azathioprine has been researched along with Lymphopenia in 33 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Lymphopenia: Reduction in the number of lymphocytes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This observation suggests that the higher frequency of lymphopenia may be associated with the elevated 6-TGN concentrations recovered in patients treated with aminosalicylates." | 7.76 | High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease (IBD) pediatric patients receiving aminosalicylates combined with azathioprine. ( Boulieu, R; Lachaux, A; Le Gall, C; Nguyen, TM, 2010) |
| "Azathioprine is commonly used in Crohn's disease." | 5.48 | A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease. ( Audrain, M; Caldari, D; Dert, C; Hémont, C; Joyau, C; Léger, A; Mirallié, S; Monteil-Ganiere, C; Thomas, C, 2018) |
| " In this subgroup, thiopurine dosing was modified in 64% (dosage reduction: 32%, medication discontinued: 32%)." | 5.43 | The Impact of Azathioprine-Associated Lymphopenia on the Onset of Opportunistic Infections in Patients with Inflammatory Bowel Disease. ( Biedermann, L; Frei, P; Fried, M; Rogler, G; Scharl, M; Scharl, S; Sulz, MC; Vavricka, SR; Vögelin, M; Zeitz, J, 2016) |
| "Lymphopenia is a recognized effect of this treatment, but lymphopenia-related complications in IBD patients have not been widely reported." | 5.37 | Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: a prospective observational study. ( Al Rifai, A; Campbell, S; McBurney, H; Newman, W; Prasad, N; Pushpakom, S; Robinson, A; Shuttleworth, E, 2011) |
| "We report on a 25-year-old female patient with Crohn's disease and profound lymphocytopenia while receiving corticosteroids and azathioprine." | 3.88 | [Severe lymphopenia in a patient with Crohn's disease]. ( Hasselblatt, P; Kreisel, W; Monasterio, C, 2018) |
| "This observation suggests that the higher frequency of lymphopenia may be associated with the elevated 6-TGN concentrations recovered in patients treated with aminosalicylates." | 3.76 | High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease (IBD) pediatric patients receiving aminosalicylates combined with azathioprine. ( Boulieu, R; Lachaux, A; Le Gall, C; Nguyen, TM, 2010) |
| " Here we report the case of a patient with myasthenia gravis receiving long-term immunosuppression with azathioprine and recurrent well-differentiated thymic carcinoma who developed CD4+ T-cell depletion and CNS cryptococcosis after multiple courses of chemotherapy and mediastinal irradiation." | 3.70 | Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis. ( Padberg, F; Schmidt, S, 1998) |
| " He had CD4 lymphocytopenia during azathioprine and topical corticosteroid therapy for atopic dermatitits (AD)." | 3.69 | Kaposi's sarcoma during immunosuppressive therapy for atopic dermatitis. ( Janssens, P; Lachapelle, JM; Lambert, M; Tennstedt, D; Vandercam, B, 1997) |
| " Subsequent to cadaveric renal transplant and 8 years of immunosuppressive treatment with prednisone and azathioprine, the patient developed multiple life-threatening infections." | 3.67 | Hypogammaglobulinemia in a renal transplant recipient with antiglomerular basement membrane disease. ( Hasbargen, J; Rickman, W; Smolin, MR, 1988) |
| "A patient with long-standing filarial chyluria developed severe lymphocytopenia, extensive mucosal candidiasis and disseminated cryptococcosis when given small doses of prednisolone and azathioprine, for the treatment of a co-existing chronic active hepatitis." | 3.66 | Filarial chyluria with opportunistic infections. ( Chandy, M; Date, A; Pulimood, BM, 1983) |
| "Azathioprine (AZA) is a purine analogue which has been used in the treatment of multiple sclerosis (MS) for over 30 years." | 2.46 | [Oral cladribine for relapsing-remitting multiple sclerosis: another purine analogue or a genuine therapeutic innovation?]. ( Schmidt, S, 2010) |
| "Azathioprine is commonly used in Crohn's disease." | 1.48 | A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease. ( Audrain, M; Caldari, D; Dert, C; Hémont, C; Joyau, C; Léger, A; Mirallié, S; Monteil-Ganiere, C; Thomas, C, 2018) |
| " In this subgroup, thiopurine dosing was modified in 64% (dosage reduction: 32%, medication discontinued: 32%)." | 1.43 | The Impact of Azathioprine-Associated Lymphopenia on the Onset of Opportunistic Infections in Patients with Inflammatory Bowel Disease. ( Biedermann, L; Frei, P; Fried, M; Rogler, G; Scharl, M; Scharl, S; Sulz, MC; Vavricka, SR; Vögelin, M; Zeitz, J, 2016) |
| "Lymphopenia is a recognized effect of this treatment, but lymphopenia-related complications in IBD patients have not been widely reported." | 1.37 | Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: a prospective observational study. ( Al Rifai, A; Campbell, S; McBurney, H; Newman, W; Prasad, N; Pushpakom, S; Robinson, A; Shuttleworth, E, 2011) |
| "Lymphopenia is a common clinical manifestation in patients with systemic lupus erythematosus (SLE)." | 1.37 | Quantitative and functional profiles of CD4+ lymphocyte subsets in systemic lupus erythematosus patients with lymphopenia. ( Alcocer-Varela, J; Crispín, JC; Díaz-Zamudio, M; Gómez-Martín, D; Vanoye, G, 2011) |
| "Common characteristics include: Crohn's disease (CD), thiopurine administration, fever lasting more than 5 days, lymphadenopathy, splenomegaly, anemia, lymphopenia, and elevated serum triglycerides and ferritin." | 1.37 | Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis. ( Biank, VF; Kugathasan, S; Margolis, D; Sheth, MK; Simpson, P; Stephens, M; Talano, J, 2011) |
| "We report on two brothers with hyperimmunoglobulinemia D (patient 1: serum immunoglobulin D [IgD] concentration initially 61 IU/ml, later on 340 IU/ml; patient 2: serum IgD concentration 144 IU/ml; normal <100 IU/ml, 97th centile) and periodic fever syndrome (HIDS)." | 1.35 | B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome. ( Ganschow, R; Sornsakrin, M; Wenner, K, 2009) |
| "Two patients presented cutaneous varicella complicated by pneumonia and esophagitis respectively, one patient had cutaneous herpes zoster and the other had fatal pneumonia possibly caused by the Herpesvirus." | 1.32 | [Opportunistic infections in patients with inflammatory bowel disease undergoing immunosuppressive therapy]. ( Bernal, I; Cabré, E; Domènech, E; García-Planella, E; Gassull, MA, 2003) |
| "Azathioprine is an effective alternative which can induce disease remission and may be less toxic." | 1.30 | The use of azathioprine in severe adult atopic eczema. ( Baldwin, P; Buckley, DA; Rogers, S, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (42.42) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Carol, HA | 1 |
| Ochfeld, EN | 1 |
| Ahmed, A | 1 |
| Thomas, C | 1 |
| Monteil-Ganiere, C | 1 |
| Mirallié, S | 1 |
| Hémont, C | 1 |
| Dert, C | 1 |
| Léger, A | 1 |
| Joyau, C | 1 |
| Caldari, D | 1 |
| Audrain, M | 1 |
| Monasterio, C | 1 |
| Kreisel, W | 1 |
| Hasselblatt, P | 1 |
| Hadjadj, J | 1 |
| Guffroy, A | 1 |
| Delavaud, C | 1 |
| Taieb, G | 1 |
| Meyts, I | 1 |
| Fresard, A | 1 |
| Streichenberger, N | 1 |
| L'Honneur, AS | 1 |
| Rozenberg, F | 1 |
| D'Aveni, M | 1 |
| Aguilar, C | 1 |
| Rosain, J | 1 |
| Picard, C | 1 |
| Mahlaoui, N | 1 |
| Lecuit, M | 1 |
| Hermine, O | 1 |
| Lortholary, O | 1 |
| Suarez, F | 1 |
| Heerasing, NM | 1 |
| Ng, JF | 1 |
| Dowling, D | 1 |
| González-Naranjo, LA | 1 |
| Betancur, OM | 1 |
| Alarcón, GS | 1 |
| Ugarte-Gil, MF | 1 |
| Jaramillo-Arroyave, D | 1 |
| Wojdyla, D | 1 |
| Pons-Estel, GJ | 1 |
| Rondón-Herrera, F | 1 |
| Vásquez-Duque, GM | 1 |
| Quintana-López, G | 1 |
| Da Silva, NA | 1 |
| Tavares Brenol, JC | 1 |
| Reyes-Llerena, G | 1 |
| Pascual-Ramos, V | 1 |
| Amigo, MC | 1 |
| Massardo, L | 1 |
| Alfaro-Lozano, J | 1 |
| Segami, MI | 1 |
| Esteva-Spinetti, MH | 1 |
| Iglesias-Gamarra, A | 1 |
| Pons-Estel, BA | 1 |
| Vögelin, M | 1 |
| Biedermann, L | 1 |
| Frei, P | 1 |
| Vavricka, SR | 1 |
| Scharl, S | 1 |
| Zeitz, J | 1 |
| Sulz, MC | 1 |
| Fried, M | 1 |
| Rogler, G | 1 |
| Scharl, M | 1 |
| Sornsakrin, M | 1 |
| Wenner, K | 1 |
| Ganschow, R | 1 |
| Nguyen, TM | 1 |
| Le Gall, C | 1 |
| Lachaux, A | 1 |
| Boulieu, R | 1 |
| Schmidt, S | 2 |
| Al Rifai, A | 1 |
| Prasad, N | 1 |
| Shuttleworth, E | 1 |
| McBurney, H | 1 |
| Pushpakom, S | 1 |
| Robinson, A | 1 |
| Newman, W | 1 |
| Campbell, S | 1 |
| Gómez-Martín, D | 1 |
| Díaz-Zamudio, M | 1 |
| Vanoye, G | 1 |
| Crispín, JC | 1 |
| Alcocer-Varela, J | 1 |
| Biank, VF | 1 |
| Sheth, MK | 1 |
| Talano, J | 1 |
| Margolis, D | 1 |
| Simpson, P | 1 |
| Kugathasan, S | 1 |
| Stephens, M | 1 |
| Fernández, O | 1 |
| Guerrero, M | 1 |
| Mayorga, C | 1 |
| Muñoz, L | 1 |
| Leán, A | 1 |
| Luque, G | 1 |
| Hervás, M | 1 |
| Fernández, V | 1 |
| Capdevila, A | 1 |
| de Ramón, E | 1 |
| Bernal, I | 1 |
| Domènech, E | 1 |
| García-Planella, E | 1 |
| Cabré, E | 1 |
| Gassull, MA | 1 |
| WHEELER, JR | 1 |
| WHITE, WF | 1 |
| CALNE, RY | 1 |
| Date, A | 1 |
| Chandy, M | 1 |
| Pulimood, BM | 1 |
| Skakal'skaia, LM | 1 |
| Vandercam, B | 1 |
| Lachapelle, JM | 1 |
| Janssens, P | 1 |
| Tennstedt, D | 1 |
| Lambert, M | 1 |
| Padberg, F | 1 |
| Buckley, DA | 1 |
| Baldwin, P | 1 |
| Rogers, S | 1 |
| Friedman, EA | 1 |
| Shilov, EM | 1 |
| Tareeva, IE | 1 |
| Gordovskaia, NB | 1 |
| Smolin, MR | 1 |
| Rickman, W | 1 |
| Hasbargen, J | 1 |
| Mansurov, KhKh | 1 |
| Asfandiiarova, NS | 1 |
| Nikolaeva, OS | 1 |
| Mansurova, FKh | 1 |
| Rasunova, TKh | 1 |
| Ring, J | 1 |
| Seifert, J | 1 |
| Lob, G | 1 |
| Coulin, K | 1 |
| Angstwurm, H | 1 |
| Frick, E | 1 |
| Brass, B | 1 |
| Mertin, J | 1 |
| Backmund, H | 1 |
| Brendel, W | 1 |
| Coté, CJ | 1 |
| Meuwissen, HJ | 1 |
| Pickering, RJ | 1 |
| Souhami, RL | 1 |
| Smith, J | 1 |
| Bradfield, JW | 1 |
| Glen, AC | 1 |
| Bell, PR | 1 |
| Briggs, JD | 1 |
| Paton, AM | 1 |
| Calman, KC | 1 |
| Linton, AL | 1 |
| Chanana, AD | 1 |
| Cronkite, EP | 1 |
| Joel, DD | 1 |
| Schiffer, LM | 1 |
| Sokolowski, J | 1 |
| Olszewski, W | 1 |
| Hauschild, G | 1 |
| Schöne, D | 1 |
| Wässer, S | 1 |
| Winter, JW | 1 |
| Gaffney, D | 1 |
| Shapiro, D | 1 |
| Spooner, RJ | 1 |
| Marinaki, AM | 1 |
| Sanderson, JD | 1 |
| Mills, PR | 1 |
1 review available for azathioprine and Lymphopenia
| Article | Year |
|---|---|
[Oral cladribine for relapsing-remitting multiple sclerosis: another purine analogue or a genuine therapeutic innovation?].
Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Animals; Azathioprine; Cladribine; Cl | 2010 |
1 trial available for azathioprine and Lymphopenia
| Article | Year |
|---|---|
Intensive immunosuppression in the treatment of multiple sclerosis.
Topics: Adult; Animals; Antilymphocyte Serum; Azathioprine; Cells, Cultured; Drainage; Drug Therapy, Combina | 1974 |
31 other studies available for azathioprine and Lymphopenia
| Article | Year |
|---|---|
In-utero exposure to immunosuppressive medications resulting in abnormal newborn screening for severe combined immunodeficiency: a case series on natural history and management.
Topics: Actins; Azathioprine; Female; Fingolimod Hydrochloride; Humans; Hydroxychloroquine; Infant; Infant, | 2022 |
A Severe Neonatal Lymphopenia Associated With Administration of Azathioprine to the Mother in a Context of Crohn's Disease.
Topics: Azathioprine; Crohn Disease; Female; Homozygote; Humans; Immunosuppressive Agents; Infant, Newborn; | 2018 |
[Severe lymphopenia in a patient with Crohn's disease].
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Azathioprine; Crohn Disease; F | 2018 |
Progressive Multifocal Leukoencephalopathy in Primary Immunodeficiencies.
Topics: Adolescent; Adult; Azathioprine; B-Lymphocytes; Female; Humans; Immunologic Deficiency Syndromes; Im | 2019 |
Does lymphopenia or macrocytosis reflect 6-thioguanine levels in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine?
Topics: Adult; Azathioprine; Biomarkers; Erythrocyte Indices; Female; Humans; Immunosuppressive Agents; Infl | 2016 |
Features associated with hematologic abnormalities and their impact in patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort.
Topics: Adolescent; Adult; Age Factors; Anemia, Hemolytic; Antibodies, Antinuclear; Antibodies, Antiphosphol | 2016 |
The Impact of Azathioprine-Associated Lymphopenia on the Onset of Opportunistic Infections in Patients with Inflammatory Bowel Disease.
Topics: Adolescent; Adult; Azathioprine; Case-Control Studies; Child; Female; Humans; Immunosuppressive Agen | 2016 |
B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome.
Topics: Agammaglobulinemia; Azathioprine; B-Lymphocytes; Child; Fever; Glucocorticoids; Heterozygote; Humans | 2009 |
High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease (IBD) pediatric patients receiving aminosalicylates combined with azathioprine.
Topics: Adolescent; Aminosalicylic Acids; Azathioprine; Biotransformation; Child; Child, Preschool; Drug The | 2010 |
Natural history of azathioprine-associated lymphopenia in inflammatory bowel disease patients: a prospective observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Disease Progression; Female; Humans; Immun | 2011 |
Quantitative and functional profiles of CD4+ lymphocyte subsets in systemic lupus erythematosus patients with lymphopenia.
Topics: Adult; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Azathioprine; CD4-Positive T-Lymphocyt | 2011 |
Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.
Topics: Adolescent; Anemia; Azathioprine; Crohn Disease; Epstein-Barr Virus Infections; Ferritins; Fever; Hu | 2011 |
Combination therapy with interferon beta-1b and azathioprine in secondary progressive multiple sclerosis. A two-year pilot study.
Topics: Adjuvants, Immunologic; Adult; Azathioprine; Disease Progression; Drug Therapy, Combination; Female; | 2002 |
[Opportunistic infections in patients with inflammatory bowel disease undergoing immunosuppressive therapy].
Topics: Acyclovir; Adult; Aged; Antiviral Agents; Azathioprine; Chickenpox; Crohn Disease; Disease Susceptib | 2003 |
SELECTIVE LYMPHOPENIA BY USE OF INTRALYMPHATIC 198-AU AND SPLENECTOMY. IMMUNOSUPPRESSIVE ACTION ON REJECTION OF CANINE RENAL HOMOGRAFTS.
Topics: Allografts; Animals; Azathioprine; Dogs; Gold Colloid; Gold Colloid, Radioactive; Histology; Immunos | 1965 |
Filarial chyluria with opportunistic infections.
Topics: Azathioprine; Candidiasis; Chyle; Cryptococcosis; Filariasis; Hepatitis, Chronic; Humans; Lymphopeni | 1983 |
[Immunomodulating treatment of immunologic disorders in chronic pulmonary heart disease].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Female; Humans; Hype | 1980 |
Kaposi's sarcoma during immunosuppressive therapy for atopic dermatitis.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Azathioprine; Betamethasone Valerate; CD4-P | 1997 |
Late onset immunodeficiency in a patient with recurrent thymic carcinoma and myasthenia gravis.
Topics: Adult; Age Factors; Azathioprine; Carcinoma; CD4-Positive T-Lymphocytes; Female; Humans; Immunologic | 1998 |
The use of azathioprine in severe adult atopic eczema.
Topics: Adult; Antimetabolites; Azathioprine; Clinical Trials as Topic; Dermatitis, Atopic; Drug Evaluation; | 1998 |
Corticosteroids in immunosuppression: partial fulfillment of a promise.
Topics: Antibody Formation; Azathioprine; Cell Membrane; Cyclophosphamide; Glucocorticoids; Graft Rejection; | 1975 |
[Effect of prednisolone and azathioprine on T- and B-lymphocyte number in peripheral blood of patients with glomerulonephritis and systemic lupus erythematosus].
Topics: Adolescent; Adult; Azathioprine; B-Lymphocytes; Glomerulonephritis; Humans; Leukocyte Count; Lupus E | 1978 |
Hypogammaglobulinemia in a renal transplant recipient with antiglomerular basement membrane disease.
Topics: Adult; Agammaglobulinemia; Anti-Glomerular Basement Membrane Disease; Azathioprine; Basement Membran | 1988 |
[Immunocorrective therapy of patients with chronic active liver diseases of a viral nature].
Topics: Adjuvants, Immunologic; Adolescent; Adult; Azathioprine; Female; Hepatitis B; Hepatitis, Chronic; Hu | 1987 |
Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy.
Topics: Azathioprine; Cytomegalovirus; Female; Glomerulonephritis; Humans; Immunoglobulin A; Immunoglobulin | 1974 |
The effect of uraemia on organ graft survival in the rat.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Azathioprine; Disease Models, Animal; Graft Rejecti | 1973 |
Lymphocyte monitoring by blood lymphocyte counts and RNA-DNA determination in patients with a renal allograft.
Topics: Adult; Azathioprine; DNA; Female; Graft Rejection; Humans; Immunosuppression Therapy; Kidney Transpl | 1971 |
Skin allograft survival in lymphocyte-depleted calves.
Topics: Animals; Azathioprine; Cattle; Graft Rejection; Immunosuppression Therapy; Lymphocytes; Lymphopenia; | 1969 |
[Biochemical and histological changes resulting from the administration of an immunosuppressive agent, Imuran azathioprine].
Topics: Animals; Azathioprine; Body Weight; Dogs; Liver; Lymph Nodes; Lymphopenia; Serum Albumin | 1970 |
[Immunosuppressive therapy of glomerulotubular lesions in childhood].
Topics: Acute Disease; Azathioprine; Blood Cell Count; Blood Proteins; Blood Sedimentation; Child; Chronic D | 1970 |
Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease.
Topics: Clinical Enzyme Tests; Cost-Benefit Analysis; Female; Gastrointestinal Agents; Genetic Techniques; G | 2007 |