azathioprine has been researched along with Mucopolysaccharidosis I in 3 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Mucopolysaccharidosis I: Systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDURONIDASE) and characterized by progressive physical deterioration with urinary excretion of DERMATAN SULFATE and HEPARAN SULFATE. There are three recognized phenotypes representing a spectrum of clinical severity from severe to mild: Hurler syndrome, Hurler-Scheie syndrome and Scheie syndrome (formerly mucopolysaccharidosis V). Symptoms may include DWARFISM; hepatosplenomegaly; thick, coarse facial features with low nasal bridge; corneal clouding; cardiac complications; and noisy breathing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mucopolysaccharidoses (MPSs) are lysosomal storage diseases caused by a deficit in the enzymes needed for glycosaminoglycan (GAG) degradation." | 1.35 | Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I. ( Dickson, P; Jabagat, C; Kakkis, ED; Krieger, A; Le, S; Lester, T; Manuel, H; McEntee, M; Passage, M; Peinovich, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dickson, P | 1 |
| Peinovich, M | 2 |
| McEntee, M | 1 |
| Lester, T | 2 |
| Le, S | 1 |
| Krieger, A | 1 |
| Manuel, H | 1 |
| Jabagat, C | 1 |
| Passage, M | 2 |
| Kakkis, ED | 1 |
| Ponder, KP | 1 |
| Kakkis, E | 1 |
| Yang, R | 1 |
| Tanaka, C | 1 |
| Anand, V | 1 |
| Lemontt, J | 1 |
3 other studies available for azathioprine and Mucopolysaccharidosis I
| Article | Year |
|---|---|
Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I.
Topics: Animals; Azathioprine; Cyclosporine; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; | 2008 |
Immune response hinders therapy for lysosomal storage diseases.
Topics: Animals; Antibodies; Azathioprine; Cyclosporine; Dogs; Iduronidase; Immune Tolerance; Immunosuppress | 2008 |
Successful induction of immune tolerance to enzyme replacement therapy in canine mucopolysaccharidosis I.
Topics: Animals; Azathioprine; Cyclosporine; Disease Models, Animal; Dogs; Humans; Iduronidase; Immune Toler | 2004 |