azathioprine has been researched along with Muscle Weakness in 22 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| "An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations." | 7.75 | Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease? ( Dincer, P; Gundesli, H; Oflazer, PS; Sabuncu, T; Zorludemir, S, 2009) |
| " These observations suggest that the development of muscular weakness in patients on azathioprine should be considered as an adverse effect of the drug." | 5.33 | Severe muscular weakness: an unusual adverse effect of azathioprine therapy. ( Arora, M; Dutta, SK; Karhadkar, AS; Schwartz, HJ, 2006) |
| "In patients with juvenile dermatomyositis, treatment with intravenous immunoglobulin and cyclosporine A were more frequent as compared to adult patients." | 3.81 | [Clinical features of patients with juvenile and adult dermatomyositis]. ( Dankó, K; Farkas, F; Nagy-Vince, M; Szalmás, O, 2015) |
| "An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations." | 3.75 | Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease? ( Dincer, P; Gundesli, H; Oflazer, PS; Sabuncu, T; Zorludemir, S, 2009) |
| " Three patients with long-standing polymyositis (PM) or dermatomyositis (DM) poorly responsive to prednisone combined with several immunosuppressants were given intravenous rituximab 1,000 mg on Days 0 and 14." | 3.73 | Rituximab as therapy for refractory polymyositis and dermatomyositis. ( Hausner-Sypek, DL; Noss, EH; Weinblatt, ME, 2006) |
| "Polymyositis is an immune-mediated inflammatory myopathy usually presenting with weakness of proximal muscles in a symmetric pattern." | 1.72 | Generalised oedema as a presenting manifestation of inflammatory myopathy. ( Chandra, A; Ghosh, SK; Karmakar, P; Karmakar, PS; Ray, AK, 2022) |
| "Its presentation with interstitial lung disease alters its prognosis." | 1.51 | Antisynthetase syndrome presenting as interstitial lung disease: a case report. ( Badshah, A; Haider, I; Humayun, M; Pervez, S, 2019) |
| "A 66-year-old woman with a history of interstitial lung disease presented with a 3-month history of dropped head syndrome (DHS), followed by camptocormia and extremity weakness." | 1.48 | Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-polymyositis Overlap Syndrome Associated with Anti-Ku Antibody. ( Higuchi, I; Jonosono, M; Mitsuyo, K; Yoshida, M; Yoshida, T, 2018) |
| "Polymyositis is an inflammatory myopathy which, like SCD, may present with myalgia but is usually associated with proximal muscle weakness." | 1.42 | Juvenile polymyositis with unremitting pain and progressive loss of motor and bulbar function on a background of sickle cell disease. ( Bali, S; D'Cruz, D; Inusa, BP; Lazaro, M, 2015) |
| "The sporadic inclusion body myositis weakness composite index, which correlated with grip strength (correlation coefficient: 0." | 1.37 | Long-term observational study of sporadic inclusion body myositis. ( Allenbach, Y; Benveniste, O; Brady, S; Dubourg, O; Eymard, B; Freebody, J; Guiguet, M; Herson, S; Hilton-Jones, D; Leite, MI; Maisonobe, T; Squier, W; Stojkovic, T, 2011) |
| " These observations suggest that the development of muscular weakness in patients on azathioprine should be considered as an adverse effect of the drug." | 1.33 | Severe muscular weakness: an unusual adverse effect of azathioprine therapy. ( Arora, M; Dutta, SK; Karhadkar, AS; Schwartz, HJ, 2006) |
| "Hypogonadism has been established as a cause of osteoporosis in males, and in this case would explain the occurrence of fractures in the absence of other major risk factors." | 1.31 | Osteoporosis with underlying connective tissue disease: an unusual case. ( De Silva, M; Prasad, R, 2002) |
| "Although most patients with inclusion body myositis have characteristic muscle biopsy findings, some cannot be distinguished histologically early from polymyositis." | 1.29 | Inclusion body myositis: clinical and pathological boundaries. ( Amato, AA; Barohn, RJ; Bryan, WW; Gronseth, GS; Jackson, CE; Katz, JS; Wolfe, GI, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 12 (54.55) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Ray, AK | 1 |
| Karmakar, P | 1 |
| Chandra, A | 1 |
| Ghosh, SK | 1 |
| Karmakar, PS | 1 |
| Yoshida, T | 1 |
| Yoshida, M | 1 |
| Mitsuyo, K | 1 |
| Jonosono, M | 1 |
| Higuchi, I | 1 |
| Badshah, A | 1 |
| Haider, I | 1 |
| Pervez, S | 1 |
| Humayun, M | 1 |
| Bali, S | 1 |
| D'Cruz, D | 1 |
| Lazaro, M | 1 |
| Inusa, BP | 1 |
| Gao, F | 1 |
| Zhao, X | 1 |
| Zhang, J | 1 |
| Cui, X | 1 |
| Zhang, Y | 2 |
| Li, Q | 1 |
| Liu, P | 1 |
| Fang, H | 1 |
| Du, Y | 1 |
| Zhang, Q | 1 |
| Yang, J | 1 |
| Szalmás, O | 1 |
| Nagy-Vince, M | 1 |
| Dankó, K | 1 |
| Farkas, F | 1 |
| Ong, SG | 1 |
| Ding, HJ | 1 |
| Kostera-Pruszczyk, A | 1 |
| Ryniewicz, B | 1 |
| Rowinska-Marcinska, K | 1 |
| Dutkiewicz, M | 1 |
| Kamińska, A | 1 |
| Oflazer, PS | 1 |
| Gundesli, H | 1 |
| Zorludemir, S | 1 |
| Sabuncu, T | 1 |
| Dincer, P | 1 |
| Mijajlovic, M | 1 |
| Mirkovic, M | 1 |
| Dackovic, J | 1 |
| Zidverc-Trajkovic, J | 1 |
| Sternic, N | 1 |
| Nakamura, H | 1 |
| Fujikawa, K | 1 |
| Kawakami, A | 1 |
| Tamai, M | 1 |
| Yamasaki, S | 1 |
| Ida, H | 1 |
| Eguchi, K | 1 |
| Rigamonti, A | 1 |
| Lauria, G | 1 |
| Piamarta, F | 1 |
| Fiumani, A | 1 |
| Agostoni, E | 1 |
| Benveniste, O | 1 |
| Guiguet, M | 1 |
| Freebody, J | 1 |
| Dubourg, O | 1 |
| Squier, W | 1 |
| Maisonobe, T | 1 |
| Stojkovic, T | 1 |
| Leite, MI | 1 |
| Allenbach, Y | 1 |
| Herson, S | 1 |
| Brady, S | 1 |
| Eymard, B | 1 |
| Hilton-Jones, D | 1 |
| Jung, KD | 1 |
| Kim, PS | 1 |
| Park, HY | 1 |
| Kim, CR | 1 |
| Byun, JY | 1 |
| Lee, DY | 1 |
| Lee, JH | 1 |
| Yang, JM | 1 |
| Lee, ES | 1 |
| Prasad, R | 1 |
| De Silva, M | 1 |
| Noss, EH | 1 |
| Hausner-Sypek, DL | 1 |
| Weinblatt, ME | 1 |
| Karhadkar, AS | 1 |
| Schwartz, HJ | 1 |
| Arora, M | 1 |
| Dutta, SK | 1 |
| Pedersen, K | 1 |
| Pandolfo, M | 1 |
| Mavroudakis, N | 1 |
| Kastrup, A | 1 |
| Gdynia, HJ | 1 |
| Nägele, T | 1 |
| Riecker, A | 1 |
| Amato, AA | 1 |
| Gronseth, GS | 1 |
| Jackson, CE | 1 |
| Wolfe, GI | 1 |
| Katz, JS | 1 |
| Bryan, WW | 1 |
| Barohn, RJ | 1 |
| Rose, MR | 1 |
| Levin, KH | 1 |
| Griggs, RC | 1 |
| Grassia, R | 1 |
| Paolo Coppeta, G | 1 |
| Staiano, T | 1 |
22 other studies available for azathioprine and Muscle Weakness
| Article | Year |
|---|---|
Generalised oedema as a presenting manifestation of inflammatory myopathy.
Topics: Azathioprine; Edema; Female; Humans; Muscle Weakness; Myositis; Polymyositis | 2022 |
Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-polymyositis Overlap Syndrome Associated with Anti-Ku Antibody.
Topics: Aged; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Female; Head Movements; Humans; Immuno | 2018 |
Antisynthetase syndrome presenting as interstitial lung disease: a case report.
Topics: Adult; Antibodies, Antinuclear; Autoantibodies; Azathioprine; Creatine Kinase; Diagnosis, Differenti | 2019 |
Juvenile polymyositis with unremitting pain and progressive loss of motor and bulbar function on a background of sickle cell disease.
Topics: Adolescent; Adrenal Cortex Hormones; Anemia, Sickle Cell; Anti-Inflammatory Agents; Autoimmunity; Az | 2015 |
Clinical features of patients with Myasthenia gravis from the Henan province, China.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Distribution; Age of Onset; Aged; Aged, 80 and over; | 2016 |
[Clinical features of patients with juvenile and adult dermatomyositis].
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Cyclosporine; Dermatomyositis; Female; Fol | 2015 |
Patient with statin-associated immune-mediated necrotizing myopathy presenting with subcutaneous edema, persistent bulbar weakness and absent anti-HMGCR.
Topics: Aged; Autoantibodies; Azathioprine; Biopsy; Bulbar Palsy, Progressive; Edema; Glucocorticoids; Human | 2017 |
Lambert-Eaton myasthenic syndrome in childhood.
Topics: Autoantibodies; Azathioprine; Calcium Channels, P-Type; Child; Humans; Immunosuppressive Agents; Lam | 2009 |
Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease?
Topics: Azathioprine; Calpain; Child; Creatine Kinase; Disease Progression; Dose-Response Relationship, Drug | 2009 |
Clinical manifestations, diagnostic criteria and therapy of Hashimoto's encephalopathy: report of two cases.
Topics: Aged; Anti-Inflammatory Agents; Azathioprine; Diagnosis, Differential; Electroencephalography; Encep | 2010 |
Long-term efficacy of intravenously administered immunoglobulin in a case of polymyositis with limited application of steroid therapy.
Topics: Aged; Azathioprine; Creatine Kinase; Cyclosporine; Humans; Immunoglobulins, Intravenous; Immunosuppr | 2010 |
Thymoma-associated myasthenia gravis without acetylcholine receptor antibodies.
Topics: Action Potentials; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Electric Stimulation; Evo | 2011 |
Long-term observational study of sporadic inclusion body myositis.
Topics: Aged; Azathioprine; Cohort Studies; Disability Evaluation; Female; Humans; Immunoglobulins, Intraven | 2011 |
Dermatomyositis associated with generalized subcutaneous edema and Evans syndrome.
Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Dermatomyositis; Edema; Female; Glucocorticoids; Humans | 2012 |
Osteoporosis with underlying connective tissue disease: an unusual case.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Accidental Falls; Adult; Anti-Ulcer Agents; Antibodies, Ant | 2002 |
Rituximab as therapy for refractory polymyositis and dermatomyositis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD19; Azathioprine; B-Lymp | 2006 |
Severe muscular weakness: an unusual adverse effect of azathioprine therapy.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Hypersensitivity; Humans; Immunosuppre | 2006 |
Chronic inflammatory demyelinating polyneuropathy in a diabetic patient: deterioration after intravenous immunoglobulins treatment and favorable response to steroid treatment.
Topics: Azathioprine; Diabetic Neuropathies; Disease Progression; Female; Humans; Immunoglobulins, Intraveno | 2007 |
Dropped-head syndrome due to steroid responsive focal myositis: a case report and review of the literature.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Azathioprine; Biopsy; Di | 2008 |
Inclusion body myositis: clinical and pathological boundaries.
Topics: Aged; Azathioprine; Biopsy; Creatine Kinase; Dermatomyositis; Diagnosis, Differential; Female; Human | 1996 |
The dropped head plus syndrome: quantitation of response to corticosteroids.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Body Mass Index; Drug Therapy, Combination; Head Movem | 1999 |
Severe muscular weakness as an isolated symptom of azathioprine hypersensitivity.
Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Drug Hypersensitivity; Humans; Male; Mercaptopurine; | 2011 |