Page last updated: 2024-10-23

azathioprine and Liver Failure, Acute

azathioprine has been researched along with Liver Failure, Acute in 9 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.

Research Excerpts

ExcerptRelevanceReference
"Giant cell hepatitis associated with autoimmune hemolytic anemia (GCH-AIHA) is a rare disorder with unfavorable prognosis, affecting infants and young children."1.91[Association of giant cell hepatitis and autoimmune hemolytic anemia in infancy]. ( Csernus, K; Dezsőfi-Gottl, A; Ottóffy, G; Tárnok, A; Tészás, A, 2023)
"16."1.46Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease? ( Jain, V; Kathuria, R; Krishnani, N; Kumari, N; Poddar, U; Sarma, MS; Srivastava, A; Yachha, SK, 2017)
"A 4 year-old boy presented with severe acute hepatic failure (AHF) without hypergammaglobulinemia, revealing AIH."1.30[Autoimmune hepatitis treated with cyclosporin revealed by acute hepatocellular failure]. ( Farriaux, JP; Gottrand, F; Launay, V; Masy, E; Michaud, L; Turck, D, 1997)
" There was no increase in concurrent immunosuppressives dosage after the conversion."1.29Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation. ( Kaplan, MM; Pedrosa, MC; Rohrer, RM, 1995)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's3 (33.33)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Csernus, K1
Tészás, A1
Ottóffy, G1
Dezsőfi-Gottl, A1
Tárnok, A1
Sakaguchi, H1
Mizuochi, T1
Haruta, M1
Takase, R1
Yoshida, S1
Yamashita, Y1
Nishikomori, R1
Caballero-Mateos, AM1
López Garrido, MÁ1
Becerra Massare, P1
de Teresa Galván, J1
Jain, V1
Srivastava, A1
Yachha, SK1
Kumari, N1
Kathuria, R1
Sarma, MS1
Poddar, U1
Krishnani, N1
Di Giorgio, A1
Bravi, M1
Bonanomi, E1
Alessio, G1
Sonzogni, A1
Zen, Y1
Colledan, M1
D'Antiga, L1
Reyes, J1
Moitinho, E1
Ginard, D1
Obrador, A1
Colbert, C1
Chavarria, A1
Berkelhammer, C1
Pedrosa, MC1
Rohrer, RM1
Kaplan, MM1
Launay, V1
Gottrand, F1
Michaud, L1
Masy, E1
Turck, D1
Farriaux, JP1

Reviews

1 review available for azathioprine and Liver Failure, Acute

ArticleYear
    Frontiers in immunology, 2021, Volume: 12

    Topics: Administration, Intravenous; Adrenal Cortex Hormones; AIRE Protein; Autoantibodies; Autoimmune Disea

2021

Other Studies

8 other studies available for azathioprine and Liver Failure, Acute

ArticleYear
[Association of giant cell hepatitis and autoimmune hemolytic anemia in infancy].
    Orvosi hetilap, 2023, Sep-10, Volume: 164, Issue:36

    Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Child; Child, Preschool; Humans; Infant; Liver Failure,

2023
Autoimmune severe acute fulminant hepatic failure (FHF) during pregnancy.
    Gastroenterologia y hepatologia, 2018, Volume: 41, Issue:4

    Topics: Abortion, Spontaneous; Adrenal Cortex Hormones; Adult; Azathioprine; Diagnosis, Differential; Early

2018
Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease?
    European journal of gastroenterology & hepatology, 2017, Volume: 29, Issue:12

    Topics: Adolescent; Alanine Transaminase; Ascites; Aspartate Aminotransferases; Autoantibodies; Autoimmune D

2017
Fulminant hepatic failure of autoimmune aetiology in children.
    Journal of pediatric gastroenterology and nutrition, 2015, Volume: 60, Issue:2

    Topics: Adolescent; Age Factors; Alanine Transaminase; Antibodies, Antinuclear; Autoantibodies; Azathioprine

2015
Immunomodulatory therapy for Crohn's disease resulting in acute liver failure.
    Inflammatory bowel diseases, 2004, Volume: 10, Issue:6

    Topics: Azathioprine; Crohn Disease; Diagnosis, Differential; Humans; Immunosuppressive Agents; Liver Failur

2004
Fulminant hepatic failure in chronic hepatitis B on withdrawal of corticosteroids, azathioprine and infliximab for Crohn's disease.
    Inflammatory bowel diseases, 2007, Volume: 13, Issue:11

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Crohn Disea

2007
Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation.
    Clinical transplantation, 1995, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Aged; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarc

1995
[Autoimmune hepatitis treated with cyclosporin revealed by acute hepatocellular failure].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1997, Volume: 4, Issue:1

    Topics: Anti-Inflammatory Agents; Autoimmune Diseases; Azathioprine; Child, Preschool; Chronic Disease; Cycl

1997