Page last updated: 2024-10-23

azathioprine and Lung Neoplasms

azathioprine has been researched along with Lung Neoplasms in 41 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
" To our knowledge this is the first reported case of LYG related to azathioprine therapy in Crohn disease."7.80Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease. ( Belletrutti, PJ; Connors, W; Griffiths, C; Patel, J, 2014)
"Treatment complications include radiation pneumonitis that may require therapy with corticosteroids which possess significant side effects."5.29Azathioprine as a steroid-sparing agent in radiation pneumonitis. ( Lillis, P; McCarty, MJ; Vukelja, SJ, 1996)
" To our knowledge this is the first reported case of LYG related to azathioprine therapy in Crohn disease."3.80Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease. ( Belletrutti, PJ; Connors, W; Griffiths, C; Patel, J, 2014)
"We report two cases of stage IV malignant melanoma arising in patients treated with azathioprine for myasthenia gravis."3.76Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review. ( Collichio, F; Dillon, P; Sharpless, N; Thomas, N, 2010)
" Events included eight patients with malignancies, two with pancytopenia taking methotrexate, three with septic arthritis, and two with septicaemias."3.71Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience. ( Bevan, J; Homer, D; Jobanputra, P; Maggs, F, 2002)
"A 47-year-old man with dermatomyositis and interstitial pneumonia had been treated with prednisolone since May, 1992, and with azathioprine since April, 1993."3.69[Primary pulmonary non-Hodgkin's lymphoma in a patient with dermatomyositis]. ( Arima, N; Kawamata, N; Kohyama, T; Mori, H; Tanaka, H; Terashi, K; Yamada, H; Yamaguchi, A, 1997)
"We report a case of broncho-alveolar carcinoma (CBA) in a man of 64 who had been treated with azathioprine for severe myasthenia gravis."3.68[Bronchiolo-alveolar carcinoma complicating myasthenia treated by azathioprine]. ( Chatté, G; Langevin, B, 1993)
"Pulmonary lymphomatoid granulomatosis (PLG) is a rare angiocentric and angiodestructive EBV-associated lymphoproliferative disorder which almost always affects the lungs."1.56An atypical case of a pulmonary mass in an immunocompromised patient. ( Bode, H; Bos, S; Cardinaels, N; Tousseyn, T; Van Bleyenbergh, P; Van Rompaey, W, 2020)
"Epithelioid hemangioendothelioma is a multifocal tumor that rarely metastasizes."1.46[Lung epithelioid hemangioendothelioma: Report of one case]. ( Bezares, K; Fernández, C; Linacre, V; Moya, R; Quiroz, M; Undurraga, Á, 2017)
"A 48 year old patient with active Crohn's disease presented with bilateral nodules over his lungs resembling malignant metastasis."1.32Mycobacterium xenopi infection in an immunosuppressed patient with Crohn's disease. ( Majoor, CJ; Schreurs, AJ; Weers-Pothoff, G, 2004)
"The case of a patient with fatigable diplopia and ptosis 3 years after removal of a large-cell lung carcinoma is presented."1.31Myasthenia gravis with a paraneoplastic marker. ( Leavitt, JA, 2000)
"Treatment complications include radiation pneumonitis that may require therapy with corticosteroids which possess significant side effects."1.29Azathioprine as a steroid-sparing agent in radiation pneumonitis. ( Lillis, P; McCarty, MJ; Vukelja, SJ, 1996)
"The conjunctiva later became scarred with foreshortening of the fornices and development of symblepharon."1.28Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma. ( Folberg, R; Goeken, JA; Krachmer, JH; Lam, S; Massicotte, SJ; Smith, AC; Stone, MS, 1992)
"The development of a reticulum cell sarcoma in the lung of a patient with systemic lupus erythematosus treated with azathioprine for 18 months is described."1.26Reticulum cell sarcoma in azathioprine-treated systemic lupus erythematosus. ( Hehir, ME; Hughes, GR; Sewell, JR, 1979)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199017 (41.46)18.7374
1990's9 (21.95)18.2507
2000's6 (14.63)29.6817
2010's6 (14.63)24.3611
2020's3 (7.32)2.80

Authors

AuthorsStudies
Cardinaels, N1
Van Rompaey, W1
Bos, S1
Bode, H1
Tousseyn, T1
Van Bleyenbergh, P1
González, LA1
Pantoja-Marquez, AE1
Johnson, P1
Nakashima, K1
Demura, Y1
Oi, M1
Tabata, M1
Tada, T1
Shiozaki, K1
Akai, M1
Ishizuka, T1
Quiroz, M1
Undurraga, Á1
Moya, R1
Fernández, C1
Bezares, K1
Linacre, V1
Alqurashi, EH1
Sayeed, A1
Alsulami, HH1
Al-Qurashi, HM1
Connors, W1
Griffiths, C1
Patel, J1
Belletrutti, PJ1
Dillon, P1
Thomas, N1
Sharpless, N1
Collichio, F1
Mylonakis, E1
Muse, VV1
Mino-Kenudson, M1
Wagner, JA1
Jobanputra, P1
Maggs, F1
Homer, D1
Bevan, J1
Miravet Sorribes, L1
Vidal Villalón, G1
Ortega Roig, M1
Ballester Fayos, J1
Majoor, CJ1
Schreurs, AJ1
Weers-Pothoff, G1
Campellone, JV1
Hageboutros, A1
Sawadogo, A1
Boursier, J1
Calès, P1
Oberti, F1
Schmidt, A1
Newsom-Davis, J2
Murray, NM1
Chrétien, J1
Theobald, I1
Limberg, B1
Magener, A1
Kauffmann, GW1
Johnson, F1
Hunt, S1
Chatté, G1
Langevin, B1
McCarty, MJ1
Lillis, P1
Vukelja, SJ1
Aebischer, MC1
Zala, LB1
Braathen, LR1
Mori, H1
Yamada, H1
Terashi, K1
Kohyama, T1
Kawamata, N1
Yamaguchi, A1
Arima, N1
Tanaka, H1
Ledson, MJ1
Convery, R1
Carty, A1
Evans, CC1
Leavitt, JA1
Sostman, HD1
Matthay, RA1
Putman, CE1
Sterioff, S1
Rios, CN1
Zachary, JB1
Williams, GM1
Wurm, K1
Benfield, JR1
Shors, E1
Schick, P1
Byfield, PE1
Okita, M1
Hehir, ME1
Sewell, JR1
Hughes, GR1
Pot-Deprun, J1
Chouroulinkov, I1
Fishman, NH1
Belzer, FO1
Lam, S1
Stone, MS1
Goeken, JA1
Massicotte, SJ1
Smith, AC1
Folberg, R1
Krachmer, JH1
Choy, DS1
Gearhart, RP1
Gould, WJ1
Sauer, J1
Jacobson, L1
Rosenthal, B1
Xerri, L1
Payan, MJ1
Choux, R1
Gros, N1
Hassoun, J1
Chamlian, A1
Blin, D1
Monties, JR1
Wellens, F1
Estenne, M1
de Francquen, P1
Goldstein, J1
Leclerc, JL1
Primo, G1
Pierce, JC1
Madge, GE1
Lee, HM1
Hume, DM1
Casey, TP1
Birkeland, SA1
Kemp, E1
Siegel, JH1
Janis, R1
Alper, JC1
Schutte, H1
Robbins, L1
Blaufox, MD1
Brambilla, G1
Caraceni, CE1
Cavanna, M1
Parodi, S1

Reviews

2 reviews available for azathioprine and Lung Neoplasms

ArticleYear
[Sarcoidosis therapy and its problems today].
    Deutsche medizinische Wochenschrift (1946), 1978, Feb-24, Volume: 103, Issue:8

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents; Antineoplasti

1978
Development of multiple carcinomas in a long term survivor of Wegener's granulomatosis treated with immunosuppressive drugs.
    New York state journal of medicine, 1989, Volume: 89, Issue:12

    Topics: Adult; Azathioprine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Gran

1989

Other Studies

39 other studies available for azathioprine and Lung Neoplasms

ArticleYear
An atypical case of a pulmonary mass in an immunocompromised patient.
    Acta clinica Belgica, 2020, Volume: 75, Issue:5

    Topics: Aged; Azathioprine; Biopsy; Bronchoscopy; Chest Pain; Crohn Disease; Dyspnea; Endosonography; Female

2020
Diffuse Cystic Lung Disease: Consider Sjögren Syndrome in the Differential Diagnosis.
    The American journal of medicine, 2020, Volume: 133, Issue:8

    Topics: Adult; Antibodies, Antinuclear; Antirheumatic Agents; Azathioprine; Cysts; Diagnosis, Differential;

2020
Infliximab Was Found to Be Effective for Treating Immunosuppressive Drug-resistant Hepatitis due to Durvalumab.
    Internal medicine (Tokyo, Japan), 2020, Dec-01, Volume: 59, Issue:23

    Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Azathioprine; Carcinoma, Non-Sma

2020
[Lung epithelioid hemangioendothelioma: Report of one case].
    Revista medica de Chile, 2017, Volume: 145, Issue:5

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Female; Hemangioendothelioma, Epithelioid; Humans; Lu

2017
Perplexing case of lung mass perfectly mimicking a malignancy.
    BMJ case reports, 2019, Jul-02, Volume: 12, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Biopsy; Bronchiolitis; Connective Tissue Diseases; Dia

2019
Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease.
    BMC gastroenterology, 2014, Jul-14, Volume: 14

    Topics: Adult; Azathioprine; Brain Neoplasms; Crohn Disease; Female; Humans; Immunocompromised Host; Immunos

2014
Regression of advanced melanoma upon withdrawal of immunosuppression: case series and literature review.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:4

    Topics: Aged; Azathioprine; Head and Neck Neoplasms; Humans; Immunosuppression Therapy; Immunosuppressive Ag

2010
Case records of the Massachusetts General Hospital. Case 28-2011. A 74-year-old man with pemphigus vulgaris and lung nodules.
    The New England journal of medicine, 2011, Sep-15, Volume: 365, Issue:11

    Topics: Aged; Azathioprine; Cryptococcosis; Diagnosis, Differential; Glucocorticoids; Humans; Immunocompromi

2011
Cancer after heart transplant: implications for practice.
    Progress in transplantation (Aliso Viejo, Calif.), 2012, Volume: 22, Issue:4

    Topics: Azathioprine; Carcinoma, Squamous Cell; Drug Therapy, Combination; Fatal Outcome; Glucocorticoids; H

2012
Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience.
    Drug safety, 2002, Volume: 25, Issue:15

    Topics: Antirheumatic Agents; Arthritis, Infectious; Azathioprine; Drug Monitoring; Humans; Hypokalemia; Lun

2002
[Lung adenocarcinoma, inflammatory bowel disease and azathioprine].
    Anales de medicina interna (Madrid, Spain : 1984), 2003, Volume: 20, Issue:4

    Topics: Adenocarcinoma; Autopsy; Azathioprine; Colitis, Ulcerative; Fatal Outcome; Humans; Lung Neoplasms; M

2003
Mycobacterium xenopi infection in an immunosuppressed patient with Crohn's disease.
    Thorax, 2004, Volume: 59, Issue:7

    Topics: Anti-Inflammatory Agents; Azathioprine; Crohn Disease; Diagnosis, Differential; Humans; Immunocompro

2004
Adie's pupils in paraneoplastic ganglionopathy with ANNA-1.
    Clinical neurology and neurosurgery, 2006, Volume: 108, Issue:7

    Topics: Aged; Antibodies, Neoplasm; Autonomic Nervous System Diseases; Azathioprine; Carcinoma, Small Cell;

2006
[Non hodgkin's lymphoma associated with chronic auto-immune hepatitis treated with azathioprine].
    Gastroenterologie clinique et biologique, 2008, Volume: 32, Issue:2

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Female; Follow-Up Studies; Hepatitis, Autoimmune; Hep

2008
Plasma exchange and immunosuppressive drug treatment in the Lambert-Eaton myasthenic syndrome.
    Neurology, 1984, Volume: 34, Issue:4

    Topics: Action Potentials; Adult; Azathioprine; Carcinoma, Small Cell; Combined Modality Therapy; Electric S

1984
[Idiopathic fibrogenous interstitial pneumopathy].
    Schweizerische medizinische Wochenschrift, 1980, Dec-06, Volume: 110, Issue:49

    Topics: Adrenal Cortex Hormones; Azathioprine; Coronary Disease; Humans; Lung; Lung Neoplasms; Pulmonary Fib

1980
[Fulminant, fatal respiratory insufficiency in long-term immunosuppression after kidney transplantation].
    Der Radiologe, 1995, Volume: 35, Issue:3

    Topics: Adult; Azathioprine; Fatal Outcome; Female; Humans; Immunologic Deficiency Syndromes; Kidney Transpl

1995
Recurrent lymphoma in a cardiac allograft recipient.
    Transplantation science, 1994, Volume: 4, Issue:1

    Topics: Azathioprine; Cyclosporine; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Lung

1994
[Bronchiolo-alveolar carcinoma complicating myasthenia treated by azathioprine].
    Revue des maladies respiratoires, 1993, Volume: 10, Issue:5

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Azathioprine; Hemorrhage; Humans; Lung Diseases; Lung Neoplasms

1993
Azathioprine as a steroid-sparing agent in radiation pneumonitis.
    Chest, 1996, Volume: 109, Issue:5

    Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Lung; Lung Neoplasms; Middle Aged; Radiation

1996
Kaposi's sarcoma as manifestation of immunosuppression in organ transplant recipients.
    Dermatology (Basel, Switzerland), 1997, Volume: 195, Issue:1

    Topics: Anti-Inflammatory Agents; Azathioprine; Combined Modality Therapy; Cyclosporine; Graft Rejection; He

1997
[Primary pulmonary non-Hodgkin's lymphoma in a patient with dermatomyositis].
    Nihon Kyobu Shikkan Gakkai zasshi, 1997, Volume: 35, Issue:7

    Topics: Azathioprine; Dermatomyositis; Humans; Immunosuppressive Agents; Lung Diseases, Interstitial; Lung N

1997
A treatment algorithm for Lambert-Eaton myasthenic syndrome.
    Annals of the New York Academy of Sciences, 1998, May-13, Volume: 841

    Topics: 4-Aminopyridine; Algorithms; Amifampridine; Azathioprine; Carcinoma, Small Cell; Clinical Protocols;

1998
Epithelioid haemangioendothelioma.
    Thorax, 1999, Volume: 54, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Female; Hemangioendothelioma, Epitheli

1999
Myasthenia gravis with a paraneoplastic marker.
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2000, Volume: 20, Issue:2

    Topics: Autoantibodies; Azathioprine; Biomarkers; Blepharoptosis; Calcium Channels; Carcinoma, Large Cell; D

2000
Cytotoxic drug-induced lung disease.
    The American journal of medicine, 1977, Volume: 62, Issue:4

    Topics: Antibiotics, Antineoplastic; Azathioprine; Bleomycin; Busulfan; Cyclophosphamide; Dose-Response Rela

1977
Neoplasia in kidney transplant recipients.
    American journal of surgery, 1975, Volume: 130, Issue:5

    Topics: Adult; Azathioprine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Huma

1975
Monitoring of immunosuppression in beagles.
    The Journal of surgical research, 1977, Volume: 23, Issue:3

    Topics: Animals; Antibodies; Azathioprine; Carcinoma, Bronchogenic; Dinitrochlorobenzene; Disease Models, An

1977
Reticulum cell sarcoma in azathioprine-treated systemic lupus erythematosus.
    Annals of the rheumatic diseases, 1979, Volume: 38, Issue:1

    Topics: Adult; Azathioprine; Female; Humans; Immunosuppression Therapy; Lung Neoplasms; Lupus Erythematosus,

1979
[Effect of immunostimulation by Corynebacterium parvum on evolution and metastatic dissemination of Lewis's tumor in mouse C57BL/6 mice].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1975, Feb-03, Volume: 280, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Azathioprine; Immunity, Cellular; Immunotherapy; L-Lactate Dehydrog

1975
Resection of de novo lung cancer after renal transplantation.
    Transplantation, 1975, Volume: 20, Issue:3

    Topics: Azathioprine; Carcinoma, Bronchogenic; Humans; Immunosuppression Therapy; Kidney Neoplasms; Kidney T

1975
Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma.
    Ophthalmology, 1992, Volume: 99, Issue:1

    Topics: Acanthosis Nigricans; Aged; Azathioprine; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Chronic

1992
An exceptional 18-year follow-up after cardiac transplantation. How can malignancies occur during immunosuppressive therapy?
    Cancer, 1989, May-01, Volume: 63, Issue:9

    Topics: Adenocarcinoma, Papillary; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Follow-Up

1989
Combined heart-lung transplantation for terminal pulmonary lymphangioleiomyomatosis.
    The Journal of thoracic and cardiovascular surgery, 1985, Volume: 89, Issue:6

    Topics: Adult; Azathioprine; Bronchial Diseases; Cyclosporins; Female; Heart Transplantation; Heart-Lung Tra

1985
Lymphoma, a complication of renal allotransplantation in man.
    JAMA, 1972, Mar-20, Volume: 219, Issue:12

    Topics: Adolescent; Adult; Azathioprine; Dactinomycin; Histocompatibility Testing; Humans; Kidney Transplant

1972
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.
    Clinical and experimental immunology, 1968, Volume: 3, Issue:4

    Topics: Albuminuria; Anemia, Hemolytic, Autoimmune; Animals; Azathioprine; Coombs Test; Glomerulonephritis;

1968
Malignant tumours following immunosuppression in renal transplantation.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1973, Volume: 10, Issue:0

    Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom

1973
Disseminated visceral Kaposi's sarcoma. Appearance after human renal homograft operation.
    JAMA, 1969, Feb-24, Volume: 207, Issue:8

    Topics: Adult; Azathioprine; Esophageal Neoplasms; Female; Humans; Kidney Transplantation; Lung Neoplasms; M

1969
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
    Bollettino della Societa italiana di biologia sperimentale, 1971, Jul-30, Volume: 47, Issue:14

    Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil;

1971