azathioprine has been researched along with Leukemia, Myeloid, Acute in 32 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 7.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Azathioprine is widely used in patients with autoimmune diseases and after organ allografting." | 4.86 | Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia. ( Kwong, YL, 2010) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 3.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Four cases of acute myelogenous leukemia and six cases of chronic myelogenous leukemia after treatment with azathioprine and prednisone for renal allotransplantation have been described in the literature." | 3.66 | [Acute leukemia after kidney allotransplantation (author's transl)]. ( Binswanger, U; Briner, J; Fehr, J; Frei, D; Largiadèr, F; Sauter, C, 1980) |
| "Azathioprine, which is an immunosuppressive agent commonly used for chronic inflammatory bowel disease, may be associated with an increased risk of certain cancers such as hematologic malignancies." | 1.91 | Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn's disease. ( Asma, M; Emna, BM; Nadia, B; Nouha, T; Yosra, S; Yosra, Z, 2023) |
| "that describes potential risk of acute myeloid leukemia or myeloproliferative disorder among thiopurine therapy." | 1.62 | The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits? ( Ha, C, 2021) |
| "Azathioprine sodium use was observed more frequently in cases (odds ratio [OR], 7." | 1.46 | Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia. ( Al-Kali, A; Castro, J; Dueck, A; Ertz-Archambault, N; Finn, L; Foran, J; Gauthier, S; Kelemen, K; Kosiorek, H; Marino, R; Mesa, RA; Palmer, J; Sproat, LZ; Taylor, GE; Tibes, R, 2017) |
| "Secondary acute myeloid leukemia is a very rare complication in patients with solid organ transplantation." | 1.42 | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. ( Guerra, C; Melo, J; Peña, C; Sepúlveda, C, 2015) |
| "We describe a case of acute nonlymphocytic leukemia with inversion of chromosome 16 in a patient with systemic lupus erythematosus treated with immunosuppressive agents including azathioprine and cyclophosphamide." | 1.28 | Acute nonlymphocytic leukemia after treatment of systemic lupus erythematosus with immunosuppressive agents. ( Kavanaugh, AF; Lipsky, PE; Schneider, NR; Vasquez, S; Wacholtz, MC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (37.50) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 13 (40.63) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Nouha, T | 1 |
| Asma, M | 1 |
| Nadia, B | 1 |
| Emna, BM | 1 |
| Yosra, Z | 1 |
| Yosra, S | 1 |
| Ha, C | 1 |
| Tibes, R | 2 |
| Ertz-Archambault, N | 2 |
| Kosiorek, H | 2 |
| Meijer, B | 1 |
| de Boer, NKH | 1 |
| Lopez, A | 1 |
| Mounier, M | 1 |
| Bouvier, AM | 1 |
| Carrat, F | 1 |
| Maynadié, M | 1 |
| Beaugerie, L | 1 |
| Peyrin-Biroulet, L | 1 |
| Deepak, P | 1 |
| Stobaugh, DJ | 1 |
| Schmutz, JL | 1 |
| Peña, C | 1 |
| Sepúlveda, C | 1 |
| Melo, J | 1 |
| Guerra, C | 1 |
| Taylor, GE | 1 |
| Kelemen, K | 1 |
| Dueck, A | 1 |
| Castro, J | 1 |
| Marino, R | 1 |
| Gauthier, S | 1 |
| Finn, L | 1 |
| Sproat, LZ | 1 |
| Palmer, J | 1 |
| Mesa, RA | 1 |
| Al-Kali, A | 1 |
| Foran, J | 1 |
| Burki, TK | 1 |
| Kwong, YL | 2 |
| Kallel, L | 1 |
| Naijaa, N | 1 |
| Fekih, M | 1 |
| Frikha, I | 1 |
| Boubaker, J | 1 |
| Bellaaj, H | 1 |
| Romdhane, NB | 1 |
| Filali, A | 1 |
| Chin, LK | 1 |
| Cheah, CY | 1 |
| Michael, PM | 1 |
| MacKinnon, RN | 1 |
| Campbell, LJ | 1 |
| Mullier, F | 1 |
| Rahier, JF | 1 |
| Maignen, F | 1 |
| Cornet, Y | 1 |
| Graux, C | 1 |
| Chatelain, C | 1 |
| Chatelain, B | 1 |
| Dogne, JM | 1 |
| You, E | 1 |
| Yang, JJ | 1 |
| Cho, SY | 1 |
| Lee, HJ | 1 |
| Lee, WI | 1 |
| Kim, HJ | 1 |
| Yoon, HJ | 1 |
| Park, TS | 1 |
| Yenson, PR | 1 |
| Forrest, D | 1 |
| Schmiegelow, K | 1 |
| Dalal, BI | 1 |
| Frei, D | 1 |
| Binswanger, U | 1 |
| Fehr, J | 1 |
| Briner, J | 1 |
| Sauter, C | 1 |
| Largiadèr, F | 1 |
| Leithner, C | 1 |
| Kübböck, J | 1 |
| Winterleitner, H | 1 |
| Pavelka, M | 1 |
| Krisch, K | 1 |
| Mok, CC | 1 |
| Lau, CS | 1 |
| Gilmore, IT | 1 |
| Holden, G | 1 |
| Rodan, KS | 1 |
| Sieber, SM | 1 |
| Vasquez, S | 1 |
| Kavanaugh, AF | 1 |
| Schneider, NR | 1 |
| Wacholtz, MC | 1 |
| Lipsky, PE | 1 |
| Guseva, SA | 1 |
| Butler, J | 1 |
| Korb, S | 1 |
| Light, J | 1 |
| Patapanian, H | 1 |
| Graham, S | 1 |
| Sambrook, PN | 1 |
| Browne, CD | 1 |
| Champion, GD | 1 |
| Cohen, ML | 1 |
| Day, RO | 1 |
| Cooper, MR | 1 |
| Hansen, KS | 1 |
| Maynard, CD | 1 |
| Elrod, IW | 1 |
| Spurr, CL | 1 |
| Rosenberg, EB | 1 |
| Herberman, RB | 1 |
| Levine, PH | 1 |
| Halterman, RH | 1 |
| McCoy, JL | 1 |
| Wunderlich, JR | 1 |
| Silvergleid, AJ | 1 |
| Schrier, SL | 1 |
| Storti, E | 1 |
| Traldi, A | 1 |
| Quaglino, D | 1 |
| Pawelski, S | 2 |
| Maj, S | 2 |
3 reviews available for azathioprine and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Topics: Adult; Aged; Autoimmune Diseases; Azathioprine; Female; Graft Rejection; Humans; Immunosuppressive A | 2010 |
A case of therapy-related myeloid neoplasm in a patient with Crohn's disease treated with azathioprine.
Topics: Aged; Antineoplastic Agents; Azathioprine; Bone Marrow; Chromosome Aberrations; Crohn Disease; Human | 2012 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
1 trial available for azathioprine and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Clinical studies on the effects of imuran and vincristine in the treatment of leukaemia.
Topics: Adult; Azathioprine; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Leukemia; Le | 1968 |
28 other studies available for azathioprine and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukemia | 2023 |
The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits?
Topics: Azathioprine; Humans; Incidence; Inflammatory Bowel Diseases; Leukemia, Myeloid, Acute; Myelodysplas | 2021 |
All Thiopurines Are Equal But Some Thiopurines Are More Equal Than Others-Reply.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
All Thiopurines Are Equal but Some Thiopurines Are More Equal Than Others.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
Increased risk of acute myeloid leukemias and myelodysplastic syndromes in patients who received thiopurine treatment for inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Cohort Studies; Female; France; Humans; Immunosuppressive Agents; I | 2014 |
Risk of Myeloid Neoplasms in Inflammatory Bowel Disease Patients Is Linked to Exposure to Thiopurines and Not With Tumor Necrosis Factor-alpha Inhibitors.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukemia, Myelo | 2015 |
[Neutrophilic eccrine hidradenitis and azathioprine hypersensitivity syndrome].
Topics: Azathioprine; Crohn Disease; Diagnosis, Differential; Drug Hypersensitivity; Hidradenitis; Humans; I | 2014 |
[Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case].
Topics: Azathioprine; Bone Marrow; Chromosomes, Human, Pair 5; Fatal Outcome; Female; Humans; Immunosuppress | 2015 |
Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Case-Control Stud | 2017 |
Azathioprine associated with myeloid neoplasm risk.
Topics: Autoimmune Diseases; Azathioprine; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Myelo | 2017 |
Acute myeloid leukemia after one month of azathioprine therapy in a Crohn's disease patient.
Topics: Adult; Azathioprine; Chromosomes, Human, Pair 21; Crohn Disease; Humans; Immunosuppressive Agents; I | 2010 |
11q23 rearrangement and duplication of MLLT1-MLL gene fusion in therapy-related acute myeloid leukemia.
Topics: Azathioprine; Chromosome Banding; Chromosomes, Human, Pair 11; Cyclosporine; Female; Gene Duplicatio | 2012 |
Therapy-related acute myeloid leukemia in Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male | 2013 |
Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.
Topics: Adult; Azathioprine; Bone Marrow; Crohn Disease; Female; Genotype; Humans; Leukemia, Myeloid, Acute; | 2008 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-1983. A young man with pancytopenia after a renal transplant.
Topics: Adult; Azathioprine; Diagnosis, Differential; Humans; Kidney Transplantation; Leukemia, Myeloid, Acu | 1983 |
[Acute leukemia after kidney allotransplantation (author's transl)].
Topics: Adult; Azathioprine; Humans; Kidney Transplantation; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; M | 1980 |
[Acute myelogenous leukaemia after renal transplantation (author's transl)].
Topics: Adult; Azathioprine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Leukemia, Myeloid, Acu | 1981 |
Secondary acute myeloid leukaemia with 7q- complicating azathioprine treatment for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Leukemia, Myeloid, Acute; Neoplasms, Seco | 1995 |
Acute leukaemia during azathioprine therapy.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Leukemia, Myeloid, Acute | 1977 |
Acute nonlymphocytic leukemia after treatment of systemic lupus erythematosus with immunosuppressive agents.
Topics: Adult; Azathioprine; Chromosomes, Human, Pair 16; Cyclophosphamide; Female; Humans; Immunosuppressiv | 1992 |
[The diagnostic significance of the test for spontaneous blood neutrophil damage in acute myeloid forms of leukemia].
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Azat | 1990 |
Acute myelogenous leukemia in a renal allograft recipient receiving cyclosporine therapy.
Topics: Azathioprine; Cyclosporins; Female; Humans; Kidney Transplantation; Leukemia, Myeloid, Acute; Middle | 1990 |
The oncogenicity of chlorambucil in rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Carcinogens; Chlorambucil; Humans; Leukemia, Mye | 1988 |
Platelet survival and sequestration patterns in thrombocytopenic disorders.
Topics: Adult; Aged; Azathioprine; Blood Platelets; Cell Survival; Chloramphenicol; Chromium Isotopes; Dexam | 1972 |
Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins.
Topics: Adolescent; Adult; Aged; Antigens; Azathioprine; Child; Child, Preschool; Chromium Isotopes; Cycloph | 1972 |
Acute myelogenous leukemia in two patients treated with azathioprine for nonmalignant diseases.
Topics: Adult; Azathioprine; Blood Cell Count; Blood Platelets; Bone Marrow; Bone Marrow Cells; Cytarabine; | 1974 |
Comparison of the results of combined treatment of acute myeloblastic leukemias with corticosteroids and either imuran or 6-mercaptopurine.
Topics: Acute Disease; Adolescent; Adult; Aged; Azathioprine; Female; Humans; Infections; Leukemia, Myeloid, | 1971 |
Comparison of the results of combined treatment of acute myeloblastic leukemias with corticosteroids and either imuran or 6-mercaptopurine.
Topics: Acute Disease; Adolescent; Adult; Aged; Azathioprine; Female; Humans; Infections; Leukemia, Myeloid, | 1971 |