azathioprine has been researched along with Lymphoma in 91 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
Excerpt | Relevance | Reference |
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"We searched MEDLINE, EMBASE, and Cochrane databases, as well as conference abstracts and international publications, for the terms "6-MP and lymphoma," "6-mercaptopurine and lymphoma," "thiopurines and lymphoma," "azathioprine and cancer and IBD," "azathioprine and malignancy and IBD," "azathioprine and lymphoma," and "lymphoproliferative and thiopurines." | 8.91 | Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis. ( Beaugerie, L; Beigel, F; Bewtra, M; Biancone, L; Blonski, WC; Brensinger, CM; Chaparro, M; Gisbert, JP; Kotlyar, DS; Lewis, JD; Lichtenstein, GR; Loftus, EV; Peyrin-Biroulet, L; Sandilya, S; Tierney, A; Van Domselaar, M, 2015) |
"The purpose of this meta-analysis was to provide a more precise estimate of the relative risk of lymphoma among IBD patients treated with azathioprine or 6-MP." | 8.82 | Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. ( Brensinger, C; Fraser, AG; Kandiel, A; Korelitz, BI; Lewis, JD, 2005) |
" Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI) phenotype, the hallmark of a defective MMR system." | 7.81 | Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model. ( Beaugerie, L; Bodo, S; Brousse, N; Buhard, O; Capel, C; Chalastanis, A; Collura, A; Cuillières-Dartigues, P; Dinard, L; Dumont, S; Duval, A; Fabiani, B; Fléjou, JF; Lafitte, P; Ledent, T; Muleris, M; Penard-Lacronique, V; Sourrouille, I; Svrcek, M; Wanherdrick, K, 2015) |
"Prospective follow-up for a median of 35 months of a French cohort of 19 486 patients with inflammatory bowel disease showed a nearly 4-fold increase in the risk of lymphoma in patients exposed to azathioprine or mercaptopurine (relative risk 3." | 7.77 | Azathioprine and mercaptopurine: lymphoma. ( , 2011) |
"Treatment of inflammatory bowel disease with azathioprine or 6-mercaptopurine appears to be associated with a small increased risk of Epstein-Barr virus-positive lymphoma." | 7.71 | Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine. ( Burgart, LJ; Dayharsh, GA; Loftus, EV; Macon, WR; Sandborn, WJ; Tremaine, WJ; Witzig, TE; Zinsmeister, AR, 2002) |
"Two hundred and two patients with rheumatoid arthritis (RA) starting treatment with large doses of azathioprine (median 300 mg/day) between 1964 and 1974 were followed up until March 1984." | 7.67 | Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: a 20 year follow up study. ( Evans, SJ; Hazleman, B; Petrie, J; Silman, AJ, 1988) |
"Many of these lymphomas are associated with Epstein-Barr virus (EBV), which might be reactivated under immunosuppression." | 5.48 | Azathioprine-induced reversible EBV-associated Hodgkin-like lymphoma after immunosuppressive therapy for autoimmune hepatitis . ( Birkmann, J; Holzgrabe, U; Munz, M; Pretscher, D; Sörgel, F; Wilhelm, M, 2018) |
" It discusses the company's epidemiologic approach to the question of association between treatment with disease-modifying antirheumatic drugs, one of which is manufactured by Burroughs Wellcome Company (Imuran brand azathioprine) and a possible increased risk of neoplasms in patients receiving these drugs as treatment for their rheumatoid arthritis." | 5.05 | Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data. ( Tilson, HH; Whisnant, J, 1985) |
"We searched MEDLINE, EMBASE, and Cochrane databases, as well as conference abstracts and international publications, for the terms "6-MP and lymphoma," "6-mercaptopurine and lymphoma," "thiopurines and lymphoma," "azathioprine and cancer and IBD," "azathioprine and malignancy and IBD," "azathioprine and lymphoma," and "lymphoproliferative and thiopurines." | 4.91 | Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis. ( Beaugerie, L; Beigel, F; Bewtra, M; Biancone, L; Blonski, WC; Brensinger, CM; Chaparro, M; Gisbert, JP; Kotlyar, DS; Lewis, JD; Lichtenstein, GR; Loftus, EV; Peyrin-Biroulet, L; Sandilya, S; Tierney, A; Van Domselaar, M, 2015) |
"The purpose of this meta-analysis was to provide a more precise estimate of the relative risk of lymphoma among IBD patients treated with azathioprine or 6-MP." | 4.82 | Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. ( Brensinger, C; Fraser, AG; Kandiel, A; Korelitz, BI; Lewis, JD, 2005) |
" We present what we believe to be the first case of primary esophageal lymphoma in a patient on long-term immunosuppression with azathioprine who was also infected with the hepatitis C virus (HCV)." | 4.81 | Primary lymphoma of the esophagus in a chronically immunosuppressed patient with hepatitis C infection: case report and review of the literature. ( Golioto, M; McGrath, K, 2001) |
" Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI) phenotype, the hallmark of a defective MMR system." | 3.81 | Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model. ( Beaugerie, L; Bodo, S; Brousse, N; Buhard, O; Capel, C; Chalastanis, A; Collura, A; Cuillières-Dartigues, P; Dinard, L; Dumont, S; Duval, A; Fabiani, B; Fléjou, JF; Lafitte, P; Ledent, T; Muleris, M; Penard-Lacronique, V; Sourrouille, I; Svrcek, M; Wanherdrick, K, 2015) |
"Prospective follow-up for a median of 35 months of a French cohort of 19 486 patients with inflammatory bowel disease showed a nearly 4-fold increase in the risk of lymphoma in patients exposed to azathioprine or mercaptopurine (relative risk 3." | 3.77 | Azathioprine and mercaptopurine: lymphoma. ( , 2011) |
"Most untreated Msh2(WT) and Msh2(+/)⁻ mice remained asymptomatic and alive at 250 days of age, whereas azathioprine-treated Msh2(WT) and Msh2(+/)⁻ mice developed lymphomas and died prematurely (median survival of 71 and 165 days of age, respectively)." | 3.76 | Azathioprine-induced carcinogenesis in mice according to Msh2 genotype. ( Antoine, N; Buhard, O; Chalastanis, A; Defaweux, V; Dumont, S; Duval, A; Fabiani, B; Fléjou, JF; Muleris, M; Penard-Lacronique, V; Renault, I; Svrcek, M; Te Riele, H; Tubacher, E, 2010) |
"Treatment of inflammatory bowel disease with azathioprine or 6-mercaptopurine appears to be associated with a small increased risk of Epstein-Barr virus-positive lymphoma." | 3.71 | Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine. ( Burgart, LJ; Dayharsh, GA; Loftus, EV; Macon, WR; Sandborn, WJ; Tremaine, WJ; Witzig, TE; Zinsmeister, AR, 2002) |
"A prospective study in the United Kingdom of 1,634 patients without transplants treated with immunosuppressive drugs (68 percent with azathioprine, 28 percent with cyclophosphamide) found an excess of non-Hodgkin's lymphoma and squamous cell skin cancer, suggesting that the excesses (although larger) of the same malignancies found among transplant recipients are not due solely to the foreign antigens of the graft." | 3.67 | Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. ( Kinlen, LJ, 1985) |
"Two hundred and two patients with rheumatoid arthritis (RA) starting treatment with large doses of azathioprine (median 300 mg/day) between 1964 and 1974 were followed up until March 1984." | 3.67 | Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: a 20 year follow up study. ( Evans, SJ; Hazleman, B; Petrie, J; Silman, AJ, 1988) |
"A woman, aged 58, who had undergone prolonged treatment with corticosteroids for generalized necrotizing vasculitis, and had received azathioprine (Imurel) for 18 months, 4 years after discontinuing the latter treatment, developed peripheral neuropathy and a rapidly progressing cerebral disorder suggesting a basal meningeal process." | 3.66 | Primary malignant lymphoma of the CNS and polyneuropathy in a patient with necrotizing vasculitis treated with immunosuppression. ( Jellinger, K; Kothbauer, P; Sunder-Plassmann, E; Weiss, R, 1979) |
"Whether the risk of lymphoma is increased by immunosuppressive treatment with azathioprine, 6-mercaptopurine or infliximab is a common concern among patients and physicians considering using these agents." | 2.41 | Review article: the risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment. ( Aithal, GP; Mansfield, JC, 2001) |
"Many of these lymphomas are associated with Epstein-Barr virus (EBV), which might be reactivated under immunosuppression." | 1.48 | Azathioprine-induced reversible EBV-associated Hodgkin-like lymphoma after immunosuppressive therapy for autoimmune hepatitis . ( Birkmann, J; Holzgrabe, U; Munz, M; Pretscher, D; Sörgel, F; Wilhelm, M, 2018) |
"We present a case of atypical idiopathic retroperitoneal fibrosis (iRPF) presenting as a large pelvic tumor, for which it proved difficult to exclude T-cell malignant lymphoma." | 1.37 | Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma. ( de Mol, M; Langerak, AW; van Bommel, EF; Westenend, PJ, 2011) |
"The age-adjusted 8-year incidence of malignant lymphoma in the Netherlands was retrieved from the Central Bureau of Statistics." | 1.37 | Risk of malignant lymphoma in patients with inflammatory bowel diseases: a Dutch nationwide study. ( Bakkal, N; Casparie, MK; de Jong, DJ; Dijkstra, G; Hommes, DW; Minnee, RC; Oldenburg, B; Pierik, M; Stokkers, P; van Bodegraven, AA; van der Woude, CJ; Vos, AC, 2011) |
"Azathioprine is an accepted treatment of inflammatory bowel disease (IBD), but concerns exist regarding its carcinogenic potential." | 1.36 | Risk of cancer in inflammatory bowel disease treated with azathioprine: a UK population-based case-control study. ( Armstrong, RG; Card, TR; West, J, 2010) |
"Rather for several types of cancer a significantly reduced risk was observed, except for breast cancer in women treated with IS." | 1.35 | Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis. ( Berthier, F; Clavelou, P; Danzon, A; de Seze, J; Debouverie, M; Defer, G; Gout, O; Lebrun, C; Rumbach, L; Vermersch, P; Wiertlevski, S, 2008) |
"Azathioprine was given to 626 of 2204 patients (855 with Crohn's disease and 1349 with ulcerative colitis)." | 1.31 | Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine. ( Fraser, AG; Jewell, DP; Orchard, TR; Robinson, EM, 2002) |
" After our early experience with group 1, we attempted to use a lower cyclosporine dosage in group 2." | 1.29 | Heart transplantation for chronic Chagas' heart disease. ( Amato-Neto, V; Bacal, F; Bellotti, G; Bocchi, EA; Fiorelli, A; Higuchi, ML; Jatene, AD; Mocelin, AO; Pileggi, F; Stolf, NA; Uip, D, 1996) |
"Because of the increased incidence of malignant lymphoma under cyclosporin A this drug should be held in reserve in the treatment of Crohn's disease, until results from controlled studies have become available." | 1.27 | [Crohn disease: initial experiences with cyclosporin A in an adolescent girl]. ( Dannecker, G; Malchow, H; Niessen, KH; Ranke, MB, 1985) |
"The incidence of malignant neoplasms in patients subjected to pharmacological immunosuppression following kidney transplantation is higher than that observed in the control population at large." | 1.27 | [Malignant neoplastic pathology in patients given a kidney transplant]. ( Boschiero, L; Dean, P; Faccincani, L; Muolo, A; Prati, GF; Recchia, G, 1987) |
"Data on the possible increased risk of malignancy in rheumatoid arthritis are still being collected, and until further information is available, the use of immunosuppressive drugs, particularly alkylating agents, in the treatment of rheumatoid arthritis should be reserved for patients with severe progressive disease or life-threatening complications." | 1.27 | Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. ( Hazleman, B, 1985) |
"They included 8 cases of malignant lymphoma (non-Hodgkin), one of subacute myeloic leukemia, one of acute lymphatic leukemia, 6 skin cancers and 9 cancers of internal organs." | 1.26 | [Malignant tumors in bearers of kidney grafts in immunosuppressive therapy]. ( Binswanger, U; Briner, J; Largiadèr, F; Uhlschmid, G; Vollenweider, A, 1982) |
" The correlation between these is poor, in many patients, at the dosage used in man." | 1.26 | The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens. ( Hazleman, BL, 1982) |
"Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 44 (48.35) | 18.7374 |
1990's | 11 (12.09) | 18.2507 |
2000's | 14 (15.38) | 29.6817 |
2010's | 20 (21.98) | 24.3611 |
2020's | 2 (2.20) | 2.80 |
Authors | Studies |
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Kobayashi, T | 1 |
Udagawa, E | 1 |
Hibi, T | 1 |
Ranjan, MK | 1 |
Kante, B | 1 |
Vuyyuru, SK | 1 |
Kumar, P | 1 |
Mundhra, SK | 1 |
Golla, R | 1 |
Sharma, R | 1 |
Sahni, P | 1 |
Das, P | 1 |
Makharia, G | 1 |
Kedia, S | 1 |
Ahuja, V | 1 |
Lemaitre, M | 1 |
Kirchgesner, J | 1 |
Rudnichi, A | 1 |
Carrat, F | 1 |
Zureik, M | 1 |
Carbonnel, F | 1 |
Dray-Spira, R | 1 |
Munz, M | 1 |
Pretscher, D | 1 |
Wilhelm, M | 1 |
Holzgrabe, U | 1 |
Sörgel, F | 1 |
Birkmann, J | 1 |
Jordan, B | 1 |
Zierz, S | 1 |
Weber, T | 1 |
Jordan, K | 1 |
Khan, N | 2 |
Abbas, AM | 2 |
Lichtenstein, GR | 2 |
Loftus, EV | 4 |
Bazzano, LA | 2 |
Beaugerie, L | 3 |
Kumar, AR | 1 |
Dudnick, RS | 1 |
Kotlyar, DS | 1 |
Lewis, JD | 4 |
Tierney, A | 1 |
Brensinger, CM | 1 |
Gisbert, JP | 1 |
Peyrin-Biroulet, L | 1 |
Blonski, WC | 1 |
Van Domselaar, M | 1 |
Chaparro, M | 1 |
Sandilya, S | 1 |
Bewtra, M | 2 |
Beigel, F | 1 |
Biancone, L | 1 |
Scott, FI | 1 |
Vajravelu, RK | 1 |
Mamtani, R | 1 |
Lee, D | 1 |
Goldberg, DS | 1 |
Bodo, S | 1 |
Svrcek, M | 2 |
Sourrouille, I | 1 |
Cuillières-Dartigues, P | 1 |
Ledent, T | 1 |
Dumont, S | 2 |
Dinard, L | 1 |
Lafitte, P | 1 |
Capel, C | 1 |
Collura, A | 1 |
Buhard, O | 2 |
Wanherdrick, K | 1 |
Chalastanis, A | 2 |
Penard-Lacronique, V | 2 |
Fabiani, B | 2 |
Fléjou, JF | 2 |
Brousse, N | 1 |
Duval, A | 2 |
Muleris, M | 2 |
Pourfarziani, V | 1 |
Taheri, S | 1 |
Lessan-Pezeshki, M | 1 |
Nourbala, MH | 1 |
Simforoosh, N | 1 |
Nemati, E | 1 |
Makhdoomi, K | 1 |
Ghafari, A | 1 |
Ahmadpour, P | 1 |
Nafar, M | 1 |
Einollahi, B | 1 |
Armstrong, RG | 1 |
West, J | 1 |
Card, TR | 1 |
Defaweux, V | 1 |
Antoine, N | 1 |
Renault, I | 1 |
Tubacher, E | 1 |
Te Riele, H | 1 |
Loganathan, S | 1 |
Zaitoun, A | 1 |
Charlton, CP | 1 |
Vos, AC | 1 |
Bakkal, N | 1 |
Minnee, RC | 1 |
Casparie, MK | 1 |
de Jong, DJ | 1 |
Dijkstra, G | 1 |
Stokkers, P | 1 |
van Bodegraven, AA | 1 |
Pierik, M | 1 |
van der Woude, CJ | 1 |
Oldenburg, B | 1 |
Hommes, DW | 1 |
van Bommel, EF | 1 |
de Mol, M | 1 |
Langerak, AW | 1 |
Westenend, PJ | 1 |
Herrinton, LJ | 1 |
Liu, L | 1 |
Weng, X | 1 |
Hutfless, S | 1 |
Allison, JE | 1 |
Sultan, K | 1 |
Korelitz, BI | 2 |
Present, D | 1 |
Katz, S | 1 |
Sunday, S | 1 |
Shapira, I | 1 |
Kaukinen, K | 1 |
Ilus, T | 1 |
Vornanen, M | 1 |
Collin, P | 1 |
Subramaniam, K | 1 |
D'Rozario, J | 1 |
Pavli, P | 1 |
Fraser, AG | 2 |
Orchard, TR | 1 |
Robinson, EM | 1 |
Jewell, DP | 2 |
McGovern, DP | 1 |
Kandiel, A | 1 |
Brensinger, C | 1 |
Finelli, PF | 1 |
Sondheimer, JM | 1 |
Ang, YS | 1 |
Farrell, RJ | 1 |
Lin, PC | 1 |
Hsiao, LT | 1 |
Chen, PM | 1 |
Jones, JL | 1 |
Lebrun, C | 1 |
Debouverie, M | 1 |
Vermersch, P | 1 |
Clavelou, P | 1 |
Rumbach, L | 1 |
de Seze, J | 1 |
Wiertlevski, S | 1 |
Defer, G | 1 |
Gout, O | 1 |
Berthier, F | 1 |
Danzon, A | 1 |
Crawford, DH | 1 |
Edwards, JM | 1 |
Sweny, P | 1 |
Hoffbrand, AV | 1 |
Janossy, G | 1 |
Sato, A | 1 |
Kobayashi, K | 1 |
Okabe, H | 1 |
Fukuda, S | 1 |
Cohen, DJ | 1 |
Loertscher, R | 1 |
Rubin, MF | 1 |
Tilney, NL | 1 |
Carpenter, CB | 1 |
Strom, TB | 1 |
Chanda, JJ | 1 |
Callen, JP | 1 |
Cohen, SM | 1 |
Erturk, E | 1 |
Skibba, JL | 1 |
Bryan, GT | 1 |
Geary, CG | 1 |
Vollenweider, A | 1 |
Largiadèr, F | 1 |
Uhlschmid, G | 1 |
Binswanger, U | 1 |
Briner, J | 1 |
Hazleman, BL | 1 |
Lloveras, JJ | 1 |
Cointault, O | 1 |
Huyn, A | 1 |
Boyer, M | 1 |
Fournial, G | 1 |
Rostaing, L | 1 |
Durand, D | 1 |
Suc, JM | 1 |
Chu, SH | 1 |
Lai, MK | 1 |
Huang, CC | 1 |
Chuang, CK | 1 |
Chen, HW | 1 |
Chen, CS | 1 |
Batiuk, TD | 1 |
Barry, JM | 1 |
Bennett, WM | 1 |
Meyer, MM | 1 |
Tolzman, D | 1 |
Norman, DJ | 1 |
Present, DH | 1 |
Luciani, J | 1 |
Benalia, H | 1 |
Bitker, MO | 1 |
Mouquet, C | 1 |
Chartier-Kastler, E | 1 |
Ourhama, S | 1 |
Jacobs, C | 1 |
Chatelain, C | 1 |
Viars, P | 1 |
Penn, I | 3 |
Bocchi, EA | 1 |
Bellotti, G | 1 |
Mocelin, AO | 1 |
Uip, D | 1 |
Bacal, F | 1 |
Higuchi, ML | 1 |
Amato-Neto, V | 1 |
Fiorelli, A | 1 |
Stolf, NA | 1 |
Jatene, AD | 1 |
Pileggi, F | 1 |
Gruessner, RW | 1 |
Niaudet, P | 1 |
Herrlinger, U | 1 |
Weller, M | 1 |
Dichgans, J | 1 |
Melms, A | 1 |
Golioto, M | 1 |
McGrath, K | 1 |
Aithal, GP | 1 |
Mansfield, JC | 1 |
Dayharsh, GA | 1 |
Sandborn, WJ | 1 |
Tremaine, WJ | 1 |
Zinsmeister, AR | 1 |
Witzig, TE | 1 |
Macon, WR | 1 |
Burgart, LJ | 1 |
Jellinger, K | 1 |
Kothbauer, P | 1 |
Weiss, R | 1 |
Sunder-Plassmann, E | 1 |
Wurm, K | 1 |
Sieber, SM | 1 |
Kinlen, LJ | 2 |
Sheil, AG | 1 |
Peto, J | 1 |
Doll, R | 1 |
Mitrou, PS | 1 |
Fischer, M | 1 |
Mitrou, G | 1 |
Röttger, P | 1 |
Jauregui, HO | 1 |
Krueger, G | 1 |
Zółtowska, A | 1 |
Maniszewska, B | 1 |
Thumb, N | 1 |
Emery, RW | 1 |
Graif, JL | 1 |
Hale, K | 1 |
Eales, F | 1 |
Von Rueden, TJ | 1 |
Pritzker, MR | 1 |
Love, K | 1 |
Arom, KV | 1 |
Urowitz, MB | 1 |
Lee, P | 1 |
Ito, A | 1 |
Mori, M | 1 |
Naito, M | 1 |
Smith, JL | 1 |
Wilkinson, AH | 1 |
Hunsicker, LG | 1 |
Tobacman, J | 1 |
Kapelanski, DP | 1 |
Johnson, M | 1 |
Wright, FH | 1 |
Behrendt, DM | 1 |
Corry, RJ | 1 |
Dannecker, G | 1 |
Malchow, H | 1 |
Niessen, KH | 1 |
Ranke, MB | 1 |
Silman, AJ | 1 |
Petrie, J | 1 |
Hazleman, B | 2 |
Evans, SJ | 1 |
Polson, RJ | 1 |
Neuberger, J | 1 |
Forman, D | 1 |
Calne, R | 1 |
Williams, R | 1 |
Prati, GF | 1 |
Recchia, G | 1 |
Dean, P | 1 |
Boschiero, L | 1 |
Faccincani, L | 1 |
Muolo, A | 1 |
Citterio, F | 1 |
Lauriola, L | 1 |
Nanni, G | 1 |
Vecchio, FM | 1 |
Magalini, SC | 1 |
Castagneto, M | 1 |
Tilson, HH | 1 |
Whisnant, J | 1 |
Krueger, TC | 1 |
Tallent, MB | 1 |
Richie, RE | 1 |
Johnson, HK | 1 |
MacDonell, RC | 1 |
Turner, B | 1 |
Lovisetto, P | 1 |
Manachino, D | 1 |
Biarese, V | 1 |
Marchi, L | 1 |
Andrione, P | 1 |
Schneck, SA | 2 |
Gleichmann, E | 2 |
Gleichmann, H | 2 |
Casey, TP | 2 |
Mellors, RC | 1 |
Rhodes, J | 1 |
Imamura, N | 1 |
Nakano, M | 1 |
Kawase, A | 1 |
Kawamura, Y | 1 |
Yokoro, K | 1 |
Cerilli, J | 1 |
Hattan, D | 1 |
Hammond, W | 1 |
Brettschneider, L | 1 |
Starzl, TE | 1 |
Swannell, AJ | 1 |
Kersley, GD | 1 |
Vredevoe, DL | 1 |
Hays, EF | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Study of Compliance, Practice Patterns, and Barriers REgarding Established National Screening Programs for Barrett's Esophagus: SCREEN-BE[NCT04408105] | 725 participants (Actual) | Observational | 2020-02-19 | Active, not recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
16 reviews available for azathioprine and Lymphoma
Article | Year |
---|---|
Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis.
Topics: Adult; Aged; Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Ly | 2015 |
[When gluten-free diet does not cure celiac disease].
Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Azathioprine; Biomarkers; Celiac Disease; | 2012 |
Lymphoma and other lymphoproliferative disorders in inflammatory bowel disease: a review.
Topics: Age Factors; Azathioprine; Epstein-Barr Virus Infections; Humans; Immunosuppressive Agents; Inflamma | 2013 |
Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Lymphoma; Male; | 2005 |
Lymphoma risk in inflammatory bowel disease: is it the disease or its treatment?
Topics: Anti-Infective Agents; Antibodies, Monoclonal; Azathioprine; Humans; Immunosuppressive Agents; Infla | 2007 |
Cyclosporine: a new immunosuppressive agent for organ transplantation.
Topics: Animals; Azathioprine; Bone Marrow Transplantation; Chemical and Drug Induced Liver Injury; Cyclospo | 1984 |
Primary lymphoma of the esophagus in a chronically immunosuppressed patient with hepatitis C infection: case report and review of the literature.
Topics: Aged; Azathioprine; Esophageal Neoplasms; Hepatitis C; Humans; Immunosuppression Therapy; Immunosupp | 2001 |
Review article: the risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment.
Topics: Antibodies, Monoclonal; Azathioprine; Epidemiologic Studies; Gastrointestinal Agents; Humans; Immuno | 2001 |
[Sarcoidosis therapy and its problems today].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents; Antineoplasti | 1978 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
The risks of antimalarial retinopathy, azathioprine lymphoma and methotrexate hepatotoxicity during the treatment of rheumatoid arthritis.
Topics: Antimalarials; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; | 1990 |
[Blood hypereosinophilias. IV. Symptomatic hypereosinophilias: connective tissue diseases, neoplasms, blood diseases, various causes].
Topics: Aged; Asthma; Azathioprine; Connective Tissue Diseases; Cortisone; Eosinophilia; Female; Hematologic | 1985 |
Immunosuppression and neoplasia. II. Is deficient immunesurveillance the only mechanism by which immunosuppression promotes neoplasia? A speculative review.
Topics: Animals; Animals, Newborn; Antilymphocyte Serum; Antimetabolites; Azathioprine; Carcinogens; Cell Di | 1973 |
Immunosuppression and neoplasia. I. A critical review of experimental carcinogenesis and the immunesurveillance theory.
Topics: Animals; Antigens, Neoplasm; Antilymphocyte Serum; Autoantibodies; Azathioprine; Benz(a)Anthracenes; | 1973 |
Murine leukemialike virus and the immunopathologic disorders of New Zealand black mice.
Topics: Anemia, Hemolytic, Autoimmune; Animals; Animals, Newborn; Antigens; Autoimmune Diseases; Azathioprin | 1969 |
Immunology in neoplasia relating to diagnosis, therapy and transplantation. Immunosuppression and oncogenesis.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinogens; Cortisone; Humans; Immunos | 1974 |
5 trials available for azathioprine and Lymphoma
Article | Year |
---|---|
Incidence and type of cancer following the use of OKT3: a single center experience with 557 organ transplants.
Topics: Adenoma, Bile Duct; Age Factors; Azathioprine; Cyclosporine; Follow-Up Studies; Humans; Immunosuppre | 1993 |
Influence of antilymphocyte globulin upon the incidence of malignancies after kidney transplantation.
Topics: Adult; Age Factors; Antilymphocyte Serum; Azathioprine; Cyclosporine; Follow-Up Studies; Humans; Imm | 1993 |
Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Bone Marrow Transplantation; Case-Control Studies; Cy | 1997 |
Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data.
Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Computers; Drug Industry; Humans; Leu | 1985 |
Azathioprine in the treatment of Crohn's disease.
Topics: Azathioprine; Clinical Trials as Topic; Colic; Crohn Disease; Humans; Leukopenia; Lymphoma; Placebos | 1972 |
70 other studies available for azathioprine and Lymphoma
Article | Year |
---|---|
Lack of Increased Risk of Lymphoma with Thiopurine Therapy Regardless of Dose and Duration of Treatment in Japanese Patients with Inflammatory Bowel Diseases.
Topics: Azathioprine; Duration of Therapy; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Ja | 2022 |
Minimal risk of lymphoma and non-melanoma skin cancer despite long-term use of thiopurines in patients with inflammatory bowel disease: A longitudinal cohort analysis from northern India.
Topics: Azathioprine; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Humans; India; Inflammatory Bowel | 2022 |
Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With Inflammatory Bowel Disease.
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Cohort Studies; Drug Therapy, | 2017 |
Azathioprine-induced reversible EBV-associated Hodgkin-like lymphoma after immunosuppressive therapy for autoimmune hepatitis
.
Topics: Azathioprine; Epstein-Barr Virus Infections; Hepatitis, Autoimmune; Herpesvirus 4, Human; Humans; Im | 2018 |
Successful use of an immune checkpoint inhibitor in a patient with myasthenia gravis in remission.
Topics: Antineoplastic Agents, Immunological; Azathioprine; Central Nervous System Neoplasms; Cholinesterase | 2019 |
Risk of lymphoma in patients with ulcerative colitis treated with thiopurines: a nationwide retrospective cohort study.
Topics: Adult; Aged; Antibodies, Monoclonal; Azathioprine; Cohort Studies; Colitis, Ulcerative; Female; Foll | 2013 |
Lymphoma: the bête noire of the long-term use of thiopurines in adult and elderly patients with inflammatory bowel disease.
Topics: Antibodies, Monoclonal; Azathioprine; Colitis, Ulcerative; Female; Humans; Immunosuppressive Agents; | 2013 |
Reply: To PMID 23891975.
Topics: Antibodies, Monoclonal; Azathioprine; Colitis, Ulcerative; Female; Humans; Immunosuppressive Agents; | 2014 |
Have we overestimated the risk of lymphoma associated with thiopurine treatment for ulcerative colitis?
Topics: Antibodies, Monoclonal; Azathioprine; Colitis, Ulcerative; Female; Humans; Immunosuppressive Agents; | 2014 |
The benefit-to-risk balance of combining infliximab with azathioprine varies with age: a markov model.
Topics: Adult; Age Factors; Aged; Azathioprine; Communicable Diseases; Crohn Disease; Drug Therapy, Combinat | 2015 |
Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model.
Topics: Adult; Aged; Animals; Azathioprine; Disease Models, Animal; DNA Mismatch Repair; Dose-Response Relat | 2015 |
Lymphoma after living donor kidney transplantation: an Iranian multicenter experience.
Topics: Adult; Azathioprine; Chi-Square Distribution; Female; Humans; Immunosuppressive Agents; Incidence; I | 2008 |
Risk of cancer in inflammatory bowel disease treated with azathioprine: a UK population-based case-control study.
Topics: Adult; Aged; Antimetabolites; Azathioprine; Case-Control Studies; Chi-Square Distribution; Female; H | 2010 |
Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Azathioprine; Carcinogens; Disease M | 2010 |
Lymphoma with central nervous system involvement in a young patient with Crohn disease treated with azathioprine.
Topics: Adolescent; Azathioprine; Brain Neoplasms; Crohn Disease; Female; Humans; Immunosuppressive Agents; | 2010 |
Azathioprine and mercaptopurine: lymphoma.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Lymphoma; Mercaptopurin | 2011 |
Risk of malignant lymphoma in patients with inflammatory bowel diseases: a Dutch nationwide study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Case-Control Studies; Child; Child, Presch | 2011 |
Idiopathic retroperitoneal fibrosis mimicking malignant lymphoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Biopsy; Clone Cells; Diagnosis, | 2011 |
Role of thiopurine and anti-TNF therapy in lymphoma in inflammatory bowel disease.
Topics: Adalimumab; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, M | 2011 |
Prognosis of lymphoma in patients following treatment with 6-mercaptopurine/azathioprine for inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Colitis, Ulcerative; Crohn Disease; Female | 2012 |
Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine.
Topics: Adolescent; Adult; Age Distribution; Aged; Azathioprine; Colorectal Neoplasms; Drug Administration S | 2002 |
Risks and benefits of azathioprine therapy.
Topics: Antimetabolites; Azathioprine; Humans; Inflammatory Bowel Diseases; Lymphoma; Risk Factors; Severity | 2005 |
Primary CNS lymphoma in myasthenic on long-term azathioprine.
Topics: Antigens, CD20; Antimetabolites, Antineoplastic; Azathioprine; Brain Neoplasms; Diagnosis, Different | 2005 |
Lymphoma after Imuran and 6-MP: a new look.
Topics: Azathioprine; Humans; Inflammatory Bowel Diseases; Lymphoma; Mercaptopurine; Risk Factors | 2005 |
Risk of lymphoma: inflammatory bowel disease and immunomodulators.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Lymphoma; Mercaptopurin | 2006 |
Acute graft-versus-host disease of the lung with atypical presentation.
Topics: Acute Disease; Anti-Inflammatory Agents; Azathioprine; Graft vs Host Disease; Hematopoietic Stem Cel | 2006 |
Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis.
Topics: Adult; Azathioprine; Breast Neoplasms; Central Nervous System Neoplasms; Cyclophosphamide; Digestive | 2008 |
Studies on long-term T-cell-mediated immunity to Epstein-BArr virus in immunosuppressed renal allograft recipients.
Topics: Azathioprine; Cyclosporins; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Kidney Transplan | 1981 |
A case of the hypereosinophilic syndrome complicated by malignant lymphoma.
Topics: Adolescent; Adult; Azathioprine; Brain Neoplasms; Eosinophilia; Female; Humans; Lymphoma; Prednisolo | 1983 |
Necrotizing vasculitis (angiitis) with granulomatosis.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Diagnosis, Differential; Granuloma, Lethal Midline; Gr | 1984 |
Azathioprine induction of lymphomas and squamous cell carcinomas in rats.
Topics: Animals; Azathioprine; Carcinoma, Squamous Cell; Ear Neoplasms; Female; Lymphoma; Rats; Rats, Inbred | 1983 |
Lymphoma and leukaemia due to drugs.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bone Marrow Diseases; Child; Female; Hodgkin Disease; | 1980 |
[Malignant tumors in bearers of kidney grafts in immunosuppressive therapy].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Breast Neoplasms; Dysgerminoma; Female; Humans; Immunosup | 1982 |
The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens.
Topics: Adult; Aged; Animals; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Transitional Cell; Chromosome | 1982 |
Decreased incidence of lymphomas after heart transplantation under low-dose immunosuppression.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Cyclosporine; Female; Heart Transplantation; Humans; Immu | 1995 |
Prognosis of posttransplant lymphomas in patients treated with cyclosporine, azathioprine, and prednisolone.
Topics: Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Graft Survival; Humans; Immuno | 1994 |
Cyclosporine and other immunosuppressive agents: current and future role in the treatment of inflammatory bowel disease.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cyclosporine; Humans; Immunosuppressive Agents; In | 1993 |
Cancers in cyclosporine-treated vs azathioprine-treated patients.
Topics: Adult; Azathioprine; Child; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Neoplasms | 1996 |
Heart transplantation for chronic Chagas' heart disease.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Cause of Death; Chagas Cardiomyopathy; Child; C | 1996 |
Postransplant lymphoproliferative disease following renal transplantation: a multicenter retrospective study of 41 cases observed between 1992 and 1996. French Speaking Transplantation Workshop.
Topics: Azathioprine; Cyclosporine; Drug Therapy, Combination; Humans; Immunophenotyping; Immunosuppression | 1998 |
Association of primary central nervous system lymphoma with long-term azathioprine therapy for myasthenia gravis?
Topics: Aged; Azathioprine; Central Nervous System Neoplasms; Humans; Immunosuppressive Agents; Lymphoma; Mi | 2000 |
Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Epstein-Barr Virus Infections; Female; Herpesvirus 4, | 2002 |
Primary malignant lymphoma of the CNS and polyneuropathy in a patient with necrotizing vasculitis treated with immunosuppression.
Topics: Azathioprine; Brain Neoplasms; Female; Humans; Immunosuppressive Agents; Lymphoma; Middle Aged; Necr | 1979 |
Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.
Topics: Adolescent; Adult; Aged; Australia; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Follow-Up | 1979 |
The oncogenic effect of immunosuppressive (cytotoxic) agents in (NZB x NZW) mice. II. Emergence of tumors in young animals treated with azathioprine and ifosfamide, including a histologic assessment of the neoplasms.
Topics: Animals; Azathioprine; Carcinogens; Carcinoma; Cyclophosphamide; Female; Hyperplasia; Ifosfamide; Ly | 1979 |
Lymphomatoid granulomatosis after immunosuppression for pemphigus.
Topics: Aged; Autopsy; Azathioprine; Granuloma; Humans; Immunosuppressive Agents; Lung; Lymphoma; Male; Pemp | 1978 |
The significance of immunosuppression and antigenic stimulation in the development of malignant lymphomas.
Topics: Animals; Antibody-Producing Cells; Antigen-Antibody Reactions; Antineoplastic Agents; Azathioprine; | 1975 |
[Changes in the lymphoreticular system of animals following long-term immunization with antityphoid vaccine].
Topics: Animals; Azathioprine; B-Lymphocytes; Cricetinae; Disease Models, Animal; Female; Guinea Pigs; Haplo | 1975 |
Changes in the lymphoreticular system of Swiss mice subjected to antigenic stimulation, immunosuppression, or both.
Topics: Animals; Azathioprine; Burkitt Lymphoma; Female; Immunization; Immunosuppression Therapy; Lymphatic | 1977 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Treatment of end-stage chronic obstructive pulmonary disease with double lung transplantation.
Topics: Adult; Antibodies, Monoclonal; Azathioprine; Cyclosporins; Cytomegalovirus Infections; Emphysema; Fe | 1991 |
Induction of uterine hemangioendothelioma and lymphoma in (C57BL/6N x C3H/2N)F1 mice by oral administration of azathioprine.
Topics: Administration, Oral; Animals; Azathioprine; Body Weight; Female; Hemangioendothelioma; Lymphoma; Ma | 1989 |
Increased frequency of posttransplant lymphomas in patients treated with cyclosporin, azathioprine, and prednisone.
Topics: Azathioprine; Cyclosporins; Drug Therapy, Combination; Heart Transplantation; Humans; Immunosuppress | 1989 |
[Crohn disease: initial experiences with cyclosporin A in an adolescent girl].
Topics: Adolescent; Azathioprine; Crohn Disease; Cyclosporins; Female; Humans; Lymphoma; Osteoporosis; Predn | 1985 |
Lymphoproliferative cancer and other malignancy in patients with rheumatoid arthritis treated with azathioprine: a 20 year follow up study.
Topics: Arthritis, Rheumatoid; Azathioprine; Follow-Up Studies; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; | 1988 |
De novo malignancies after liver transplantation.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Azathioprine; Child; Colonic Neoplasms; Cyclosporins; Dysge | 1988 |
[Malignant neoplastic pathology in patients given a kidney transplant].
Topics: Azathioprine; Humans; Immunosuppression Therapy; Kidney Transplantation; Lymphoma; Neoplasms; Sarcom | 1987 |
Polyclonal lymphoma confined to renal allograft: case report.
Topics: Adult; Azathioprine; Cyclosporins; Humans; Immunosuppression Therapy; Kidney Neoplasms; Kidney Trans | 1987 |
Neoplasia in immunosuppressed renal transplant patients: a 20-year experience.
Topics: Adolescent; Adult; Aged; Antilymphocyte Serum; Azathioprine; Cadaver; Child; Child, Preschool; Cyclo | 1985 |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppres | 1985 |
Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squa | 1985 |
De-novo brain tumours in renal-transplant recipients.
Topics: Adolescent; Adult; Azathioprine; Brain; Brain Neoplasms; Cadaver; Follow-Up Studies; Humans; Immunos | 1971 |
Immunosuppression and intracerebral lymphomas.
Topics: Adolescent; Adult; Age Factors; Azathioprine; Brain Neoplasms; Humans; Immune Tolerance; Immunosuppr | 1971 |
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.
Topics: Albuminuria; Anemia, Hemolytic, Autoimmune; Animals; Azathioprine; Coombs Test; Glomerulonephritis; | 1968 |
Neurology and neuropathology of immunosuppressive therapy and acquired immunological deficiency.
Topics: Adolescent; Adult; Agammaglobulinemia; Aspergillus; Azathioprine; Brain; Brain Diseases; Candida; Ce | 1971 |
Synergistic action of N-nitrosobutylurea and azathioprine in induction of leukemia in C57BL mice.
Topics: AKR murine leukemia virus; Animals; Antigens, Viral; Azathioprine; Drug Synergism; Female; Immune Se | 1973 |
Malignant lymphomas in transplantation patients.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Humans; Immunosuppre | 1969 |
Preliminary results with azathioprine treatment in rheumatoid arthritis.
Topics: Alkaline Phosphatase; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Drug Synergism; Fem | 1969 |
The development of lymphomas in mice with autoimmune disorders treated with azathioprine.
Topics: Animals; Autoimmune Diseases; Azathioprine; Female; Injections, Intramuscular; Lupus Erythematosus, | 1968 |
Effect of antilymphocytic and antithymocytic sera on the development of mouse lymphoma.
Topics: AKR murine leukemia virus; Animals; Antilymphocyte Serum; Azathioprine; Hemagglutination; Immune Ser | 1969 |