 |
| Natori, H | 1 |
| Vandenberghe, EA | 1 |
| Mecucci, C | 1 |
| Delannoy, A | 1 |
| Van den Berghe, H | 1 |
| Bammatter, F | 1 |
| Binswanger, U | 1 |
| Fehr, J | 1 |
2 reviews available for azathioprine and Myelodysplastic Syndromes
| Article | Year |
|---|---|
Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Topics: Adult; Aged; Autoimmune Diseases; Azathioprine; Female; Graft Rejection; Humans; Immunosuppressive A | 2010 |
[Association of systemic diseases and myelodysplastic syndromes. A retrospective study of 14 cases].
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Blood Transfusion; Cyclophosp | 2003 |
24 other studies available for azathioprine and Myelodysplastic Syndromes
| Article | Year |
|---|---|
[A case of "colitis-like intestinal Behçet's disease" accompanied by ulcerative colitis after the development of myelodysplastic syndrome].
Topics: Aged; Azathioprine; Behcet Syndrome; Colitis, Ulcerative; Humans; Male; Myelodysplastic Syndromes; U | 2022 |
The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits?
Topics: Azathioprine; Humans; Incidence; Inflammatory Bowel Diseases; Leukemia, Myeloid, Acute; Myelodysplas | 2021 |
All Thiopurines Are Equal But Some Thiopurines Are More Equal Than Others-Reply.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
All Thiopurines Are Equal but Some Thiopurines Are More Equal Than Others.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
Anaemia in a renal allograft recipient: an unusual cause.
Topics: Aged; Anemia; Azathioprine; Copper; Diet, Vegetarian; Humans; Immunosuppressive Agents; Kidney Trans | 2014 |
Increased risk of acute myeloid leukemias and myelodysplastic syndromes in patients who received thiopurine treatment for inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Cohort Studies; Female; France; Humans; Immunosuppressive Agents; I | 2014 |
Risk of Myeloid Neoplasms in Inflammatory Bowel Disease Patients Is Linked to Exposure to Thiopurines and Not With Tumor Necrosis Factor-alpha Inhibitors.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukemia, Myelo | 2015 |
Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Case-Control Stud | 2017 |
Autoimmune pancreatitis associated with myelodysplastic syndrome.
Topics: Aged; Amylases; Autoantibodies; Autoimmune Diseases; Azathioprine; Bile Ducts; Bilirubin; Blood Cell | 2010 |
Therapy-related myelodysplastic syndrome with 17p deletion following long-term azathioprine treatment.
Topics: Adult; Azathioprine; Chromosome Deletion; Chromosomes, Human, Pair 17; Female; Humans; Myasthenia Gr | 2010 |
Progressive multifocal leukoencephalopathy in myelodysplastic syndrome involving pure red cell aplasia.
Topics: Aged; Azathioprine; Female; Humans; Immunosuppressive Agents; Leukoencephalopathy, Progressive Multi | 2010 |
Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus.
Topics: Antimetabolites; Azathioprine; Child; Fatal Outcome; Female; Humans; Lupus Erythematosus, Systemic; | 2012 |
Clonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: a cautionary tale.
Topics: Adult; Azathioprine; Crohn Disease; Humans; Male; Myelodysplastic Syndromes; Neutrophils; Sulfasalaz | 2002 |
Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation.
Topics: Acute Disease; Azathioprine; Base Pair Mismatch; Bone Marrow; DNA Repair; Follow-Up Studies; Heart T | 2004 |
[Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations].
Topics: Anemia; Azathioprine; Bone Marrow; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Hum | 2004 |
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azathioprine; Cell Transformation, Neoplastic; | 2005 |
Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation.
Topics: Adult; Azathioprine; B-Lymphocytes; Biopsy; Bone Marrow; Causality; Female; Humans; Immunosuppressiv | 2006 |
Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis.
Topics: Adolescent; Adult; Azathioprine; Female; Humans; Immunosuppressive Agents; Incidence; Male; Middle A | 2006 |
Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosis.
Topics: Acute Disease; Azathioprine; Disease Progression; Fatal Outcome; Female; Glatiramer Acetate; Humans; | 2006 |
[A case of repeated pyoderma gangrenosum with myelodysplastic syndrome].
Topics: Adult; Azathioprine; Humans; Male; Myelodysplastic Syndromes; Prednisolone; Pyoderma Gangrenosum; Re | 1993 |
Spontaneous remission in a patient with therapy-related myelodysplastic syndrome (t-MDS) with monosomy 7.
Topics: Adult; Anemia, Refractory; Azathioprine; Chromosomes, Human, Pair 7; Female; Humans; Immunosuppressi | 1996 |
[Relapsing polychondritis in a patient with myelodysplastic syndrome].
Topics: Azathioprine; Dapsone; gamma-Globulins; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Optic | 1990 |
Deletion of 5q by t(5;17) in therapy-related myelodysplastic syndrome.
Topics: Adult; Azathioprine; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 17; Chromosom | 1990 |
[Reversible azathioprine associated dysmyeloproliferative syndrome after kidney allotransplantation].
Topics: Adult; Azathioprine; Bone Marrow; Cyclosporins; Follow-Up Studies; Graft Rejection; Humans; Kidney F | 1987 |