azathioprine has been researched along with Lymphoma, Large B-Cell, Diffuse in 34 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic immunosuppression is a known risk factor for various malignancies, and azathioprine in particular has been reported in association with solid and hematologic malignancies, including diffuse large B-cell lymphoma." | 8.31 | Primary hepatic Epstein-Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report. ( Marell, PS; Shi, M; Wingo, MT, 2023) |
| "A 52-year-old woman was treated for colorectal diffuse large B-cell lymphoma (DLBCL) after a prolonged treatment period of azathioprine (AZA) and infliximab (IFX) for Crohn's disease (CD)." | 7.96 | Diffuse large B-cell lymphoma of the colon and rectum in a patient with colonic Crohn's disease treated with infliximab and azathioprine. ( Daikuhara, S; Hirayama, A; Sato, K; Suga, T; Tanaka, E; Uehara, T, 2020) |
| "Azathioprine is used for immunosuppression in myasthenia gravis (MG)." | 7.81 | Brainstem lymphoma in a myasthenia gravis patient on azathioprine. ( Katirji, B; Termsarasab, P, 2015) |
| "Side effects of long-term use of azathioprine in myasthenia gravis are infrequently reported." | 7.71 | Prostatic involvement of a testicular lymphoma in a patient with myasthenia gravis on long-term azathioprine. ( Barthelmes, L; Seale, JR; Thomas, KJ, 2002) |
| " Chronic immunosuppression is a known risk factor for various malignancies, and azathioprine in particular has been reported in association with solid and hematologic malignancies, including diffuse large B-cell lymphoma." | 4.31 | Primary hepatic Epstein-Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report. ( Marell, PS; Shi, M; Wingo, MT, 2023) |
| "A 52-year-old woman was treated for colorectal diffuse large B-cell lymphoma (DLBCL) after a prolonged treatment period of azathioprine (AZA) and infliximab (IFX) for Crohn's disease (CD)." | 3.96 | Diffuse large B-cell lymphoma of the colon and rectum in a patient with colonic Crohn's disease treated with infliximab and azathioprine. ( Daikuhara, S; Hirayama, A; Sato, K; Suga, T; Tanaka, E; Uehara, T, 2020) |
| "We report a case of a 40 year old female who presented with a three month history of headaches with a background of Myasthenia Gravis (MG), treated with azathioprine." | 3.88 | An unusual presentation of cerebellar lymphoma. ( Astradsson, A; Harley, B; Muthurajah, V; Shivapathasundram, G; Wickremesekera, A, 2018) |
| "Azathioprine is used for immunosuppression in myasthenia gravis (MG)." | 3.81 | Brainstem lymphoma in a myasthenia gravis patient on azathioprine. ( Katirji, B; Termsarasab, P, 2015) |
| "Side effects of long-term use of azathioprine in myasthenia gravis are infrequently reported." | 3.71 | Prostatic involvement of a testicular lymphoma in a patient with myasthenia gravis on long-term azathioprine. ( Barthelmes, L; Seale, JR; Thomas, KJ, 2002) |
| "A 57-year old woman with perianal Crohn's disease receiving azathioprine and infliximab developed this type of lymphoma after a short period of time on the treatment." | 1.37 | Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection. ( Aldeguer, M; Arevalo, N; Benito, DM; de Fuenmayor, ML; Foncillas, MA; Plaza, R; Ponferrada, A, 2011) |
| "Multiple brain tumors were found and diagnosed as having B-cell, diffuse large cell type malignant lymphoma." | 1.30 | [A case of malignant lymphoma after renal transplantation]. ( Ikeda, K; Inoue, S; Matsuura, O; Murakami, S; Oyama, H; Sugiyama, T; Yamao, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (50.00) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 4 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Marell, PS | 1 |
| Shi, M | 1 |
| Wingo, MT | 1 |
| Christin, A | 1 |
| de Leval, L | 1 |
| Obeid, M | 1 |
| Suzuki, K | 1 |
| Ohe, R | 1 |
| Kabasawa, T | 1 |
| Aung, NY | 1 |
| Yano, M | 1 |
| Katsumi, S | 1 |
| Yanagiya, R | 1 |
| Yamamoto, M | 1 |
| Toubai, T | 1 |
| Ishizawa, K | 1 |
| Yamakawa, M | 1 |
| Quera, R | 1 |
| Flores, L | 1 |
| Simian, D | 1 |
| Kronberg, U | 1 |
| Vial, MT | 1 |
| de Guevara, DL | 1 |
| García-Rodríguez, MJ | 1 |
| Harley, B | 1 |
| Shivapathasundram, G | 1 |
| Astradsson, A | 1 |
| Muthurajah, V | 1 |
| Wickremesekera, A | 1 |
| Sato, K | 1 |
| Suga, T | 1 |
| Hirayama, A | 1 |
| Daikuhara, S | 1 |
| Uehara, T | 1 |
| Tanaka, E | 1 |
| Termsarasab, P | 1 |
| Katirji, B | 1 |
| Quesada, AE | 1 |
| Huh, YO | 1 |
| Wang, W | 1 |
| Medeiros, LJ | 1 |
| Thakral, B | 1 |
| Otto, F | 1 |
| Neuen-Jacob, E | 1 |
| Arendt, G | 1 |
| Stüve, O | 1 |
| Hartung, HP | 1 |
| McAleer, MA | 1 |
| D'Arcy, CA | 1 |
| Mulligan, NJ | 1 |
| Sheahan, K | 1 |
| Collins, P | 1 |
| Staufer, K | 1 |
| Sterneck, M | 1 |
| Schaefer, H | 1 |
| Nashan, B | 1 |
| Fischer, L | 1 |
| Plaza, R | 1 |
| Ponferrada, A | 1 |
| Benito, DM | 1 |
| Arevalo, N | 1 |
| Foncillas, MA | 1 |
| de Fuenmayor, ML | 1 |
| Aldeguer, M | 1 |
| Flynn, AD | 1 |
| Azar, JM | 1 |
| Chiorean, MV | 1 |
| Barthelmes, L | 1 |
| Thomas, KJ | 1 |
| Seale, JR | 1 |
| Gündüz, E | 1 |
| Korkmaz, C | 1 |
| Kaşifoğlu, T | 1 |
| Gülbaş, Z | 1 |
| Pirofsky, B | 1 |
| Dawson, PJ | 1 |
| Reid, RH | 1 |
| Geary, CG | 1 |
| Oyama, H | 1 |
| Yamao, K | 1 |
| Sugiyama, T | 1 |
| Matsuura, O | 1 |
| Murakami, S | 1 |
| Ikeda, K | 1 |
| Inoue, S | 1 |
| Tan, CW | 1 |
| Wilson, GE | 1 |
| Howat, JM | 1 |
| Shreeve, DR | 1 |
| Viteri, A | 1 |
| Vernace, SJ | 1 |
| Schaffner, F | 1 |
| Krueger, G | 1 |
| Schneck, SA | 1 |
| Penn, I | 2 |
| Pierce, JC | 1 |
| Madge, GE | 1 |
| Lee, HM | 1 |
| Hume, DM | 1 |
| Allison, AC | 1 |
| Birkeland, SA | 1 |
| Kemp, E | 1 |
| Miller, G | 1 |
| Coope, D | 1 |
| Sneddon, I | 1 |
| Wishart, JM | 1 |
| Imamura, N | 1 |
| Nakano, M | 1 |
| Kawase, A | 1 |
| Kawamura, Y | 1 |
| Yokoro, K | 1 |
| Myers, BD | 1 |
| Kessler, E | 1 |
| Levi, J | 1 |
| Pick, A | 1 |
| Rosenfeld, JB | 1 |
| Tikvah, P | 1 |
| Donohue, LR | 1 |
| Guisan, Y | 1 |
| Enderlin, F | 1 |
| Harder, F | 1 |
| Brunner, F | 1 |
| Thiel, G | 1 |
| Bernhardt, JP | 1 |
| Schädeli, J | 1 |
| Mihatsch, M | 1 |
| Moser, KD | 1 |
| Araoz, CA | 1 |
| Smith, PL | 1 |
| Deodhar, SD | 1 |
| Konomi, K | 1 |
| Nakamoto, S | 1 |
| Kuruvila, KC | 1 |
| Hammond, W | 1 |
| Brettschneider, L | 1 |
| Starzl, TE | 1 |
1 review available for azathioprine and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Colposcopic and cytologic evaluation of women undergoing immunosuppressive therapy.
Topics: Antigens, Neoplasm; Azathioprine; Carcinoma in Situ; Carcinoma, Squamous Cell; Colposcopy; Female; G | 1974 |
1 trial available for azathioprine and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Clinical experience with antilymphocyte globulin (ALG) in renal transplantation.
Topics: Anaphylaxis; Antilymphocyte Serum; Azathioprine; Clinical Trials as Topic; Drug Synergism; Graft Rej | 1971 |
32 other studies available for azathioprine and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Primary hepatic Epstein-Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report.
Topics: Azathioprine; Epstein-Barr Virus Infections; Female; Hematologic Neoplasms; Herpesvirus 4, Human; Hu | 2023 |
A Diffuse Medullary Hypercaptation With No Bone Lesion.
Topics: Aged; Anti-Inflammatory Agents; Autoimmune Diseases; Azathioprine; Fatal Outcome; Humans; Immunosupp | 2020 |
A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis.
Topics: Aged; Azathioprine; Colitis, Ulcerative; Colorectal Neoplasms; Humans; Iatrogenic Disease; Immunocom | 2020 |
[Rectal diffuse large B cell lymphoma appearing after immunosuppression for ulcerative colitis. Report of one case].
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Biopsy; Colitis, Ulcerative; Cyclophos | 2017 |
An unusual presentation of cerebellar lymphoma.
Topics: Adult; Azathioprine; Cerebellar Neoplasms; Epstein-Barr Virus Infections; Female; Humans; Immunocomp | 2018 |
Diffuse large B-cell lymphoma of the colon and rectum in a patient with colonic Crohn's disease treated with infliximab and azathioprine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Azathioprine; Colorectal Neopl | 2020 |
Brainstem lymphoma in a myasthenia gravis patient on azathioprine.
Topics: Aged, 80 and over; Azathioprine; Brain Stem Neoplasms; Disease Progression; Fatal Outcome; Humans; I | 2015 |
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma in a patient treated with azathioprine for ulcerative colitis.
Topics: Anaplastic Lymphoma Kinase; Azathioprine; Colitis, Ulcerative; Humans; Immunocompromised Host; Immun | 2016 |
A 69-year-old man with left hemispheric necrotizing mass lesion.
Topics: Aged; Azathioprine; Brain; Brain Stem; Encephalitis, Viral; Epstein-Barr Virus Infections; Humans; I | 2009 |
Primary cutaneous lymphoma associated with Epstein-Barr virus and azathioprine therapy.
Topics: Aged; Azathioprine; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, | 2010 |
Sirolimus addition to tacrolimus-based immunosuppression induces complete remission of post-transplant lymphoproliferative disorder in a liver transplant recipient.
Topics: Azathioprine; Female; Humans; Immunosuppression Therapy; Liver Transplantation; Lymphoma, Large B-Ce | 2010 |
Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Az | 2011 |
Spontaneous regression of colonic lymphoma following infliximab and azathioprine withdrawal in patients with Crohn's disease.
Topics: Adult; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Colonic | 2013 |
Prostatic involvement of a testicular lymphoma in a patient with myasthenia gravis on long-term azathioprine.
Topics: Azathioprine; Fatal Outcome; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Middle | 2002 |
Unusual presentation of non-Hodgkin lymphoma: polyarthritis and uveitis mimicking a rheumatologic disease.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middl | 2008 |
Lack of oncogenicity with immunosuppressive therapy.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Female; Friend murine leukemia virus; Immunosuppression | 1980 |
Lymphoma and leukaemia due to drugs.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bone Marrow Diseases; Child; Female; Hodgkin Disease; | 1980 |
[A case of malignant lymphoma after renal transplantation].
Topics: Adult; Azathioprine; Brain Neoplasms; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immuno | 1997 |
Rectal lymphoma in ulcerative colitis treated with azathioprine.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, | 2001 |
Extrahepatic malignancy in chronic liver disease: report of six cases.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chronic Disease; Cystadenocarcinoma; Female; Hepatitis | 1976 |
The significance of immunosuppression and antigenic stimulation in the development of malignant lymphomas.
Topics: Animals; Antibody-Producing Cells; Antigen-Antibody Reactions; Antineoplastic Agents; Azathioprine; | 1975 |
De-novo brain tumours in renal-transplant recipients.
Topics: Adolescent; Adult; Azathioprine; Brain; Brain Neoplasms; Cadaver; Follow-Up Studies; Humans; Immunos | 1971 |
Lymphoma, a complication of renal allotransplantation in man.
Topics: Adolescent; Adult; Azathioprine; Dactinomycin; Histocompatibility Testing; Humans; Kidney Transplant | 1972 |
Tumour development following immunosuppression.
Topics: Adult; Animals; Antilymphocyte Serum; Azathioprine; Child; Cricetinae; Female; Humans; Immunity, Cel | 1970 |
Malignant tumours following immunosuppression in renal transplantation.
Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom | 1973 |
Epstein-Barr viral nuclear antigen (EBNA) in tumor cell imprints of experimental lymphoma of marmosets.
Topics: Animals; Antigens, Viral; Azathioprine; Burkitt Lymphoma; Cell Line; Cell Nucleus; Cell Transformati | 1974 |
Immunosuppression and malignancy.
Topics: Adult; Azathioprine; Dermatomyositis; Female; Humans; Immunosuppression Therapy; Lymphoma, Large B-C | 1972 |
Synergistic action of N-nitrosobutylurea and azathioprine in induction of leukemia in C57BL mice.
Topics: AKR murine leukemia virus; Animals; Antigens, Viral; Azathioprine; Drug Synergism; Female; Immune Se | 1973 |
Kaposi sarcoma in kidney transplant recipients.
Topics: Adult; Antilymphocyte Serum; Autopsy; Azathioprine; Brain Neoplasms; Cadaver; Female; Graft Rejectio | 1974 |
[Malignant tumors following transplantation. Case reports and review of the literature].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Graft Rejection; Humans; Kidney | 1973 |
Immunosuppressive therapy and reticulum cell sarcomas of the brain. A report of 2 cases.
Topics: Adult; Azathioprine; Brain Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male | 1972 |
Malignant lymphomas in transplantation patients.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Humans; Immunosuppre | 1969 |