Page last updated: 2024-10-23

azathioprine and Lymphohistiocytosis, Hemophagocytic

azathioprine has been researched along with Lymphohistiocytosis, Hemophagocytic in 23 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Lymphohistiocytosis, Hemophagocytic: A group of related disorders characterized by LYMPHOCYTOSIS; HISTIOCYTOSIS; and hemophagocytosis. The two major forms are familial and reactive.

Research Excerpts

ExcerptRelevanceReference
"In this paper, we describe a case of an acute cytomegalovirus (CMV) infection in a 35-year-old male patient with Crohn's disease being in remission while receiving azathioprine therapy."3.88Severe complication during remission of Crohn's disease: hemophagocytic lymphohistiocytosis due to acute cytomegalovirus infection. ( Aichinger, W; Kirchgatterer, A; Miechowiecki, J; Prammer, W; Stainer, W; Tuppy, H; Wallner, G, 2018)
"The azathioprine was stopped, and he received intravenous ganciclovir and corticosteroids with suppression of the CMV viral load and resolution of the HLH."1.51Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis. ( Abbara, A; Cockbain, BC; Cooke, G; Mora Peris, B; So, CW, 2019)
"Azathioprine treatment was complicated with pancytopenia and septic shock."1.39[Acute cytomegalovirus infection-associated hemophagocytic syndrome in a patient treated with azathioprine]. ( Gartner, B; Issekutz, A; Kárász, T; Kullmann, T; Oláh, A; Rácz, I, 2013)
"Common characteristics include: Crohn's disease (CD), thiopurine administration, fever lasting more than 5 days, lymphadenopathy, splenomegaly, anemia, lymphopenia, and elevated serum triglycerides and ferritin."1.37Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis. ( Biank, VF; Kugathasan, S; Margolis, D; Sheth, MK; Simpson, P; Stephens, M; Talano, J, 2011)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (17.39)29.6817
2010's18 (78.26)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Chevalier, K1
Schmidt, J1
Coppo, P2
Galicier, L1
Noël, N1
Lambotte, O1
Chapman, S1
El-Matary, W1
Miechowiecki, J1
Stainer, W1
Wallner, G1
Tuppy, H1
Aichinger, W1
Prammer, W1
Kirchgatterer, A1
Cockbain, BC1
Mora Peris, B1
Abbara, A1
So, CW1
Cooke, G1
Mikolajczyk, AE1
Rubin, DT1
McConville, JF1
Kullmann, T1
Kárász, T1
Gartner, B1
Issekutz, A1
Oláh, A1
Rácz, I1
Hernández-Camba, A1
Lakhwani, S1
Ramos, L1
Raya, JM1
Quintero, E1
Frederiksen, JK1
Ross, CW1
Vignesh, P1
Gupta, A1
Chatterjee, D1
Vinay, K1
Nahar Saikia, U1
Dogra, S1
Steele, CL1
Doré, M1
Ammann, S1
Loughrey, M1
Montero, A1
Burns, SO1
Morris, EC1
Gaspar, B1
Gilmour, K1
Bibi, S1
Shendi, H1
Devlin, L1
Speckmann, C1
Edgar, DM1
Francolla, KA1
Altman, A1
Sylvester, FA1
Serrate, C1
Silva-Moreno, M1
Dartigues, P1
Poujol-Robert, A1
Sokol, H1
Gorin, NC1
Petrache, A1
Møller, MB1
Frederiksen, H1
Yeh, HM1
Liu, MF1
Chang, KK1
Liu, SM1
Chen, CH1
N'Guyen, Y1
Baumard, S1
Salmon, JH1
Lemoine, L1
Lévêque, N1
Servettaz, A1
Jaussaud, R1
Strady, C1
Andreoletti, L1
Biank, VF1
Sheth, MK1
Talano, J1
Margolis, D1
Simpson, P1
Kugathasan, S1
Stephens, M1
Presti, MA1
Costantino, G1
Della Torre, A1
Belvedere, A1
Cascio, A1
Fries, W1
van Langenberg, DR1
Morrison, G1
Foley, A1
Buttigieg, RJ1
Gibson, PR1
Fitzgerald, MP1
Armstrong, L1
Hague, R1
Russell, RK1
Weinkove, R1
Dickson, M1
Eliadou, E1
Stace, NH1
Goossens, L1
Ferguson, P1
Subramaniam, K1
D'Rozario, J1
Pavli, P1
Babu, TG1
Boctor, D1
Davey, A1
Bond, MC1
Jacobson, K1
Hirose, I1
Ymamaguchi, H1
Inaguma, D1
Ono, K1
Shimada, S1
Kawada, J1
Shiraki, K1
Kimura, H1

Reviews

2 reviews available for azathioprine and Lymphohistiocytosis, Hemophagocytic

ArticleYear
Hemophagocytic Lymphohistiocytosis Associated With Cytomegalovirus Infection: 5 Cases and a Systematic Review of the Literature.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023, 01-13, Volume: 76, Issue:2

    Topics: Antiviral Agents; Azathioprine; Cytomegalovirus; Cytomegalovirus Infections; Humans; Lymphohistiocyt

2023
Lymphoma and other lymphoproliferative disorders in inflammatory bowel disease: a review.
    Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:1

    Topics: Age Factors; Azathioprine; Epstein-Barr Virus Infections; Humans; Immunosuppressive Agents; Inflamma

2013

Other Studies

21 other studies available for azathioprine and Lymphohistiocytosis, Hemophagocytic

ArticleYear
Screening for Epstein-Barr Virus Status and Risk of Hemophagocytic Lymphohistiocytosis in Children With Inflammatory Bowel Disease on Azathioprine.
    Gastroenterology, 2017, Volume: 153, Issue:4

    Topics: Azathioprine; Child; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Inflammatory Bowel

2017
Severe complication during remission of Crohn's disease: hemophagocytic lymphohistiocytosis due to acute cytomegalovirus infection.
    Zeitschrift fur Gastroenterologie, 2018, Volume: 56, Issue:3

    Topics: Adult; Antiviral Agents; Azathioprine; Crohn Disease; Cytomegalovirus; Cytomegalovirus Infections; H

2018
Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis.
    BMJ case reports, 2019, 02-11, Volume: 12, Issue:2

    Topics: Adrenal Cortex Hormones; Antiviral Agents; Azathioprine; Colitis, Ulcerative; Cytomegalovirus Infect

2019
A diagnosis that eats at you.
    Gastroenterology, 2013, Volume: 145, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; Cytomegalovirus Infections; Humans; Immunocompromised Host;

2013
[Acute cytomegalovirus infection-associated hemophagocytic syndrome in a patient treated with azathioprine].
    Orvosi hetilap, 2013, Dec-08, Volume: 154, Issue:49

    Topics: Antiviral Agents; Azathioprine; Colitis, Ulcerative; Colonoscopy; Combined Modality Therapy; Critica

2013
Cytomegalovirus-associated hemophagocytic syndrome in a patient with Crohn's disease receiving azathioprine.
    Journal of gastrointestinal and liver diseases : JGLD, 2013, Volume: 22, Issue:4

    Topics: Adult; Anti-Infective Agents; Antiviral Agents; Azathioprine; Bone Marrow Examination; Crohn Disease

2013
Cytomegalovirus-associated hemophagocytic lymphohistiocytosis in a patient with myasthenia gravis treated with azathioprine.
    Blood, 2014, Apr-10, Volume: 123, Issue:15

    Topics: Azathioprine; Cytomegalovirus Infections; Female; Humans; Immunocompromised Host; Immunosuppressive

2014
Panniculitis as the first sign of haemophagocytic lymphohistiocytosis in a 12-year-old boy.
    Scandinavian journal of rheumatology, 2016, Volume: 45, Issue:5

    Topics: Azathioprine; Child; Glucocorticoids; Humans; Immunosuppressive Agents; Lymphohistiocytosis, Hemopha

2016
X-linked Inhibitor of Apoptosis Complicated by Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) and Granulomatous Hepatitis.
    Journal of clinical immunology, 2016, Volume: 36, Issue:7

    Topics: Azathioprine; Biomarkers; Biopsy; Bone Marrow; Child, Preschool; Female; Genetic Diseases, X-Linked;

2016
Hemophagocytic syndrome in an adolescent with Crohn disease receiving azathioprine and infliximab.
    Journal of pediatric gastroenterology and nutrition, 2008, Volume: 47, Issue:2

    Topics: Adolescent; Antibodies, Monoclonal; Azathioprine; Crohn Disease; Epstein-Barr Virus Infections; Fema

2008
Epstein-Barr virus-associated lymphoproliferation awareness in hemophagocytic syndrome complicating thiopurine treatment for Crohn's disease.
    Inflammatory bowel diseases, 2009, Volume: 15, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Crohn Disease; Drug Th

2009
[Hemophagocytosis associated with cytomegalovirus infection and azathioprine treatment for inflammatory bowel disease].
    Ugeskrift for laeger, 2010, Jan-04, Volume: 172, Issue:1

    Topics: Adult; Azathioprine; Colitis, Ulcerative; Cytomegalovirus Infections; Diagnosis, Differential; Femal

2010
Adult-onset Still's disease complicated with hemophagocytic syndrome.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2010, Volume: 109, Issue:1

    Topics: Azathioprine; Bone Marrow; Drug Therapy, Combination; Female; Fever; Glucocorticoids; Humans; Immuno

2010
Cytomegalovirus associated hemophagocytic lymphohistiocytosis in patients suffering from Crohn's disease treated by azathioprine: a series of four cases.
    Inflammatory bowel diseases, 2011, Volume: 17, Issue:9

    Topics: Adult; Azathioprine; Colitis, Ulcerative; Crohn Disease; Cytomegalovirus; Cytomegalovirus Infections

2011
Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.
    The Journal of pediatrics, 2011, Volume: 159, Issue:5

    Topics: Adolescent; Anemia; Azathioprine; Crohn Disease; Epstein-Barr Virus Infections; Ferritins; Fever; Hu

2011
Severe CMV-related pneumonia complicated by the hemophagocytic lymphohistiocytic (HLH) syndrome in quiescent Crohn's colitis: harmful cure?
    Inflammatory bowel diseases, 2011, Volume: 17, Issue:11

    Topics: Azathioprine; Crohn Disease; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Im

2011
Cytomegalovirus disease, haemophagocytic syndrome, immunosuppression in patients with IBD: 'a cocktail best avoided, not stirred'.
    Journal of Crohn's & colitis, 2011, Volume: 5, Issue:5

    Topics: Adult; Azathioprine; Cytomegalovirus Infections; Female; Humans; Immunocompromised Host; Immunosuppr

2011
A case of EBV driven haemophagocytic lymphohistiocytosis complicating a teenage Crohn's disease patient on azathioprine, successfully treated with rituximab.
    Journal of Crohn's & colitis, 2013, Volume: 7, Issue:4

    Topics: Adolescent; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Crohn Disease; Epstein-Barr Virus

2013
Fever and pancytopenia in a patient with Crohn's disease.
    Gut, 2013, Volume: 62, Issue:9

    Topics: Angiography; Antiviral Agents; Azathioprine; Cecum; Crohn Disease; Digestive System Surgical Procedu

2013
Cytomegalovirus-associated hemophagocytic syndrome in a child with Crohn disease receiving azathioprine.
    Journal of pediatric gastroenterology and nutrition, 2004, Volume: 39, Issue:4

    Topics: Antibodies, Viral; Azathioprine; Child; Crohn Disease; Cytomegalovirus; Cytomegalovirus Infections;

2004
Fatal varicella infection in a girl with systemic lupus erythematosus after oral acyclovir prophylaxis.
    European journal of pediatrics, 2006, Volume: 165, Issue:4

    Topics: Acyclovir; Adolescent; Antiviral Agents; Aspergillosis; Azathioprine; Brain; Chickenpox; Disseminate

2006