Page last updated: 2024-10-23

azathioprine and Jaundice

azathioprine has been researched along with Jaundice in 29 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.

Research Excerpts

ExcerptRelevanceReference
"Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years."7.68Long term treatment of myasthenia gravis with azathioprine. ( Fonseca, V; Havard, CW, 1990)
"Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases."5.51Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019)
"Pancytopenia was most likely azathioprine-related."3.74[Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease]. ( Günther, U; Loddenkemper, C; Preiss, JC; Schumann, M; Siegmund, B; Somasundaram, R; Zeitz, M, 2008)
"Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years."3.68Long term treatment of myasthenia gravis with azathioprine. ( Fonseca, V; Havard, CW, 1990)
"Azathioprine was hepatotoxic in doses of 200 mg daily or more."2.64Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients. ( Hahn, BH; Kantor, OS; Osterland, CK, 1975)
"Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases."1.51Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019)
"A 15-year-old girl was diagnosed with influenza and prescribed 40 mg laninamivir."1.51Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate. ( Arinaga-Hino, T; Hirai, S; Ide, T; Kawaguchi, T; Nagamatsu, H; Shimizu, M; Takata, A; Tanikawa, K; Tateishi, H; Tokushige, T; Torimura, T, 2019)
"16."1.46Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease? ( Jain, V; Kathuria, R; Krishnani, N; Kumari, N; Poddar, U; Sarma, MS; Srivastava, A; Yachha, SK, 2017)
"Treatment with prednisone, azathioprine, and ursodeoxycholic acid led to a good response."1.39Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy. ( Bahri, I; Boudawara, T; Gargouri, L; Maalej, B; Mahfoudh, A; Majdoub, I; Mnif, H; Mnif, L; Safi, F; Tahri, N; Turki, F, 2013)
"Treatment with prednisone and azathioprine, plus, in three children, cyclosporine, resulted in complete remission in eight, partial remission in six, and failure in two."1.37Giant cell hepatitis with autoimmune hemolytic anemia in early childhood: long-term outcome in 16 children. ( Bernard, O; Choulot, JJ; Fabre, M; Gori, L; Jacquemin, E; Maggiore, G; Pacifico, L; Resti, M; Sciveres, M, 2011)
"We describe the case of a girl with type 1 diabetes mellitus who developed icterus due to autoimmune hepatitis, a disease rarely found in children."1.36A girl with type 1 diabetes and a yellowish appearance. ( Hovinga, IC; Mearin, ML; Mul, D; Stam, ED, 2010)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199018 (62.07)18.7374
1990's2 (6.90)18.2507
2000's1 (3.45)29.6817
2010's8 (27.59)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Muratori, P1
Lenzi, M1
Migliori, M1
Muratori, L1
Jain, V1
Srivastava, A1
Yachha, SK1
Kumari, N1
Kathuria, R1
Sarma, MS1
Poddar, U1
Krishnani, N1
Gisi, K1
Ispiroglu, M1
Kantarceken, B1
Sayar, H1
Kawaguchi, T1
Arinaga-Hino, T1
Shimizu, M1
Tanikawa, K1
Tokushige, T1
Hirai, S1
Nagamatsu, H1
Tateishi, H1
Takata, A1
Ide, T1
Torimura, T1
Gargouri, L1
Mnif, L1
Safi, F1
Turki, F1
Majdoub, I1
Maalej, B1
Bahri, I1
Mnif, H1
Boudawara, T1
Tahri, N1
Mahfoudh, A1
Schumann, M1
Preiss, JC1
Loddenkemper, C1
Günther, U1
Somasundaram, R1
Siegmund, B1
Zeitz, M1
Maggiore, G1
Sciveres, M1
Fabre, M1
Gori, L1
Pacifico, L1
Resti, M1
Choulot, JJ1
Jacquemin, E1
Bernard, O1
Hovinga, IC1
Stam, ED1
Mearin, ML1
Mul, D1
Moseley, RH1
Manoogian, B1
Shehab, T1
Saint, S1
Montag, H1
Mozes, MF1
Ascher, NL1
Balfour, HH1
Simmons, RL1
Najarian, JS1
Cameron, JS1
Hahn, BH1
Kantor, OS1
Osterland, CK1
Sterneck, M1
Wiesner, R1
Ascher, N1
Roberts, J1
Ferrell, L1
Ludwig, J1
Lake, J1
Fonseca, V1
Havard, CW1
Reddy, KR1
Major, GA1
Moore, PG1
Schlumpf, V1
Chia, KM1
Leone, G1
Pola, P1
Guerrera, G1
Bizzi, B1
Starzl, TE1
Porter, KA1
Brettschneider, L1
Penn, I1
Bell, P1
Putnam, CW1
McGuire, RL1
Pirson, Y1
van Ypersele de Strihou, C1
Noel, H1
Alexandre, GP2
Troch, R1
Garnier, H1
Clot, JP1
Kestens, PJ1
Otte, JB1
Lambotte, L1
Loubeau, JM1
Orban, JC1
Haxhe, JJ1
Maldague, P1
Morelle, J1
Currey, HL1
Thiel, G1
Smith, MG1
Golding, PL1
Eddleston, AL1
Mitchell, CG1
Kemp, A1
Williams, R2

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hit Hard and Early. The Effect of High Dose Methylprednisolone on Nailfold Capillary Changes and Biomarkers in Early SSc: a 12-week Randomised Explorative Double-blind Placebo-controlled Trial.[NCT03059979]Early Phase 130 participants (Anticipated)Interventional2017-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for azathioprine and Jaundice

ArticleYear
Problems with immunosuppressive agents in renal disease.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9

    Topics: Animals; Azathioprine; Cyclophosphamide; Granulomatosis with Polyangiitis; Humans; Immunosuppressive

1975
Azathioprine hepatotoxicity after liver transplantation.
    Hepatology (Baltimore, Md.), 1991, Volume: 14, Issue:5

    Topics: Adult; Aspartate Aminotransferases; Azathioprine; Biopsy; Female; Humans; Jaundice; Liver; Liver Tra

1991
[New development in infectious hepatitis].
    Zhonghua yi xue za zhi, 1973, Volume: 2

    Topics: Azathioprine; Chronic Disease; Female; Hepatitis A; Hepatitis B; Hepatitis B Antigens; Humans; Jaund

1973
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
    Transactions of the St. John's Hospital Dermatological Society, 1970, Volume: 56, Issue:2

    Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine;

1970
[Liver transplantation in humans].
    Schweizerische medizinische Wochenschrift, 1970, Jan-31, Volume: 100, Issue:5

    Topics: Antilymphocyte Serum; Azathioprine; Biliary Tract Diseases; Graft Rejection; Hepatectomy; Histocompa

1970

Trials

2 trials available for azathioprine and Jaundice

ArticleYear
Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients.
    Annals of internal medicine, 1975, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Antibodies, Antinuclear; Azathioprine; Clinical Trials as Topic; Drug Therapy, Co

1975
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
    Transactions of the St. John's Hospital Dermatological Society, 1970, Volume: 56, Issue:2

    Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine;

1970

Other Studies

23 other studies available for azathioprine and Jaundice

ArticleYear
Antimitochondrial antibodies positive autoimmune hepatitis with acute onset.
    Scandinavian journal of gastroenterology, 2017, Volume: 52, Issue:8

    Topics: Autoantibodies; Azathioprine; Biopsy; Female; Glucocorticoids; Hepatitis, Autoimmune; Humans; Immuno

2017
Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease?
    European journal of gastroenterology & hepatology, 2017, Volume: 29, Issue:12

    Topics: Adolescent; Alanine Transaminase; Ascites; Aspartate Aminotransferases; Autoantibodies; Autoimmune D

2017
Severe cholestasis due to azathioprine in Behcet's disease.
    BMJ case reports, 2019, Mar-31, Volume: 12, Issue:3

    Topics: Adult; Azathioprine; Behcet Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; I

2019
Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate.
    Internal medicine (Tokyo, Japan), 2019, Sep-01, Volume: 58, Issue:17

    Topics: Adolescent; Antiviral Agents; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Guanidin

2019
Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2013, Volume: 20, Issue:12

    Topics: Alkaline Phosphatase; Azathioprine; Biomarkers; Child; Cholagogues and Choleretics; Cholangitis, Scl

2013
[Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease].
    Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:38

    Topics: Ascites; Azathioprine; Blood Cell Count; Crohn Disease; Diagnosis, Differential; Fatigue; Focal Nodu

2008
Giant cell hepatitis with autoimmune hemolytic anemia in early childhood: long-term outcome in 16 children.
    The Journal of pediatrics, 2011, Volume: 159, Issue:1

    Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Bilirubin; Coom

2011
A girl with type 1 diabetes and a yellowish appearance.
    BMJ case reports, 2010, Nov-26, Volume: 2010

    Topics: Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Child; Diabetes Mellitus, Type 1; Drug Thera

2010
Clinical problem-solving. An intricate interplay.
    The New England journal of medicine, 2012, Oct-04, Volume: 367, Issue:14

    Topics: alpha 1-Antitrypsin; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Diagnosis, Differential

2012
[Azathioprine and its side effects].
    Zeitschrift fur Hautkrankheiten, 1984, Dec-01, Volume: 59, Issue:23

    Topics: Aged; Azathioprine; Gastrectomy; Hepatic Encephalopathy; Humans; Jaundice; Male; Methylprednisolone;

1984
Jaundice after renal allotransplantation.
    Annals of surgery, 1978, Volume: 188, Issue:6

    Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Azathioprine; Bilirubin; Blood Transfusion

1978
Long term treatment of myasthenia gravis with azathioprine.
    Postgraduate medical journal, 1990, Volume: 66, Issue:772

    Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Humans; Hypertension, Portal; Jaundice; Long

1990
'Acute hepatitis' with fluctuating symptoms.
    Hospital practice (Office ed.), 1986, Oct-15, Volume: 21, Issue:10

    Topics: Adult; Azathioprine; Female; Hepatitis; Humans; Jaundice; Prednisone; Prognosis

1986
Profound circulatory collapse due to azathioprine.
    Journal of the Royal Society of Medicine, 1985, Volume: 78, Issue:12

    Topics: Acute Kidney Injury; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Jaundice; Middle Aged; Pan

1985
[Case from practice (41). Patient: M.G., born 5-14-1931, business employee in a management position].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1985, Oct-29, Volume: 74, Issue:44

    Topics: Azathioprine; Female; Hepatitis, Chronic; Humans; Jaundice; Middle Aged; Prednisone

1985
[Acquired von Willebrand's syndrome during collagen disorder (author's transl)].
    Haematologica, 1974, Volume: 59, Issue:2

    Topics: Adult; Azathioprine; Blood Coagulation Tests; Collagen Diseases; Factor VIII; Female; Hemorrhagic Di

1974
Clinical and pathologic observations after orthotopic transplantation of the human liver.
    Surgery, gynecology & obstetrics, 1969, Volume: 128, Issue:2

    Topics: Adolescent; Adult; Alkaline Phosphatase; Azathioprine; Bilirubin; Blood Proteins; Carcinoma, Hepatoc

1969
Liver disease in transplanted patients.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1973, Volume: 10, Issue:0

    Topics: Azathioprine; Clinical Enzyme Tests; Cytomegalovirus; Cytomegalovirus Infections; Female; Graft Reje

1973
Editorial: Children with jaundice.
    British medical journal, 1974, Jun-15, Volume: 2, Issue:5919

    Topics: Adult; Azathioprine; Biopsy; Child; Chronic Disease; Hepatitis; Humans; Jaundice; Liver; Liver Funct

1974
[A case of orthotopic transplantation of the liver. II].
    La Presse medicale, 1969, Jul-12, Volume: 77, Issue:34

    Topics: Adult; Anti-Bacterial Agents; Antilymphocyte Serum; Azathioprine; Blood Coagulation Disorders; Blood

1969
[Differential diagnosis of early jaundice after orthotopic transplantation of the liver in humans].
    Revue medico-chirurgicale des maladies du foie, 1970, Volume: 45, Issue:4

    Topics: Adult; Azathioprine; Cholestasis; Diagnosis, Differential; Humans; Immunosuppressive Agents; Ischemi

1970
Cell-mediated immune responses in chronic liver diseases.
    British medical journal, 1972, Feb-26, Volume: 1, Issue:5799

    Topics: Acidosis, Renal Tubular; Antigens; Autoimmune Diseases; Azathioprine; Cell Migration Inhibition; Chr

1972
Chronic hepatitis.
    Transactions of the Medical Society of London, 1968, Volume: 84

    Topics: Adult; Aged; Antibody Formation; Aspartate Aminotransferases; Azathioprine; Bilirubin; Blood Protein

1968