azathioprine has been researched along with IgA Vasculitis in 27 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
IgA Vasculitis: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To establish the profile of patients with renal involvement due to IgA vasculitisand to describe our experience with the use of azathioprine to treat patients with nephritis." | 7.91 | The profile and clinical outcomes of patients with renal involvement due to IgA vasculitis: is azathioprine a good option for treatment? ( Andrade, MC; Clemente, G; Fernandez, JD; Fraga, MM; Len, CA; Schinzel, V; Terreri, MT, 2019) |
| " We also examined the efficacy of treatment with prednisone (1 to 2 mg/kg/d) and azathioprine (1 to 2 mg/kg/d) for severe Henoch-Schonlein purpura (HSP) nephritis." | 7.70 | Effective therapy for severe Henoch-Schonlein purpura nephritis with prednisone and azathioprine: a clinical and histopathologic study. ( Bernard, C; Drummond, KN; Foster, BJ; Sharma, AK, 2000) |
| " He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects." | 5.62 | Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis. ( Sugimoto, H; Takei, T; Yamaguchi, Y; Yumura, W, 2021) |
| "Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP." | 5.35 | Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. ( Ando, T; Hayashi, K; Joh, T; Miyabe, K; Naitoh, I; Nakazawa, T; Ohara, H; Okumura, F; Sano, H; Takahashi, S; Tanaka, H; Yoshida, M, 2009) |
| "To establish the profile of patients with renal involvement due to IgA vasculitisand to describe our experience with the use of azathioprine to treat patients with nephritis." | 3.91 | The profile and clinical outcomes of patients with renal involvement due to IgA vasculitis: is azathioprine a good option for treatment? ( Andrade, MC; Clemente, G; Fernandez, JD; Fraga, MM; Len, CA; Schinzel, V; Terreri, MT, 2019) |
| " We also examined the efficacy of treatment with prednisone (1 to 2 mg/kg/d) and azathioprine (1 to 2 mg/kg/d) for severe Henoch-Schonlein purpura (HSP) nephritis." | 3.70 | Effective therapy for severe Henoch-Schonlein purpura nephritis with prednisone and azathioprine: a clinical and histopathologic study. ( Bernard, C; Drummond, KN; Foster, BJ; Sharma, AK, 2000) |
| "Vasculitis is commoner than supposed, since its manifestations are Protean." | 2.37 | Acute renal disease in vasculitis. ( Cameron, JS, 1988) |
| " He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects." | 1.62 | Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis. ( Sugimoto, H; Takei, T; Yamaguchi, Y; Yumura, W, 2021) |
| "Azathioprine is a DMARD that has been reported to be effective in HSP nephritis and in adult cutaneous leukocytoclastic vasculitis, a condition with cutaneous histology similar to HSP." | 1.43 | Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: a report of 6 cases. ( Baszis, KW; Fotis, L; Moore, TL; Pepmueller, PH; Tuttle, PV; White, AJ, 2016) |
| "Of 363 patients with IgA nephropathy, 67 patients had vasculitic IgA nephropathy (33 Henoch-Schönlein purpura; 34 IgA)." | 1.35 | Vasculitic IgA nephropathy: prognosis and outcome. ( Adu, D; Harper, L; Howie, AJ; Lepenies, J; Nightingale, P; Pankhurst, T, 2009) |
| "Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP." | 1.35 | Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. ( Ando, T; Hayashi, K; Joh, T; Miyabe, K; Naitoh, I; Nakazawa, T; Ohara, H; Okumura, F; Sano, H; Takahashi, S; Tanaka, H; Yoshida, M, 2009) |
| "We report four children with Wegener granulomatosis in whom the initial clinical findings suggested Henoch-Schönlein purpura." | 1.27 | Wegener granulomatosis in pediatric patients. ( Beatty, EC; Duggan, E; Hall, SL; Hellerstein, S; Mauer, SM; Miller, LC, 1985) |
| "Three patients had a systemic lupus erythematosus, two had primitive extracapillary glomerulonephritis, one had panarteritis nodosa, and another a Schönlein-Henoch syndrome." | 1.26 | [Plasmapheresis in the treatment of extracapillary glomerulonephritis (author's transl)]. ( Anaya, A; Barbolla, ML; Botella, J; Fernández Fernández, J; Gallego, JL; Sanz Guajardo, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.93) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Sugimoto, H | 1 |
| Yamaguchi, Y | 1 |
| Yumura, W | 1 |
| Takei, T | 1 |
| Dhanjal, S | 1 |
| Saso, A | 1 |
| Eleftheriou, D | 1 |
| Laurent, S | 1 |
| Schinzel, V | 1 |
| Fernandez, JD | 1 |
| Clemente, G | 1 |
| Fraga, MM | 1 |
| Andrade, MC | 1 |
| Len, CA | 1 |
| Terreri, MT | 1 |
| Bui, T | 1 |
| Chandrakasan, S | 1 |
| Poulik, J | 1 |
| Fathalla, BM | 1 |
| Waelkens, B | 1 |
| Van Moerkercke, W | 1 |
| Lerut, E | 1 |
| Sprangers, B | 1 |
| Fotis, L | 1 |
| Tuttle, PV | 1 |
| Baszis, KW | 1 |
| Pepmueller, PH | 1 |
| Moore, TL | 1 |
| White, AJ | 1 |
| Pankhurst, T | 1 |
| Lepenies, J | 1 |
| Nightingale, P | 1 |
| Howie, AJ | 1 |
| Adu, D | 1 |
| Harper, L | 1 |
| Trapani, S | 1 |
| Mariotti, P | 1 |
| Resti, M | 1 |
| Nappini, L | 1 |
| de Martino, M | 1 |
| Falcini, F | 1 |
| Naitoh, I | 1 |
| Nakazawa, T | 1 |
| Ohara, H | 1 |
| Sano, H | 1 |
| Ando, T | 1 |
| Hayashi, K | 1 |
| Tanaka, H | 1 |
| Okumura, F | 1 |
| Miyabe, K | 1 |
| Yoshida, M | 1 |
| Takahashi, S | 1 |
| Joh, T | 1 |
| Singh, S | 1 |
| Kumar, L | 1 |
| Joshi, K | 1 |
| Minz, RW | 1 |
| Datta, U | 1 |
| Shin, JI | 4 |
| Park, JM | 3 |
| Shin, YH | 2 |
| Kim, JH | 2 |
| Lee, JS | 4 |
| Kim, PK | 2 |
| Jeong, HJ | 4 |
| Shenoy, M | 1 |
| Bradbury, MG | 1 |
| Lewis, MA | 1 |
| Webb, NJ | 1 |
| Dosa, S | 1 |
| Cairns, SA | 1 |
| Mallick, NP | 1 |
| Lawler, W | 1 |
| Williams, G | 1 |
| Sanz Guajardo, D | 1 |
| Barbolla, ML | 1 |
| Fernández Fernández, J | 1 |
| Gallego, JL | 1 |
| Anaya, A | 1 |
| Botella, J | 1 |
| Worth, DP | 1 |
| Bergstein, J | 1 |
| Leiser, J | 1 |
| Andreoli, SP | 1 |
| Foster, BJ | 1 |
| Bernard, C | 1 |
| Drummond, KN | 1 |
| Sharma, AK | 1 |
| Rák, K | 1 |
| Berio, A | 1 |
| Cottafava, F | 1 |
| Torchio, A | 1 |
| Brida di Priò, S | 1 |
| Baletto, MC | 1 |
| Jardim, HM | 1 |
| Leake, J | 1 |
| Risdon, RA | 1 |
| Barratt, TM | 1 |
| Dillon, MJ | 1 |
| Cameron, JS | 1 |
| Hall, SL | 1 |
| Miller, LC | 1 |
| Duggan, E | 1 |
| Mauer, SM | 1 |
| Beatty, EC | 1 |
| Hellerstein, S | 1 |
| White, RH | 1 |
| Amini, M | 1 |
| Najafi, I | 1 |
| Ganji, MR | 1 |
| Hakemi, MS | 1 |
| Nouri, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Trial of Plasma Exchange as Adjunctive Therapy for Severe Crescentic GlomerUlonephritis of IgA NEphropathy (RESCUE Study)[NCT02647255] | Phase 2/Phase 3 | 10 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to Due to the rarity and rapid progressive course of the disease, patients were less likely to participate in randomization.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for azathioprine and IgA Vasculitis
| Article | Year |
|---|---|
Severe hemorrhagic bullous lesions in Henoch Schonlein purpura: three pediatric cases and review of the literature.
Topics: Azathioprine; Blister; Child; Female; Glucocorticoids; Hemorrhage; Humans; IgA Vasculitis; Immunosup | 2010 |
Acute renal disease in vasculitis.
Topics: Actuarial Analysis; Acute Disease; Azathioprine; Cyclophosphamide; Granulomatosis with Polyangiitis; | 1988 |
1 trial available for azathioprine and IgA Vasculitis
| Article | Year |
|---|---|
Response of crescentic Henoch-Schoenlein purpura nephritis to corticosteroid and azathioprine therapy.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Creatinine; Drug Therapy, Combination; Female; Gl | 1998 |
24 other studies available for azathioprine and IgA Vasculitis
| Article | Year |
|---|---|
Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Azathioprine; Humans; IgA Vasculitis; Immunoglobul | 2021 |
Necrotic cutaneous vasculitic skin lesions: a case of atypical Henoch-Schönlein purpura in a child with heterozygosity for factor V Leiden.
Topics: Aspirin; Azathioprine; Biopsy; Child, Preschool; Factor V; Humans; IgA Vasculitis; Immunosuppressive | 2017 |
The profile and clinical outcomes of patients with renal involvement due to IgA vasculitis: is azathioprine a good option for treatment?
Topics: Adolescent; Antirheumatic Agents; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Female; H | 2019 |
Granulomatosis with polyangiitis presenting as Henoch-Schönlein purpura in children.
Topics: Abdominal Pain; Anti-Infective Agents; Antibodies, Antineutrophil Cytoplasmic; Azathioprine; Child; | 2013 |
Henoch-Schönlein Purpura complicated with major gastro-intestinal hemorrhage.
Topics: Aged, 80 and over; Azathioprine; Gastrointestinal Hemorrhage; Humans; IgA Vasculitis; Immunosuppress | 2014 |
Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: a report of 6 cases.
Topics: Azathioprine; Child; Female; Glucocorticoids; Humans; IgA Vasculitis; Immunosuppressive Agents; Male | 2016 |
Vasculitic IgA nephropathy: prognosis and outcome.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Biopsy; Blood Pre | 2009 |
Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy.
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Drug Therapy, Combination; Female; Heari | 2009 |
Severe Henoch-Schönlein nephritis: resolution with azathioprine and steroids.
Topics: Azathioprine; Biopsy, Needle; Child; Child, Preschool; Cohort Studies; Dexamethasone; Dose-Response | 2002 |
Can azathioprine and steroids alter the progression of severe Henoch-Schönlein nephritis in children?
Topics: Adolescent; Azathioprine; Biopsy; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination | 2005 |
Role of mesangial fibrinogen deposition in the pathogenesis of crescentic Henoch-Schonlein nephritis in children.
Topics: Age of Onset; Analysis of Variance; Azathioprine; Biopsy; Child; Cyclosporine; Female; Fibrinogen; G | 2005 |
Successful use of cyclosporin A in severe Schönlein-Henoch nephritis resistant to both methylprednisolone pulse and azathioprine.
Topics: Azathioprine; Child; Cyclosporine; Drug Resistance, Multiple; Glucocorticoids; Humans; IgA Vasculiti | 2006 |
Azathioprine and tubulointerstitial nephritis in HSP.
Topics: Azathioprine; Child; Contraindications; Humans; IgA Vasculitis; Immunosuppressive Agents; Kidney; Ne | 2006 |
Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression.
Topics: Adolescent; Adrenal Cortex Hormones; Age of Onset; Azathioprine; Child; Cyclophosphamide; Female; Fo | 2007 |
Relapsing Henoch-Schönlein syndrome with renal involvement in a patient with an IgA monoclonal gammopathy. A study of the results of immunosuppressant and cytotoxic therapy.
Topics: Adult; Antineoplastic Agents; Azathioprine; Bence Jones Protein; Biopsy; Female; Humans; Hypergammag | 1980 |
[Plasmapheresis in the treatment of extracapillary glomerulonephritis (author's transl)].
Topics: Arteritis; Azathioprine; Blood Proteins; Cyclophosphamide; Glomerulonephritis; Humans; IgA Vasculiti | 1980 |
Immunosuppression in rapidly progressive Henoch-Schoenlein nephritis.
Topics: Adult; Azathioprine; Female; Glomerulonephritis; Humans; IgA Vasculitis; Immunosuppressive Agents; P | 1996 |
Effective therapy for severe Henoch-Schonlein purpura nephritis with prednisone and azathioprine: a clinical and histopathologic study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Azathioprine; Child; Child, Preschool; Female; Humans; | 2000 |
[Results in the treatment of immune thrombocytolytic purpura (ITP)].
Topics: Adult; Azathioprine; Dactinomycin; Humans; IgA Vasculitis; Middle Aged; Prednisolone; Splenectomy; S | 1976 |
[The Schönlein-Henoch syndrome with renal involvement. Personal cases].
Topics: Anti-Bacterial Agents; Azathioprine; Child; Child, Preschool; Cortisone; Female; Humans; IgA Vasculi | 1978 |
Crescentic glomerulonephritis in children.
Topics: Adolescent; Adrenal Cortex Hormones; Anticoagulants; Azathioprine; Child; Child, Preschool; Cyclopho | 1992 |
Wegener granulomatosis in pediatric patients.
Topics: Adolescent; Azathioprine; Child; Cyclophosphamide; Diagnosis, Differential; Female; Granulomatosis w | 1985 |
Mesangial proliferative glomerulonephritis in childhood.
Topics: Adolescent; Adrenal Cortex Hormones; Azathioprine; Child; Child, Preschool; Female; Follow-Up Studie | 1973 |
Foot-drop: an unusual complaint in Henoch-Schönlein purpura.
Topics: Administration, Oral; Adolescent; Cyclophosphamide; Dose-Response Relationship, Drug; Gait Disorders | 2009 |