azathioprine has been researched along with Liver Neoplasms in 83 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To our knowledge this is the first reported case of LYG related to azathioprine therapy in Crohn disease." | 7.80 | Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease. ( Belletrutti, PJ; Connors, W; Griffiths, C; Patel, J, 2014) |
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 7.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| " Patients received immunosuppressor treatment with azathioprine (AZA) and developed hepatic hemangiomas without detectable hepatic pathology previous to the treatment with AZA." | 7.68 | [Hepatic hemangiomas and rheumatoid arthritis in patients treated with azathioprine]. ( Calvo Catalá, FJ; González-Cruz, I; Hortelano Martínez, E; Liñana Santafé, JJ; Martínez San Juan, V, 1992) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 5.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "All reported cases of hepatocellular carcinoma in association with Crohn's disease involve patients treated previously with azathioprine or both azathioprine and steroids." | 5.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| " The variety of acute hepatitis include hepatitis A, hepatitis B, cytomegalovirus hepatitis, herpes simplex hepatitis and azathioprine hepatitis." | 4.75 | Liver disease in renal transplant recipients. ( Anuras, S; Sopko, J, 1978) |
| "We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine." | 3.83 | Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. ( Arrenberg, P; Brinkert, F; Grabhorn, E; Krech, T; Lohse, A; Schramm, C, 2016) |
| " To our knowledge this is the first reported case of LYG related to azathioprine therapy in Crohn disease." | 3.80 | Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease. ( Belletrutti, PJ; Connors, W; Griffiths, C; Patel, J, 2014) |
| "Reported herein is a case of hepatocellular carcinoma (HCC) occurring in a 25-year-old Japanese man who was diagnosed with Crohn's disease (CD) at 14 years of age; treatment included predonisolone, azathioprine, and infliximab." | 3.75 | Hepatocellular carcinoma occurring in a young Crohn's disease patient. ( Enaka, M; Kawachi, K; Kunisaki, R; Morimoto, M; Murakami, A; Nagano, Y; Nozawa, A; Sasaki, T; Tanabe, M; Tanaka, Y; Ueda, M, 2009) |
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 3.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| "Azathioprine and rheumatoid arthritis are known to be associated with an increased risk of the development of non-Hodgkin's lymphoma; however, the manifestation of fulminant hepatic failure is extremely uncommon in patients with non-Hodgkin's lymphoma." | 3.69 | Azathioprine-induced lymphoma manifesting as fulminant hepatic failure. ( Aguilar, HI; Burgart, LJ; Geller, A; Rakela, J, 1997) |
| " Patients received immunosuppressor treatment with azathioprine (AZA) and developed hepatic hemangiomas without detectable hepatic pathology previous to the treatment with AZA." | 3.68 | [Hepatic hemangiomas and rheumatoid arthritis in patients treated with azathioprine]. ( Calvo Catalá, FJ; González-Cruz, I; Hortelano Martínez, E; Liñana Santafé, JJ; Martínez San Juan, V, 1992) |
| "Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) was recognized as a new disease entity; however, IgG4-associated de novo AIH after the liver transplantation had not been reported yet." | 2.49 | Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review. ( Jia, JD; Rakhda, MI; Wang, TI; Zhao, XY, 2013) |
| " Adequately dosed steroids are the mainstay of remission induction treatment, while remission maintenance is best achieved by azathioprine." | 2.47 | Autoimmune hepatitis. ( Lohse, AW; Mieli-Vergani, G, 2011) |
| "Left breast cancer was diagnosed 9 years after the renal transplantation, then colon cancers and meningeal epidermal meningioma were diagnosed, 10 years and 12 years post-transplant, respectively." | 2.42 | Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case. ( Asahara, T; Dohi, K; Fukuda, Y; Hayamizu, K; Ikeda, S; Kataoka, T; Kitayama, T; Marubayashi, S; Ohdan, H; Okajima, M; Okimoto, T; Sugino, K; Tashiro, H, 2004) |
| "Ascites, variceal bleeding, and hepatocellular carcinoma were found in 1." | 1.46 | Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. ( Choi, HY; Jang, ES; Jeong, SH; Ki, M; Kim, BH; Kim, KA, 2017) |
| "Hepatoblastoma is a primary liver cancer that affects children, due to the sensitivity of this tumor to insulin-like growth factor 1 (IGF-1)." | 1.39 | Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. ( Fernández-Moreno, MD; Gisbert, JP; González-Rodríguez, Á; Guijarro, LG; Hernández-Breijo, B; Lobo, MV; Monserrat, J; Román, ID; Valverde, ÁM, 2013) |
| "The development of hepatocellular carcinoma (HCC) is attributed to several factors, including chronic viral infection, alcohol consumption, exposure to aflatoxin B1 and metabolic disorders." | 1.37 | Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease. ( Cui, DJ; Ouyang, Q; Zheng, SM, 2011) |
| "Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 °C incubator with 5% CO₂." | 1.37 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma. ( Cuevas, EP; Díaz-Laviada, I; Fernández-Moreno, MD; Gisbert, JP; Guijarro, LG; Hernández-Breijo, B; Monserrat, J; Ramírez-Rubio, S; Román, ID; Vara, D, 2011) |
| "We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients." | 1.36 | Hepatocellular carcinoma occurring in a Crohn's disease patient. ( Andoh, A; Fujiyama, Y; Hotta, M; Ishida, M; Kojima, F; Kurumi, Y; Naka, S; Nakahara, T; Okabe, H; Saito, Y; Shiomi, H; Takikita-Suzuki, M; Tani, T; Tsujikawa, T, 2010) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 1.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "All reported cases of hepatocellular carcinoma in association with Crohn's disease involve patients treated previously with azathioprine or both azathioprine and steroids." | 1.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| "Although the prognosis of type 1 autoimmune hepatitis is generally good with immunosuppressive treatment, the disease progresses in some patients despite the treatment." | 1.33 | Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis. ( Ikeda, H; Iwasaki, Y; Kobashi, H; Makino, Y; Miyake, Y; Okamaoto, R; Sakaguchi, K; Shiratori, Y; Takaguchi, K; Terada, R, 2006) |
| "The occurrence of hepatocellular carcinoma (HCC) in renal transplant recipients has typically been associated with hepatitis B or C infection." | 1.30 | Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series. ( Adams, MB; Franco, J; Komorowski, RA; Saeian, K, 1999) |
| "The thrombocytopenia was diagnosed as idiopathic thrombocytopenic purpura." | 1.30 | [Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura]. ( Kariya, K; Kawamura, S; Munakata, A; Nakahata, R; Takami, H; Tamai, Y; Tsushima, K; Yoshimura, T, 1999) |
| " There was no increase in concurrent immunosuppressives dosage after the conversion." | 1.29 | Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation. ( Kaplan, MM; Pedrosa, MC; Rohrer, RM, 1995) |
| "Azathioprine was administered to 25 patients with severe, progressive polyarthritis in a mean dose of 1." | 1.26 | Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effects in 25 patients. ( Pinals, RS, 1976) |
| "Later, primary hepatocellular carcinoma assumes increasing importance." | 1.25 | Viral hepatitis and cirrhosis. ( Sherlock, S, 1975) |
| "Two patients developed reticulum cell sarcomata after they had been treated with azathioprine and prednisone in the course of cadaveric renal transplantation." | 1.25 | Reticulum cell sarcoma after renal homotransplantation and azathioprine and prednisone therapy. ( Doak, PB; Montgomerie, JZ; North, JD; Smith, F, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (50.60) | 18.7374 |
| 1990's | 10 (12.05) | 18.2507 |
| 2000's | 13 (15.66) | 29.6817 |
| 2010's | 18 (21.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, BH | 1 |
| Choi, HY | 1 |
| Ki, M | 1 |
| Kim, KA | 1 |
| Jang, ES | 1 |
| Jeong, SH | 1 |
| Mavilia, M | 1 |
| McAuliffe, A | 1 |
| Hafeez, S | 1 |
| Vaziri, H | 1 |
| Zhao, XY | 1 |
| Rakhda, MI | 1 |
| Wang, TI | 1 |
| Jia, JD | 1 |
| Hernández-Breijo, B | 2 |
| Monserrat, J | 2 |
| Román, ID | 2 |
| González-Rodríguez, Á | 1 |
| Fernández-Moreno, MD | 2 |
| Lobo, MV | 1 |
| Valverde, ÁM | 1 |
| Gisbert, JP | 2 |
| Guijarro, LG | 2 |
| Rodríguez-Perálvarez, M | 1 |
| De la Mata, M | 1 |
| Burroughs, AK | 1 |
| Connors, W | 1 |
| Griffiths, C | 1 |
| Patel, J | 1 |
| Belletrutti, PJ | 1 |
| Brinkert, F | 1 |
| Arrenberg, P | 1 |
| Krech, T | 1 |
| Grabhorn, E | 1 |
| Lohse, A | 1 |
| Schramm, C | 1 |
| van de Meeberg, MM | 1 |
| Derikx, LA | 1 |
| Sinnige, HA | 1 |
| Nooijen, P | 1 |
| Schipper, DL | 1 |
| Nissen, LH | 1 |
| Moran, G | 1 |
| Dillon, J | 1 |
| Green, J | 1 |
| Apostolidis, L | 1 |
| Kahlert, C | 1 |
| Siegmund, A | 1 |
| Thom, R | 1 |
| Horstmann, S | 1 |
| Jäger, D | 1 |
| Lordick, F | 1 |
| Maggs, J | 1 |
| Cullen, S | 1 |
| Krok, KL | 1 |
| Munoz, SJ | 1 |
| Murakami, A | 1 |
| Tanaka, Y | 1 |
| Ueda, M | 1 |
| Nagano, Y | 1 |
| Kunisaki, R | 1 |
| Morimoto, M | 1 |
| Enaka, M | 1 |
| Tanabe, M | 1 |
| Kawachi, K | 1 |
| Sasaki, T | 1 |
| Nozawa, A | 1 |
| Ochenrider, MG | 1 |
| Patterson, DJ | 1 |
| Aboulafia, DM | 1 |
| Ishida, M | 1 |
| Naka, S | 1 |
| Shiomi, H | 1 |
| Tsujikawa, T | 1 |
| Andoh, A | 1 |
| Nakahara, T | 1 |
| Saito, Y | 1 |
| Kurumi, Y | 1 |
| Takikita-Suzuki, M | 1 |
| Kojima, F | 1 |
| Hotta, M | 1 |
| Tani, T | 1 |
| Fujiyama, Y | 1 |
| Okabe, H | 1 |
| Thai, A | 1 |
| Prindiville, T | 1 |
| Lohse, AW | 1 |
| Mieli-Vergani, G | 1 |
| Zheng, SM | 1 |
| Cui, DJ | 1 |
| Ouyang, Q | 1 |
| Ramírez-Rubio, S | 1 |
| Cuevas, EP | 1 |
| Vara, D | 1 |
| Díaz-Laviada, I | 1 |
| Hino-Arinaga, T | 1 |
| Ide, T | 1 |
| Kuromatsu, R | 1 |
| Miyajima, I | 1 |
| Ogata, K | 1 |
| Kuwahara, R | 1 |
| Hisamochi, A | 1 |
| Torimura, T | 1 |
| Sata, M | 1 |
| Rashidi, A | 1 |
| Lee, ME | 1 |
| Fisher, SI | 1 |
| de Vries, HS | 1 |
| de Heij, T | 1 |
| Roelofs, HM | 1 |
| te Morsche, RH | 1 |
| Peters, WH | 1 |
| de Jong, DJ | 1 |
| Bašić Kinda, S | 1 |
| Duraković, N | 1 |
| Dotlić, S | 1 |
| Serventi Seiwerth, R | 1 |
| Davidović Mrsić, S | 1 |
| Dubravčić, K | 1 |
| Aurer, I | 1 |
| Navarro, JT | 1 |
| Ribera, JM | 1 |
| Mate, JL | 1 |
| Granada, I | 1 |
| Juncà, J | 1 |
| Batlle, M | 1 |
| Millá, F | 1 |
| Feliu, E | 1 |
| Kitayama, T | 1 |
| Marubayashi, S | 1 |
| Hayamizu, K | 1 |
| Tashiro, H | 1 |
| Ohdan, H | 1 |
| Ikeda, S | 1 |
| Okimoto, T | 1 |
| Okajima, M | 1 |
| Kataoka, T | 1 |
| Sugino, K | 1 |
| Asahara, T | 1 |
| Fukuda, Y | 1 |
| Dohi, K | 1 |
| Chen, SC | 1 |
| Cummings, OW | 1 |
| Hartley, MP | 1 |
| Filomena, CA | 1 |
| Cho, WK | 1 |
| Miyake, Y | 1 |
| Iwasaki, Y | 1 |
| Terada, R | 1 |
| Okamaoto, R | 1 |
| Ikeda, H | 1 |
| Makino, Y | 1 |
| Kobashi, H | 1 |
| Takaguchi, K | 1 |
| Sakaguchi, K | 1 |
| Shiratori, Y | 1 |
| Muirhead, R | 1 |
| Ritchie, DM | 1 |
| Samarasena, J | 1 |
| Borgaonkar, M | 1 |
| Sakata, T | 1 |
| Watanabe, A | 1 |
| Takei, N | 1 |
| Shiota, T | 1 |
| Nakatsukasa, H | 1 |
| Fujiwara, M | 1 |
| Kobayashi, M | 1 |
| Nagashima, H | 1 |
| Calne, R | 1 |
| Lee, FL | 1 |
| Murray, SM | 1 |
| Prior, J | 1 |
| Shreeve, DR | 1 |
| Bismuth, H | 1 |
| Pedrosa, MC | 1 |
| Rohrer, RM | 1 |
| Kaplan, MM | 1 |
| Lipkowitz, GS | 1 |
| Madden, RL | 1 |
| Cherqui, D | 1 |
| Duvoux, C | 1 |
| Charlotte, F | 1 |
| Humeres, R | 1 |
| Lauzet, JY | 1 |
| Métreau, JM | 1 |
| Salvat, A | 1 |
| Rotman, N | 1 |
| Julien, M | 1 |
| Fagniez, PL | 1 |
| Konstantinov, BA | 1 |
| Eramishantsev, AK | 1 |
| Goté, SV | 1 |
| Tsirulńikova, OM | 1 |
| Skipenko, OG | 1 |
| Lebezev, VM | 1 |
| Shertsinger, AG | 1 |
| Lokshin, LS | 1 |
| Volgger, B | 1 |
| Marth, C | 1 |
| Zeimet, A | 1 |
| Müller-Holzner, E | 1 |
| Ruth, N | 1 |
| Dapunt, O | 1 |
| Aguilar, HI | 1 |
| Burgart, LJ | 1 |
| Geller, A | 1 |
| Rakela, J | 1 |
| Saeian, K | 1 |
| Franco, J | 1 |
| Komorowski, RA | 1 |
| Adams, MB | 1 |
| Yoshimura, T | 1 |
| Tamai, Y | 1 |
| Takami, H | 1 |
| Kariya, K | 1 |
| Nakahata, R | 1 |
| Tsushima, K | 1 |
| Munakata, A | 1 |
| Kawamura, S | 1 |
| Cattan, S | 1 |
| Wendum, D | 1 |
| Chazouilleres, O | 1 |
| Schmitz, J | 1 |
| Gendre, JP | 1 |
| Russmann, S | 1 |
| Zimmermann, A | 1 |
| Krähenbühl, S | 1 |
| Kern, B | 1 |
| Reichen, J | 1 |
| Sherlock, S | 1 |
| Sopko, J | 1 |
| Anuras, S | 1 |
| Pinals, RS | 1 |
| Liñana Santafé, JJ | 1 |
| Calvo Catalá, FJ | 1 |
| Hortelano Martínez, E | 1 |
| González-Cruz, I | 1 |
| Martínez San Juan, V | 1 |
| O'Grady, JG | 1 |
| Johnson, PJ | 1 |
| Zaman, S | 1 |
| Calne, RY | 2 |
| Williams, R | 5 |
| Gruber, S | 1 |
| Dehner, LP | 1 |
| Simmons, RL | 1 |
| Alpert, E | 1 |
| Starzl, TE | 6 |
| Schur, PH | 1 |
| Isselbacher, KJ | 1 |
| Smith, MG | 3 |
| Doniach, D | 1 |
| Pierce, JC | 1 |
| Madge, GE | 1 |
| Lee, HM | 1 |
| Hume, DM | 1 |
| Groth, CG | 3 |
| Brettschneider, L | 6 |
| Moon, JB | 2 |
| Fulginiti, VA | 2 |
| Cotton, EK | 1 |
| Porter, KA | 3 |
| Casey, TP | 1 |
| Penn, I | 5 |
| Bell, P | 2 |
| Putnam, CW | 3 |
| McGuire, RL | 1 |
| Gütgemann, A | 4 |
| Schriefers, KH | 2 |
| Esser, G | 2 |
| Lee, TS | 1 |
| Paquet, KJ | 2 |
| Käufer, C | 3 |
| Lie, TS | 4 |
| Fortner, JG | 2 |
| Shiu, MH | 2 |
| Balner, H | 1 |
| Wilson, CB | 1 |
| Sichuk, G | 1 |
| Kawano, N | 1 |
| Holmes, JT | 1 |
| Beattie, EJ | 1 |
| Blanchard, H | 2 |
| Kashiwagi, N | 1 |
| Starzi, TE | 1 |
| Giles, G | 1 |
| Picache, R | 1 |
| Prejean, JD | 1 |
| Griswold, DP | 1 |
| Weisburger, JH | 2 |
| Birtch, AG | 1 |
| Moore, FD | 1 |
| Pagaltsos, AP | 1 |
| Eddleston, AL | 1 |
| Anthony, CW | 1 |
| Pritzker, K | 1 |
| Kinne, DW | 1 |
| Howland, WS | 1 |
| Kim, DK | 1 |
| Castro, EB | 1 |
| Yeh, SD | 1 |
| Benua, RS | 1 |
| Krumins, S | 1 |
| Siedek, M | 1 |
| Prange, CH | 1 |
| Rommelsheim, K | 1 |
| Fillmann, B | 1 |
| Birkeland, SA | 1 |
| Kemp, E | 1 |
| Ulrich, J | 1 |
| Wüthrich, R | 1 |
| Klatskin, G | 1 |
| Kantor, FS | 1 |
| von Bally, K | 1 |
| Ebata, H | 1 |
| Nakano, H | 1 |
| Guisan, Y | 1 |
| Enderlin, F | 1 |
| Harder, F | 1 |
| Brunner, F | 1 |
| Thiel, G | 2 |
| Bernhardt, JP | 1 |
| Schädeli, J | 1 |
| Mihatsch, M | 1 |
| Martin, AJ | 1 |
| Doak, PB | 1 |
| Montgomerie, JZ | 1 |
| North, JD | 1 |
| Smith, F | 1 |
| Kommerell, B | 1 |
| Breuer, J | 1 |
| Breuer, H | 1 |
| Eiseman, B | 1 |
| Hammond, W | 1 |
| Frankel, HH | 1 |
| Yamamoto, RS | 1 |
| Weisburger, EK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA, Versus Standard Dose Tacrolimus, ECMPA Plus Corticosteroids in Patients Undergoing Liver Transplant[NCT02123108] | Phase 4 | 59 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02123108)
Timeframe: 12 months post liver transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 3 |
| Tacrolimus Group | 4 |
(NCT02123108)
Timeframe: 12 months post liver transplantation
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 0 |
| Tacrolimus Group | 0 |
(NCT02123108)
Timeframe: 12 months post transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 2 |
| Tacrolimus Group | 5 |
Number of participants who experienced dialysis independence or improvement based upon kidney function labs as a measure of renal recovery/ function following OLT in patients after undergoing orthotopic liver transplant (NCT02123108)
Timeframe: 12 months post-transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 28 |
| Tacrolimus Group | 26 |
Participants at risk minus incidence of death within the first year post-transplant (NCT02123108)
Timeframe: 12 months post liver transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 28 |
| Tacrolimus Group | 26 |
13 reviews available for azathioprine and Liver Neoplasms
| Article | Year |
|---|---|
Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review.
Topics: Antiviral Agents; Azathioprine; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; H | 2013 |
Liver transplantation: immunosuppression and oncology.
Topics: Antilymphocyte Serum; Azathioprine; Calcineurin Inhibitors; Carcinoma, Hepatocellular; Humans; Immun | 2014 |
Management of autoimmune liver disease.
Topics: Autoantibodies; Azathioprine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellul | 2009 |
Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review.
Topics: Adalimumab; Adolescent; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Ag | 2010 |
Hepatosplenic T-cell lymphoma and inflammatory bowel disease.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Humans; Immunophenotyping; Immunosup | 2010 |
Autoimmune hepatitis.
Topics: Algorithms; Azathioprine; Carcinoma, Hepatocellular; Clinical Trials as Topic; Female; Hepatitis, Au | 2011 |
Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case.
Topics: Azathioprine; Breast Neoplasms; Carcinoma, Ductal, Breast; Colonic Neoplasms; Colonic Polyps; Drug T | 2004 |
[Value of a powerful initial immunosuppression after liver transplantation. Prospective study of 60 cases].
Topics: Adult; Aged; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejection; Hepatit | 1994 |
Liver disease in renal transplant recipients.
Topics: Animals; Azathioprine; Budd-Chiari Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Ch | 1978 |
Clinical liver transplantation.
Topics: Adenoma, Bile Duct; Adult; Angiography; Aortography; Azathioprine; Bacterial Infections; Biliary Tra | 1969 |
Experience in liver transplantation.
Topics: Adenocarcinoma; Adolescent; Adult; Alkalosis; Animals; Antilymphocyte Serum; Azathioprine; Blood Coa | 1969 |
[Liver transplantation (current status and perspectives)].
Topics: Animals; Antilymphocyte Serum; Azathioprine; Bile Ducts; Blood Group Antigens; Dogs; Graft Rejection | 1973 |
[Liver transplantation in humans].
Topics: Antilymphocyte Serum; Azathioprine; Biliary Tract Diseases; Graft Rejection; Hepatectomy; Histocompa | 1970 |
1 trial available for azathioprine and Liver Neoplasms
| Article | Year |
|---|---|
Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Li
Topics: Antilymphocyte Serum; Azathioprine; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Female | 1995 |
69 other studies available for azathioprine and Liver Neoplasms
| Article | Year |
|---|---|
Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Carcinoma, Hepato | 2017 |
Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction.
Topics: Adult; Anemia, Hemolytic; Azathioprine; Biopsy; Chronic Disease; Colitis, Ulcerative; Fatal Outcome; | 2018 |
Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azathioprine; Cell Line, Tumor; Drug Therapy, Combinatio | 2013 |
Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease.
Topics: Adult; Azathioprine; Brain Neoplasms; Crohn Disease; Female; Humans; Immunocompromised Host; Immunos | 2014 |
Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis.
Topics: Adolescent; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Liver Neo | 2016 |
Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Biopsy; Crohn Disease; Drug Administra | 2016 |
Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree?
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Glucocorticoids; Humans | 2009 |
Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Benzenesulfonates; Carcinoma, Hepatoce | 2009 |
Management of autoimmune and cholestatic liver disorders.
Topics: Anti-Inflammatory Agents; Azathioprine; Carcinoma, Hepatocellular; Cholagogues and Choleretics; Chol | 2009 |
Hepatocellular carcinoma occurring in a young Crohn's disease patient.
Topics: Adolescent; Adult; Age of Onset; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Cr | 2009 |
Hepatocellular carcinoma occurring in a Crohn's disease patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liv | 2010 |
Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease.
Topics: Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liver Neop | 2011 |
Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azathioprine; Buthionine Sulfoximine; Carcinoma | 2011 |
Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1.
Topics: Aged; Alanine Transaminase; Azathioprine; Biomarkers; Carcinoma, Hepatocellular; Cholagogues and Cho | 2012 |
Hepatosplenic αβ T-cell lymphoma associated with azathioprine therapy.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Liver Neoplasms; Lupus Erythematosus, System | 2012 |
Infliximab exerts no direct hepatotoxic effect on HepG2 cells in vitro.
Topics: Analysis of Variance; Antibodies, Monoclonal; Azathioprine; Cell Survival; Dose-Response Relationshi | 2012 |
Hepatosplenic αβ T-cell lymphoma arising after long-term azathioprine therapy successfully treated with allogeneic bone marrow transplant.
Topics: Azathioprine; Bone Marrow Transplantation; Crohn Disease; Humans; Immunosuppressive Agents; Liver Ne | 2013 |
Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; | 2003 |
Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab.
Topics: Adult; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Gastr | 2006 |
Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anti-Inflammatory Agents; Azathioprine; Carcinoma, He | 2006 |
Partial regression of Merkel cell carcinoma in response to withdrawal of azathioprine in an immunosuppression-induced case of metastatic Merkel cell carcinoma.
Topics: Azathioprine; Carcinoma, Merkel Cell; Fatal Outcome; Head and Neck Neoplasms; Humans; Immunocompromi | 2007 |
Development of hepatocellular carcinoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adult; Azathioprine; Biopsy; Carcinoma, Hepatocellular; Crohn Disease; Diagnosis, Differential; Fata | 2007 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Hepatic transplantation.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Graft Rejection; Humans; Immunosuppression Th | 1980 |
Primary liver cell cancer occurring in association with Crohn's disease treated with prednisolone and azathioprine.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Humans; Liver Neoplasms; Pred | 1983 |
Liver grafting.
Topics: Azathioprine; Cyclosporins; Graft Rejection; Graft Survival; Humans; Liver Diseases; Liver Neoplasms | 1983 |
Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarc | 1995 |
Transmission of Kaposi's sarcoma by solid organ donation.
Topics: Adult; Azathioprine; Cyclosporine; Disease Transmission, Infectious; Fatal Outcome; Female; Follow-U | 1994 |
[Orthotopic liver transplantation (first clinical experience)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Carcinoma, Hepatocellular; Child; Cyclospo | 1993 |
Fulminant course of a microinvasive vulvar carcinoma in an immunosuppressed woman.
Topics: Adult; Azathioprine; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; Condylomata Acuminata | 1997 |
Azathioprine-induced lymphoma manifesting as fulminant hepatic failure.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; F | 1997 |
Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Humans; Immunosuppressive Agents; Kidney Transplantat | 1999 |
[Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura].
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Immunosuppressiv | 1999 |
Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Glycogen; Humans; Immunosuppr | 2000 |
Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Colitis, Ulcerative; Hepatic Veno-Occlusive Disease; | 2001 |
Viral hepatitis and cirrhosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Azathioprine; Carcinoma, Hepatocellular; Chronic Disease; Di | 1975 |
Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effects in 25 patients.
Topics: Adenocarcinoma; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Breast Neoplasms; Carcinoma; Femal | 1976 |
[Hepatic hemangiomas and rheumatoid arthritis in patients treated with azathioprine].
Topics: Arthritis, Rheumatoid; Azathioprine; Hemangioma; Humans; Liver Neoplasms; Male; Middle Aged | 1992 |
Decreased rate of growth of hepatocellular carcinoma recurrence after liver transplantation in patients maintained on cyclosporine immunosuppression.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Humans; Liver Neoplasms; Liver Transplantatio | 1988 |
De novo hepatocellular carcinoma without chronic liver disease but with 17 years of azathioprine immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Humans; Kidney Transplantation; Liver Neoplasms; Mal | 1987 |
Serum -fetoprotein in hepatoma patients after liver transplantation.
Topics: Adolescent; Adult; Alanine Transaminase; Alpha-Globulins; Aspartate Aminotransferases; Autopsy; Azat | 1971 |
Effect of orthotopic liver transplantation on serum-autoantibodies.
Topics: Antibodies, Antinuclear; Aspartate Aminotransferases; Autoantibodies; Azathioprine; Bilirubin; Carci | 1971 |
Lymphoma, a complication of renal allotransplantation in man.
Topics: Adolescent; Adult; Azathioprine; Dactinomycin; Histocompatibility Testing; Humans; Kidney Transplant | 1972 |
Extended survival in 3 cases of orthotopic homotransplantation of the human liver.
Topics: Acidosis; Azathioprine; Biliary Tract; Cadaver; Child, Preschool; Female; gamma-Globulins; Humans; I | 1968 |
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.
Topics: Albuminuria; Anemia, Hemolytic, Autoimmune; Animals; Azathioprine; Coombs Test; Glomerulonephritis; | 1968 |
Clinical and pathologic observations after orthotopic transplantation of the human liver.
Topics: Adolescent; Adult; Alkaline Phosphatase; Azathioprine; Bilirubin; Blood Proteins; Carcinoma, Hepatoc | 1969 |
[Report of experience with homologous liver transplantation].
Topics: Adult; Alkaline Phosphatase; Antibodies, Anti-Idiotypic; Azathioprine; Bilirubin; Blood Proteins; Bo | 1969 |
A case of homologous liver transplantation.
Topics: Adult; Aldosterone; Ampicillin; Azathioprine; Cadaver; Carcinoma, Hepatocellular; Heparin; Humans; L | 1969 |
Observations on prolonged immune suppression for human liver homografts.
Topics: Antilymphocyte Serum; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Fluorescent Anti | 1971 |
Orthotopic liver transplantation in man.
Topics: Adrenal Gland Diseases; Adult; Anticoagulants; Antilymphocyte Serum; Azathioprine; Blood Coagulation | 1969 |
Transplantation of allogeneic tumors in rats and mice treated with azathioprine, prednisone and antilymphocyte serum.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinoma, Hepatocellular; Immunosuppre | 1972 |
Total haemolytic complement after liver transplantation and in liver disease.
Topics: Acute Disease; Adult; Aspartate Aminotransferases; Azathioprine; Bilirubin; Carcinoma, Hepatocellula | 1972 |
Disseminated toxoplasmosis in a liver transplant patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Female; Humans; Immunosuppression Therapy; Liver Neo | 1972 |
Neoplasia in renal transplant recipients.
Topics: Adolescent; Azathioprine; Carcinoma, Hepatocellular; Hepatitis; Humans; Immunosuppressive Agents; Ki | 1972 |
Clinical liver heterotopic (auxiliary) transplantation.
Topics: Adenoma, Bile Duct; Adult; Aged; Antibodies; Antilymphocyte Serum; Azathioprine; Bilirubin; Child, P | 1973 |
[Prolonged ischemic tolerance time of the human liver with successful grafting (author's transl)].
Topics: Adolescent; Antilymphocyte Serum; Azathioprine; Blood Pressure; Carcinoma, Hepatocellular; Drug Ther | 1974 |
Malignant tumours following immunosuppression in renal transplantation.
Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom | 1973 |
Multiple sclerosis: reticulum cell sarcoma of the nervous system in a patient treated with immunosuppressive drugs.
Topics: Adrenocorticotropic Hormone; Adult; Autopsy; Azathioprine; Biopsy, Needle; Brain Neoplasms; Cortison | 1974 |
Mitochondrial antibody in primary biliary cirrhosis and other diseases.
Topics: Antibodies; Azathioprine; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Ch | 1972 |
Liver transplantation: a clinical and immunological appraisal.
Topics: Adult; Animals; Autoantibodies; Azathioprine; Biliary Fistula; Cell Migration Inhibition; Complement | 1972 |
[Malignant tumors following transplantation. Case reports and review of the literature].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Graft Rejection; Humans; Kidney | 1973 |
Orthotopic homotransplantation of the human liver.
Topics: Adolescent; Adult; Azathioprine; Bile Ducts; Cadaver; Child; Child, Preschool; Hepatic Artery; Human | 1968 |
Reticulum cell sarcoma after renal homotransplantation and azathioprine and prednisone therapy.
Topics: Adult; Azathioprine; Brain Neoplasms; Female; Herpes Simplex; Humans; Kidney Transplantation; Liver | 1968 |
[Possibilities and limitations of modern therapy of hepatic coma. Exchange transfusion, liver perfusion, and liver transplantation].
Topics: Adult; Animals; Azathioprine; Exchange Transfusion, Whole Blood; Female; Hepatic Encephalopathy; Hum | 1969 |
[Clinical chemistry studies of a patient following transplantation of a human liver].
Topics: Adenosine Triphosphate; Adult; Alanine Transaminase; Alkaline Phosphatase; Antilymphocyte Serum; Asp | 1970 |
Liver transplantation.
Topics: Antilymphocyte Serum; Atrophy; Azathioprine; Biliary Tract; Congenital Abnormalities; Histocompatibi | 1970 |
[Liver transplantation in man].
Topics: Acidosis; Adult; Azathioprine; Bile Duct Neoplasms; Brain Death; Brain Diseases; Electroencephalogra | 1970 |
Malignant lymphomas in transplantation patients.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Humans; Immunosuppre | 1969 |
Chronic toxicity of azathioprine and the effect of this immunosuppressant on liver tumor induction by the carcinogen N-hydroxy-N-2-fluorenylacetamide.
Topics: Amides; Animals; Animals, Laboratory; Azathioprine; Body Weight; Carcinogens; Diet; Female; Liver; L | 1970 |