azathioprine has been researched along with Lichen Planus in 10 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a saw-tooth pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azathioprine has been shown to be effective steroid sparing treatment for generalized lichen planus." | 5.29 | Erosive and generalized lichen planus responsive to azathioprine. ( English, JS; Lear, JT, 1996) |
| "Azathioprine has been shown to be effective steroid sparing treatment for generalized lichen planus." | 1.29 | Erosive and generalized lichen planus responsive to azathioprine. ( English, JS; Lear, JT, 1996) |
| "Oral lichen planus was found mainly in women and most commonly on the buccal mucosa." | 1.28 | A prospective study of findings and management in 214 patients with oral lichen planus. ( Giannotti, K; Gorsky, M; Lozada-Nur, F; Silverman, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Massa, AF | 1 |
| Campos, MA | 1 |
| Baptista, A | 1 |
| Costa, C | 1 |
| Lima, O | 1 |
| Osório Ferreira, E | 1 |
| Sakuma-Oyama, Y | 1 |
| Powell, AM | 1 |
| Albert, S | 1 |
| Oyama, N | 1 |
| Bhogal, BS | 2 |
| Black, MM | 2 |
| Bailin, PL | 1 |
| Matkaluk, RM | 1 |
| Paige, DG | 1 |
| Harper, JI | 1 |
| Lear, JT | 1 |
| English, JS | 1 |
| Krunic, AL | 1 |
| Kokai, D | 1 |
| Bacetic, B | 1 |
| Kesic, V | 1 |
| Nikolic, MM | 1 |
| Petkovic, S | 1 |
| Clark, RE | 1 |
| Verma, KK | 1 |
| Sirka, CS | 1 |
| Khaitan, BK | 1 |
| Klein, LR | 1 |
| Callen, JP | 1 |
| Silverman, S | 1 |
| Gorsky, M | 1 |
| Lozada-Nur, F | 1 |
| Giannotti, K | 1 |
| Crompton, DO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label Pilot Study to Evaluate the Safety and Efficacy of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus[NCT01041625] | Phase 2 | 10 participants (Anticipated) | Interventional | 2010-02-28 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for azathioprine and Lichen Planus
| Article | Year |
|---|---|
Cutaneous reactions to rheumatological drugs.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Azathioprine; Cushing Syndrome; Cy | 1982 |
9 other studies available for azathioprine and Lichen Planus
| Article | Year |
|---|---|
Paediatric anogenital Crohn's disease 11 years after Lichen planus - same background for two different entities?
Topics: Anal Canal; Azathioprine; Child; Ciprofloxacin; Crohn Disease; Drug Therapy, Combination; Female; Ge | 2016 |
Lichen planus pemphigoides evolving into pemphigoid nodularis.
Topics: Autoantigens; Azathioprine; Carrier Proteins; Collagen Type XVII; Cytoskeletal Proteins; Dystonin; E | 2003 |
Lichen planus pemphigoides in a child--immunopathological findings.
Topics: Azathioprine; Child; Drug Combinations; Humans; Lichen Planus; Male; Prednisolone; Skin | 1993 |
Erosive and generalized lichen planus responsive to azathioprine.
Topics: Aged; Azathioprine; Female; Humans; Immunosuppressive Agents; Lichen Planus; Middle Aged; Treatment | 1996 |
Retroperitoneal round-cell liposarcoma associated with paraneoplastic pemphigus presenting as lichen planus pemphigoides-like eruption.
Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Azathioprine; Diagnosis, Differential; Fe | 1997 |
Generalized severe lichen planus treated with azathioprine.
Topics: Administration, Oral; Adult; Azathioprine; Female; Follow-Up Studies; Humans; Immunosuppressive Agen | 1999 |
Azathioprine: effective steroid-sparing therapy for generalized lichen planus.
Topics: Azathioprine; Biopsy; Chronic Disease; Humans; Lichen Planus; Male; Middle Aged; Remission Induction | 1992 |
A prospective study of findings and management in 214 patients with oral lichen planus.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Azathioprine; Carboxymethylcellulose Sodium; F | 1991 |
Immuno-suppressive drug treatment of keratitis sicca, including an example of lichen planus of the conjunctiva.
Topics: Aged; Autoimmune Diseases; Azathioprine; Conjunctivitis; Female; Humans; Keratoconjunctivitis; Liche | 1968 |