azathioprine has been researched along with Leukopenia in 218 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2." | 9.12 | 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. ( Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C, 2007) |
| "To examine serum C-reactive protein levels and the prevalence of leukopenia in patients with Crohn's disease or ulcerative colitis undergoing treatment with azathioprine and/or mesalazine." | 8.12 | C-reactive protein levels and prevalence of leukopenia in patients with inflammatory bowel disease treated with azathioprine and/or mesalazine: a real-life study. ( Catapani, WR; Santos, RCFD; Takahashi, AAR; Waisberg, J, 2022) |
| "Azathioprine (AZA)-induced leukopenia is a common but life-threatening complication of inflammatory bowel disease." | 8.12 | A rare case of Azathioprine-induced leukopenia in an European woman. ( Jean-Charles, C; Séverine, W; Xavier, K, 2022) |
| "Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use is due to potential toxicities, including severe leukopenia." | 8.12 | Implementation of NUDT15 Genotyping to Prevent Azathioprine-Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population. ( Chang, CJ; Chang, YC; Chang, YT; Chen, CB; Chen, HC; Chen, WT; Chi, MH; Chung, WH; Huang, PW; Huang, YH; Hui, RC; Jan Wu, YJ; Kao, HW; Lin, YJ; Lu, CW; Ng, CY; Tsai, TF; Wang, CW; Yu, KH, 2022) |
| "Leukopenia is a serious, frequent side effect associated with azathioprine use." | 7.96 | Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice. ( Anandi, P; Barker, KA; Birdwell, K; Chung, CP; Cox, NJ; Dickson, AL; Dupont, WD; Feng, Q; Hung, A; Kawai, VK; Liu, G; Octaria, R; Plummer, D; Stein, CM; Wei, WQ, 2020) |
| "The frequency of leukopenia incidents and its dependence on the dose of azathioprine and kidney function were analyzed in 149 patients during the first 3 months after kidney transplantation." | 7.66 | Frequency of leukopenia incidents following azathioprine therapy after kidney transplantation. ( Horpacsy, G; May, G; Mebel, M; Oesterwitz, H, 1978) |
| "A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease." | 7.66 | Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982) |
| "Azathioprine (AZA) is a thiopurine prodrug which is widely used in patients with inflammatory bowel disease (IBD)." | 5.42 | The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases. ( Bi, H; Ding, L; Gao, X; Hu, P; Huang, M; Liu, H; Zhang, F; Zhang, Y, 2015) |
| " The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia." | 5.35 | Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. ( de Boer, NK; Kanis, BM; van Asseldonk, DP; van Bodegraven, AA, 2009) |
| "There are substantial global differences in the preference for mercaptopurine (MP) or its prodrug azathioprine (AZA) as first-choice thiopurine to treat inflammatory bowel diseases." | 5.24 | More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing. ( Broekman, MMTJ; Coenen, MJH; de Jong, DJ; Derijks, LJJ; Guchelaar, HJ; Hooymans, PM; Klungel, OH; Scheffer, H; van Marrewijk, CJ; Verbeek, ALM; Wanten, GJA; Wong, DR, 2017) |
| "A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2." | 5.12 | 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. ( Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C, 2007) |
| "Ninety-four patients receiving immunosuppressive therapy with azathioprine and prednisone after human cadaver kidney transplantation developed urinary tract infections and were treated with co-trimoxazole or another antibiotic in a controlled randomized prospective trial." | 5.04 | Co-trimoxazole and azathioprine: a safe combination. ( Hall, CL, 1974) |
| "To examine serum C-reactive protein levels and the prevalence of leukopenia in patients with Crohn's disease or ulcerative colitis undergoing treatment with azathioprine and/or mesalazine." | 4.12 | C-reactive protein levels and prevalence of leukopenia in patients with inflammatory bowel disease treated with azathioprine and/or mesalazine: a real-life study. ( Catapani, WR; Santos, RCFD; Takahashi, AAR; Waisberg, J, 2022) |
| "Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use is due to potential toxicities, including severe leukopenia." | 4.12 | Implementation of NUDT15 Genotyping to Prevent Azathioprine-Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population. ( Chang, CJ; Chang, YC; Chang, YT; Chen, CB; Chen, HC; Chen, WT; Chi, MH; Chung, WH; Huang, PW; Huang, YH; Hui, RC; Jan Wu, YJ; Kao, HW; Lin, YJ; Lu, CW; Ng, CY; Tsai, TF; Wang, CW; Yu, KH, 2022) |
| "Azathioprine (AZA)-induced leukopenia is a common but life-threatening complication of inflammatory bowel disease." | 4.12 | A rare case of Azathioprine-induced leukopenia in an European woman. ( Jean-Charles, C; Séverine, W; Xavier, K, 2022) |
| "Leukopenia is a serious, frequent side effect associated with azathioprine use." | 3.96 | Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice. ( Anandi, P; Barker, KA; Birdwell, K; Chung, CP; Cox, NJ; Dickson, AL; Dupont, WD; Feng, Q; Hung, A; Kawai, VK; Liu, G; Octaria, R; Plummer, D; Stein, CM; Wei, WQ, 2020) |
| "Azathioprine (AZA)-metabolizing enzyme gene polymorphism is strongly related to thiopurine-induced leukocytopenia, which has not been well recognized in dermatological practice." | 3.88 | Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study. ( Fujii, M; Honma, M; Igawa, S; Iinuma, S; Ishida-Yamamoto, A; Kanno, K; Kishibe, K; Kishibe, M; Nozaki, H; Ohtsubo, S; Okamoto, K, 2018) |
| "6-TGN measurement is a helpful method of preventing disease relapse and avoiding leukopenia in individual azathioprine maintenance therapy." | 3.83 | Measurement of red blood cell 6-thioguanine nucleotide is beneficial in azathioprine maintenance therapy of Chinese Crohn's disease patients. ( Han, W; Hu, J; Hu, N; Liu, Q; Mei, Q; Wang, Y, 2016) |
| "Azathioprine in combination with N-acetylcysteine (NAC) and steroids is a standard therapy for idiopathic pulmonary fibrosis (IPF)." | 3.76 | Thiopurine S- methyltransferase [corrected] testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis. ( Eckman, MH; Hagaman, JT; Kinder, BW, 2010) |
| " Under immunosuppressive treatment with azathioprine and steroids, the patient developed cytomegalovirus (CMV) enteritis which was triggered by therapy-induced leukopenia." | 3.75 | [A 55-year-old woman with thymoma and hypogammaglobulinemia (Good syndrome), ulcerative colitis, and cytomegalovirus infection]. ( Baba, HA; Gerken, G; Kahraman, A; Maldonado-Lopez, E; Miller, M; Treichel, U, 2009) |
| "Our results confirm that TPMT genotyping prior to the treatment with azathioprine could predict patients with genetic predisposition for serious leucopenia and seems to be a useful genetic marker for individualisation of the therapy." | 3.75 | Importance of thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity. ( Bartos, M; Bartosova, L; Batovsky, M; Chylkova, A; Dvorackova, D; Hosek, J; Kolorz, M; Zboril, V, 2009) |
| "Of all azathioprine treated patients, 11 experienced an adverse event for which azathioprine was stopped: pancreatitis (n = 4), leucopenia (n = 2) and 'general malaise' (n = 5)." | 3.73 | Pharmacogenetics of thiopurine therapy in paediatric IBD patients. ( Benninga, MA; De Ridder, L; Escher, JC; Hommes, DW; Stokkers, PC; Van der Woude, JC; Van Deventer, HJ; Van Dieren, JM; Van Vuuren, AJ, 2006) |
| "although azathioprine (AZA) is an effective immunomodulator in treating Crohn's disease, some patients develop leukopenia and risk severe infections." | 3.71 | Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease. ( Mardini, H; Regueiro, M, 2002) |
| " They developed leukopenia or thrombocytopenia during azathioprine or 6-mercaptopurine treatment." | 3.70 | Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. ( Bonaz, B; Broly, F; Catala, P; Colombel, JF; Debuysere, H; Ferrari, N; Gendre, JP; Libersa, C; Marteau, P; Modigliani, R; Soulé, JC; Touze, Y, 2000) |
| "This paper describes 108 consecutively treated patients receiving 109 cadaveric (CD) and living donor (LD) renal allografts using a protocol of quadruple sequential immunosuppression with a rabbit anti-human thymocyte IgG (Thymoglobuline), azathioprine, tapering corticosteroids, and delayed introduction of cyclosporine A." | 3.69 | Sequential biological immunosuppression. Induction therapy with rabbit antithymocyte globulin. ( Flemming, C; Guttmann, RD, 1997) |
| "In a series of 106 pediatric liver transplantations, five patients were identified with recurrent rejection who could not tolerate the addition of azathioprine (Aza) to their immunosuppressive therapy because of leukopenia." | 3.68 | Selective use of splenectomy after liver transplantation in children. ( Andrews, WS; McMullin, ND; Megison, SM, 1990) |
| " Azathioprine in different doses, and cyclophosamide and methylprednisolone combinations did not result in predictable leukocytopenia without significant mortality." | 3.67 | Development of a leukocytopenic baby guinea pig model with azathioprine and cyclophosphamide. ( Cleveland, RP; Kumar, A; Leonard, MC, 1989) |
| "Azathioprine toxicity was examined in 64 consecutively treated patients with various neuromuscular diseases." | 3.67 | Azathioprine toxicity in neuromuscular disease. ( Griggs, RC; Kissel, JT; Levy, RJ; Mendell, JR, 1986) |
| "A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease." | 3.66 | Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982) |
| "The frequency of leukopenia incidents and its dependence on the dose of azathioprine and kidney function were analyzed in 149 patients during the first 3 months after kidney transplantation." | 3.66 | Frequency of leukopenia incidents following azathioprine therapy after kidney transplantation. ( Horpacsy, G; May, G; Mebel, M; Oesterwitz, H, 1978) |
| " A matched case-control study of host risk factors showed that leukopenia, prior administration of antibiotics, and treatment with azathioprine and antilymphocyte serum were not significantly related to the development of aspergillosis." | 3.66 | Invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy. ( Gustafson, TL; Hutcheson, RH; Johnson, HK; Lavely, GB; Schaffner, W; Stratton, CW, 1983) |
| "Among Chinese patients with Crohn's disease, dose optimisation by NUDT15 C415T reduced the rate of thiopurine-induced leucopenia, without significant influence on efficacy." | 3.01 | Randomised clinical trial: dose optimising strategy by NUDT15 genotyping reduces leucopenia during thiopurine treatment of Crohn's disease. ( Cao, Q; Chao, K; Gao, X; Guo, H; Hu, P; Huang, J; Huang, M; Huang, Y; Li, M; Lin, L; Tang, J; Wang, X; Yang, Q; Ye, L; Zhang, C; Zhu, X, 2021) |
| " The purpose of this study was to explore the association between these polymorphisms and the occurrence of azathioprine adverse effects in 112 renal transplant recipients undergoing triple immunosuppressive therapy including azathioprine, cyclosporine, and prednisone." | 2.71 | The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients. ( Domański, L; Droździk, M; Dziewanowski, K; Gawrońska-Szklarz, B; Kurzawski, M, 2005) |
| "Azathioprine is an effective and useful drug in severe AD although it is not always well-tolerated." | 2.70 | Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial. ( Agarwal, S; Ahmed, I; Barclay, G; Berth-Jones, J; Graham-Brown, RA; Hotchkiss, K; Takwale, A; Tan, E, 2002) |
| "Azathioprine was hepatotoxic in doses of 200 mg daily or more." | 2.64 | Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients. ( Hahn, BH; Kantor, OS; Osterland, CK, 1975) |
| " Nevertheless, prospective studies of genotype-guided dosing of thiopurines are warranted to prove clinical benefit and cost-effectiveness of pretreatment NUDT15 gene testing across different populations." | 2.58 | Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis. ( Canonico, PL; Cargnin, S; Genazzani, AA; Terrazzino, S, 2018) |
| "Leukopenia was significantly associated with low and intermediate enzymatic activity (low activity OR 80." | 2.46 | Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs. ( Ansari, MT; Booth, RA; Daniel, R; Doucette, S; Galipeau, J; Hoch, JS; Karsh, J; Loit, E; Mani, S; Sears, M; Skidmore, B; Sy, R; Tricco, AC; Tsertsvadze, A; Tsouros, S; Weeks, L; Yazdi, F; Yurkiewich, A, 2010) |
| "Probably, the most important and potentially lethal adverse event of azathioprine (AZA) and mercaptopurine (MP) is myelosuppression." | 2.44 | Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. ( Gisbert, JP; Gomollón, F, 2008) |
| "Azathioprine and 6-MP were used to treat an average of 7% of patients - a surprisingly low number given the proven efficacy of these agents." | 2.41 | Frequency of use and standards of care for the use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease: a systematic review of the literature and a survey of Canadian gastroenterologists. ( Veldhuyzen van Zanten, SJ; Wallace, TM, 2001) |
| "Azathioprine has been available for 30 years and is used in a variety of dermatologic conditions." | 2.38 | Azathioprine in dermatology. ( Colver, GB; Harris, DW; Younger, IR, 1991) |
| " NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians." | 1.56 | Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis. ( Kakuta, Y; Kawata, Y; Okamoto, D; Sato, H; Terai, S; Tominaga, K; Tomiyoshi, K; Yokoyama, J, 2020) |
| "A total of 131 adult patients with Crohn's disease receiving thiopurine treatment were included." | 1.56 | Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease. ( Baek, SY; Choi, R; Hong, SN; Kim, K; Kim, TJ; Kim, YH; Lee, MN; Lee, SY, 2020) |
| "Azathioprine (AZA) is a commonly used immunosuppressant in patients with autoimmune diseases." | 1.56 | NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series. ( Balasubramanian, P; Devasia, AJ; George, B; Illangeswaran, RSS; Raj, IX, 2020) |
| "The included patients had either Crohn's disease (54; 65." | 1.51 | Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine. ( Akiyama, S; Arai, M; Fujii, T; Fukuda, K; Hamada, S; Hashiguchi, M; Hisamatsu, T; Iwao, Y; Kanai, T; Kiyohara, H; Matsuoka, K; Mizuno, S; Mochizuki, M; Motobayashi, M; Nagahori, M; Naganuma, M; Nanki, K; Ogata, H; Ohtsuka, K; Saito, E; Shimizu, M; Sugimoto, S; Suzuki, K; Takenaka, K; Watanabe, M, 2019) |
| "Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs." | 1.48 | NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study. ( Andoh, A; Araki, H; Endo, K; Hanai, H; Hiraoka, S; Hisamatsu, T; Hokari, R; Ikeya, K; Ishiguro, Y; Kakuta, Y; Kawai, Y; Kinouchi, Y; Kobayashi, T; Masamune, A; Matsumoto, T; Miura, M; Mizuno, S; Moroi, R; Motoya, S; Naganuma, M; Nagasaki, M; Naito, T; Nakagawa, S; Nakagawa, T; Nakamura, S; Nakase, H; Nishida, A; Okamoto, D; Onodera, K; Sakuraba, H; Sasaki, M; Shiga, H; Shimosegawa, T; Shinozaki, M; Suzuki, Y; Takagawa, T; Takahara, M; Toyonaga, T; Yanai, S, 2018) |
| " The median dosage for NUDT15 c." | 1.46 | Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis. ( Cao, Q; Chao, K; Gao, X; Hu, P; Huang, M; Huang, Y; Huang, Z; Lan, P; Liang, J; Lin, L; Qian, J; Sun, Y; Wang, X; Wu, K; Xue, X; Yang, H; Zhang, Y; Zhu, X, 2017) |
| "Thiopurine-induced leukopenia is a relatively common adverse event related to thiopurine medication in Korean pediatric Crohn's disease." | 1.43 | NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease. ( Hwang, EH; Kang, B; Kim, SY; Lee, YJ; Park, JH; Shin, JH, 2016) |
| "Thiopurine-induced severe hair loss causes cosmetic problems, and it takes a long time to recover." | 1.43 | NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD. ( Endo, K; Kakuta, Y; Kimura, T; Kinouchi, Y; Kuroha, M; Naito, T; Negoro, K; Onodera, M; Shiga, H; Shimosegawa, T, 2016) |
| "Azathioprine (AZA) is a thiopurine prodrug which is widely used in patients with inflammatory bowel disease (IBD)." | 1.42 | The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases. ( Bi, H; Ding, L; Gao, X; Hu, P; Huang, M; Liu, H; Zhang, F; Zhang, Y, 2015) |
| "Secondary acute myeloid leukemia is a very rare complication in patients with solid organ transplantation." | 1.42 | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. ( Guerra, C; Melo, J; Peña, C; Sepúlveda, C, 2015) |
| "Although leukopenia is a well-recognized side effect of AZA/6-MP treatment, its association with therapeutic effects has yet to be determined." | 1.42 | Leukopenia predicts remission in patients with inflammatory bowel disease and Behcet's disease on thiopurine maintenance. ( Cheon, JH; Hong, SP; Kim, DH; Kim, TI; Kim, WH; Park, MS; Park, SJ, 2015) |
| "Azathioprine (AZA) has been widely used in the therapy of inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH)." | 1.40 | Differences in the adverse effects of azathioprine between inflammatory bowel disease and autoimmune hepatitis in Korean patients. ( Cho, KB; Choi, WY; Chung, WJ; Hwang, JS; Jang, BK; Kim, ES; Kim, YJ; Lee, YJ; Park, KS, 2014) |
| " This study aims to detect TPMT polymorphisms and TPMT enzyme activity in Chinese SLE patients and to describe the association between TPMT genotypes and adverse effects of AZA." | 1.40 | Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus. ( Chen, D; Lian, F; Liang, L; Qiu, Q; Wang, Y; Xu, H; Yang, X; Ye, Y; Yuan, S; Zhan, Z, 2014) |
| "To assess the levels of red blood cell thiopurine methyltransferase (TPMT) in subjects with inflammatory bowel disease (IBD) and to determine how these levels impacted thiopurine dosing and leukopenia over the first six months of therapy." | 1.39 | The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease. ( Bernstein, CN; Chisick, L; Oleschuk, C, 2013) |
| "A 36-year-old woman with systemic lupus erythematosus was admitted to our hospital with malaise, myalgia, dysphagia, fever, preserved muscle strength, leukocytosis (15,600 cells), and increased creatine kinase of 1,358 IU/L that reached 75,000 IU/L in few days." | 1.37 | Fatal rhabdomyolysis in systemic lupus erythematosus. ( Bonfa, E; da Mota, LM; de Carvalho, JF, 2011) |
| "Azathioprine (AZA) is a commonly used immunosuppressant for systemic lupus erythematosus (SLE)." | 1.35 | Azathioprine-induced fatal myelosuppression in systemic lupus erythematosus patient carrying TPMT*3C polymorphism. ( Angsuthum, S; Avihingsanon, Y; Boonsrirat, U; Hirankarn, N; Kongpunvijit, J; Tassaneeyakul, W; Vannaprasaht, S, 2008) |
| "This study was to evaluate the frequency and the course of the adverse effects of AZA/6-MP in Korean patients with inflammatory bowel disease (IBD)." | 1.35 | [The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease]. ( Cheon, JH; Kim, JH; Kim, WH, 2008) |
| " The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia." | 1.35 | Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. ( de Boer, NK; Kanis, BM; van Asseldonk, DP; van Bodegraven, AA, 2009) |
| "Fourteen members of the Japanese Society for Pediatric Inflammatory Bowel Disease reported 35 retrospective cases that received AZA/6-MP and were evaluated for adverse drug effects." | 1.35 | Efficacy and safety of azathioprine and 6-mercaptopurine in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease. ( Etani, Y; Kobayashi, A; Konno, M; Maisawa, S; Nakacho, M; Sasaki, M; Shimizu, T; Sumazaki, R; Tajiri, H; Tomomasa, T; Toyoda, S; Ushijima, K; Yoden, A, 2008) |
| "Two patients developed acute pancreatitis." | 1.34 | Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. ( Bohane, TD; Day, AS; Lee, D; Naidoo, D; Ooi, CY, 2007) |
| "Two patients presented cutaneous varicella complicated by pneumonia and esophagitis respectively, one patient had cutaneous herpes zoster and the other had fatal pneumonia possibly caused by the Herpesvirus." | 1.32 | [Opportunistic infections in patients with inflammatory bowel disease undergoing immunosuppressive therapy]. ( Bernal, I; Cabré, E; Domènech, E; García-Planella, E; Gassull, MA, 2003) |
| "A retrospective cohort analysis of clinical data regarding adverse events of azathioprine in Crohn's disease." | 1.32 | Side effects of azathioprine in patients with Crohn's disease. ( de Jong, DJ; Goullet, M; Naber, TH, 2004) |
| "Leukopenia was significantly associated with high 6-TG levels ( P = 0." | 1.31 | 6-mercaptopurine metabolite levels in children with inflammatory bowel disease. ( Gokhale, R; Gupta, P; Kirschner, BS, 2001) |
| "GUIDELINE: Because leukopenia is relatively common after kidney transplantation, regular screening and careful evaluation of its causes are recommended." | 1.31 | European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.9.2. Haematological complications. Leukopenia. ( , 2002) |
| "In patients with Crohn's disease on long term azathioprine therapy, it is clear that myelosuppression, particularly leucopenia, is caused by other factors in addition to variable TPMT activity and therefore monitoring of blood cell counts throughout treatment is essential." | 1.31 | TPMT in the treatment of Crohn's disease with azathioprine. ( Lennard, L, 2002) |
| "Azathioprine is an immunosuppressor used with ciclosporin and corticosteroids after organ transplantation." | 1.29 | [Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation]. ( Amirou, M; Bayle, F; Bechtel, Y; Bessard, G; Boujet, C; Serre-Debeauvais, F; Vialtel, P, 1995) |
| "Isolated thrombocytopenia was never clinically severe." | 1.29 | Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. ( Connell, WR; Kamm, MA; Lennard-Jones, JE; Ritchie, JK, 1993) |
| "Azathioprine treatment played only a minor role in the development of thrombocytopenia but patients with low (100-200 mio." | 1.29 | Bone marrow function during quadruple immunosuppressive therapy after renal transplantation. ( Heaf, J, 1993) |
| "The use of azathioprine in ulcerative colitis is unclear." | 1.28 | The role of azathioprine in the management of ulcerative colitis. ( Axon, AT; Burke, DA; Foster, PN; Johnston, D; Lobo, AJ, 1990) |
| "Azathioprine was administered to 25 patients with severe, progressive polyarthritis in a mean dose of 1." | 1.26 | Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effects in 25 patients. ( Pinals, RS, 1976) |
| " Statistical analysis showed that the association of leucopenia and trimethoprim-sulphamethoxazole therapy was dependent on the time after the transplantation procedure and was not related to the dosage of immunosuppressive chemotherapy or renal function." | 1.25 | Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation. ( Hulme, B; Reeves, DS, 1971) |
| "Azathioprine (Imuran) was administered to seven patients with ulcerative colitis suffering from a relapse which could not be controlled by adrenocortical steroids." | 1.25 | Treatment of ulcerative colitis with azathioprine. ( Gilon, E; Theodor, E; Waks, U, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 97 (44.50) | 18.7374 |
| 1990's | 14 (6.42) | 18.2507 |
| 2000's | 43 (19.72) | 29.6817 |
| 2010's | 44 (20.18) | 24.3611 |
| 2020's | 20 (9.17) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, K | 2 |
| Huang, Y | 2 |
| Zhu, X | 2 |
| Tang, J | 1 |
| Wang, X | 2 |
| Lin, L | 2 |
| Guo, H | 1 |
| Zhang, C | 2 |
| Li, M | 1 |
| Yang, Q | 1 |
| Huang, J | 1 |
| Ye, L | 1 |
| Hu, P | 3 |
| Huang, M | 4 |
| Cao, Q | 2 |
| Gao, X | 4 |
| Pavelcova, K | 1 |
| Hanova, P | 1 |
| Ciferska, H | 1 |
| Hasikova, L | 1 |
| Stiburkova, B | 1 |
| Shingare, A | 1 |
| Dhope, N | 1 |
| Bahadur, MM | 1 |
| Luo, X | 1 |
| Yan, S | 1 |
| Jin, L | 1 |
| Zhu, H | 1 |
| Zhang, X | 3 |
| Ge, W | 1 |
| Banerjee, R | 1 |
| Raghunathan, N | 1 |
| Santos, RCFD | 1 |
| Catapani, WR | 1 |
| Takahashi, AAR | 1 |
| Waisberg, J | 1 |
| Lee, HN | 1 |
| Ding, SL | 1 |
| Wang, CW | 1 |
| Chi, MH | 1 |
| Tsai, TF | 1 |
| Yu, KH | 1 |
| Kao, HW | 1 |
| Chen, HC | 1 |
| Chen, CB | 1 |
| Lu, CW | 1 |
| Chen, WT | 1 |
| Chang, YC | 1 |
| Chang, CJ | 2 |
| Chang, YT | 1 |
| Jan Wu, YJ | 1 |
| Huang, YH | 1 |
| Ng, CY | 1 |
| Huang, PW | 1 |
| Lin, YJ | 1 |
| Hui, RC | 1 |
| Chung, WH | 1 |
| Liu, J | 1 |
| Wen, Z | 1 |
| Huang, S | 1 |
| Ai, X | 1 |
| Qian, J | 2 |
| Suzuki, S | 1 |
| Uchiyama, K | 2 |
| Motoi, Y | 1 |
| Yoshii, Y | 1 |
| Inoue, Y | 1 |
| Kubota, T | 2 |
| Odahara, S | 2 |
| Ohtaki, Y | 1 |
| Takami, S | 2 |
| Ito, Z | 2 |
| Sato, N | 1 |
| Ohkusa, T | 2 |
| Koido, S | 2 |
| Saruta, M | 1 |
| Yang, J | 1 |
| Wang, P | 1 |
| Qin, Z | 1 |
| Jia, M | 1 |
| Tian, X | 1 |
| Zheng, Y | 1 |
| Zhang, A | 1 |
| Liu, S | 1 |
| Chen, S | 2 |
| Tan, WZ | 1 |
| Sutiman, N | 2 |
| Lim, C | 1 |
| Lee, SS | 1 |
| Leong, WF | 2 |
| Tjai, M | 2 |
| Wang, C | 1 |
| Kong, CSC | 1 |
| Chuah, SW | 2 |
| Schwender, BJ | 2 |
| Chan, W | 2 |
| Shim, HH | 2 |
| Lim, WC | 2 |
| Khor, CC | 2 |
| Ling, KL | 2 |
| Chowbay, B | 2 |
| Anandi, P | 1 |
| Dickson, AL | 1 |
| Feng, Q | 1 |
| Wei, WQ | 1 |
| Dupont, WD | 1 |
| Plummer, D | 1 |
| Liu, G | 1 |
| Octaria, R | 1 |
| Barker, KA | 1 |
| Kawai, VK | 1 |
| Birdwell, K | 1 |
| Cox, NJ | 1 |
| Hung, A | 1 |
| Stein, CM | 1 |
| Chung, CP | 1 |
| Tomiyoshi, K | 1 |
| Sato, H | 1 |
| Tominaga, K | 1 |
| Kawata, Y | 1 |
| Okamoto, D | 2 |
| Kakuta, Y | 4 |
| Yokoyama, J | 1 |
| Terai, S | 1 |
| Choi, R | 1 |
| Lee, MN | 2 |
| Kim, K | 1 |
| Baek, SY | 1 |
| Kim, TJ | 1 |
| Hong, SN | 1 |
| Kim, YH | 1 |
| Lee, SY | 2 |
| Lahtinen, P | 1 |
| Jalanka, J | 1 |
| Hartikainen, A | 1 |
| Mattila, E | 1 |
| Hillilä, M | 1 |
| Punkkinen, J | 1 |
| Koskenpato, J | 1 |
| Anttila, VJ | 1 |
| Tillonen, J | 1 |
| Satokari, R | 1 |
| Arkkila, P | 1 |
| Digby-Bell, J | 1 |
| Ward, MG | 1 |
| Devasia, AJ | 1 |
| Illangeswaran, RSS | 1 |
| Raj, IX | 1 |
| George, B | 1 |
| Balasubramanian, P | 1 |
| Séverine, W | 1 |
| Xavier, K | 1 |
| Jean-Charles, C | 1 |
| Miao, Q | 1 |
| Yan, L | 1 |
| Zhou, Y | 1 |
| Li, Y | 1 |
| Zou, Y | 1 |
| Wang, L | 1 |
| Bai, Y | 1 |
| Zhang, J | 1 |
| Ding, L | 2 |
| Zhang, FB | 1 |
| Liu, H | 2 |
| Bi, HC | 1 |
| Huang, L | 1 |
| Wang, XD | 1 |
| Chen, BL | 1 |
| Zhang, Y | 3 |
| Lv, C | 1 |
| Hu, PJ | 1 |
| Wu, K | 1 |
| Yang, H | 1 |
| Liang, J | 1 |
| Huang, Z | 1 |
| Sun, Y | 1 |
| Xue, X | 1 |
| Lan, P | 1 |
| Broekman, MMTJ | 2 |
| Coenen, MJH | 2 |
| van Marrewijk, CJ | 3 |
| Wanten, GJA | 1 |
| Wong, DR | 3 |
| Verbeek, ALM | 2 |
| Klungel, OH | 3 |
| Hooymans, PM | 3 |
| Guchelaar, HJ | 3 |
| Scheffer, H | 3 |
| Derijks, LJJ | 2 |
| de Jong, DJ | 4 |
| Coucoutsi, C | 1 |
| Emmanouil, G | 1 |
| Goulielmos, G | 1 |
| Sfakianaki, O | 1 |
| Koutroubakis, IE | 1 |
| Kouroumalis, EA | 1 |
| Wanten, GJ | 1 |
| Nadiger, V | 1 |
| Choon Kong, CS | 1 |
| Cheung, YB | 1 |
| Shah, SAV | 1 |
| Paradkar, MU | 1 |
| Desai, DC | 1 |
| Ashavaid, TF | 2 |
| Nomura, H | 1 |
| Kurihara, Y | 1 |
| Saito, M | 1 |
| Fukushima, A | 1 |
| Shintani, Y | 1 |
| Shiiyama, R | 1 |
| Toshima, S | 1 |
| Kamata, A | 1 |
| Yamagami, J | 1 |
| Funakoshi, T | 1 |
| Kameyama, K | 1 |
| Amagai, M | 1 |
| Kubo, A | 1 |
| Umegaki-Arao, N | 1 |
| Kawai, Y | 1 |
| Takagawa, T | 1 |
| Ikeya, K | 1 |
| Sakuraba, H | 1 |
| Nishida, A | 1 |
| Nakagawa, S | 1 |
| Miura, M | 1 |
| Toyonaga, T | 1 |
| Onodera, K | 1 |
| Shinozaki, M | 1 |
| Ishiguro, Y | 1 |
| Mizuno, S | 2 |
| Takahara, M | 1 |
| Yanai, S | 1 |
| Hokari, R | 1 |
| Nakagawa, T | 1 |
| Araki, H | 1 |
| Motoya, S | 1 |
| Naito, T | 3 |
| Moroi, R | 1 |
| Shiga, H | 2 |
| Endo, K | 2 |
| Kobayashi, T | 1 |
| Naganuma, M | 2 |
| Hiraoka, S | 1 |
| Matsumoto, T | 1 |
| Nakamura, S | 1 |
| Nakase, H | 1 |
| Hisamatsu, T | 2 |
| Sasaki, M | 3 |
| Hanai, H | 1 |
| Andoh, A | 2 |
| Nagasaki, M | 1 |
| Kinouchi, Y | 2 |
| Shimosegawa, T | 2 |
| Masamune, A | 1 |
| Suzuki, Y | 1 |
| Cargnin, S | 1 |
| Genazzani, AA | 1 |
| Canonico, PL | 1 |
| Terrazzino, S | 1 |
| Kishibe, M | 1 |
| Nozaki, H | 1 |
| Fujii, M | 1 |
| Iinuma, S | 1 |
| Ohtsubo, S | 1 |
| Igawa, S | 1 |
| Kanno, K | 1 |
| Honma, M | 1 |
| Kishibe, K | 1 |
| Okamoto, K | 1 |
| Ishida-Yamamoto, A | 1 |
| Otsuka, M | 1 |
| Koga, T | 1 |
| Sumiyoshi, R | 1 |
| Furukawa, K | 1 |
| Okamoto, M | 1 |
| Endo, Y | 1 |
| Tsuji, S | 1 |
| Takatani, A | 1 |
| Shimizu, T | 2 |
| Igawa, T | 1 |
| Kawashiri, SY | 1 |
| Iwamoto, N | 1 |
| Ichinose, K | 1 |
| Tamai, M | 1 |
| Nakamura, H | 1 |
| Origuchi, T | 1 |
| Kawakami, A | 1 |
| Akiyama, S | 1 |
| Matsuoka, K | 1 |
| Fukuda, K | 1 |
| Hamada, S | 1 |
| Shimizu, M | 1 |
| Nanki, K | 1 |
| Kiyohara, H | 1 |
| Arai, M | 1 |
| Sugimoto, S | 1 |
| Iwao, Y | 1 |
| Ogata, H | 1 |
| Motobayashi, M | 1 |
| Suzuki, K | 1 |
| Takenaka, K | 1 |
| Fujii, T | 1 |
| Saito, E | 1 |
| Nagahori, M | 1 |
| Ohtsuka, K | 1 |
| Mochizuki, M | 1 |
| Watanabe, M | 1 |
| Hashiguchi, M | 1 |
| Kanai, T | 1 |
| Nguyen, TV | 1 |
| Nguyen, TM | 1 |
| Lachaux, A | 1 |
| Boulieu, R | 1 |
| Chen, D | 1 |
| Lian, F | 1 |
| Yuan, S | 1 |
| Wang, Y | 2 |
| Zhan, Z | 1 |
| Ye, Y | 1 |
| Qiu, Q | 1 |
| Xu, H | 1 |
| Liang, L | 1 |
| Yang, X | 1 |
| Ahmed, WM | 1 |
| Khalaf, AA | 1 |
| Moselhy, WA | 1 |
| Safwat, GM | 1 |
| Park, MS | 1 |
| Kim, DH | 2 |
| Park, SJ | 2 |
| Hong, SP | 1 |
| Kim, TI | 1 |
| Kim, WH | 3 |
| Cheon, JH | 3 |
| Gisbert, JP | 2 |
| Lee, YJ | 2 |
| Choi, WY | 1 |
| Park, KS | 2 |
| Kim, YJ | 1 |
| Cho, KB | 1 |
| Kim, ES | 1 |
| Jang, BK | 1 |
| Chung, WJ | 1 |
| Hwang, JS | 1 |
| Peña, C | 1 |
| Sepúlveda, C | 1 |
| Melo, J | 1 |
| Guerra, C | 1 |
| Coenen, MJ | 1 |
| Derijks, LJ | 2 |
| Vermeulen, SH | 1 |
| Verbeek, AL | 1 |
| Peters, WH | 1 |
| te Morsche, RH | 1 |
| Newman, WG | 1 |
| Franke, B | 1 |
| Onodera, M | 1 |
| Kuroha, M | 1 |
| Kimura, T | 1 |
| Negoro, K | 1 |
| Sanderson, JD | 1 |
| Kang, B | 2 |
| Choi, SY | 1 |
| Kim, MJ | 1 |
| Woo, SY | 1 |
| Kim, JW | 1 |
| Choe, YH | 1 |
| Kobayashi, H | 1 |
| Saito, K | 1 |
| Zhang, F | 1 |
| Bi, H | 1 |
| Hwang, EH | 1 |
| Park, JH | 1 |
| Shin, JH | 1 |
| Kim, SY | 1 |
| Fangbin, Z | 2 |
| Xiang, G | 2 |
| Liang, D | 2 |
| Hui, L | 1 |
| Xueding, W | 1 |
| Baili, C | 1 |
| Huichang, B | 1 |
| Yinglian, X | 1 |
| Peng, C | 1 |
| Lizi, Z | 1 |
| Yanjun, C | 1 |
| Feng, X | 2 |
| Minhu, C | 2 |
| Min, H | 2 |
| Pinjin, H | 2 |
| Wong, FC | 1 |
| Leung, AW | 1 |
| Kwok, JS | 1 |
| Chan, MH | 1 |
| Li, CK | 1 |
| Yuen, YP | 1 |
| Liu, Q | 1 |
| Mei, Q | 1 |
| Han, W | 1 |
| Hu, J | 1 |
| Hu, N | 1 |
| Shah, SA | 1 |
| Paradkar, M | 1 |
| Desai, D | 1 |
| Kim, HS | 1 |
| Jung, ES | 1 |
| Park, J | 1 |
| Aum, S | 1 |
| Eun, S | 1 |
| Lee, J | 1 |
| Rüther, U | 1 |
| Yeo, GSH | 1 |
| Ma, M | 1 |
| Lee, JH | 1 |
| Lee, MG | 1 |
| Di Salvo, A | 1 |
| Fabiano, C | 1 |
| Mannara, V | 1 |
| Dimarco, M | 1 |
| Orlando, A | 1 |
| Affronti, M | 1 |
| Macaluso, FS | 1 |
| Cottone, M | 1 |
| Kim, JH | 1 |
| Cha, JM | 1 |
| Kim, HJ | 1 |
| Gomollón, F | 1 |
| Tajiri, H | 1 |
| Tomomasa, T | 1 |
| Yoden, A | 1 |
| Konno, M | 1 |
| Maisawa, S | 1 |
| Sumazaki, R | 1 |
| Toyoda, S | 1 |
| Etani, Y | 1 |
| Nakacho, M | 1 |
| Ushijima, K | 1 |
| Kobayashi, A | 1 |
| Ban, H | 1 |
| Tanaka, A | 1 |
| Tsujikawa, T | 1 |
| Saito, Y | 1 |
| Fujiyama, Y | 1 |
| Kahraman, A | 1 |
| Miller, M | 1 |
| Maldonado-Lopez, E | 1 |
| Baba, HA | 1 |
| Treichel, U | 1 |
| Gerken, G | 1 |
| van Asseldonk, DP | 1 |
| Kanis, BM | 1 |
| de Boer, NK | 1 |
| van Bodegraven, AA | 1 |
| Taéron, C | 1 |
| Lewis, JD | 1 |
| Abramson, O | 1 |
| Pascua, M | 1 |
| Liu, L | 1 |
| Asakura, LM | 1 |
| Velayos, FS | 1 |
| Hutfless, SM | 1 |
| Alison, JE | 1 |
| Herrinton, LJ | 1 |
| Takatsu, N | 1 |
| Matsui, T | 1 |
| Murakami, Y | 1 |
| Ishihara, H | 1 |
| Hisabe, T | 1 |
| Nagahama, T | 1 |
| Maki, S | 1 |
| Beppu, T | 1 |
| Takaki, Y | 1 |
| Hirai, F | 1 |
| Yao, K | 1 |
| Kolorz, M | 2 |
| Bartosova, L | 2 |
| Hosek, J | 1 |
| Dvorackova, D | 1 |
| Chylkova, A | 1 |
| Zboril, V | 2 |
| Batovsky, M | 2 |
| Bartos, M | 2 |
| Hagaman, JT | 1 |
| Kinder, BW | 1 |
| Eckman, MH | 1 |
| Jung, HY | 1 |
| Choe, JY | 1 |
| Park, SH | 1 |
| Kim, SK | 1 |
| de Carvalho, JF | 1 |
| da Mota, LM | 1 |
| Bonfa, E | 1 |
| Soman, S | 1 |
| Ashok, D | 1 |
| Connolly, SA | 1 |
| Cordell, SJ | 1 |
| Taylor, CJ | 1 |
| Campbell, DI | 1 |
| Levine, AB | 1 |
| Erkan, D | 1 |
| Dewit, O | 1 |
| Moreels, T | 1 |
| Baert, F | 1 |
| Peeters, H | 1 |
| Reenaers, C | 1 |
| de Vos, M | 1 |
| Van Hootegem, P | 1 |
| Muls, V | 1 |
| Veereman, G | 1 |
| Mana, F | 1 |
| Van Outryve, M | 1 |
| Holvoet, J | 1 |
| Naegels, S | 1 |
| Piessevaux, H | 1 |
| Horsmans, Y | 1 |
| Gala, JL | 1 |
| Wroblova, K | 1 |
| Suchankova, J | 1 |
| Ulicny, B | 1 |
| Pav, I | 1 |
| Hou, JK | 1 |
| Kramer, JR | 1 |
| Richardson, P | 1 |
| Sansgiry, S | 1 |
| El-Serag, HB | 1 |
| Chisick, L | 1 |
| Oleschuk, C | 1 |
| Bernstein, CN | 1 |
| Lennard, L | 3 |
| Berth-Jones, J | 1 |
| Takwale, A | 1 |
| Tan, E | 1 |
| Barclay, G | 1 |
| Agarwal, S | 1 |
| Ahmed, I | 1 |
| Hotchkiss, K | 1 |
| Graham-Brown, RA | 1 |
| Garcia, I | 1 |
| Regueiro, M | 1 |
| Mardini, H | 1 |
| Hamuryudan, V | 1 |
| Ozyazgan, Y | 1 |
| Fresko, Y | 1 |
| Mat, C | 1 |
| Yurdakul, S | 1 |
| Yazici, H | 1 |
| Filik, L | 1 |
| Ulker, A | 1 |
| Dagli, U | 1 |
| Parlak, E | 1 |
| Tunc, B | 1 |
| Disibeyaz, S | 1 |
| Bernal, I | 1 |
| Domènech, E | 1 |
| García-Planella, E | 1 |
| Cabré, E | 1 |
| Gassull, MA | 1 |
| VEITH, FJ | 2 |
| LUCK, J | 1 |
| MURRAY, JE | 4 |
| FIGUEROA, JE | 1 |
| NAKAMOTO, S | 2 |
| POUTASSE, EF | 1 |
| KOLFF, WJ | 1 |
| GOLDMAN, R | 1 |
| GOODWIN, WE | 1 |
| KAUFMAN, JJ | 1 |
| MARTIN, DC | 1 |
| GLASSOCK, RJ | 1 |
| NOUROK, DS | 1 |
| WHEELER, JR | 1 |
| WHITE, WF | 1 |
| CALNE, RY | 1 |
| LUCK, RJ | 1 |
| ROENIGK, HH | 2 |
| HASERICK, JR | 1 |
| MCCORMACK, LJ | 1 |
| Clunie, GP | 1 |
| Buchheidt, D | 1 |
| Hummel, M | 1 |
| Diehl, S | 1 |
| Hehlmann, R | 1 |
| Goullet, M | 1 |
| Naber, TH | 1 |
| Fabre, MA | 1 |
| Jones, DC | 1 |
| Bunce, M | 1 |
| Morris, PJ | 3 |
| Friend, PJ | 1 |
| Welsh, KI | 1 |
| Marshall, SE | 1 |
| Achkar, JP | 1 |
| Stevens, T | 1 |
| Easley, K | 1 |
| Brzezinski, A | 1 |
| Seidner, D | 1 |
| Lashner, B | 1 |
| Allorge, D | 1 |
| Hamdan, R | 1 |
| Broly, F | 2 |
| Libersa, C | 2 |
| Colombel, JF | 2 |
| Kitiyakara, T | 1 |
| Hayat, J | 1 |
| McIntyre, AS | 1 |
| Kurzawski, M | 1 |
| Dziewanowski, K | 1 |
| Gawrońska-Szklarz, B | 1 |
| Domański, L | 1 |
| Droździk, M | 1 |
| Duley, JA | 2 |
| Florin, TH | 1 |
| Zelinkova, Z | 1 |
| Stokkers, PC | 2 |
| Vogels, EW | 1 |
| van Kampen, AH | 1 |
| Curvers, WL | 1 |
| Cohn, D | 1 |
| van Deventer, SJ | 1 |
| Hommes, DW | 2 |
| De Ridder, L | 1 |
| Van Dieren, JM | 1 |
| Van Deventer, HJ | 1 |
| Van der Woude, JC | 1 |
| Van Vuuren, AJ | 1 |
| Benninga, MA | 1 |
| Escher, JC | 1 |
| Cooke, ME | 1 |
| Potena, L | 1 |
| Luikart, H | 1 |
| Valantine, HA | 1 |
| Ooi, CY | 1 |
| Bohane, TD | 1 |
| Lee, D | 1 |
| Naidoo, D | 1 |
| Day, AS | 1 |
| Zhu, B | 1 |
| Chen, N | 1 |
| Lin, Y | 1 |
| Ren, H | 1 |
| Zhang, W | 1 |
| Wang, W | 1 |
| Pan, X | 1 |
| Yu, H | 1 |
| Boonsrirat, U | 1 |
| Angsuthum, S | 1 |
| Vannaprasaht, S | 1 |
| Kongpunvijit, J | 1 |
| Hirankarn, N | 1 |
| Tassaneeyakul, W | 1 |
| Avihingsanon, Y | 1 |
| French, ME | 1 |
| Dunnill, MS | 1 |
| Hunnisett, AG | 1 |
| Ting, A | 2 |
| Thompson, JF | 1 |
| Wood, RF | 1 |
| Barry, JM | 1 |
| Larson, B | 1 |
| Fischer, SM | 1 |
| Norman, DJ | 1 |
| Bennett, WM | 1 |
| Lewis, RM | 1 |
| Banowsky, LH | 1 |
| Nicastro-Lutton, JJ | 1 |
| Cruz, AB | 1 |
| Saunders, PH | 1 |
| Gustafson, TL | 1 |
| Schaffner, W | 1 |
| Lavely, GB | 1 |
| Stratton, CW | 1 |
| Johnson, HK | 1 |
| Hutcheson, RH | 1 |
| Brown, CB | 1 |
| Fox, M | 1 |
| Maddocks, JL | 1 |
| Krel', AA | 2 |
| Kanevskaia, MZ | 2 |
| Rashchupkina, ZP | 1 |
| Bolotin, EV | 2 |
| Chichasova, NV | 1 |
| Huskisson, EC | 1 |
| Bailey, RR | 1 |
| Rubin, L | 1 |
| Urowitz, MB | 1 |
| Pruzanski, W | 1 |
| Shamberger, RC | 1 |
| Devereux, DF | 1 |
| Brennan, MF | 1 |
| Schellekens, H | 1 |
| van Eerd, PM | 1 |
| de Reus, A | 1 |
| Weck, PK | 1 |
| Stebbing, N | 1 |
| Squifflet, JP | 1 |
| Sutherland, DE | 1 |
| Rynasiewicz, JJ | 1 |
| Field, J | 1 |
| Heil, J | 1 |
| Najarian, JS | 2 |
| Pollak, R | 1 |
| Nishikawa, RA | 1 |
| Mozes, MF | 2 |
| Jonasson, O | 2 |
| Kusaba, R | 1 |
| Otubo, O | 1 |
| Sugimoto, H | 1 |
| Takahashi, I | 1 |
| Yamada, Y | 1 |
| Yamauchi, J | 1 |
| Akiyama, N | 1 |
| Inou, T | 1 |
| Hogge, DE | 1 |
| Wilson, DR | 1 |
| Shumak, KH | 1 |
| Cattran, DC | 1 |
| Whisnant, JK | 1 |
| Pelkey, J | 1 |
| Reinicke, H | 1 |
| Weber, FW | 1 |
| Hausamen, TU | 1 |
| Frappier, J | 1 |
| Legendre, C | 2 |
| Soria-Royer, C | 2 |
| Barbanel, C | 1 |
| Kreis, H | 2 |
| Beaune, P | 2 |
| Serre-Debeauvais, F | 1 |
| Bayle, F | 1 |
| Amirou, M | 1 |
| Bechtel, Y | 1 |
| Boujet, C | 1 |
| Vialtel, P | 1 |
| Bessard, G | 1 |
| Schütz, E | 2 |
| Gummert, J | 1 |
| Mohr, FW | 1 |
| Armstrong, VW | 2 |
| Oellerich, M | 2 |
| Kerstens, PJ | 1 |
| Stolk, JN | 1 |
| Hilbrands, LB | 1 |
| van de Putte, LB | 1 |
| De Abreu, RA | 1 |
| Boerbooms, AM | 1 |
| Mircheva, J | 1 |
| Premel, S | 1 |
| Connell, WR | 1 |
| Kamm, MA | 1 |
| Ritchie, JK | 1 |
| Lennard-Jones, JE | 1 |
| Heaf, J | 1 |
| Amato, MP | 1 |
| Pracucci, G | 1 |
| Ponziani, G | 1 |
| Siracusa, G | 1 |
| Fratiglioni, L | 1 |
| Amaducci, L | 1 |
| Xiwen, B | 1 |
| Lixin, Y | 1 |
| Junjie, M | 1 |
| Guttmann, RD | 1 |
| Flemming, C | 1 |
| Ferrari, N | 1 |
| Debuysere, H | 1 |
| Marteau, P | 1 |
| Gendre, JP | 1 |
| Bonaz, B | 1 |
| Soulé, JC | 1 |
| Modigliani, R | 1 |
| Touze, Y | 1 |
| Catala, P | 1 |
| Korelitz, BI | 1 |
| Khan, ZH | 1 |
| Mayberry, JF | 1 |
| Spiers, N | 1 |
| Wicks, AC | 1 |
| Suhail, SM | 1 |
| Vathsala, A | 1 |
| Lou, HX | 1 |
| Woo, KT | 1 |
| Wallace, TM | 1 |
| Veldhuyzen van Zanten, SJ | 1 |
| Lowry, PW | 2 |
| Franklin, CL | 2 |
| Weaver, AL | 2 |
| Szumlanski, CL | 1 |
| Mays, DC | 2 |
| Loftus, EV | 1 |
| Tremaine, WJ | 2 |
| Lipsky, JJ | 2 |
| Weinshilboum, RM | 1 |
| Sandborn, WJ | 2 |
| Pike, MG | 1 |
| Gupta, P | 1 |
| Gokhale, R | 1 |
| Kirschner, BS | 1 |
| Fisher, KA | 1 |
| Mahajan, SK | 1 |
| Hill, JL | 1 |
| Stuart, FP | 1 |
| Katz, AI | 1 |
| Rai, GS | 1 |
| Wilkinson, R | 1 |
| Taylor, RM | 1 |
| Uldall, PR | 1 |
| Kerr, DN | 1 |
| Oesterwitz, H | 1 |
| Horpacsy, G | 1 |
| May, G | 1 |
| Mebel, M | 1 |
| Spigos, DS | 1 |
| Thomas, PA | 1 |
| Trifonov, IuI | 1 |
| Putnam, CW | 1 |
| Halgrimson, CG | 1 |
| Groth, CG | 1 |
| Kashiwagi, N | 1 |
| Porter, KA | 1 |
| Starzl, TE | 1 |
| Cameron, JS | 3 |
| Pinals, RS | 1 |
| Hahn, BH | 1 |
| Kantor, OS | 1 |
| Osterland, CK | 1 |
| Celinska-Szpytko, E | 1 |
| Konieczna, B | 1 |
| Mackiewicz, S | 1 |
| Chocair, PR | 1 |
| Simmonds, HA | 1 |
| Younger, IR | 1 |
| Harris, DW | 1 |
| Colver, GB | 1 |
| Lobo, AJ | 1 |
| Foster, PN | 1 |
| Burke, DA | 1 |
| Johnston, D | 1 |
| Axon, AT | 1 |
| Megison, SM | 1 |
| McMullin, ND | 1 |
| Andrews, WS | 1 |
| Kumar, A | 1 |
| Leonard, MC | 1 |
| Cleveland, RP | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Bliddal, H | 1 |
| Helin, P | 1 |
| Jones, RM | 1 |
| Murie, JA | 1 |
| Allen, RD | 1 |
| Stratta, RJ | 1 |
| Armbrust, MJ | 1 |
| Oh, CS | 1 |
| Pirsch, JD | 1 |
| Kalayoglu, M | 1 |
| Sollinger, HW | 1 |
| Belzer, FO | 1 |
| García Buey, L | 1 |
| Moreno Otero, R | 1 |
| García Sánchez, A | 1 |
| González Estecha, A | 1 |
| Pajares, JM | 1 |
| Oka, T | 1 |
| Omori, Y | 1 |
| Aikawa, I | 1 |
| Yasumura, T | 1 |
| Yoshimura, N | 1 |
| Nakai, I | 1 |
| Kissel, JT | 1 |
| Levy, RJ | 1 |
| Mendell, JR | 1 |
| Griggs, RC | 1 |
| Boulton-Jones, M | 1 |
| Robinson, R | 1 |
| Ogg, C | 1 |
| Brooke, BN | 1 |
| Javett, SL | 1 |
| Davison, OW | 1 |
| Willoughby, JM | 1 |
| Beckett, J | 1 |
| Kumar, PJ | 1 |
| Dawson, AM | 1 |
| McDonald, J | 1 |
| Murphy, AV | 1 |
| Arneil, GC | 1 |
| Lorenzen, I | 2 |
| Videbaek, A | 2 |
| Diethelm, AG | 1 |
| Dubernard, JM | 1 |
| Busch, GJ | 2 |
| Brun, C | 1 |
| MacDonald, AS | 1 |
| Alexander, JL | 1 |
| Junge-Hülsing, G | 4 |
| Müller, US | 4 |
| Wagner, H | 2 |
| Büchner, RT | 1 |
| Oberwittler, W | 1 |
| Hauss, WH | 3 |
| Hrubesch, M | 1 |
| Büchner, T | 1 |
| Wirth, W | 3 |
| Thöne, F | 2 |
| Spencer, ES | 1 |
| Simmons, RL | 1 |
| Tallent, MB | 1 |
| Kjellstrand, CM | 1 |
| Lie, TS | 2 |
| Breuer, J | 1 |
| Haesslein, HC | 1 |
| Pierce, JC | 3 |
| Lee, HM | 1 |
| Hume, DM | 2 |
| Barratt, M | 1 |
| Brodehl, J | 1 |
| Rhodes, J | 1 |
| Sloane, CE | 1 |
| Deodhar, S | 1 |
| Anderson, RJ | 1 |
| Schafer, LA | 1 |
| Olin, DB | 1 |
| Eickhoff, TC | 1 |
| Linshaw, MA | 1 |
| Gruskin, AB | 1 |
| Ku, G | 1 |
| Varghese, Z | 1 |
| Fernando, ON | 1 |
| Baillod, R | 1 |
| Hopewell, JP | 1 |
| Moorhead, JF | 1 |
| Kauffman, HM | 1 |
| Swanson, MK | 1 |
| McGregor, WR | 1 |
| Rodgers, RE | 1 |
| Fox, PS | 1 |
| Hall, CL | 1 |
| Jontofsohn, R | 1 |
| Junkers, K | 1 |
| Halbfass, HJ | 1 |
| Heinze, V | 1 |
| George, CR | 1 |
| Tremann, JA | 1 |
| Quadracci, LJ | 1 |
| Striker, GE | 1 |
| Marchioro, TL | 1 |
| Platzer, S | 1 |
| Asamer, H | 1 |
| Födisch, HJ | 1 |
| Gabl, F | 1 |
| Huber, H | 1 |
| Judmaier, G | 1 |
| Spath, P | 1 |
| Burton, JL | 1 |
| Greaves, MW | 1 |
| Cohen, SL | 1 |
| Urizar, RE | 1 |
| Tinglof, B | 1 |
| McIntosh, R | 1 |
| Litman, N | 1 |
| Barnett, E | 1 |
| Wilkerson, J | 1 |
| Smith, F | 1 |
| Vernier, RL | 1 |
| Hulme, B | 1 |
| Reeves, DS | 1 |
| Cook, ES | 1 |
| Nutini, LG | 1 |
| Bach, JF | 1 |
| Dardenne, M | 1 |
| Woods, JE | 1 |
| DeWeerd, JH | 1 |
| Johnson, WJ | 1 |
| Anderson, CF | 1 |
| Nebe, H | 1 |
| Hoensch, H | 1 |
| Hartwich, G | 1 |
| Zweiman, B | 1 |
| Silberberg, DH | 1 |
| Sokolowski, J | 1 |
| Olszewski, W | 1 |
| Pachiolo, R | 1 |
| Genova, R | 1 |
| Kardaszewicz, E | 1 |
| Japa, J | 1 |
| Kämpfen, P | 1 |
| Hodler, J | 1 |
| De Groote, J | 1 |
| Maes, H | 1 |
| Vandenbroucke, J | 1 |
| Magyar, I | 1 |
| Hewitt, J | 1 |
| Escande, JP | 1 |
| Leibowitch, M | 1 |
| Franceschini, P | 1 |
| Hauschild, G | 1 |
| Schöne, D | 1 |
| Wässer, S | 1 |
| Parrow, A | 1 |
| Ogston, D | 1 |
| Dawson, AA | 1 |
| Philip, JF | 1 |
| Theodor, E | 1 |
| Gilon, E | 1 |
| Waks, U | 1 |
| Bouroncle, BA | 1 |
| Doan, CA | 1 |
| Butler, HE | 1 |
| Morgan, JM | 1 |
| Smythe, CM | 1 |
| Booth, RA | 1 |
| Ansari, MT | 1 |
| Tricco, AC | 1 |
| Loit, E | 1 |
| Weeks, L | 1 |
| Doucette, S | 1 |
| Skidmore, B | 1 |
| Hoch, JS | 1 |
| Tsouros, S | 1 |
| Sears, M | 1 |
| Sy, R | 1 |
| Karsh, J | 1 |
| Mani, S | 1 |
| Galipeau, J | 1 |
| Yurkiewich, A | 1 |
| Daniel, R | 1 |
| Tsertsvadze, A | 1 |
| Yazdi, F | 1 |
| Reinshagen, M | 1 |
| Behrens, C | 1 |
| von Tirpitz, C | 1 |
| Stallmach, A | 1 |
| Herfarth, H | 1 |
| Stein, J | 1 |
| Bias, P | 1 |
| Adler, G | 1 |
| Shipkova, M | 1 |
| Kruis, W | 1 |
| von Ahsen, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Thiopurine Dose Optimization by NUDT 15 R139C on Reducing Thiopurine-induced Leucopenia in Inflammatory Bowel Disease[NCT02929706] | 400 participants (Anticipated) | Interventional | 2016-07-31 | Recruiting | |||
| Pharmacogenetic Testing in the Clinical Setting: is Screening for TPMT Genotype a Cost-effective Treatment Strategy? - The First Prospective Randomized Controlled Trial Within the Dutch Health Care System.[NCT00521950] | 853 participants (Actual) | Interventional | 2007-09-30 | Completed | |||
| Cyclophosphamide and Hydroxychloroquine for the Treatment of Severe Thrombocytopenia in Systemic Lupus Erythematosus[NCT02444728] | Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Because of insufficient enrollement) | ||
| Hit Hard and Early. The Effect of High Dose Methylprednisolone on Nailfold Capillary Changes and Biomarkers in Early SSc: a 12-week Randomised Explorative Double-blind Placebo-controlled Trial.[NCT03059979] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 reviews available for azathioprine and Leukopenia
| Article | Year |
|---|---|
Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis.
Topics: Antineoplastic Agents; Azathioprine; Humans; Leukopenia; Mercaptopurine; Polymorphism, Genetic; Pyro | 2018 |
Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review.
Topics: Azathioprine; Bone Marrow Diseases; Humans; Inflammatory Bowel Diseases; Leukopenia; Mercaptopurine | 2008 |
Clinical assessment and management of cytopenias in lupus patients.
Topics: Anemia; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Glucocorticoids; Humans; Immunoglobuli | 2011 |
Relevance of thiopurine methyltransferase status in rheumatology patients receiving azathioprine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Biomarkers; Erythrocytes; Genotype; Human | 2004 |
Thiopurine therapies: problems, complexities, and progress with monitoring thioguanine nucleotides.
Topics: Azathioprine; Drug Monitoring; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Leukopenia; Me | 2005 |
Mycophenolate mofetil in induction and maintenance therapy of severe lupus nephritis: a meta-analysis of randomized controlled trials.
Topics: Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Infection Control; Leukopenia; Lup | 2007 |
The effect of chemotherapeutic agents on wound healing.
Topics: Adrenal Cortex Hormones; Anemia; Animals; Antineoplastic Agents; Azathioprine; Collagen; Cyclophosph | 1981 |
Frequency of use and standards of care for the use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease: a systematic review of the literature and a survey of Canadian gastroenterologists.
Topics: Azathioprine; Canada; Drug Utilization; Gastroenterology; Health Care Surveys; Humans; Immunosuppres | 2001 |
Problems with immunosuppressive agents in renal disease.
Topics: Animals; Azathioprine; Cyclophosphamide; Granulomatosis with Polyangiitis; Humans; Immunosuppressive | 1975 |
Azathioprine in dermatology.
Topics: Azathioprine; Drug Interactions; Eczema; Humans; Leukopenia; Pemphigoid, Bullous; Pemphigus; Skin Di | 1991 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
[Liver disease caused by azathioprine: clinical case and review of the literature].
Topics: Aged; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Leukopenia; Liver Diseases; Male | 1988 |
Cytotoxic agents in childhood glomerulonephritis.
Topics: Adult; Agranulocytosis; Animals; Azathioprine; Child; Cyclophosphamide; Fertility; Glomerulonephriti | 1972 |
[Immunosuppressive therapy of the nephrotic syndrome in childhood].
Topics: Azathioprine; Child; Chlorambucil; Cyclophosphamide; Cystitis; Drug Resistance; Humans; Immunosuppre | 1972 |
Management of the nephrotic syndrome.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Chlorambucil; Clinical Trials as Topic; Cyclophos | 1974 |
Organ transplantation-today and tomorrow.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Dogs; Drainage; Ethics, Medical; Heart Transplantation; | 1969 |
Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.
Topics: Autoimmune Diseases; Chronic Disease; Female; Humans; Leukopenia; Male; Mercaptopurine; Methyltransf | 2010 |
19 trials available for azathioprine and Leukopenia
| Article | Year |
|---|---|
Randomised clinical trial: dose optimising strategy by NUDT15 genotyping reduces leucopenia during thiopurine treatment of Crohn's disease.
Topics: Anemia; Azathioprine; Crohn Disease; Genotype; Humans; Leukopenia; Mercaptopurine; Pyrophosphatases | 2021 |
More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Inflammatory Bowel Dise | 2017 |
Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype.
Topics: Adult; Azathioprine; Case-Control Studies; Female; Genotype; Humans; Inflammatory Bowel Diseases; Le | 2017 |
Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Dosage Calcu | 2015 |
Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial.
Topics: Adolescent; Adult; Aged; Azathioprine; Cross-Over Studies; Dermatitis, Atopic; Double-Blind Method; | 2002 |
Efficacy and safety of dual versus triple tacrolimus-based therapy in kidney transplantation: two-year follow-up.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Diabetes Mellitus, Type 1; Drug Therapy, C | 2002 |
Interferon alfa combined with azathioprine for the uveitis of Behçet's disease: an open study.
Topics: Adult; Angiogenesis Inhibitors; Azathioprine; Behcet Syndrome; Drug Monitoring; Drug Therapy, Combin | 2002 |
Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease.
Topics: Adult; Antirheumatic Agents; Azathioprine; Dose-Response Relationship, Drug; Endpoint Determination; | 2004 |
The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.
Topics: Adolescent; Adult; Aged; Alleles; Azathioprine; Bone Marrow Diseases; Child; Cyclosporine; Dose-Resp | 2005 |
A controlled trial of cyclosporine in renal transplantation with conversion to azathioprine and prednisolone after three months.
Topics: Adult; Azathioprine; Clinical Trials as Topic; Creatinine; Cyclosporins; Cytomegalovirus Infections; | 1983 |
Azathioprine myelotoxicity related to elevated 6-thioguanine nucleotides in heart transplantation.
Topics: Adult; Aged; Azathioprine; Cyclosporine; Erythrocytes; Female; Heart Transplantation; Humans; Leukoc | 1995 |
Safety and efficacy of mycophenolate mofetil for prophylaxis in Asian renal transplant recipients.
Topics: Asian People; Azathioprine; Creatinine; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Hu | 2000 |
Prediction of azathioprine intolerance in transplant patients.
Topics: Azathioprine; Drug Tolerance; Granulocytes; Humans; Hydrocortisone; Kidney Transplantation; Leukocyt | 1976 |
Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Azathioprine; Clinical Trials as Topic; Drug Therapy, Co | 1975 |
Controlled trial of azathioprine in Crohn's disease.
Topics: Azathioprine; Blood Cell Count; Blood Platelets; Blood Sedimentation; Clinical Trials as Topic; Croh | 1971 |
Azathioprine in the treatment of Crohn's disease.
Topics: Azathioprine; Clinical Trials as Topic; Colic; Crohn Disease; Humans; Leukopenia; Lymphoma; Placebos | 1972 |
Management of the nephrotic syndrome.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Chlorambucil; Clinical Trials as Topic; Cyclophos | 1974 |
Co-trimoxazole and azathioprine: a safe combination.
Topics: Administration, Oral; Azathioprine; Cadaver; Clinical Trials as Topic; Drug Therapy, Combination; Hu | 1974 |
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Crohn Disease; Dose-Response Relati | 2007 |
183 other studies available for azathioprine and Leukopenia
| Article | Year |
|---|---|
The Examination of a TPMT Gene Before Administration of Azathioprine in Rheumatology Practice and Identification of a Novel Variant p.W29R.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Leukopenia; Methyltransferases; Rheumatology | 2022 |
Novel risk factor for valganciclovir toxicity-NUDT15 genetic variant.
Topics: Azathioprine; Humans; Leukopenia; Pyrophosphatases; Risk Factors; Valganciclovir | 2022 |
Inosine Triphosphate Pyrophosphatase and NUDT15 are Good Predictors of Clinical Outcomes in Thiopurine-Treated Chinese Patients with Inflammatory Bowel Disease.
Topics: Azathioprine; Biomarkers; China; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Leukopeni | 2022 |
Editorial: a paradigm shift in NUDT15 assessment-towards predictive and personalised medicine in Crohn's disease?
Topics: Azathioprine; Crohn Disease; Humans; Leukopenia; Precision Medicine | 2022 |
C-reactive protein levels and prevalence of leukopenia in patients with inflammatory bowel disease treated with azathioprine and/or mesalazine: a real-life study.
Topics: Adult; Azathioprine; C-Reactive Protein; Humans; Inflammatory Bowel Diseases; Leukopenia; Mesalamine | 2022 |
The first Aotearoa New Zealand case of NUDT15-variant-related thiopurine-induced myelotoxicity.
Topics: Abscess; Adult; Azathioprine; Humans; Leukopenia; Male; New Zealand; Pyrophosphatases; Stomatitis | 2022 |
Implementation of NUDT15 Genotyping to Prevent Azathioprine-Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population.
Topics: Autoimmune Diseases; Azathioprine; Genotype; Humans; Immunosuppressive Agents; Leukopenia; Methyltra | 2022 |
Topics: Azathioprine; China; Genotype; Humans; Leukopenia; Pyrophosphatases; Sulfurtransferases; Xanthine De | 2022 |
Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease.
Topics: Azathioprine; East Asian People; Humans; Inflammatory Bowel Diseases; Leukopenia; Mercaptopurine; Py | 2023 |
Topics: Adolescent; Adult; Aged; Alleles; Asian People; Azathioprine; Biomarkers; Child; Female; Genetic Pre | 2019 |
An intronic FTO variant rs16952570 confers protection against thiopurine-induced myelotoxicities in multiethnic Asian IBD patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Asian Peo | 2020 |
Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
Topics: Adult; Age Factors; Azathioprine; Databases, Genetic; Female; Genetic Association Studies; Humans; I | 2020 |
Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.
Topics: Alopecia; Asian People; Azathioprine; Codon; Colitis, Ulcerative; Genetic Predisposition to Disease; | 2020 |
Effects of various genetic polymorphisms on thiopurine treatment-associated outcomes for Korean patients with Crohn's disease.
Topics: Adult; Azathioprine; Crohn Disease; Genotype; Humans; Leukopenia; Methyltransferases; Polymorphism, | 2020 |
Letter: faecal microbiota transplantation for irritable bowel syndrome. Authors' reply.
Topics: Anemia; Azathioprine; Fecal Microbiota Transplantation; Humans; Irritable Bowel Syndrome; Leukopenia | 2020 |
Editorial: balancing safety and efficacy-6-TGN thresholds in NUDT15 intermediate metabolisers treated with thiopurines.
Topics: Azathioprine; Humans; Leukopenia; Mercaptopurine | 2020 |
NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series.
Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Genotype; Humans; Leukopenia; Methyltransferases; Purpu | 2020 |
A rare case of Azathioprine-induced leukopenia in an European woman.
Topics: Adult; Asian People; Azathioprine; Crohn Disease; Female; Humans; Leukopenia; Pyrophosphatases | 2022 |
Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.
Topics: Adult; Aged; Alleles; Azathioprine; China; Female; Genetic Association Studies; Guanine Nucleotides; | 2021 |
Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients.
Topics: Adolescent; Adult; Aged; Asian People; Azathioprine; Child; Child, Preschool; Female; Humans; Immuno | 2021 |
Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.
Topics: Adolescent; Adult; Aged; Asian People; Azathioprine; Child; Child, Preschool; China; Cohort Studies; | 2017 |
Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Case-Control Studies; Drug-Related Side Ef | 2017 |
Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients.
Topics: Adult; Alleles; Asian People; Azathioprine; Female; Genetic Variation; Haplotypes; Humans; Inflammat | 2018 |
Preemptive NUDT15 genotyping: redefining the management of patients with thiopurine-induced toxicity.
Topics: Adult; Azathioprine; Female; Genotype; Humans; India; Leukopenia; Male; Methyltransferases; Pyrophos | 2018 |
Azathioprine-induced alopecia and leukopenia associated with NUDT15 polymorphisms.
Topics: Adult; Alopecia; Azathioprine; Female; Humans; Immunosuppressive Agents; Leukopenia; Loss of Functio | 2018 |
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.
Topics: Alopecia; Antibodies, Monoclonal; Azathioprine; Biomarkers, Pharmacological; Genetic Predisposition | 2018 |
Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study.
Topics: Alopecia; Asian People; Azathioprine; Case-Control Studies; Female; Humans; Immunosuppressive Agents | 2018 |
Novel multiple heterozygous NUDT15 variants cause an azathioprine-induced severe leukopenia in a patient with systemic lupus erythematosus.
Topics: Azathioprine; Heterozygote; Humans; Immunosuppressive Agents; Leukopenia; Lupus Erythematosus, Syste | 2019 |
Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Erythrocyte Indic | 2019 |
Usefulness of thiopurine metabolites in predicting azathioprine resistance in pediatric IBD patients.
Topics: Adolescent; Antimetabolites; Azathioprine; Child; Child, Preschool; Drug Resistance; Female; Humans; | 2013 |
Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus.
Topics: Adult; Alleles; Alopecia; Asian People; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort | 2014 |
Royal jelly attenuates azathioprine induced toxicity in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Anemia; Animals; Antimetabolites, Antineoplastic; Aspart | 2014 |
Leukopenia predicts remission in patients with inflammatory bowel disease and Behcet's disease on thiopurine maintenance.
Topics: Adolescent; Adult; Aged; Azathioprine; Behcet Syndrome; Colitis, Ulcerative; Comorbidity; Crohn Dise | 2015 |
Is less more: does leukopenia predict remission in patients with inflammatory bowel disease receiving thiopurine treatment?
Topics: Azathioprine; Behcet Syndrome; Colitis, Ulcerative; Crohn Disease; Female; Humans; Immunosuppressive | 2015 |
Differences in the adverse effects of azathioprine between inflammatory bowel disease and autoimmune hepatitis in Korean patients.
Topics: Adolescent; Adult; Aged; Azathioprine; Base Sequence; Female; Genotype; Hepatitis, Autoimmune; Human | 2014 |
[Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case].
Topics: Azathioprine; Bone Marrow; Chromosomes, Human, Pair 5; Fatal Outcome; Female; Humans; Immunosuppress | 2015 |
NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.
Topics: Adult; Alopecia; Anti-Inflammatory Agents; Asian People; Azathioprine; Chi-Square Distribution; Coli | 2016 |
TPMT Testing Before Starting Azathioprine or Mercaptopurine: Surely Just Do It?
Topics: Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Female; Gastrointestinal | 2015 |
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Crohn Diseas | 2015 |
A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD).
Topics: Adult; Alleles; Azathioprine; Erythrocytes; Female; Genotype; Guanine Nucleotides; Humans; Immunosup | 2015 |
The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases.
Topics: Adolescent; Adult; Alleles; Analysis of Variance; Asian People; Azathioprine; Female; Genetic Predis | 2015 |
NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease.
Topics: Age Factors; Alopecia; Asian People; Azathioprine; Crohn Disease; Female; Gastrointestinal Agents; G | 2016 |
Prospective Evaluation of Pharmacogenomics and Metabolite Measurements upon Azathioprine Therapy in Inflammatory Bowel Disease: An Observational Study.
Topics: Adult; Aged; Azathioprine; China; Drug Monitoring; Female; Genetic Testing; Guanine Nucleotides; Hum | 2016 |
NUDT15 variant and thiopurine-induced leukopenia in Hong Kong.
Topics: Adult; Azathioprine; Child; Female; Hong Kong; Humans; Leukopenia; Male; Mercaptopurine; Middle Aged | 2016 |
Measurement of red blood cell 6-thioguanine nucleotide is beneficial in azathioprine maintenance therapy of Chinese Crohn's disease patients.
Topics: Adult; Azathioprine; Crohn Disease; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Huma | 2016 |
Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.
Topics: Aged; Asian People; Azathioprine; Female; Gene Frequency; Genetic Association Studies; Genetic Varia | 2017 |
A coding variant in
Topics: Adolescent; Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Azathioprine; Case- | 2017 |
Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders.
Topics: Adult; Autoimmune Diseases; Azathioprine; Female; Hematologic Diseases; Heterozygote; Homozygote; Hu | 2016 |
[The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].
Topics: Adolescent; Adult; Azathioprine; Behcet Syndrome; Cohort Studies; Drug Therapy, Combination; Female; | 2008 |
[The frequency and the course of the adverse effects of azathioprine/6-mercaptopurine treatment in patients with inflammatory bowel disease].
Topics: Antimetabolites, Antineoplastic; Azathioprine; Cohort Studies; Drug Therapy, Combination; Humans; In | 2008 |
Efficacy and safety of azathioprine and 6-mercaptopurine in Japanese pediatric patients with ulcerative colitis: a survey of the Japanese Society for Pediatric Inflammatory Bowel Disease.
Topics: Adolescent; Algorithms; Azathioprine; Child; Colitis, Ulcerative; Drug Therapy, Combination; Female; | 2008 |
Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Asian People; Azathioprine; Bone Marrow; Case-Control Studies; Colitis, Ulc | 2008 |
[A 55-year-old woman with thymoma and hypogammaglobulinemia (Good syndrome), ulcerative colitis, and cytomegalovirus infection].
Topics: Agammaglobulinemia; Antiviral Agents; Azathioprine; Cidofovir; Colitis, Ulcerative; Cytomegalovirus | 2009 |
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.
Topics: Adult; Azathioprine; Crohn Disease; Erythema Infectiosum; Female; Humans; Immunosuppressive Agents; | 2009 |
[Azathioprine].
Topics: Azathioprine; Humans; Immunosuppressive Agents; Leukopenia; Transplantation Immunology | 2009 |
Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendations.
Topics: Adult; Aged; Antimetabolites; Azathioprine; Bone Marrow; Cohort Studies; Drug Monitoring; Female; Hu | 2009 |
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
Topics: Adult; Alopecia; Aminosalicylic Acids; Anti-Inflammatory Agents; Asian People; Azathioprine; Chemica | 2009 |
Importance of thiopurine S-Methyltransferase gene polymorphisms for prediction of azathioprine toxicity.
Topics: Adult; Alleles; Azathioprine; Female; Genetic Predisposition to Disease; Genotype; Humans; Leukopeni | 2009 |
Thiopurine S- methyltransferase [corrected] testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis.
Topics: Acetylcysteine; Azathioprine; Computer Simulation; Cost-Benefit Analysis; Decision Support Technique | 2010 |
Invasive aspergillosis related with azathioprine-induced leucopenia without mutant allele of thioprine methyltransferase in a patient with rheumatoid arthritis.
Topics: Aged; Amphotericin B; Antifungal Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; | 2011 |
Fatal rhabdomyolysis in systemic lupus erythematosus.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Antibodies, Antinuclear; Arthritis; Azathioprine; | 2011 |
Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine.
Topics: Adolescent; Azathioprine; Child; Cohort Studies; Erythrocyte Indices; Female; Humans; Immunosuppress | 2010 |
Limitations of extensive TPMT genotyping in the management of azathioprine-induced myelosuppression in IBD patients.
Topics: Adolescent; Adult; Aged; Azathioprine; DNA Mutational Analysis; Drug Hypersensitivity; Female; Genot | 2011 |
Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance, and pancreatitis in azathioprine-treated patients.
Topics: Azathioprine; Gastrointestinal Diseases; Gene Expression Regulation; Genetic Predisposition to Disea | 2012 |
Myelosuppression monitoring after immunomodulator initiation in veterans with inflammatory bowel disease: a national practice audit.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Azathioprine; Delivery of Health Care; Drug Monitoring; | 2012 |
Should thiopurine methyltransferase genotypes and phenotypes be measured before thiopurine therapy in patients with inflammatory bowel disease?
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; China; Drug Interactions; | 2012 |
The utility of thiopurine methyltransferase enzyme testing in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Colitis, Ulcerative; Crohn Disease; Dose-R | 2013 |
TPMT in the treatment of Crohn's disease with azathioprine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Biomarkers; Crohn Disease; Drug Interactions; | 2002 |
Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.
Topics: Adolescent; Adult; Azathioprine; Crohn Disease; Female; Genotype; Humans; Immunosuppressive Agents; | 2002 |
Leukopenia and remission during azathioprine treatment.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Humans; Leukopenia; Retrospective Studies | 2003 |
[Opportunistic infections in patients with inflammatory bowel disease undergoing immunosuppressive therapy].
Topics: Acyclovir; Adult; Aged; Antiviral Agents; Azathioprine; Chickenpox; Crohn Disease; Disease Susceptib | 2003 |
SPLENECTOMY IN IMMUNOSUPPRESSIVE REGIMENS IN DOG AND MAN.
Topics: Azathioprine; Dogs; Hypersplenism; Immunosuppressive Agents; Kidney Transplantation; Leukocytosis; L | 1964 |
RENAL HOMOTRANSPLANTATION IN MAN; REPORT OF SIX CONSECUTIVE CASES.
Topics: Adolescent; Anuria; Azathioprine; Blood Chemical Analysis; Dactinomycin; Drug Therapy; Hypertension; | 1964 |
SIXTEEN CASES OF RENAL HOMOTRANSPLANTATION .
Topics: Anuria; Azathioprine; Blood Group Incompatibility; Dactinomycin; Glomerulonephritis; Hypertension; I | 1964 |
SELECTIVE LYMPHOPENIA BY USE OF INTRALYMPHATIC 198-AU AND SPLENECTOMY. IMMUNOSUPPRESSIVE ACTION ON REJECTION OF CANINE RENAL HOMOGRAFTS.
Topics: Allografts; Animals; Azathioprine; Dogs; Gold Colloid; Gold Colloid, Radioactive; Histology; Immunos | 1965 |
THE EFFECTS OF SPLENECTOMY ON IMMUNOSUPPRESSIVE REGIMENS IN DOG AND MAN.
Topics: Adolescent; Azaserine; Azathioprine; Biomedical Research; Blood Platelets; Dogs; Drug Therapy; Immun | 1965 |
SYSTEMIC LUPUS ERYTHEMATOSUS AND RENAL TRANSPLANTATION: REPORT OF TWO CASES.
Topics: Adolescent; Azathioprine; Humans; Kidney; Kidney Transplantation; Kidneys, Artificial; Leukopenia; L | 1965 |
Fatal cerebral involvement in systemic aspergillosis: a rare complication of steroid-treated autoimmune bicytopenia.
Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Autoimmune Diseases; | 2004 |
Side effects of azathioprine in patients with Crohn's disease.
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents; Azathioprine; Chemical and Drug Induced Liver In | 2004 |
The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation.
Topics: Azathioprine; Dose-Response Relationship, Drug; Gene Frequency; Genotype; Humans; Immunosuppressive | 2004 |
ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Crohn Disease; Drug Therapy, Combination; Gen | 2005 |
Cost-effectiveness of thiopurine methyltransferase genotype screening in IBD.
Topics: Azathioprine; Cost-Benefit Analysis; Genetic Testing; Genotype; Humans; Immunosuppressive Agents; In | 2005 |
Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Chemical and Drug Induced Liver Injury; Cr | 2006 |
Pharmacogenetics of thiopurine therapy in paediatric IBD patients.
Topics: Adolescent; Azathioprine; Chi-Square Distribution; Child; Female; Gene Frequency; Genetic Predisposi | 2006 |
Peripheral blood leukocyte counts in cytomegalovirus infected heart transplant patients: impact of acute disease versus subclinical infection.
Topics: Adult; Aged; Azathioprine; Case-Control Studies; Cohort Studies; Cytomegalovirus; Cytomegalovirus In | 2006 |
Thiopurine metabolite monitoring in paediatric inflammatory bowel disease.
Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Hype | 2007 |
Azathioprine-induced fatal myelosuppression in systemic lupus erythematosus patient carrying TPMT*3C polymorphism.
Topics: Adult; Alleles; Azathioprine; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Leukopenia; L | 2008 |
Successful low dose captopril rechallenge following drug-induced leucopenia.
Topics: Adolescent; Adult; Azathioprine; Captopril; Drug Synergism; Female; Humans; Leukopenia; Proline | 1981 |
Beneficial effect of pre-transplant splenectomy for leukopenia in primary cadaver kidney transplants.
Topics: Azathioprine; Cadaver; Graft Survival; Humans; Kidney Transplantation; Leukopenia; Splenectomy | 1983 |
Selective posttransplant splenectomy in recipients of cadaveric renal allografts.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Cyclophosphamide; Female; Graft Survival; | 1983 |
Invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antilymphocyte Serum; Aspergillosis; Aspergillus fum | 1983 |
Azathioprine metabolism in kidney transplant recipients.
Topics: Adult; Allopurinol; Azathioprine; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Hum | 1984 |
[Chlorbutin, azathioprine, D-penicillamine, and levamisole (Decaris) in the treatment of rheumatoid arthritis patients. I. Comparative analysis of side effects].
Topics: Arthritis, Rheumatoid; Azathioprine; Bronchial Spasm; Chlorambucil; Drug Eruptions; Dyspepsia; Human | 1981 |
Azathioprine.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Female; Gastrointestinal Diseases; Humans; Leukopeni | 1984 |
Leukopenia due to a trimethoprim-azathioprine interaction.
Topics: Azathioprine; Drug Interactions; Humans; Leukopenia; Male; Middle Aged; Trimethoprim | 1984 |
Systemic lupus erythematosus with paraproteinemia.
Topics: Adult; Aged; Antibodies, Antinuclear; Azathioprine; Female; Glomerulonephritis; Glycoproteins; HLA A | 1984 |
Antiviral and side effects of interferons produced by recombinant DNA techniques as tested in rhesus monkeys.
Topics: Animals; Aspirin; Azathioprine; DNA, Recombinant; Drug Therapy, Combination; Escherichia coli; Fever | 1982 |
Combined immunosuppressive therapy with cyclosporin A and azathioprine. A synergistic effect in three of four experimental models.
Topics: Animals; Azathioprine; Cyclosporins; Dogs; Drug Synergism; Drug Therapy, Combination; Female; Graft | 1982 |
Azathioprine-induced leukopenia--clinical significance in renal transplantation.
Topics: Adult; Azathioprine; Cadaver; Female; Humans; Kidney Transplantation; Leukocyte Count; Leukopenia; M | 1980 |
Immunosuppressive effect of bredinin in the management of patients with renal transplantation.
Topics: Adolescent; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Graft Rejection; Hu | 1981 |
Reversible azathioprine-induced erythrocyte aplasia in a renal transplant recipient.
Topics: Adult; Anemia, Aplastic; Azathioprine; Female; Humans; Kidney Transplantation; Leukopenia | 1982 |
Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities.
Topics: Adult; Aged; Anorexia; Arthritis, Rheumatoid; Azathioprine; Bacterial Infections; Chemical and Drug | 1982 |
[Myelosuppression with macrocytic anaemia and leucopenia during treatment with azathioprine in myasthenia gravis].
Topics: Allopurinol; Anemia, Macrocytic; Azathioprine; Drug Interactions; Female; Humans; Leukopenia; Middle | 1982 |
[Homozygote deficiency of thiopurine methyltransferase. A contraindication to the use of azathioprine in kidney transplantation].
Topics: Azathioprine; Contraindications; Female; Glomerulonephritis, Membranoproliferative; Graft Rejection; | 1995 |
[Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation].
Topics: Azathioprine; Female; Humans; Immune Tolerance; Kidney Diseases; Kidney Transplantation; Leukopenia; | 1995 |
5-nucleotidase and azathioprine-related bone-marrow toxicity.
Topics: 5'-Nucleotidase; Azathioprine; Bone Marrow; Humans; Leukopenia; Male; Middle Aged | 1993 |
Thiopurine-methyl-transferase activity to assess azathioprine myelotoxicity in renal transplant recipients.
Topics: Azathioprine; Bone Marrow; Humans; Kidney Transplantation; Leukopenia; Methyltransferases | 1993 |
Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.
Topics: Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Diseases; Female; Humans; Inflammatory Bow | 1993 |
Bone marrow function during quadruple immunosuppressive therapy after renal transplantation.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Cyclosporine; Female; Humans; Immunosuppression Therapy; | 1993 |
Long-term safety of azathioprine therapy in multiple sclerosis.
Topics: Adenocarcinoma; Adult; Aged; Azathioprine; Breast Neoplasms; Carcinoma in Situ; Female; Humans; Inci | 1993 |
Treatment of peripheral leukopenia after cadaveric kidney transplantation.
Topics: Adenine; Adult; Azathioprine; Blood Transfusion; Cadaver; Drug Therapy, Combination; Female; Glycery | 1996 |
Sequential biological immunosuppression. Induction therapy with rabbit antithymocyte globulin.
Topics: Actuarial Analysis; Adult; Animals; Antilymphocyte Serum; Azathioprine; Cadaver; Cohort Studies; Cre | 1997 |
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Azathioprine; Bone Marrow; Crohn Disease; DNA M | 2000 |
Steroids may prevent leukopenia, interfering with response to IV azathioprine in treatment of Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Immunosuppressive Agents; Injections, Intravenous; Leukopenia; | 2000 |
Retrospective case series analysis of patients with inflammatory bowel disease on azathioprine. A district general hospital experience.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Drug Administration Schedule; Female; Humans; Immunosu | 2000 |
Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide.
Topics: Adult; Aminosalicylic Acids; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Azathiop | 2001 |
Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Female; Humans; Immunosuppressive Agents; | 2001 |
6-mercaptopurine metabolite levels in children with inflammatory bowel disease.
Topics: Adolescent; Antimetabolites, Antineoplastic; Azathioprine; Child; Cross-Sectional Studies; Erythrocy | 2001 |
European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.9.2. Haematological complications. Leukopenia.
Topics: Azathioprine; Humans; Kidney Transplantation; Leukopenia; Mycophenolic Acid | 2002 |
Adverse effect of splenectomy in renal transplantation.
Topics: Azathioprine; Graft Rejection; Humans; Kidney Transplantation; Leukopenia; Prognosis; Splenectomy; T | 1978 |
Frequency of leukopenia incidents following azathioprine therapy after kidney transplantation.
Topics: Azathioprine; Female; Graft Rejection; Humans; Kidney; Kidney Transplantation; Leukopenia; Male; Pos | 1978 |
Transcatheteric partial splenic embolization (PSE) for azathioprine intolerance in renal transplant recipients.
Topics: Azathioprine; Bone Marrow Cells; Drug Tolerance; Embolization, Therapeutic; Humans; Kidney Transplan | 1979 |
[Cytopenic syndrome in rheumatoid arthritis patients treated with leukeran and azathioprine].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Female; Humans; Leukopenia; Male; Mi | 1979 |
Immunosuppression with cyclophosphamide in the dog.
Topics: Animals; Antibody Formation; Azathioprine; Cyclophosphamide; Dogs; Dose-Response Relationship, Drug; | 1975 |
Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effects in 25 patients.
Topics: Adenocarcinoma; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Breast Neoplasms; Carcinoma; Femal | 1976 |
[Azathioprine and cyclophosphamide in the treatment of rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Drug Evaluation; Female; Humans; | 1975 |
Thiopurine methyltransferase activity and efficacy of azathioprine immunosuppression in transplant recipients.
Topics: Adult; Azathioprine; Cyclosporine; Erythrocytes; Female; Humans; Kidney Transplantation; Leukopenia; | 1991 |
The role of azathioprine in the management of ulcerative colitis.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Female; Humans; Leukopenia; Lymphoma, Non-Hodgkin; Male; M | 1990 |
Selective use of splenectomy after liver transplantation in children.
Topics: Azathioprine; Child; Follow-Up Studies; Graft Rejection; Humans; Hypersplenism; Leukopenia; Liver Tr | 1990 |
Development of a leukocytopenic baby guinea pig model with azathioprine and cyclophosphamide.
Topics: Animals; Azathioprine; Body Weight; Cyclophosphamide; Disease Models, Animal; Guinea Pigs; Leukocyte | 1989 |
Leucopenia in adult Still's disease during treatment with azathioprine and sulphasalazine.
Topics: Adult; Arthritis, Juvenile; Aspirin; Azathioprine; Drug Therapy, Combination; Humans; Leukopenia; Ma | 1987 |
Triple therapy in cadaver renal transplantation.
Topics: Adolescent; Adult; Azathioprine; Cyclosporins; Drug Therapy, Combination; Female; Graft Rejection; G | 1988 |
Withdrawal of steroid immunosuppression in renal transplant recipients.
Topics: Adult; Azathioprine; Cyclosporins; Female; Graft Rejection; Haplotypes; Histocompatibility Testing; | 1988 |
Combination therapy of cyclosporine and azathioprine in living-related kidney transplant recipients compared with patients converted totally from cyclosporine to azathioprine.
Topics: Azathioprine; Creatinine; Cyclosporins; Dose-Response Relationship, Drug; Drug Administration Schedu | 1988 |
Azathioprine toxicity in neuromuscular disease.
Topics: Allopurinol; Azathioprine; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Leukopen | 1986 |
Treatment of lupus nephritis with cyclophosphamide.
Topics: Adolescent; Adult; Age Factors; Azathioprine; Biopsy; Chlorambucil; Cortisone; Cyclophosphamide; Fem | 1970 |
Further experience with azathioprine for Crohn's disease.
Topics: Adolescent; Adult; Azathioprine; Crohn Disease; Female; Humans; Intestinal Fistula; Klebsiella Infec | 1970 |
Long-term assessment of cyclophosphamide therapy for nephrosis in children.
Topics: Adolescent; Age Factors; Alopecia; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Cystitis | 1974 |
Treatment of collagen diseases with cytostatics.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Asthma; | 1965 |
Critical re-evaluation of immunosuppressive therapy in canine renal allografts.
Topics: Animals; Azaserine; Azathioprine; Blood Urea Nitrogen; Dactinomycin; Dogs; Kidney; Kidney Transplant | 1968 |
Treatment of immunologic diseases with cytostatics.
Topics: Anemia; Anemia, Hemolytic, Autoimmune; Asthma; Autoimmune Diseases; Azathioprine; Dyspepsia; gamma-G | 1969 |
Medroxyprogesterone antilymphocyte globulin, prednisone, and azathioprine in the treatment of dog renal allografts.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Dogs; gamma-Globulins; Histocompatibility; Immunosuppre | 1969 |
[Cytostatic agents and mesenchyma. 2. The effect of azathioprine and prednisolone on the growth of granuloma and on mucopolysaccharide metabolism in mesenchymal cells].
Topics: Animals; Antineoplastic Agents; Azathioprine; Connective Tissue; Connective Tissue Cells; Drug Syner | 1971 |
[Experimental findings on the site of action and on pharmacodynamics of cytostatic and antiphlogistic drugs in inflammation].
Topics: Animals; Azathioprine; Cyclophosphamide; Glycosaminoglycans; Granulation Tissue; Hematopoietic Syste | 1972 |
[Animal experiments on the anti-inflammatory and immunosuppressive effect of cytostatic agents].
Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Cyclic P-Oxides; Cyclophosphamide; Dose-Response Re | 1973 |
Clinical aspects of cytomegalovirus infection in kidney-graft recipients.
Topics: Antibodies; Azathioprine; Blood Group Antigens; Blood Transfusion; Complement Fixation Tests; Creati | 1974 |
Prevention of death after renal transplantation. I. Recognizable patterns leading to death in long-term survivors.
Topics: Adolescent; Adult; Azathioprine; Cadaver; Child; Death; Female; Graft vs Host Reaction; Humans; Infe | 1970 |
[Problems of immunosuppressive therapy in human liver transplantation. I].
Topics: Adult; Alkaline Phosphatase; Antilymphocyte Serum; Azathioprine; Bilirubin; Blood Proteins; Diabetes | 1970 |
Leukopenia and azathioprine management in renal homotransplantation.
Topics: Antilymphocyte Serum; Azathioprine; Humans; Kidney Transplantation; Leukocyte Count; Leukopenia; Spl | 1972 |
Azathioprine and prednisone.
Topics: Azathioprine; Gastrointestinal Hemorrhage; Humans; Immunosuppression Therapy; Injections, Intravenou | 1972 |
Pemphigus treatment with azathioprine. Clinical and immunologic correlation.
Topics: Adult; Aged; Antibodies; Azathioprine; Blood Platelets; Dose-Response Relationship, Drug; Fatigue; F | 1973 |
Infectious risk factors in the immunosuppressed host.
Topics: Adolescent; Adult; Agammaglobulinemia; Age Factors; Antilymphocyte Serum; Azathioprine; Child; Femal | 1973 |
Serum IgG and renal transplantation.
Topics: Adult; Azathioprine; Creatinine; Escherichia coli Infections; Female; Graft Rejection; Hematocrit; H | 1973 |
Splenectomy in renal transplantation.
Topics: Adolescent; Adult; Azathioprine; Cadaver; Child; Foreign-Body Reaction; Graft Rejection; Humans; Hyp | 1974 |
[Leukopenias following kidney transplantation].
Topics: Azathioprine; Graft Rejection; Humans; Kidney Transplantation; Leukopenia; Transplantation, Homologo | 1974 |
The spleen in chronic renal failure and renal transplantation.
Topics: Adolescent; Adult; Anemia; Azathioprine; Bone Marrow Cells; Child; Female; Hemosiderin; Humans; Kidn | 1972 |
[Correlation of clinical and morphological parameters in chronic hepatitis during long-term treatment with azathioprine].
Topics: Adult; Anemia, Macrocytic; Autoantibodies; Azathioprine; Chronic Disease; Female; Follow-Up Studies; | 1973 |
Azathioprine in Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Intestinal Fistula; Leukopenia; Nausea | 1973 |
Azathioprine for pemphigus and pemphigoid--a 4 year follow-up.
Topics: Adult; Aged; Anemia; Azathioprine; Bone Neoplasms; Drug Evaluation; Drug Hypersensitivity; Female; F | 1974 |
Immunosuppressive therapy of proliferative glomerulonephritis in children.
Topics: Adolescent; Autoantibodies; Azathioprine; Child; Complement System Proteins; Creatinine; Female; Flu | 1969 |
Toxicity of azathioprine.
Topics: Azathioprine; Gastrointestinal Diseases; Histocompatibility; Humans; Infections; Kidney Transplantat | 1970 |
Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation.
Topics: Azathioprine; Cadaver; Creatinine; Folic Acid Antagonists; Humans; Kidney Transplantation; Leukopeni | 1971 |
Counteraction of leukopenia caused by mechlorethamine and azathioprine.
Topics: Animals; Antineoplastic Agents; Azathioprine; Dogs; Erythrocyte Count; Female; Kidney Transplantatio | 1971 |
The metabolism of azathioprine in renal failure.
Topics: Acute Kidney Injury; Azathioprine; Bone Marrow Diseases; Hemagglutination Tests; Humans; Immunosuppr | 1971 |
Splenectomy in renal transplantation. Influence on azathioprine sensitivity.
Topics: Adolescent; Adult; Azathioprine; Drug Tolerance; Female; Humans; Kidney Transplantation; Leukopenia; | 1971 |
[Immunosuppressive therapy in experimental and clinical liver transplantation].
Topics: Anaphylaxis; Animals; Anti-Bacterial Agents; Antilymphocyte Serum; Azathioprine; Depression, Chemica | 1970 |
[Experiences in administration of antimetabolites in treatment of dermatomyosis].
Topics: Adrenal Cortex Hormones; Adult; Aged; Antimetabolites; Azathioprine; Dermatomyositis; Female; Follow | 1972 |
[Effects of immunosuppressive agents and cytostatics on connective tissue metabolism and antibody production].
Topics: Animals; Antibody Formation; Azathioprine; Connective Tissue; Cyclophosphamide; Granulation Tissue; | 1972 |
[Pancytopenia and bone-marrow changes in chronic active hepatitis].
Topics: Adult; Aged; Anemia, Aplastic; Azathioprine; Bone Marrow Examination; Chronic Disease; Female; Hepat | 1972 |
In vitro lymphocyte responsiveness of human subjects receiving azathioprine.
Topics: Antigens; Azathioprine; Blood Cell Count; Candida; Culture Techniques; Humans; Hypersensitivity, Del | 1971 |
Biochemical and histological changes following imuran (azathioprine) administration.
Topics: Animals; Azathioprine; Blood Coagulation; Blood Protein Disorders; Body Weight; Bone Marrow; Dogs; K | 1971 |
Results of immunodepressive treatment in the nephrotic syndrome.
Topics: Alopecia; Azathioprine; Child, Preschool; Cyclophosphamide; Glucocorticoids; Humans; Immunosuppressi | 1970 |
[Effect of long-term immunosuppressive treatment on the hematopoietic system].
Topics: Anemia, Aplastic; Azathioprine; Hematopoiesis; Hematopoietic System; Humans; Immunosuppressive Agent | 1970 |
[Treatment of chronic glomerulonephritis with imuran].
Topics: Adolescent; Adult; Aged; Azathioprine; Biopsy; Blood Sedimentation; Child; Chronic Disease; Colic; D | 1970 |
[Long-term therapy of chronic hepatitis].
Topics: Adolescent; Adult; Aged; Antacids; Azathioprine; Child; Child, Preschool; Chronic Disease; Diet Ther | 1970 |
[Immunosuppressive treatment of chronic hepatitis].
Topics: Adolescent; Adult; Aged; Azathioprine; Blood Proteins; Chronic Disease; Depression, Chemical; Dexame | 1970 |
[Trial therapy of psoriasis with azathioprine].
Topics: Adult; Aged; Anemia; Azathioprine; Female; Humans; Leukopenia; Male; Middle Aged; Myocardial Infarct | 1970 |
[Immunosuppressive therapy of glomerulotubular lesions in childhood].
Topics: Acute Disease; Azathioprine; Blood Cell Count; Blood Proteins; Blood Sedimentation; Child; Chronic D | 1970 |
[Immunosuppressive treatment in rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Humans; Immune Tolerance; Immuno | 1971 |
Methotrexate and the platelet count.
Topics: Antineoplastic Agents; Azathioprine; Blood Cell Count; Blood Platelets; Fluorouracil; Humans; Leukop | 1968 |
Treatment of ulcerative colitis with azathioprine.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Colitis, Ulcerative; Female; Humans; Leuko | 1968 |
Treatment of refractory idiopathic thrombocytopenic purpura.
Topics: Adult; Aged; Azathioprine; Child; Drug Synergism; Female; Humans; Leukopenia; Male; Middle Aged; Pre | 1969 |
Mercaptopurine and acquired tubular dysfunction in adult nephrosis.
Topics: Acidosis; Adult; Anemia; Azathioprine; Glomerulonephritis; Glycosuria; Humans; Leukopenia; Male; Nep | 1965 |