azathioprine has been researched along with Leukemia in 34 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " It discusses the company's epidemiologic approach to the question of association between treatment with disease-modifying antirheumatic drugs, one of which is manufactured by Burroughs Wellcome Company (Imuran brand azathioprine) and a possible increased risk of neoplasms in patients receiving these drugs as treatment for their rheumatoid arthritis." | 5.05 | Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data. ( Tilson, HH; Whisnant, J, 1985) |
| "The relative increased risk of breast cancer in MS women under IS treatment warrants further attention." | 1.35 | Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis. ( Berthier, F; Clavelou, P; Danzon, A; de Seze, J; Debouverie, M; Defer, G; Gout, O; Lebrun, C; Rumbach, L; Vermersch, P; Wiertlevski, S, 2008) |
| "Acute leukemia is described in two patients treated with cytotoxic agents for a destructive, seropositive rheumatoid arthritis." | 1.27 | Acute leukemia in rheumatoid arthritis treated with cytotoxic agents. ( Dotten, DA; Ogryzlo, MA; Seidenfeld, AM; Smythe, HA; Urowitz, MB, 1984) |
| "Data on the possible increased risk of malignancy in rheumatoid arthritis are still being collected, and until further information is available, the use of immunosuppressive drugs, particularly alkylating agents, in the treatment of rheumatoid arthritis should be reserved for patients with severe progressive disease or life-threatening complications." | 1.27 | Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens. ( Hazleman, B, 1985) |
| "The visceral carcinomas (2 breast cancers, 1 carcinoma respectively of the pancreas, the rectum, the liver, the kidneys, the renal pelvis, and the urinary bladder, and one seminoma) were treated by generally accepted surgical principles as far as treatment of the patients was possible." | 1.26 | [Malignant tumors in bearers of kidney grafts in immunosuppressive therapy]. ( Binswanger, U; Briner, J; Largiadèr, F; Uhlschmid, G; Vollenweider, A, 1982) |
| " The correlation between these is poor, in many patients, at the dosage used in man." | 1.26 | The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens. ( Hazleman, BL, 1982) |
| "Acute leukemia is described in two patients treated with cytotoxic agents for a destructive, seropositive rheumatoid arthritis." | 1.26 | Acute leukemia in rheumatoid arthritis treated with cytotoxic agents. ( Dotten, DA; Ogryzlo, MA; Seidenfeld, AM; Smythe, HA; Urowitz, MB, 1976) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (79.41) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, J | 1 |
| Lee, YM | 1 |
| Jee, JG | 1 |
| de Wit, K | 1 |
| White, B | 1 |
| Goldsmith, D | 1 |
| MATHE, G | 2 |
| AMIEL, JL | 1 |
| SCHWARZENBERG, L | 1 |
| CATTAN, A | 1 |
| SCHNEIDER, M | 1 |
| DEVRIES, MJ | 1 |
| TUBIANA, M | 1 |
| LALANNE, C | 1 |
| BINET, JL | 1 |
| PAPIERNIK, M | 1 |
| SEMAN, G | 1 |
| MATSUKURA, M | 1 |
| MERY, AM | 1 |
| SCHWARZMANN, V | 1 |
| FLAISLER, A | 1 |
| Coulthard, S | 1 |
| Hogarth, L | 1 |
| Lebrun, C | 1 |
| Debouverie, M | 1 |
| Vermersch, P | 1 |
| Clavelou, P | 1 |
| Rumbach, L | 1 |
| de Seze, J | 1 |
| Wiertlevski, S | 1 |
| Defer, G | 1 |
| Gout, O | 1 |
| Berthier, F | 1 |
| Danzon, A | 1 |
| Seidenfeld, AM | 2 |
| Smythe, HA | 2 |
| Ogryzlo, MA | 2 |
| Urowitz, MB | 2 |
| Dotten, DA | 2 |
| Balthazar, PA | 1 |
| Geary, CG | 1 |
| Vollenweider, A | 1 |
| Largiadèr, F | 1 |
| Uhlschmid, G | 1 |
| Binswanger, U | 1 |
| Briner, J | 1 |
| Hazleman, BL | 1 |
| Schmähl, D | 1 |
| Habs, M | 1 |
| Lorenz, M | 1 |
| Wagner, I | 1 |
| Lennard, L | 1 |
| Lilleyman, JS | 1 |
| Maury, S | 1 |
| Mary, JY | 1 |
| Rabian, C | 1 |
| Schwarzinger, M | 1 |
| Toubert, A | 1 |
| Scieux, C | 1 |
| Carmagnat, M | 1 |
| Esperou, H | 1 |
| Ribaud, P | 1 |
| Devergie, A | 1 |
| Guardiola, P | 1 |
| Vexiau, P | 1 |
| Charron, D | 1 |
| Gluckman, E | 1 |
| Socié, G | 1 |
| Storb, R | 1 |
| Thumb, N | 1 |
| Fijał'k, Z | 1 |
| Chodkowski, J | 1 |
| Warowna, M | 1 |
| Kaniowski, M | 1 |
| Tilson, HH | 1 |
| Whisnant, J | 1 |
| Krueger, TC | 1 |
| Tallent, MB | 1 |
| Richie, RE | 1 |
| Johnson, HK | 1 |
| MacDonell, RC | 1 |
| Turner, B | 1 |
| Ihle, BU | 1 |
| Constable, J | 1 |
| Gordon, S | 1 |
| Mahony, JF | 1 |
| Hazleman, B | 1 |
| Krug, K | 1 |
| Joseph, RR | 1 |
| Tourtellotte, CD | 1 |
| Barry, WE | 1 |
| Smalley, RV | 1 |
| Durant, JR | 1 |
| Meier, H | 1 |
| Myers, DD | 1 |
| Rosenberg, EB | 1 |
| Herberman, RB | 1 |
| Levine, PH | 1 |
| Halterman, RH | 1 |
| McCoy, JL | 1 |
| Wunderlich, JR | 1 |
| McNicol, GP | 1 |
| Davies, JA | 1 |
| Storti, E | 1 |
| Traldi, A | 1 |
| Quaglino, D | 1 |
| Palmer, DL | 1 |
| Rifkind, D | 1 |
| Brown, DW | 1 |
| Wilmanns, W | 1 |
| Boll, I | 1 |
| Klimas, J | 1 |
| Willigerodt, B | 1 |
| Genovesi, E | 1 |
| Taglioretti, D | 1 |
| Giangrande, A | 1 |
| Koutsilieri, S | 1 |
| Caudle, KE | 1 |
| Alzghari, SK | 1 |
| Monte, AA | 1 |
| Relling, MV | 1 |
| Patrinos, GP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylactic Infusion of Donor Lymphocytes in Cord Blood Transplantation[NCT02328885] | Phase 1/Phase 2 | 17 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for azathioprine and Leukemia
| Article | Year |
|---|---|
The thiopurines: an update.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cell Line, Tumor; Guanine Nucleotides; Human | 2005 |
Bone marrow transplantation for the treatment of aplastic anemia and acute leukemia.
Topics: Acute Disease; Anemia, Aplastic; Azathioprine; Blood Platelets; Blood Transfusion; Bone Marrow Trans | 1978 |
Advances in medicine.
Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced | 1972 |
[Antimetabolites].
Topics: Allopurinol; Animals; Antimetabolites; Azathioprine; Cell Division; Chemical Phenomena; Chemistry; C | 1971 |
Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango.
Topics: Female; Genotype; Humans; Leukemia; Male; Mercaptopurine; Methyltransferases; Pyrophosphatases; Thio | 2019 |
2 trials available for azathioprine and Leukemia
| Article | Year |
|---|---|
Pharmaco-epidemiology--drugs, arthritis, and neoplasms: industry contribution to the data.
Topics: Arthritis, Rheumatoid; Azathioprine; Clinical Trials as Topic; Computers; Drug Industry; Humans; Leu | 1985 |
Clinical studies on the effects of imuran and vincristine in the treatment of leukaemia.
Topics: Adult; Azathioprine; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Leukemia; Le | 1968 |
27 other studies available for azathioprine and Leukemia
| Article | Year |
|---|---|
Thiopurine Drugs Repositioned as Tyrosinase Inhibitors.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Azathioprine; Catalytic Domain; Drug Repositioning; | 2017 |
Thiopurine toxicity.
Topics: Antineoplastic Agents; Azathioprine; Humans; Immunosuppressive Agents; Leukemia | 2013 |
SUCCESSFUL ALLOGENIC BONE MARROW TRANSPLANTATION IN MAN: CHIMERISM, INDUCED SPECIFIC TOLERANCE AND POSSIBLE ANTI-LEUKEMIC EFFECTS.
Topics: Antineoplastic Agents; Azathioprine; Bone Marrow Transplantation; Chimerism; Electrons; Genetic Dise | 1965 |
Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis.
Topics: Adult; Azathioprine; Breast Neoplasms; Central Nervous System Neoplasms; Cyclophosphamide; Digestive | 2008 |
Acute leukemia in rheumatoid arthritis treated with cytotoxic agents.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Humans; Leukemia | 1984 |
[Leukemia and other neoplasms possibly induced by immunosuppressors in non-malignant diseases (author's transl)].
Topics: Animals; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Leukemia; N | 1980 |
Lymphoma and leukaemia due to drugs.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bone Marrow Diseases; Child; Female; Hodgkin Disease; | 1980 |
[Malignant tumors in bearers of kidney grafts in immunosuppressive therapy].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Breast Neoplasms; Dysgerminoma; Female; Humans; Immunosup | 1982 |
The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens.
Topics: Adult; Aged; Animals; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Transitional Cell; Chromosome | 1982 |
Occurrence of second tumors in man after anticancer drug treatment.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathiopri | 1982 |
Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Humans; Leukemia; Mercaptopurine; Methyltransferases; | 1996 |
Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients.
Topics: Adolescent; Adult; Azathioprine; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocyt | 2001 |
Acute leukemia in rheumatoid arthritis treated with cytotoxic agents.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Azathioprine; Cyclophosphamide; Female; Humans; Leukemia | 1976 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Polarographic studies of drugs of purine derivatives--II.
Topics: Azathioprine; Cells, Cultured; Electrochemistry; Electrodes; Leukemia; Mercaptopurine; Pharmaceutica | 1989 |
Neoplasia in immunosuppressed renal transplant patients: a 20-year experience.
Topics: Adolescent; Adult; Aged; Antilymphocyte Serum; Azathioprine; Cadaver; Child; Child, Preschool; Cyclo | 1985 |
Myelodysplasia in cadaver renal allografts: a report of four cases.
Topics: Adult; Azathioprine; Bone Marrow; Chromosome Aberrations; Chromosomes, Human, 16-18; Chromosomes, Hu | 1985 |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppres | 1985 |
[Therapy of idiopathic thrombopenic purpura using immunosuppressive agents].
Topics: Adolescent; Adult; Azathioprine; Cyclophosphamide; Dactinomycin; Female; Humans; Immunosuppressive A | 1973 |
Prolonged immunological disorder terminating in hematological malignancy: A human analogue of animal disease?
Topics: Aged; Animal Diseases; Animals; Autoimmune Diseases; Azathioprine; Blood Protein Disorders; Blood Pr | 1970 |
Chemical co-carcinogenesis: differential action of various compounds, derepression of endogenous C-type RNA genomes, and influence of different genotypes of mice.
Topics: Age Factors; Animals; Antigens, Viral; Azathioprine; Benz(a)Anthracenes; Carcinogens; Complement Fix | 1973 |
Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins.
Topics: Adolescent; Adult; Aged; Antigens; Azathioprine; Child; Child, Preschool; Chromium Isotopes; Cycloph | 1972 |
[Bone marrow transplantation].
Topics: Animals; Antilymphocyte Serum; Azathioprine; Bone Marrow Transplantation; Cyclophosphamide; Humans; | 1970 |
131 I-labeled colloidal human serum albumin in the study of reticuloendothelial system function. 3. Phagocytosis and catabolism compared in normal, leukemic, and immunosuppressed human subjects.
Topics: Acute Disease; Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Computers; Humans; Immunosupp | 1971 |
[Effects of 6-mercaptopurine and azathioprine on human bone marrow in vitro].
Topics: Azathioprine; Bone Marrow; Bone Marrow Cells; Humans; In Vitro Techniques; Leukemia; Mercaptopurine; | 1971 |
[Our experience in the therapy of acute leukemia in childhood. Pharmacotherapy--enzymetherapy--immunotherapy].
Topics: Antibiotics, Antineoplastic; Asparaginase; Azathioprine; Child; Child, Preschool; Cyclophosphamide; | 1970 |
Azathioprine in myeloproliferative and autoimmune disorders.
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases; Azathioprine; Colitis, | 1968 |