azathioprine has been researched along with Merkel Cell Cancer in 4 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cases of Merkel cell carcinoma have become increasingly more common in the last two decades, and its incidence has been predicted to climb further." | 1.51 | Inferior outcomes in immunocompromised Merkel cell carcinoma patients: Can they be overcome by the use of PD1/PDL1 inhibitors? ( Codreanu, I; Dasanu, CA; Del Rosario, M; Hyams, DM; Plaxe, SC, 2019) |
| "Azathioprine and cyclosporin have been used as immunosuppressants for many years, but long-term use has also been associated with neoplasia." | 1.30 | Merkel cell carcinoma arising after therapeutic immunosuppression. ( Bunker, CB; Gooptu, C; Morris, PJ; Price, M; Ross, J; Wall, S; Wojnarowska, F; Woollons, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dasanu, CA | 1 |
| Del Rosario, M | 1 |
| Codreanu, I | 1 |
| Hyams, DM | 1 |
| Plaxe, SC | 1 |
| Clarke, CA | 1 |
| Robbins, HA | 1 |
| Tatalovich, Z | 1 |
| Lynch, CF | 1 |
| Pawlish, KS | 1 |
| Finch, JL | 1 |
| Hernandez, BY | 1 |
| Fraumeni, JF | 1 |
| Madeleine, MM | 1 |
| Engels, EA | 1 |
| Muirhead, R | 1 |
| Ritchie, DM | 1 |
| Gooptu, C | 1 |
| Woollons, A | 1 |
| Ross, J | 1 |
| Price, M | 1 |
| Wojnarowska, F | 1 |
| Morris, PJ | 1 |
| Wall, S | 1 |
| Bunker, CB | 1 |
4 other studies available for azathioprine and Merkel Cell Cancer
| Article | Year |
|---|---|
Inferior outcomes in immunocompromised Merkel cell carcinoma patients: Can they be overcome by the use of PD1/PDL1 inhibitors?
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic A | 2019 |
Risk of merkel cell carcinoma after solid organ transplantation.
Topics: Adult; Aged; Azathioprine; Carcinoma, Merkel Cell; Cyclosporine; Female; Humans; Immunocompromised H | 2015 |
Partial regression of Merkel cell carcinoma in response to withdrawal of azathioprine in an immunosuppression-induced case of metastatic Merkel cell carcinoma.
Topics: Azathioprine; Carcinoma, Merkel Cell; Fatal Outcome; Head and Neck Neoplasms; Humans; Immunocompromi | 2007 |
Merkel cell carcinoma arising after therapeutic immunosuppression.
Topics: Aged; Azathioprine; Carcinoma, Merkel Cell; Cyclosporine; Female; Humans; Immunocompromised Host; Im | 1997 |