Page last updated: 2024-10-23

azathioprine and Leukemia

azathioprine has been researched along with Leukemia in 34 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
" It discusses the company's epidemiologic approach to the question of association between treatment with disease-modifying antirheumatic drugs, one of which is manufactured by Burroughs Wellcome Company (Imuran brand azathioprine) and a possible increased risk of neoplasms in patients receiving these drugs as treatment for their rheumatoid arthritis."5.05Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data. ( Tilson, HH; Whisnant, J, 1985)
"The relative increased risk of breast cancer in MS women under IS treatment warrants further attention."1.35Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis. ( Berthier, F; Clavelou, P; Danzon, A; de Seze, J; Debouverie, M; Defer, G; Gout, O; Lebrun, C; Rumbach, L; Vermersch, P; Wiertlevski, S, 2008)
"Acute leukemia is described in two patients treated with cytotoxic agents for a destructive, seropositive rheumatoid arthritis."1.27Acute leukemia in rheumatoid arthritis treated with cytotoxic agents. ( Dotten, DA; Ogryzlo, MA; Seidenfeld, AM; Smythe, HA; Urowitz, MB, 1984)
"Data on the possible increased risk of malignancy in rheumatoid arthritis are still being collected, and until further information is available, the use of immunosuppressive drugs, particularly alkylating agents, in the treatment of rheumatoid arthritis should be reserved for patients with severe progressive disease or life-threatening complications."1.27Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. ( Hazleman, B, 1985)
"The visceral carcinomas (2 breast cancers, 1 carcinoma respectively of the pancreas, the rectum, the liver, the kidneys, the renal pelvis, and the urinary bladder, and one seminoma) were treated by generally accepted surgical principles as far as treatment of the patients was possible."1.26[Malignant tumors in bearers of kidney grafts in immunosuppressive therapy]. ( Binswanger, U; Briner, J; Largiadèr, F; Uhlschmid, G; Vollenweider, A, 1982)
" The correlation between these is poor, in many patients, at the dosage used in man."1.26The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens. ( Hazleman, BL, 1982)
"Acute leukemia is described in two patients treated with cytotoxic agents for a destructive, seropositive rheumatoid arthritis."1.26Acute leukemia in rheumatoid arthritis treated with cytotoxic agents. ( Dotten, DA; Ogryzlo, MA; Seidenfeld, AM; Smythe, HA; Urowitz, MB, 1976)
"Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc."1.25[Side effects in immunosuppressive therapy]. ( Thumb, N, 1975)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199027 (79.41)18.7374
1990's1 (2.94)18.2507
2000's3 (8.82)29.6817
2010's3 (8.82)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Choi, J1
Lee, YM1
Jee, JG1
de Wit, K1
White, B1
Goldsmith, D1
MATHE, G2
AMIEL, JL1
SCHWARZENBERG, L1
CATTAN, A1
SCHNEIDER, M1
DEVRIES, MJ1
TUBIANA, M1
LALANNE, C1
BINET, JL1
PAPIERNIK, M1
SEMAN, G1
MATSUKURA, M1
MERY, AM1
SCHWARZMANN, V1
FLAISLER, A1
Coulthard, S1
Hogarth, L1
Lebrun, C1
Debouverie, M1
Vermersch, P1
Clavelou, P1
Rumbach, L1
de Seze, J1
Wiertlevski, S1
Defer, G1
Gout, O1
Berthier, F1
Danzon, A1
Seidenfeld, AM2
Smythe, HA2
Ogryzlo, MA2
Urowitz, MB2
Dotten, DA2
Balthazar, PA1
Geary, CG1
Vollenweider, A1
Largiadèr, F1
Uhlschmid, G1
Binswanger, U1
Briner, J1
Hazleman, BL1
Schmähl, D1
Habs, M1
Lorenz, M1
Wagner, I1
Lennard, L1
Lilleyman, JS1
Maury, S1
Mary, JY1
Rabian, C1
Schwarzinger, M1
Toubert, A1
Scieux, C1
Carmagnat, M1
Esperou, H1
Ribaud, P1
Devergie, A1
Guardiola, P1
Vexiau, P1
Charron, D1
Gluckman, E1
Socié, G1
Storb, R1
Thumb, N1
Fijał'k, Z1
Chodkowski, J1
Warowna, M1
Kaniowski, M1
Tilson, HH1
Whisnant, J1
Krueger, TC1
Tallent, MB1
Richie, RE1
Johnson, HK1
MacDonell, RC1
Turner, B1
Ihle, BU1
Constable, J1
Gordon, S1
Mahony, JF1
Hazleman, B1
Krug, K1
Joseph, RR1
Tourtellotte, CD1
Barry, WE1
Smalley, RV1
Durant, JR1
Meier, H1
Myers, DD1
Rosenberg, EB1
Herberman, RB1
Levine, PH1
Halterman, RH1
McCoy, JL1
Wunderlich, JR1
McNicol, GP1
Davies, JA1
Storti, E1
Traldi, A1
Quaglino, D1
Palmer, DL1
Rifkind, D1
Brown, DW1
Wilmanns, W1
Boll, I1
Klimas, J1
Willigerodt, B1
Genovesi, E1
Taglioretti, D1
Giangrande, A1
Koutsilieri, S1
Caudle, KE1
Alzghari, SK1
Monte, AA1
Relling, MV1
Patrinos, GP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prophylactic Infusion of Donor Lymphocytes in Cord Blood Transplantation[NCT02328885]Phase 1/Phase 217 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for azathioprine and Leukemia

ArticleYear
The thiopurines: an update.
    Investigational new drugs, 2005, Volume: 23, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cell Line, Tumor; Guanine Nucleotides; Human

2005
Bone marrow transplantation for the treatment of aplastic anemia and acute leukemia.
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1978, Issue:84

    Topics: Acute Disease; Anemia, Aplastic; Azathioprine; Blood Platelets; Blood Transfusion; Bone Marrow Trans

1978
Advances in medicine.
    The Practitioner, 1972, Volume: 209, Issue:252

    Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced

1972
[Antimetabolites].
    Der Internist, 1971, Volume: 12

    Topics: Allopurinol; Animals; Antimetabolites; Azathioprine; Cell Division; Chemical Phenomena; Chemistry; C

1971
Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango.
    American journal of hematology, 2019, Volume: 94, Issue:7

    Topics: Female; Genotype; Humans; Leukemia; Male; Mercaptopurine; Methyltransferases; Pyrophosphatases; Thio

2019

Trials

2 trials available for azathioprine and Leukemia

ArticleYear
Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data.
    The American journal of medicine, 1985, Jan-21, Volume: 78, Issue:1A

    Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Computers; Drug Industry; Humans; Leu

1985
Clinical studies on the effects of imuran and vincristine in the treatment of leukaemia.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Adult; Azathioprine; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Leukemia; Le

1968

Other Studies

27 other studies available for azathioprine and Leukemia

ArticleYear
Thiopurine Drugs Repositioned as Tyrosinase Inhibitors.
    International journal of molecular sciences, 2017, Dec-28, Volume: 19, Issue:1

    Topics: Acute Disease; Antimetabolites, Antineoplastic; Azathioprine; Catalytic Domain; Drug Repositioning;

2017
Thiopurine toxicity.
    British journal of hospital medicine (London, England : 2005), 2013, Volume: 74 Suppl 10

    Topics: Antineoplastic Agents; Azathioprine; Humans; Immunosuppressive Agents; Leukemia

2013
SUCCESSFUL ALLOGENIC BONE MARROW TRANSPLANTATION IN MAN: CHIMERISM, INDUCED SPECIFIC TOLERANCE AND POSSIBLE ANTI-LEUKEMIC EFFECTS.
    Blood, 1965, Volume: 25

    Topics: Antineoplastic Agents; Azathioprine; Bone Marrow Transplantation; Chimerism; Electrons; Genetic Dise

1965
Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2008, Volume: 14, Issue:3

    Topics: Adult; Azathioprine; Breast Neoplasms; Central Nervous System Neoplasms; Cyclophosphamide; Digestive

2008
Acute leukemia in rheumatoid arthritis treated with cytotoxic agents.
    The Journal of rheumatology, 1984, Volume: 11, Issue:5

    Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Humans; Leukemia

1984
[Leukemia and other neoplasms possibly induced by immunosuppressors in non-malignant diseases (author's transl)].
    AMB : revista da Associacao Medica Brasileira, 1980, Volume: 26, Issue:2

    Topics: Animals; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Leukemia; N

1980
Lymphoma and leukaemia due to drugs.
    British journal of hospital medicine, 1980, Volume: 24, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bone Marrow Diseases; Child; Female; Hodgkin Disease;

1980
[Malignant tumors in bearers of kidney grafts in immunosuppressive therapy].
    Schweizerische medizinische Wochenschrift, 1982, Jan-23, Volume: 112, Issue:4

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Breast Neoplasms; Dysgerminoma; Female; Humans; Immunosup

1982
The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens.
    Annals of the rheumatic diseases, 1982, Volume: 41 Suppl 1

    Topics: Adult; Aged; Animals; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Transitional Cell; Chromosome

1982
Occurrence of second tumors in man after anticancer drug treatment.
    Cancer treatment reviews, 1982, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathiopri

1982
Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:4

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Humans; Leukemia; Mercaptopurine; Methyltransferases;

1996
Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients.
    British journal of haematology, 2001, Volume: 115, Issue:3

    Topics: Adolescent; Adult; Azathioprine; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocyt

2001
Acute leukemia in rheumatoid arthritis treated with cytotoxic agents.
    The Journal of rheumatology, 1976, Volume: 3, Issue:3

    Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Female; Humans; Leukemia

1976
[Side effects in immunosuppressive therapy].
    Acta medica Austriaca, 1975, Volume: 2, Issue:4

    Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu

1975
Polarographic studies of drugs of purine derivatives--II.
    Journal of pharmaceutical and biomedical analysis, 1989, Volume: 7, Issue:12

    Topics: Azathioprine; Cells, Cultured; Electrochemistry; Electrodes; Leukemia; Mercaptopurine; Pharmaceutica

1989
Neoplasia in immunosuppressed renal transplant patients: a 20-year experience.
    Southern medical journal, 1985, Volume: 78, Issue:5

    Topics: Adolescent; Adult; Aged; Antilymphocyte Serum; Azathioprine; Cadaver; Child; Child, Preschool; Cyclo

1985
Myelodysplasia in cadaver renal allografts: a report of four cases.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1985, Volume: 5, Issue:5

    Topics: Adult; Azathioprine; Bone Marrow; Chromosome Aberrations; Chromosomes, Human, 16-18; Chromosomes, Hu

1985
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
    The American journal of medicine, 1985, Jan-21, Volume: 78, Issue:1A

    Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppres

1985
[Therapy of idiopathic thrombopenic purpura using immunosuppressive agents].
    Das Deutsche Gesundheitswesen, 1973, Mar-02, Volume: 28, Issue:10

    Topics: Adolescent; Adult; Azathioprine; Cyclophosphamide; Dactinomycin; Female; Humans; Immunosuppressive A

1973
Prolonged immunological disorder terminating in hematological malignancy: A human analogue of animal disease?
    Annals of internal medicine, 1970, Volume: 72, Issue:5

    Topics: Aged; Animal Diseases; Animals; Autoimmune Diseases; Azathioprine; Blood Protein Disorders; Blood Pr

1970
Chemical co-carcinogenesis: differential action of various compounds, derepression of endogenous C-type RNA genomes, and influence of different genotypes of mice.
    Bibliotheca haematologica, 1973, Volume: 39

    Topics: Age Factors; Animals; Antigens, Viral; Azathioprine; Benz(a)Anthracenes; Carcinogens; Complement Fix

1973
Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins.
    International journal of cancer, 1972, May-15, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Aged; Antigens; Azathioprine; Child; Child, Preschool; Chromium Isotopes; Cycloph

1972
[Bone marrow transplantation].
    La Presse medicale, 1970, Sep-26, Volume: 78, Issue:40

    Topics: Animals; Antilymphocyte Serum; Azathioprine; Bone Marrow Transplantation; Cyclophosphamide; Humans;

1970
131 I-labeled colloidal human serum albumin in the study of reticuloendothelial system function. 3. Phagocytosis and catabolism compared in normal, leukemic, and immunosuppressed human subjects.
    The Journal of infectious diseases, 1971, Volume: 123, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Computers; Humans; Immunosupp

1971
[Effects of 6-mercaptopurine and azathioprine on human bone marrow in vitro].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:4

    Topics: Azathioprine; Bone Marrow; Bone Marrow Cells; Humans; In Vitro Techniques; Leukemia; Mercaptopurine;

1971
[Our experience in the therapy of acute leukemia in childhood. Pharmacotherapy--enzymetherapy--immunotherapy].
    Minerva pediatrica, 1970, Dec-15, Volume: 22, Issue:50

    Topics: Antibiotics, Antineoplastic; Asparaginase; Azathioprine; Child; Child, Preschool; Cyclophosphamide;

1970
Azathioprine in myeloproliferative and autoimmune disorders.
    Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases; Azathioprine; Colitis,

1968