azathioprine has been researched along with Kidney Failure in 21 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Kidney Failure: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Her renal biopsy showed acute tubulointerstitial nephritis and no active glomerulonephritis." | 5.33 | Azathioprine induced acute interstitial nephritis as the cause of rapidly progressive renal failure in a patient with Wegener's granulomatosis. ( Bir, K; Carette, S; Herzenberg, AM, 2006) |
| " Development of this complication was associated with elevated intravenous FK 506 dosing schedules, with the mean cumulative dose 43% higher than treated patients with unaffected kidney function." | 2.67 | Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. ( Bismuth, H; Calne, R; Devlin, J; Groth, C; McMaster, P; Neuhaus, P; Otto, G; Pichlmayr, R; Williams, R, 1994) |
| "Her renal biopsy showed acute tubulointerstitial nephritis and no active glomerulonephritis." | 1.33 | Azathioprine induced acute interstitial nephritis as the cause of rapidly progressive renal failure in a patient with Wegener's granulomatosis. ( Bir, K; Carette, S; Herzenberg, AM, 2006) |
| "The recurrence of immunoglobulin A nephropathy (IgAN) after renal transplantation has been described in 40% to 50% of cases." | 1.31 | An unusual recurrence of crescentic nephritis after renal transplantation for IgA nephropathy. ( Benabdallah, L; Bruneel, MF; Carron, PL; Kreis, H; Morelon, E; Noël, LH; Peraldi, MN; Rerolle, JP, 2002) |
| " A nonnephrotoxic and powerful immunosuppressant such as mycophenolate mofetil (MMF) could allow a reduction of cyclosporine dosage or its withdrawal and an improvement in renal function in these patients." | 1.30 | Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetil. ( Alvárez-Cienfuegos, J; Girala, M; Gómez-Manero, N; Herrero, JI; Pardo, F; Prieto, J; Quiroga, J; Sangro, B, 1999) |
| "Wegener's granulomatosis is a well-defined systemic vasculitic syndrome that primarily affects the upper and lower respiratory tracts and the kidney." | 1.29 | Case report: Hashimoto's thyroiditis associated with Wegener's granulomatosis. ( Gal, AA; LiVolsi, VA; Masor, JJ, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haris, Á | 1 |
| Polner, K | 1 |
| Arányi, J | 1 |
| Braunitzer, H | 1 |
| Kaszás, I | 1 |
| Mucsi, I | 1 |
| González-Vílchez, F | 1 |
| de Prada, JA | 1 |
| Exposito, V | 1 |
| García-Camarero, T | 1 |
| Fernández-Friera, L | 1 |
| Llano, M | 1 |
| Ruano, J | 1 |
| Martín-Durán, R | 1 |
| Caltik, A | 1 |
| Demircin, G | 1 |
| Bülbül, M | 1 |
| Erdogan, O | 1 |
| Akyüz, SG | 1 |
| Arda, N | 1 |
| Bataille, S | 1 |
| Moal, V | 1 |
| Gaudart, J | 1 |
| Indreies, M | 1 |
| Purgus, R | 1 |
| Dussol, B | 1 |
| Zandotti, C | 1 |
| Berland, Y | 1 |
| Vacher-Coponat, H | 1 |
| Chan, PT | 1 |
| Mok, CC | 1 |
| Neau-Cransac, M | 1 |
| Morel, D | 1 |
| Bernard, PH | 1 |
| Merville, P | 1 |
| Revel, P | 1 |
| Potaux, L | 1 |
| Saric, J | 1 |
| Benabdallah, L | 1 |
| Rerolle, JP | 1 |
| Peraldi, MN | 1 |
| Noël, LH | 1 |
| Bruneel, MF | 1 |
| Carron, PL | 1 |
| Morelon, E | 1 |
| Kreis, H | 1 |
| QUIJANO, M | 1 |
| GOMEZMONT, F | 1 |
| ORTIZQUEZADA, F | 1 |
| RONCES, R | 1 |
| HAMBURGER, J | 1 |
| CROSNIER, J | 1 |
| DORMONT, J | 1 |
| Sugimoto, T | 1 |
| Kanasaki, K | 1 |
| Koyama, T | 1 |
| Yokomaku, Y | 1 |
| Yasuda, H | 1 |
| Kashiwagi, A | 1 |
| Koya, D | 1 |
| Bir, K | 1 |
| Herzenberg, AM | 1 |
| Carette, S | 1 |
| Anastassiades, E | 1 |
| Howarth, D | 1 |
| Howarth, JE | 1 |
| Shanks, D | 1 |
| Waters, HM | 1 |
| Hyde, K | 1 |
| Yin, JA | 1 |
| Geary, CG | 1 |
| Gokal, R | 1 |
| Hausen, B | 2 |
| Demertzis, S | 2 |
| Rohde, R | 1 |
| Albes, JM | 1 |
| Schäfers, HJ | 2 |
| Borst, HG | 1 |
| Masor, JJ | 1 |
| Gal, AA | 1 |
| LiVolsi, VA | 1 |
| Wahlers, TH | 1 |
| Wagenbreth, I | 1 |
| Haverich, A | 1 |
| Moroni, G | 1 |
| Banfi, G | 1 |
| Maccario, M | 1 |
| Mereghetti, M | 1 |
| Ponticelli, C | 1 |
| Baker, LR | 2 |
| Tucker, B | 2 |
| Macdougall, IC | 2 |
| Oommen, R | 2 |
| Herrero, JI | 1 |
| Quiroga, J | 1 |
| Sangro, B | 1 |
| Girala, M | 1 |
| Gómez-Manero, N | 1 |
| Pardo, F | 1 |
| Alvárez-Cienfuegos, J | 1 |
| Prieto, J | 1 |
| Devlin, J | 1 |
| Williams, R | 1 |
| Neuhaus, P | 1 |
| McMaster, P | 1 |
| Calne, R | 1 |
| Pichlmayr, R | 1 |
| Otto, G | 1 |
| Bismuth, H | 1 |
| Groth, C | 1 |
| Rahman, M | 1 |
| Wahab, MA | 1 |
| Rashid, HU | 1 |
| Kibria, SG | 1 |
| Rahman, S | 1 |
| Khan, MF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment: a Single-center, Prospective Cohort Study[NCT05326399] | 369 participants (Anticipated) | Observational | 2022-06-01 | Recruiting | |||
| CellCept (Mycophenolate Mofetil, MMF) Maintenance Immunosuppression in Liver Transplant Recipients With Long-term Follow-up Post-transplantation for Non-Autoimmune Liver Disease - A Prospective, Randomized, Multicenter Trial.[NCT00206076] | Phase 4 | 19 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
assessed by liver biopsy using Banff International Consensus Schema (NCT00206076)
Timeframe: 12 months
| Intervention | participants (Number) |
|---|---|
| MMF, CNI Discontinued | 0 |
| MMF; CNI Decreased | 0 |
(NCT00206076)
Timeframe: 12 months
| Intervention | participants (Number) |
|---|---|
| MMF, CNI Discontinued | 2 |
| MMF; CNI Decreased | 1 |
(NCT00206076)
Timeframe: 12 months
| Intervention | participants (Number) |
|---|---|
| CNI Discontinued | 6 |
| CNI Reduction | 9 |
1 review available for azathioprine and Kidney Failure
| Article | Year |
|---|---|
Pauci-immune crescentic glomerulonephritis in limited cutaneous systemic sclerosis.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Azathioprine; Biopsy; Cyclophosphamide | 2012 |
3 trials available for azathioprine and Kidney Failure
| Article | Year |
|---|---|
Cytomegalovirus risk factors in renal transplantation with modern immunosuppression.
Topics: Adult; Antiviral Agents; Azathioprine; Chemoprevention; Cyclosporine; Cytomegalovirus; Cytomegalovir | 2010 |
Influence of azathioprine on the ferrokinetics of patients with renal failure before and after treatment with erythropoietin.
Topics: Anemia; Azathioprine; Bone Marrow; Drug Interactions; Erythropoiesis; Erythropoietin; Female; Ferrit | 1994 |
Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients.
Topics: Adolescent; Adult; Aged; Azathioprine; Cohort Studies; Creatinine; Cyclosporine; Drug Therapy, Combi | 1994 |
17 other studies available for azathioprine and Kidney Failure
| Article | Year |
|---|---|
Clinical outcomes of ANCA-associated vasculitis in elderly patients.
Topics: Age Factors; Aged; Anti-Inflammatory Agents; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculi | 2014 |
Avoidance of calcineurin inhibitors with use of proliferation signal inhibitors in de novo heart transplantation with renal failure.
Topics: Administration, Oral; Adrenal Cortex Hormones; Azathioprine; Calcineurin Inhibitors; Cell Division; | 2008 |
An unusual case of ANA negative systemic lupus erythematosus presented with vasculitis, long-standing serositis and full-house nephropathy.
Topics: Administration, Oral; Adolescent; Antibodies, Antinuclear; Azathioprine; Cyclophosphamide; Dipyridam | 2013 |
Renal failure after liver transplantation: outcome after calcineurin inhibitor withdrawal.
Topics: Adolescent; Adult; Aged; Azathioprine; Calcineurin Inhibitors; Child; Creatinine; Female; Humans; Im | 2002 |
An unusual recurrence of crescentic nephritis after renal transplantation for IgA nephropathy.
Topics: Azathioprine; Drug Administration Schedule; Female; Glomerulonephritis; Glomerulonephritis, IGA; Gra | 2002 |
[FIRST EXPERIENCES IN RENAL TRANSPLANTATION IN HUMANS].
Topics: Acute Kidney Injury; Allergy and Immunology; Antineoplastic Agents; Azathioprine; Dactinomycin; Glom | 1964 |
EXPERIENCE WITH 45 RENAL HOMOTRANSPLANTATIONS IN MAN.
Topics: Acute Kidney Injury; Azathioprine; Cobalt Isotopes; Drug Therapy; Immune Tolerance; Immunosuppressiv | 1965 |
A case of myeloperoxidase-antineutrophil cytoplasmic antibody positive-polyarteritis nodosa complicated by interstitial pneumonia and rapidly progressive renal failure.
Topics: Aged; Angiography; Anti-Inflammatory Agents; Antibodies, Antineutrophil Cytoplasmic; Azathioprine; F | 2007 |
Azathioprine induced acute interstitial nephritis as the cause of rapidly progressive renal failure in a patient with Wegener's granulomatosis.
Topics: Acute Disease; Azathioprine; Diagnosis, Differential; Drug Hypersensitivity; Female; Granulomatosis | 2006 |
Low-dose cyclosporine therapy in triple-drug immunosuppression for heart transplant recipients.
Topics: Adult; Azathioprine; Contraindications; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejec | 1994 |
Case report: Hashimoto's thyroiditis associated with Wegener's granulomatosis.
Topics: Azathioprine; Eye Diseases; Female; Granulomatosis with Polyangiitis; Humans; Kidney; Middle Aged; P | 1994 |
The impact of early postoperative cyclosporine serum levels on the incidence of cardiac allograft rejection.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Cohort Studies; Cyclosporine; Female; Follow-Up Studies; | 1993 |
Extracapillary glomerulonephritis and renal amyloidosis.
Topics: Aged; Amyloidosis; Azathioprine; Biopsy; Cyclophosphamide; Female; Glomerulonephritis; Glucocorticoi | 1996 |
Treatment of progressive renal failure and nephrotic syndrome with azathioprine and prednisolone.
Topics: Anti-Inflammatory Agents; Azathioprine; Glomerulonephritis, Membranous; Humans; Immunosuppressive Ag | 1997 |
Treatment of progressive renal failure in idiopathic membranous nephropathy with azathioprine and prednisolone.
Topics: Azathioprine; Disease Progression; Follow-Up Studies; Glomerulonephritis, Membranous; Glucocorticoid | 1998 |
Conversion of liver transplant recipients on cyclosporine with renal impairment to mycophenolate mofetil.
Topics: Aged; Azathioprine; Biopsy; Blood Pressure; Creatinine; Cyclosporine; Drug Therapy, Combination; Fem | 1999 |
Short-term cyclosporine conversion in living related donor renal transplantation--preliminary observations.
Topics: Adult; Azathioprine; Blood Pressure; Cyclosporine; Family; Follow-Up Studies; Humans; Kidney Transpl | 1992 |