azathioprine has been researched along with Jaundice in 29 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years." | 7.68 | Long term treatment of myasthenia gravis with azathioprine. ( Fonseca, V; Havard, CW, 1990) |
| "Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases." | 5.51 | Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019) |
| "Pancytopenia was most likely azathioprine-related." | 3.74 | [Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease]. ( Günther, U; Loddenkemper, C; Preiss, JC; Schumann, M; Siegmund, B; Somasundaram, R; Zeitz, M, 2008) |
| "Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years." | 3.68 | Long term treatment of myasthenia gravis with azathioprine. ( Fonseca, V; Havard, CW, 1990) |
| "Azathioprine was hepatotoxic in doses of 200 mg daily or more." | 2.64 | Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients. ( Hahn, BH; Kantor, OS; Osterland, CK, 1975) |
| "Azathioprine (AZA) is an immunosuppressive drug that is widely used in the treatment of autoimmune diseases." | 1.51 | Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019) |
| "A 15-year-old girl was diagnosed with influenza and prescribed 40 mg laninamivir." | 1.51 | Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate. ( Arinaga-Hino, T; Hirai, S; Ide, T; Kawaguchi, T; Nagamatsu, H; Shimizu, M; Takata, A; Tanikawa, K; Tateishi, H; Tokushige, T; Torimura, T, 2019) |
| "16." | 1.46 | Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease? ( Jain, V; Kathuria, R; Krishnani, N; Kumari, N; Poddar, U; Sarma, MS; Srivastava, A; Yachha, SK, 2017) |
| "Treatment with prednisone, azathioprine, and ursodeoxycholic acid led to a good response." | 1.39 | Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy. ( Bahri, I; Boudawara, T; Gargouri, L; Maalej, B; Mahfoudh, A; Majdoub, I; Mnif, H; Mnif, L; Safi, F; Tahri, N; Turki, F, 2013) |
| "Treatment with prednisone and azathioprine, plus, in three children, cyclosporine, resulted in complete remission in eight, partial remission in six, and failure in two." | 1.37 | Giant cell hepatitis with autoimmune hemolytic anemia in early childhood: long-term outcome in 16 children. ( Bernard, O; Choulot, JJ; Fabre, M; Gori, L; Jacquemin, E; Maggiore, G; Pacifico, L; Resti, M; Sciveres, M, 2011) |
| "We describe the case of a girl with type 1 diabetes mellitus who developed icterus due to autoimmune hepatitis, a disease rarely found in children." | 1.36 | A girl with type 1 diabetes and a yellowish appearance. ( Hovinga, IC; Mearin, ML; Mul, D; Stam, ED, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (62.07) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muratori, P | 1 |
| Lenzi, M | 1 |
| Migliori, M | 1 |
| Muratori, L | 1 |
| Jain, V | 1 |
| Srivastava, A | 1 |
| Yachha, SK | 1 |
| Kumari, N | 1 |
| Kathuria, R | 1 |
| Sarma, MS | 1 |
| Poddar, U | 1 |
| Krishnani, N | 1 |
| Gisi, K | 1 |
| Ispiroglu, M | 1 |
| Kantarceken, B | 1 |
| Sayar, H | 1 |
| Kawaguchi, T | 1 |
| Arinaga-Hino, T | 1 |
| Shimizu, M | 1 |
| Tanikawa, K | 1 |
| Tokushige, T | 1 |
| Hirai, S | 1 |
| Nagamatsu, H | 1 |
| Tateishi, H | 1 |
| Takata, A | 1 |
| Ide, T | 1 |
| Torimura, T | 1 |
| Gargouri, L | 1 |
| Mnif, L | 1 |
| Safi, F | 1 |
| Turki, F | 1 |
| Majdoub, I | 1 |
| Maalej, B | 1 |
| Bahri, I | 1 |
| Mnif, H | 1 |
| Boudawara, T | 1 |
| Tahri, N | 1 |
| Mahfoudh, A | 1 |
| Schumann, M | 1 |
| Preiss, JC | 1 |
| Loddenkemper, C | 1 |
| Günther, U | 1 |
| Somasundaram, R | 1 |
| Siegmund, B | 1 |
| Zeitz, M | 1 |
| Maggiore, G | 1 |
| Sciveres, M | 1 |
| Fabre, M | 1 |
| Gori, L | 1 |
| Pacifico, L | 1 |
| Resti, M | 1 |
| Choulot, JJ | 1 |
| Jacquemin, E | 1 |
| Bernard, O | 1 |
| Hovinga, IC | 1 |
| Stam, ED | 1 |
| Mearin, ML | 1 |
| Mul, D | 1 |
| Moseley, RH | 1 |
| Manoogian, B | 1 |
| Shehab, T | 1 |
| Saint, S | 1 |
| Montag, H | 1 |
| Mozes, MF | 1 |
| Ascher, NL | 1 |
| Balfour, HH | 1 |
| Simmons, RL | 1 |
| Najarian, JS | 1 |
| Cameron, JS | 1 |
| Hahn, BH | 1 |
| Kantor, OS | 1 |
| Osterland, CK | 1 |
| Sterneck, M | 1 |
| Wiesner, R | 1 |
| Ascher, N | 1 |
| Roberts, J | 1 |
| Ferrell, L | 1 |
| Ludwig, J | 1 |
| Lake, J | 1 |
| Fonseca, V | 1 |
| Havard, CW | 1 |
| Reddy, KR | 1 |
| Major, GA | 1 |
| Moore, PG | 1 |
| Schlumpf, V | 1 |
| Chia, KM | 1 |
| Leone, G | 1 |
| Pola, P | 1 |
| Guerrera, G | 1 |
| Bizzi, B | 1 |
| Starzl, TE | 1 |
| Porter, KA | 1 |
| Brettschneider, L | 1 |
| Penn, I | 1 |
| Bell, P | 1 |
| Putnam, CW | 1 |
| McGuire, RL | 1 |
| Pirson, Y | 1 |
| van Ypersele de Strihou, C | 1 |
| Noel, H | 1 |
| Alexandre, GP | 2 |
| Troch, R | 1 |
| Garnier, H | 1 |
| Clot, JP | 1 |
| Kestens, PJ | 1 |
| Otte, JB | 1 |
| Lambotte, L | 1 |
| Loubeau, JM | 1 |
| Orban, JC | 1 |
| Haxhe, JJ | 1 |
| Maldague, P | 1 |
| Morelle, J | 1 |
| Currey, HL | 1 |
| Thiel, G | 1 |
| Smith, MG | 1 |
| Golding, PL | 1 |
| Eddleston, AL | 1 |
| Mitchell, CG | 1 |
| Kemp, A | 1 |
| Williams, R | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hit Hard and Early. The Effect of High Dose Methylprednisolone on Nailfold Capillary Changes and Biomarkers in Early SSc: a 12-week Randomised Explorative Double-blind Placebo-controlled Trial.[NCT03059979] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for azathioprine and Jaundice
| Article | Year |
|---|---|
Problems with immunosuppressive agents in renal disease.
Topics: Animals; Azathioprine; Cyclophosphamide; Granulomatosis with Polyangiitis; Humans; Immunosuppressive | 1975 |
Azathioprine hepatotoxicity after liver transplantation.
Topics: Adult; Aspartate Aminotransferases; Azathioprine; Biopsy; Female; Humans; Jaundice; Liver; Liver Tra | 1991 |
[New development in infectious hepatitis].
Topics: Azathioprine; Chronic Disease; Female; Hepatitis A; Hepatitis B; Hepatitis B Antigens; Humans; Jaund | 1973 |
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; | 1970 |
[Liver transplantation in humans].
Topics: Antilymphocyte Serum; Azathioprine; Biliary Tract Diseases; Graft Rejection; Hepatectomy; Histocompa | 1970 |
2 trials available for azathioprine and Jaundice
| Article | Year |
|---|---|
Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Azathioprine; Clinical Trials as Topic; Drug Therapy, Co | 1975 |
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; | 1970 |
23 other studies available for azathioprine and Jaundice
| Article | Year |
|---|---|
Antimitochondrial antibodies positive autoimmune hepatitis with acute onset.
Topics: Autoantibodies; Azathioprine; Biopsy; Female; Glucocorticoids; Hepatitis, Autoimmune; Humans; Immuno | 2017 |
Autoimmune acute liver failure and seronegative autoimmune liver disease in children: Are they different from classical disease?
Topics: Adolescent; Alanine Transaminase; Ascites; Aspartate Aminotransferases; Autoantibodies; Autoimmune D | 2017 |
Severe cholestasis due to azathioprine in Behcet's disease.
Topics: Adult; Azathioprine; Behcet Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; I | 2019 |
Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate.
Topics: Adolescent; Antiviral Agents; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Guanidin | 2019 |
Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy.
Topics: Alkaline Phosphatase; Azathioprine; Biomarkers; Child; Cholagogues and Choleretics; Cholangitis, Scl | 2013 |
[Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease].
Topics: Ascites; Azathioprine; Blood Cell Count; Crohn Disease; Diagnosis, Differential; Fatigue; Focal Nodu | 2008 |
Giant cell hepatitis with autoimmune hemolytic anemia in early childhood: long-term outcome in 16 children.
Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Bilirubin; Coom | 2011 |
A girl with type 1 diabetes and a yellowish appearance.
Topics: Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Child; Diabetes Mellitus, Type 1; Drug Thera | 2010 |
Clinical problem-solving. An intricate interplay.
Topics: alpha 1-Antitrypsin; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Diagnosis, Differential | 2012 |
[Azathioprine and its side effects].
Topics: Aged; Azathioprine; Gastrectomy; Hepatic Encephalopathy; Humans; Jaundice; Male; Methylprednisolone; | 1984 |
Jaundice after renal allotransplantation.
Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Azathioprine; Bilirubin; Blood Transfusion | 1978 |
Long term treatment of myasthenia gravis with azathioprine.
Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Humans; Hypertension, Portal; Jaundice; Long | 1990 |
'Acute hepatitis' with fluctuating symptoms.
Topics: Adult; Azathioprine; Female; Hepatitis; Humans; Jaundice; Prednisone; Prognosis | 1986 |
Profound circulatory collapse due to azathioprine.
Topics: Acute Kidney Injury; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Jaundice; Middle Aged; Pan | 1985 |
[Case from practice (41). Patient: M.G., born 5-14-1931, business employee in a management position].
Topics: Azathioprine; Female; Hepatitis, Chronic; Humans; Jaundice; Middle Aged; Prednisone | 1985 |
[Acquired von Willebrand's syndrome during collagen disorder (author's transl)].
Topics: Adult; Azathioprine; Blood Coagulation Tests; Collagen Diseases; Factor VIII; Female; Hemorrhagic Di | 1974 |
Clinical and pathologic observations after orthotopic transplantation of the human liver.
Topics: Adolescent; Adult; Alkaline Phosphatase; Azathioprine; Bilirubin; Blood Proteins; Carcinoma, Hepatoc | 1969 |
Liver disease in transplanted patients.
Topics: Azathioprine; Clinical Enzyme Tests; Cytomegalovirus; Cytomegalovirus Infections; Female; Graft Reje | 1973 |
Editorial: Children with jaundice.
Topics: Adult; Azathioprine; Biopsy; Child; Chronic Disease; Hepatitis; Humans; Jaundice; Liver; Liver Funct | 1974 |
[A case of orthotopic transplantation of the liver. II].
Topics: Adult; Anti-Bacterial Agents; Antilymphocyte Serum; Azathioprine; Blood Coagulation Disorders; Blood | 1969 |
[Differential diagnosis of early jaundice after orthotopic transplantation of the liver in humans].
Topics: Adult; Azathioprine; Cholestasis; Diagnosis, Differential; Humans; Immunosuppressive Agents; Ischemi | 1970 |
Cell-mediated immune responses in chronic liver diseases.
Topics: Acidosis, Renal Tubular; Antigens; Autoimmune Diseases; Azathioprine; Cell Migration Inhibition; Chr | 1972 |
Chronic hepatitis.
Topics: Adult; Aged; Antibody Formation; Aspartate Aminotransferases; Azathioprine; Bilirubin; Blood Protein | 1968 |