Page last updated: 2024-10-23

azathioprine and Hypertension

azathioprine has been researched along with Hypertension in 119 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Angiotensin converting enzyme inhibitors (ACEI) and theophylline have been reported to decrease the elevated hemoglobin (Hgb) and hematocrit (Hct) levels in the renal transplant recipients with erythrocytosis."9.10A prospective, randomized, open labeled crossover trial of fosinopril and theophylline in post renal transplant erythrocytosis. ( Lal, SM; Trivedi, H, 2003)
"Fifty-two patients with severe rheumatoid arthritis (RA) from four Australian centres were randomised to receive cyclosporin A (CSA) (n = 25) or azathioprine (AZA) (n = 27) for six months."9.07A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis. ( Ahern, MJ; Bayliss, C; Bradley, J; Harrison, W; Hollingsworth, P; Laing, B, 1991)
"Our report describes the outcome of a twin pregnancy in a woman who was maintained on tacrolimus after a living related renal transplant."7.70Outcome of twin pregnancy in a renal transplant recipient treated with tacrolimus. ( Anderson, V; Baqi, N; Hidalgo, G; Kumar, A; Markell, MS; Piecuch, S; Singh, A; Vyas, S, 1999)
"Gingival hyperplasia is a common side-effect of immunosuppression with cyclosporine A."7.69Nifedipine aggravates cyclosporine A-induced gingival hyperplasia. ( Albers, N; Beier, C; Bohnhorst, B; Bökenkamp, A; Brodehl, J; Offner, G, 1994)
"Chronic allograft nephropathy was significantly higher in patients receiving cyclosporine, possibly due to the risk of drug-induced nephrotoxicity, glomerular disease recurrence, and hypertension."5.13Steroid and azathioprine versus steroid, cyclosporine, and azathioprine therapies in primary haplo-identical living donor kidney transplantation: twenty-year experience. ( Bakr, MA; Bayoumy, A; Fouda, MA; Gheith, OA; Ghoneim, M; Shokeir, AA; Sobh, M, 2008)
"Angiotensin converting enzyme inhibitors (ACEI) and theophylline have been reported to decrease the elevated hemoglobin (Hgb) and hematocrit (Hct) levels in the renal transplant recipients with erythrocytosis."5.10A prospective, randomized, open labeled crossover trial of fosinopril and theophylline in post renal transplant erythrocytosis. ( Lal, SM; Trivedi, H, 2003)
"Fifty-two patients with severe rheumatoid arthritis (RA) from four Australian centres were randomised to receive cyclosporin A (CSA) (n = 25) or azathioprine (AZA) (n = 27) for six months."5.07A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis. ( Ahern, MJ; Bayliss, C; Bradley, J; Harrison, W; Hollingsworth, P; Laing, B, 1991)
"To assess the risk of long-term cardiovascular and metabolic outcomes and all-cause mortality in patients with pemphigus managed by rituximab compared with those receiving treatment with first-line corticosteroid-sparing agents (azathioprine and mycophenolate mofetil [MMF])."4.31Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus. ( Kridin, K; Ludwig, RJ; Mruwat, N, 2023)
"To compare the risk of incident hypertension between initiators of tumor necrosis factor (TNF)-α inhibitors and initiators of nonbiologic disease modifying antirheumatic drugs (hereafter referred to as nonbiologics) in rheumatoid arthritis patients taking methotrexate monotherapy."3.83Tumor Necrosis Factor-α Inhibitor Use and the Risk of Incident Hypertension in Patients with Rheumatoid Arthritis. ( Danaei, G; Desai, RJ; Kim, SC; Liao, KP; Schneeweiss, S; Solomon, DH, 2016)
" Is the evidence now sufficient to support the routine use of regimens including CNIs in LN? Although CNIs appear to have similar efficacy to MMF-based regimens as induction therapy, and are comparable with azathioprine as maintenance treatment, CNI toxicities, such as new-onset hypertension, hyperglycaemia and nephrotoxicity, have been problematic."3.83Con: The use of calcineurin inhibitors in the treatment of lupus nephritis. ( Fernandez Nieto, M; Jayne, DR, 2016)
" Compared to controls, cases were higher in body mass index, anti-dsDNA antibody, prevalence of hypertension, antiphospholipid syndrome, and use of immunosuppressive medication, especially azathioprine and methotrexate; they were lower in IgM."3.78Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus. ( Aghdassi, E; Fortin, PR; Gladman, DD; Hirschfield, GM; Huang, D; Mosko, J; Su, J; Urowitz, MB, 2012)
"Endothelin-1 (ET-1) has been associated with the development of hypertension in cyclosporine-treated renal transplant recipients."3.72Cyclosporine increases endothelin-1 plasma levels in renal transplant recipients. ( Cabral, RD; Cauduro, RL; Costa, C; Garcia, RG; Gonçalves, LE; Lhulier, F; Manfro, RC, 2004)
"Our report describes the outcome of a twin pregnancy in a woman who was maintained on tacrolimus after a living related renal transplant."3.70Outcome of twin pregnancy in a renal transplant recipient treated with tacrolimus. ( Anderson, V; Baqi, N; Hidalgo, G; Kumar, A; Markell, MS; Piecuch, S; Singh, A; Vyas, S, 1999)
"To determine whether cyclosporine A-induced hypertension in renal transplant recipients is accompanied by impairment of endothelium-dependent vasodilatation, which has been suggested by in-vitro and in-vivo animal experiments."3.70Forearm vasorelaxation in hypertensive renal transplant patients: the impact of withdrawal of cyclosporine. ( Lameris, TW; Man in't Veld, AJ; van den Dorpel, MA; van den Meiracker, AH; Weimar, W, 1998)
" 51Chromium-ethylenediamine tetraacetic acid, para-amino hippuric acid, lithium, and sodium clearances, measurements of serum and urinary electrolytes, and urinary concentration tests were performed."3.69Kidney function in cyclosporine-treated pediatric heart transplant recipients. ( Holmberg, C; Jalanko, H; Laine, J; Leijala, M; Sairanen, H, 1997)
"We studied rejection, allograft function and side effects, such as hypertension, renal dysfunction and hypercholesterolemia, in seven patients switched from cyclosporine-based triple-drug immunosuppression to FK 506."3.69Immunosuppression switch in pediatric heart transplant recipients: cyclosporine to FK 506. ( Armitage, JM; Fricker, FJ; Swenson, JM, 1995)
"Gingival hyperplasia is a common side-effect of immunosuppression with cyclosporine A."3.69Nifedipine aggravates cyclosporine A-induced gingival hyperplasia. ( Albers, N; Beier, C; Bohnhorst, B; Bökenkamp, A; Brodehl, J; Offner, G, 1994)
"Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone."3.68De novo hypertension after liver transplantation. ( Textor, SC, 1993)
"Hypertension in the cyclosporine group responded differently from that seen in the azathioprine group and from previously described forms of post-transplantation hypertension."3.67Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent. ( Curtis, JJ; Diethelm, AG; Jones, P; Luke, RG, 1988)
"The suggestion that hypertension is more prevalent in renal allograft recipients receiving cyclosporine (CyA), particularly those displaying nephrotoxicity, was tested by reviewing 200 patients' courses, including 92 cadaver (CAD) and 58 living-related (LRD) transplants using CyA and prednisone immunosuppression, and 19 CAD and 31 LRD transplants using azathioprine (Aza) and prednisone, all of whom had at least 1 year posttransplant complete outpatient follow-up."3.67Influence of cyclosporine on posttransplant blood pressure response. ( Flechner, SM; Jarowenko, MV; Kahan, BD; Lorber, MI; Van Buren, CT, 1987)
" Amelioration of proteinuria and the plasma coagulation defect followed therapy with corticosteroids and azathioprine."3.65Factor IX deficiency in the nephrotic syndrome: studies with prothrombin complex concentrate. ( Natelson, EA; Rahman, F; Zanger, B, 1975)
"Of 202 patients with dilated cardiomyopathy, 84 patients with increased HLA expression were randomized to receive either immunosuppression or placebo for 3 months; they were then followed for 2 years."2.70Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. ( Glanowska, G; Niklewski, T; Nowalany-Kozielska, E; Polonski, L; Rozek, MM; Wilczewski, P; Wodniecki, J; Wojciechowska, C; Wojnicz, R; Zembala, M, 2001)
" Development of this complication was associated with elevated intravenous FK 506 dosing schedules, with the mean cumulative dose 43% higher than treated patients with unaffected kidney function."2.67Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients. ( Bismuth, H; Calne, R; Devlin, J; Groth, C; McMaster, P; Neuhaus, P; Otto, G; Pichlmayr, R; Williams, R, 1994)
"Hypertension is a common complication after renal transplantation and is associated with increased mortality."2.66Hypertension after renal transplantation. A comparison of cyclosporine and conventional immunosuppression. ( Arias, M; Chapman, JR; Dunnill, MS; Marcen, R; Morris, PJ; Raine, AE, 1987)
"Forty-one patients with systemic lupus erythematosus and glomerulonephritis were studied in a randomized drug trial."2.65Alternative modes of cyclophosphamide and azathioprine therapy in lupus nephritis. ( Balow, JE; Decker, JL; Dinant, HJ; Klippel, JH; Plotz, PH; Steinberg, AD, 1982)
"One patient developed Kaposi sarcoma of the cervix."2.40[Pregnancy after heart and heart-lung transplantation. Apropos of 10 cases and review of the literature]. ( Fernandez, H; Frydman, R; Troché, V; Ville, Y, 1997)
" Immunologic and hematologic consequences included rejection episodes (25%), decreased cyclosporine requirement (higher levels with lower doses), and leukopenia that required azathioprine dosage reduction."2.39Steroid withdrawal after renal transplantation. ( Hricik, DE; Schulak, JA, 1994)
"Pregnancy hypertension was found in three pregnancies, one of which progressed to pre-eclampsia."1.91Pregnancy after kidney transplantation: Ibn Sina Rabat University hospital experience ( Azzouzi, A; Bayahia, R; Benamar, L; Bouattar, T; Driouch, L; Ouzeddoun, N, 2023)
"Pregnancy hypertension was found in three pregnancies, one of which progressed to pre-eclampsia."1.91Pregnancy after kidney transplantation: Ibn Sina Rabat University hospital experience ( Azzouzi, A; Bayahia, R; Benamar, L; Bouattar, T; Driouch, L; Ouzeddoun, N, 2023)
"We report a case of disseminated superficial actinic porokeratosis (DSAP) with neutrophilic pustules within cornoid lamellae on histopathologic examination, corresponding to pustules along the elevated rim clinically as well."1.35Pustular porokeratosis. ( Miller, DD; Ruben, BS, 2009)
"The most common variant was pemphigus vulgaris (79 %), and the sites most frequently affected were the oral mucosa, trunk, and scalp."1.35[Epidemiology of pemphigus in the Hospital Universitario Virgen Macarena, Seville, Spain, 2005-2006]. ( Camacho, FM; Coronel-Pérez, IM; Pérez-Bernal, AM; Rodríguez-Rey, EM, 2009)
"Azathioprine was given to 43."1.35Lupus nephritis among 624 cases of systemic lupus erythematosus in Riyadh, Saudi Arabia. ( Al Arfaj, AS; Al Saleh, S; Khalil, N, 2009)
"Tacrolimus has improved hyperlipidaemia in our cyclosporin previously treated patients and increased the resistance to oxidation of high and low-density lipoproteins."1.31[Effect of cyclosporin and tacrolimus on lipoprotein oxidation after renal transplantation]. ( Alsina, J; Fiol, C; Gil-Vernet, S; Gómez-Gerique, N; Grinyó, JM; Hurtado, I; Martínez Castelao, A; Ramos, R; Sabaté, I; Serón, D; Yzaguirre, MT, 2002)
"Hyperlipidemia (cholesterol, triglycerides) was more severe in hypertensive than in normotensive patients."1.30Hypertension is associated with hyperlipidemia, coronary heart disease and chronic graft failure in kidney transplant recipients. ( Bölscher, S; Geiger, H; Kachel, HG; Lenz, T; Peschke, B; Scheuermann, EH, 1999)
"Six were treated for hypertension."1.29Five years' follow-up of renal glomerular and tubular functions in heart transplant recipients. ( Andereassen, AK; Berg, KJ; Geiran, O; Hartmann, A; Holdaas, H; Simonsen, S, 1996)
"Mean birth weight was 2."1.28[Pregnancy after renal transplantation. 27 patients and review of the literature]. ( Edouard, D; Fernandez, H; Frydman, R; Ville, Y, 1992)
"One uncomplicated pregnancy is ongoing at 29 weeks' gestation."1.28[Pregnancy after hepatic transplantation. 17 pregnancies]. ( Bismuth, H; Fernandez, H; Frydman, R; Samuel, D; Ville, Y, 1992)
" CsA dosage remained unchanged in the range of 200 mg/m2/day; CsA whole blood trough level was 120 to 130 ng/mL throughout the years."1.28Long-term results of cyclosporin A therapy in children. ( Bökenkamp, A; Brodehl, J; Hoyer, PF; Offner, G, 1992)

Research

Studies (119)

TimeframeStudies, this research(%)All Research%
pre-199053 (44.54)18.7374
1990's39 (32.77)18.2507
2000's18 (15.13)29.6817
2010's6 (5.04)24.3611
2020's3 (2.52)2.80

Authors

AuthorsStudies
Kridin, K3
Mruwat, N3
Ludwig, RJ3
Driouch, L2
Azzouzi, A2
Ouzeddoun, N2
Benamar, L2
Bayahia, R2
Bouattar, T2
Patel, VN1
Kaelber, DC1
Rodrigues, M1
Amaral, D1
Barreira, JL1
Brito, I1
Desai, RJ1
Solomon, DH1
Schneeweiss, S1
Danaei, G1
Liao, KP1
Kim, SC1
Fernandez Nieto, M1
Jayne, DR1
Gheith, OA1
Bakr, MA1
Fouda, MA1
Shokeir, AA1
Bayoumy, A1
Sobh, M1
Ghoneim, M1
Al Arfaj, AS1
Khalil, N1
Al Saleh, S1
Coronel-Pérez, IM1
Rodríguez-Rey, EM1
Pérez-Bernal, AM1
Camacho, FM1
Miller, DD1
Ruben, BS1
Huang, D1
Aghdassi, E1
Su, J1
Mosko, J1
Hirschfield, GM1
Gladman, DD1
Urowitz, MB1
Fortin, PR1
Ayodele, OE1
Okpechi, IG1
Swanepoel, CR1
Jungraithmayr, T2
Staskewitz, A2
Kirste, G2
Böswald, M2
Bulla, M2
Burghard, R2
Dippell, J2
Greiner, C2
Klare, B2
Klaus, G2
Leichter, H1
Misselwitz, J2
Patzer, L1
Querfeld, U2
Rascher, W1
Tönshoff, B2
Wiesel, M2
Brandis, M1
Zimmerhackl, LB2
Martínez Castelao, A1
Ramos, R1
Serón, D1
Gil-Vernet, S1
Fiol, C1
Gómez-Gerique, N1
Yzaguirre, MT1
Hurtado, I1
Sabaté, I1
Alsina, J1
Grinyó, JM1
Helmchen, U1
Leichter, HE1
Mihatsch, MJ1
Michalk, DV1
Plank, C1
Weber, LT1
Trivedi, H1
Lal, SM1
QUIJANO, M1
GOMEZMONT, F1
ORTIZQUEZADA, F1
RONCES, R1
FIGUEROA, JE1
NAKAMOTO, S3
POUTASSE, EF2
KOLFF, WJ3
GOLDMAN, R1
GOODWIN, WE1
KAUFMAN, JJ1
MARTIN, DC1
GLASSOCK, RJ1
NOUROK, DS1
STRAFFON, RA1
Schulak, JA2
Cauduro, RL1
Costa, C1
Lhulier, F1
Garcia, RG1
Cabral, RD1
Gonçalves, LE1
Manfro, RC1
Kari, JA1
Trompeter, RS1
Hong, MKh1
Angus, PW1
Jones, RM1
Vaughan, RB1
Gow, PJ1
Edwards, NL1
Castro, LA1
Eigler, J1
Land, W1
Rankin, LI1
Hamilton, DV1
Carmichael, DJ1
Evans, DB2
Calne, RY3
Dinant, HJ1
Decker, JL1
Klippel, JH1
Balow, JE1
Plotz, PH1
Steinberg, AD1
Ben Hmida, M1
Baumelou, A1
Desruesnnes, M1
Cabrol, A1
Pavie, A1
Grandjbakhch, I1
Cabrol, C1
Swenson, JM1
Fricker, FJ1
Armitage, JM1
Punch, JD1
Shieck, VL1
Campbell, DA1
Bromberg, JS1
Turcotte, JG1
Merion, RM1
Hilbrands, LB1
Demacker, PN1
Hoitsma, AJ1
Stalenhoef, AF1
Koene, RA1
Maachi, K1
Berthoux, P1
Burgard, G1
Alamartine, E1
Berthoux, F1
Pabico, RC1
Yarger, J1
Byer, B1
Kremer, M1
McKenna, BA1
Cerilli, GJ1
Frem, GJ1
Rennke, HG1
Sayegh, MH1
Bökenkamp, A2
Bohnhorst, B1
Beier, C1
Albers, N1
Offner, G2
Brodehl, J2
Hricik, DE1
Gossmann, J1
Kachel, HG2
Schoeppe, W1
Scheuermann, EH2
Textor, SC1
Pham, SM1
Kormos, RL1
Kawai, A1
Murali, S1
Hattler, BG1
Demetris, AJ1
Griffith, BP1
Guan, D1
Wang, R1
Lu, J1
Wang, M1
Xu, C1
Kuriyama, R1
Kogure, H1
Itoh, S1
Kikuchi, K1
Ichikawa, N1
Nomura, Y1
Degawa, H1
Meigata, K1
Watanabe, K1
Beck, Y1
Tomikawa, S1
Nagao, T1
Uchida, H1
Boran, M1
Güneş, Z1
Doruk, F1
Gönenç, F1
Cetin, S1
Ader, JL1
Tack, I1
Durand, D1
Tran-Van, T1
Rostaing, L1
Suc, JM1
Hartmann, A1
Andereassen, AK1
Holdaas, H1
Simonsen, S1
Geiran, O1
Berg, KJ1
Jacobs, U1
Klein, B1
Miersch, WD1
Molitor, D1
Klehr, HU1
Laine, J1
Jalanko, H1
Leijala, M1
Sairanen, H1
Holmberg, C1
Troché, V1
Ville, Y3
Frydman, R3
Fernandez, H3
van den Dorpel, MA1
van den Meiracker, AH1
Lameris, TW1
Weimar, W1
Man in't Veld, AJ1
Walker, S1
Habib, S1
Thompson, D1
Khaghani, A1
Yacoub, M1
Banner, N1
Friemann, S1
Feuring, E1
Padberg, W1
Ernst, W1
Van Buren, D1
Payne, J1
Geevarghese, S1
MacDonell, R1
Chapman, W1
Wright, JK1
Helderman, JH1
Richie, R1
Pinson, CW1
Vyas, S1
Kumar, A1
Piecuch, S1
Hidalgo, G1
Singh, A1
Anderson, V1
Markell, MS1
Baqi, N1
Peschke, B1
Geiger, H1
Bölscher, S1
Lenz, T1
Pearson, ER1
D'Souza, RJ1
Hamilton-Wood, C1
Nicholls, AJ1
Beaman, M1
Shimizu, T1
Tanabe, K1
Tokumoto, T1
Ishikawa, N1
Shimmura, H1
Oshima, T1
Toma, H1
Yamaguchi, Y1
Devlin, J1
Williams, R1
Neuhaus, P1
McMaster, P1
Calne, R2
Pichlmayr, R2
Otto, G1
Bismuth, H2
Groth, C1
Jain, A1
Kashyap, R1
Marsh, W1
Rohal, S1
Khanna, A1
Fung, JJ1
Nakache, R1
Weinbroum, A1
Merhav, H1
Katz, P1
Kaplan, E1
Wojnicz, R1
Nowalany-Kozielska, E1
Wojciechowska, C1
Glanowska, G1
Wilczewski, P1
Niklewski, T1
Zembala, M1
Polonski, L1
Rozek, MM1
Wodniecki, J1
Müller, T1
Ruffingshofer, D1
Bidmon, B1
Arbeiter, K1
Balzar, E1
Aufricht, C1
Canavese, JC1
Jacquot, C1
Idatte, JM1
Bedrossian, J1
Weiss, Y1
Safar, M1
Bariety, J1
Kampf, D1
Höfer, W1
Misgeld, V1
Alexander, M1
Pierce, JC2
Kay, S1
Lee, HM3
Rahman, F1
Zanger, B1
Natelson, EA1
Jardim, HM1
Leake, J1
Risdon, RA1
Barratt, TM1
Dillon, MJ1
Thiel, G1
Fellmann, T1
Rosman, J1
Bock, A1
Landmann, J1
Mihatsch, M1
Edouard, D1
Samuel, D1
Hoyer, PF1
Ahern, MJ1
Harrison, W1
Hollingsworth, P1
Bradley, J1
Laing, B1
Bayliss, C1
Pirsch, JD1
Armbrust, MJ1
Knechtle, SJ1
Reed, A1
D'Alessandro, AM1
Sollinger, HW1
Belzer, FO1
Hiesse, C1
Neyrat, N1
Deglise-Favre, A1
Lantz, O1
Bensadoun, H1
Benoit, G1
Charpentier, B1
Fries, D1
Edwards, BS1
Hunt, SA1
Fowler, MB1
Valantine, HA1
Anderson, LM1
Lerman, A1
Delmonico, FL1
Conti, D1
Auchincloss, H1
Russell, PS1
Tolkoff-Rubin, N1
Fang, LT1
Cosimi, AB1
Scott, JP2
Hay, IF2
Higenbottam, TW2
Evans, D1
Vouhé, PR1
Le Bidois, J1
Dartevelle, P1
Touati, G1
Pouard, P1
Mauriat, P1
Jayais, P1
Sidi, D1
Kachaner, J1
Neveux, JY1
Hariharan, S1
First, MR1
Munda, R1
Penn, I1
Schroeder, TJ1
Fidler, J1
Weiskittel, P1
Alexander, JW1
Eid, A1
Perkins, JD1
Rakela, J1
Krom, RA1
Landsberg, D1
Rae, A1
Chiu, A1
Werb, R1
Taylor, P1
Chan-Yan, C1
Manson, AD1
Farrell, RJ1
Casale, AS1
Reitz, BA1
Greene, PS1
Augustine, S1
Baumgartner, WA1
Olmer, M1
Noordally, R1
Berland, Y1
Casanova, P1
Coulange, C1
Rampal, M1
Curtis, JJ1
Luke, RG1
Jones, P1
Diethelm, AG1
Kootte, AM1
Lensen, LM1
van Bockel, JH1
Paul, LC1
Schorn, T1
Frei, U1
Brackmann, H1
Lorenz, M1
Vogt, P1
Wiese, B1
Koch, KM1
Chapman, JR2
Marcen, R1
Arias, M1
Raine, AE1
Dunnill, MS1
Morris, PJ2
Jarowenko, MV1
Flechner, SM1
Van Buren, CT1
Lorber, MI1
Kahan, BD1
Frist, WH1
Stinson, EB1
Oyer, PE1
Baldwin, JC1
Shumway, NE1
Nunez, D1
Buscemi, G1
Giannetto, V1
Vaccaro, F1
Locascio, G1
Picone, FP1
Bellavia, C1
Romano, M1
Rapisarda, LM1
Najarian, JS1
Fryd, DS1
Strand, M1
Canafax, DM1
Ascher, NL1
Payne, WD1
Simmons, RL1
Sutherland, DE1
Jordan, ML1
Novick, AC1
Steinmuller, D1
Braun, W1
Buszta, C1
Mintz, D1
Goormastic, M1
Streem, S1
Barnhart, GR1
Hastillo, A1
Goldman, MH1
Szentpetery, S1
Wolfgang, TC1
Mohanakumar, T1
Katz, MR1
Rider, S1
Hanrahan, J1
Lower, RR1
Yacoub, MH1
Reid, CJ1
Al-Khadimi, RH1
Radley-Smith, R1
Ferguson, RM1
Sommer, BG1
Milford, EL1
Kirkman, RL1
Tilney, NL2
Strom, TB1
Carpenter, CB1
Friedman, A1
Kincaid-Smith, P1
Loughridge, L1
MacGillivray, JB1
Swales, JD1
Barnard, CN1
Strohmeyer, G1
Spuck, W1
Martini, GA1
Claman, HN1
Karr, RM1
Kohler, PF1
Mass, MF1
McIntosh, RM1
Sams, WM1
Small, P1
Stanford, RE1
Thorne, EG1
Williams, GM1
Hume, DM2
Bell, MJ1
Martin, LW1
Gonzales, LL1
McEnery, PT1
West, CD1
Sterling, WA1
Cade, R1
Spooner, G1
Schlein, E1
Pickering, M1
DeQuesada, A1
Holcomb, A1
Juncos, L1
Richard, G1
Shires, D1
Levin, D1
Hackett, R1
Free, J1
Hunt, R1
Fregly, M1
Rosenbaum, JL1
Akhtar, M1
Kramer, MS1
Raja, RM1
Manchanda, R1
Lazaro, N1
Makker, SP1
Heymann, W1
Scheitlin, W1
Brunner, F1
Stevens, LE1
Reemtsma, K1
Latimer, RG1
Maxwell, JG1
Weaver, DH1
Ward, JS1
Swenson, O1
Given, G1
King, LR1
Idriss, FS1
Ahmadian, Y1
Murray, JE1
Nies, AS1
Oates, JA1
Hokkanen, E1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Prospective Randomized Controlled Trial to Compare a Calcineurin Inhibitor Free Immunosuppression With a Low Dose Tacrolimus Based Immunosuppression in Old for Old Kidney Transplantation."[NCT00912678]Phase 490 participants (Actual)Interventional2002-03-31Completed
RANDOMIZED, MULTICENTRIC STUDY COMPARING THE EFFECT OF TWO REGIMENS OF COMBINED IMMUNOSUPPRESSIVE THERAPY IN THE TREATMENT OF INFLAMMATORY CARDIOMYOPATHY CZECH-ICIT (CZECH INFLAMMATORY CARDIOMYOPATHY IMMUNOSUPPRESSION TRIAL)[NCT01877746]Phase 3234 participants (Anticipated)Interventional2013-01-31Recruiting
Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry[NCT05158751]100 participants (Anticipated)Observational2023-01-31Not yet recruiting
Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients[NCT01157234]Phase 432 participants (Actual)Interventional2010-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Diastolic Blood Pressure (Millimeter, Mercury) Change From Baseline to Month-12 Between the Groups

Absolute Change in Diastolic Blood Pressure (DBP), (millimeter, Mercury)= Month-12 sitting trough Diastolic Blood Pressure (millimeter, Mercury) level minus baseline sitting trough Diastolic Blood Pressure (millimeter, Mercury). (NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionmillimeter, mercury (Least Squares Mean)
Nebivolol-0.66
Metoprolol-2.35

Estimated Glomerular Filtration Rate (ml/Minute) Change From Baseline to Month-12 Between the Groups

The changed percentage in Estimated Glomerular Filtration Rate (eGFR), (based on the Modification of Diet in Renal Disease Equation)=[Month-12 GFR level minus baseline eGFR level] divided by [baseline eGFR level] multiplied by 100, where all levels are in ml/min. (NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol2.16
Metoprolol10.43

Mean Arterial Blood Pressure (Millimeter, Mercury) Change From Baseline to Month-12 Between the Groups

"Absolute change in Mean Arterial Blood Pressure, (MAP), (millimeter, Mercury= Month-12 sitting trough MAP minus baseline sitting trough MAP.~Mean Arterial Pressure= 2/3 trough diastolic blood pressure + 1/3 trough systolic blood pressure" (NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionmillimeter, Mercury (Least Squares Mean)
Nebivolol-1.07
Metoprolol-3.19

Number of Antihypertensive Drug Classes Change From Baseline to Month-12 Between the Groups.

Percent change in quantity of Anti-Hypertensive Drug Classes (AHDC)=[Month-12 absolute number of AHDC minus baseline absolute number of AHDC] divided by [baseline absolute number of AHDC] multiplied by 100. (NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol-8.14
Metoprolol8.70

Percent Change in Plasma Nitric Oxide Level From Baseline to Month-12 of Treatment With Nebivolol in Transplant Recipients < 50 Years Old Compared With Metoprolol in Transplant Recipients < 50 Years Old

(NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol < 50 Years Old51.55
Metoprolol <50 Years Old-16.64

Percent Change in Plasma Nitric Oxide Level From Baseline to Month-12 of Treatment With Nebivolol in Transplant Recipients <50 Years Old Compared With Metoprolol in Transplant Recipients >/= 50 Years Old.

(NCT01157234)
Timeframe: Baseline and Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol <50 Year Old51.55
Metoprolol >/= 50 Year Old-17.99

Percent Change in Plasma Nitric Oxide Level From Baseline to Month-12 of Treatment With Nebivolol in Transplant Recipients >/= 50 Years Old Compared With Metoprolol in Transplant Recipients Age >/= 50 Years Old.

(NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol >/=50 Years Old-15.25
Metoprolol >/=50 Years Old-17.99

Percent Change in Plasma Nitric Oxide Level From Baseline to Month-twelve of Treatment With Nebivolol in Transplant Recipients >/= 50 Years Old Compared With Nebivolol in Transplant Recipients < 50 Years Old.

(NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol >/=50 Years Old-15.25
Metoprolol <50 Years Old-16.64

Plasma Nitric Oxide Level (Nmol/L) at Month-12 Between the Groups.

(NCT01157234)
Timeframe: 12 Months

Interventionnmol/L (Least Squares Mean)
Nebivolol50.07
Metoprolol38.13

Plasma Nitric Oxide Level Change From Baseline to Month 12 Between the Groups.

Percent change in Nitric Oxide (NO) blood level (nmol/L)=[Month-12 NO blood level minus baseline NO blood level] divided by [baseline NO blood level] multiplied by 100, where all levels are in nmol/L. (NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionpercent change (Least Squares Mean)
Nebivolol11.47
Metoprolol-17.27

Systolic Blood Pressure (Millimeter, Mercury) Change From Baseline to Month-12 of Treatment Between the Groups

Absolute change in Systolic Blood Pressure (SBP), (millimeter, Mercury)=Month-12 sitting trough SBP level minus baseline sitting trough SBP level (NCT01157234)
Timeframe: Change in Baseline, Month-12

Interventionmillimeter, Mercury (Least Squares Mean)
Nebivolol-2.65
Metoprolol-3.88

Reviews

8 reviews available for azathioprine and Hypertension

ArticleYear
Steroid immunosuppression in kidney transplantation: a passing era.
    The Journal of surgical research, 2004, Volume: 117, Issue:1

    Topics: Adrenal Cortex Hormones; Azathioprine; Blood Pressure; Cyclosporine; Diabetes Mellitus; Graft Reject

2004
What is the calcineurin inhibitor of choice for pediatric renal transplantation?
    Pediatric transplantation, 2004, Volume: 8, Issue:5

    Topics: Azathioprine; Calcineurin Inhibitors; Child; Clinical Trials as Topic; Cyclosporine; Growth and Deve

2004
[After care of kidney transplant patients].
    Der Internist, 1983, Volume: 24, Issue:9

    Topics: Adrenal Cortex Hormones; Aftercare; Antilymphocyte Serum; Azathioprine; Cyclosporins; Graft Rejectio

1983
Steroid withdrawal after renal transplantation.
    Clinical transplantation, 1994, Volume: 8, Issue:2 Pt 2

    Topics: Adrenal Cortex Hormones; Azathioprine; Blood Glucose; Cyclosporine; Drug Administration Schedule; Gr

1994
[Pregnancy after heart and heart-lung transplantation. Apropos of 10 cases and review of the literature].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1997, Volume: 26, Issue:6

    Topics: Adrenal Cortex Hormones; Azathioprine; Birth Weight; Cardiomyopathy, Hypertrophic; Cesarean Section;

1997
[Lupus erythematosus, modern aspects (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1977, May-10, Volume: 66, Issue:19

    Topics: Antacids; Antibodies, Antinuclear; Antigen-Antibody Complex; Azathioprine; Chlorambucil; Cyclophosph

1977
[Clinico-pathological correlations in lupus nephritis with reference to therapeutic and prognostic aspects (author's transl)].
    Immunitat und Infektion, 1979, Volume: 7, Issue:4

    Topics: Azathioprine; Female; Humans; Hypertension; Kidney; Lupus Erythematosus, Systemic; Male; Nephritis;

1979
Long-term safety profile of sandimmune in renal transplantation.
    Transplantation proceedings, 1992, Volume: 24, Issue:4 Suppl 2

    Topics: Azathioprine; Cadaver; Creatinine; Cyclosporine; Graft Rejection; Graft Survival; Humans; Hypertensi

1992

Trials

24 trials available for azathioprine and Hypertension

ArticleYear
Steroid and azathioprine versus steroid, cyclosporine, and azathioprine therapies in primary haplo-identical living donor kidney transplantation: twenty-year experience.
    Iranian journal of kidney diseases, 2008, Volume: 2, Issue:1

    Topics: Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Rejec

2008
Pediatric renal transplantation with mycophenolate mofetil-based immunosuppression without induction: results after three years.
    Transplantation, 2003, Feb-27, Volume: 75, Issue:4

    Topics: Acute Disease; Adolescent; Azathioprine; Blood Pressure; Child; Cyclosporine; Female; Follow-Up Stud

2003
A prospective, randomized, open labeled crossover trial of fosinopril and theophylline in post renal transplant erythrocytosis.
    Renal failure, 2003, Volume: 25, Issue:1

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Azathioprine; Biomar

2003
Alternative modes of cyclophosphamide and azathioprine therapy in lupus nephritis.
    Annals of internal medicine, 1982, Volume: 96, Issue:6 Pt 1

    Topics: Administration, Oral; Adult; Azathioprine; Clinical Trials as Topic; Creatinine; Cyclophosphamide; D

1982
Corticosteroid withdrawal after liver transplantation.
    Surgery, 1995, Volume: 118, Issue:4

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Azathioprine; Cyclosporine; Diabetes Mellitus,

1995
The effects of cyclosporine and prednisone on serum lipid and (apo)lipoprotein levels in renal transplant recipients.
    Journal of the American Society of Nephrology : JASN, 1995, Volume: 5, Issue:12

    Topics: Adult; Apolipoproteins; Arteriosclerosis; Azathioprine; Cholesterol, HDL; Cyclosporine; Female; Graf

1995
Results of a 1-year randomized controlled trial with omega-3 fatty acid fish oil in renal transplantation under triple immunosuppressive therapy.
    Transplantation proceedings, 1995, Volume: 27, Issue:1

    Topics: Adult; Analysis of Variance; Azathioprine; Creatinine; Cyclosporine; Drug Therapy, Combination; Fatt

1995
Effects of cyclosporine A on chronic renal transplant rejection.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Azathioprine; Blood Pressure; Child; Chronic Disease; Cyclosporine; Drug Therapy,

1994
Tacrolimus (FK 506) in clinical cardiac transplantation: a five-year experience.
    Transplantation proceedings, 1996, Volume: 28, Issue:2

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Communicable Diseases; Coronary Disease; Cyclosporine; Dr

1996
Effects of nicardipine on blood cyclosporine levels in renal transplant patients.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Adult; Azathioprine; Calcium Channel Blockers; Creatinine; Cyclosporine; Female; Humans; Hypertensio

1996
Impact of Sandimmune, Neoral, and Prograf on rejection incidence and renal function in primary liver transplant recipients.
    Transplantation proceedings, 1998, Volume: 30, Issue:5

    Topics: Adult; Analysis of Variance; Azathioprine; Communicable Diseases; Creatinine; Cyclosporine; Diabetes

1998
Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients.
    Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7 Suppl 1

    Topics: Adolescent; Adult; Aged; Azathioprine; Cohort Studies; Creatinine; Cyclosporine; Drug Therapy, Combi

1994
Management of massive proteinuria following renal transplantation with mycophenolate mofetil and blood pressure normalization.
    Transplantation proceedings, 2001, Volume: 33, Issue:3

    Topics: Azathioprine; Biopsy; Blood Pressure; Cholesterol; Creatinine; Cyclosporine; Drug Therapy, Combinati

2001
Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results.
    Circulation, 2001, Jul-03, Volume: 104, Issue:1

    Topics: Adult; Azathioprine; Biopsy; Cardiomyopathy, Dilated; Chronic Disease; Drug Therapy, Combination; En

2001
Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results.
    Circulation, 2001, Jul-03, Volume: 104, Issue:1

    Topics: Adult; Azathioprine; Biopsy; Cardiomyopathy, Dilated; Chronic Disease; Drug Therapy, Combination; En

2001
Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results.
    Circulation, 2001, Jul-03, Volume: 104, Issue:1

    Topics: Adult; Azathioprine; Biopsy; Cardiomyopathy, Dilated; Chronic Disease; Drug Therapy, Combination; En

2001
Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results.
    Circulation, 2001, Jul-03, Volume: 104, Issue:1

    Topics: Adult; Azathioprine; Biopsy; Cardiomyopathy, Dilated; Chronic Disease; Drug Therapy, Combination; En

2001
A randomised double-blind trial of cyclosporin and azathioprine in refractory rheumatoid arthritis.
    Australian and New Zealand journal of medicine, 1991, Volume: 21, Issue:6

    Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Blood Pressure; Creatinine; Cyclosporine; Double-B

1991
Randomized prospective trial of elective cyclosporine withdrawal from triple therapy at 6 months after cadaveric renal transplantation.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 2

    Topics: Azathioprine; Cyclosporins; Graft Survival; Humans; Hypertension; Immunosuppression Therapy; Kidney;

1991
Long-term, low-dose cyclosporine treatment of renal allograft recipients. A randomized trial.
    Transplantation, 1990, Volume: 49, Issue:5

    Topics: Adult; Azathioprine; Costs and Cost Analysis; Creatinine; Cyclosporins; Dose-Response Relationship,

1990
A randomized study comparing high- and low-dose regimens of cyclosporine in renal transplantation.
    Transplantation proceedings, 1988, Volume: 20, Issue:3 Suppl 3

    Topics: Azathioprine; Cyclosporins; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Survi

1988
Hypertension after renal transplantation. A comparison of cyclosporine and conventional immunosuppression.
    Transplantation, 1987, Volume: 43, Issue:6

    Topics: Adult; Azathioprine; Blood Pressure; Creatinine; Cyclosporins; Female; Humans; Hypertension; Immunos

1987
A single institution, randomized, prospective trial of cyclosporin versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients.
    Annals of surgery, 1985, Volume: 201, Issue:2

    Topics: Adolescent; Adult; Antilymphocyte Serum; Aspartate Aminotransferases; Azathioprine; Clinical Trials

1985
Cyclosporine nephrotoxicity and the consequences of conversion to azathioprine.
    Transplantation proceedings, 1985, Volume: 17, Issue:4 Suppl 1

    Topics: Azathioprine; Clinical Trials as Topic; Creatinine; Cyclosporins; Graft Rejection; Graft Survival; H

1985
A prospective randomized trial of pretransfusion/azathioprine/prednisone versus cyclosporine/prednisone immunosuppression in cardiac transplant recipients: preliminary results.
    Circulation, 1985, Volume: 72, Issue:3 Pt 2

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Clinical Trials as Topic; Cyclosporins; Drug Therapy, Com

1985
Clinical experience with cyclosporine and azathioprine at Brigham and Women's Hospital.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1985, Volume: 5, Issue:6

    Topics: Adult; Azathioprine; Cadaver; Clinical Trials as Topic; Cost-Benefit Analysis; Creatinine; Cyclospor

1985
Comparison of azathioprine, prednisone, and heparin alone or combined in treating lupus nephritis.
    Nephron, 1973, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Azathioprine; Child; Cushing Syndrome; Diabetes Mellitus; Drug Combinations; Fema

1973

Other Studies

87 other studies available for azathioprine and Hypertension

ArticleYear
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Pregnancy after kidney transplantation: Ibn Sina Rabat University hospital experience
    Nephrologie & therapeutique, 2023, 03-15, Volume: 19, Issue:1

    Topics: Azathioprine; Cesarean Section; Child; Child, Preschool; Creatinine; Female; Graft Rejection; Hospit

2023
Pregnancy after kidney transplantation: Ibn Sina Rabat University hospital experience
    Nephrologie & therapeutique, 2023, 04-26, Volume: 19, Issue:2

    Topics: Azathioprine; Cesarean Section; Child; Child, Preschool; Creatinine; Female; Graft Rejection; Hospit

2023
Using aggregated, de-identified electronic health record data for multivariate pharmacosurveillance: a case study of azathioprine.
    Journal of biomedical informatics, 2014, Volume: 52

    Topics: Adverse Drug Reaction Reporting Systems; Azathioprine; Data Mining; Drug-Related Side Effects and Ad

2014
Childhood polyarteritis nodosa presenting as stroke and arterial hypertension.
    BMJ case reports, 2014, Oct-29, Volume: 2014

    Topics: Adrenal Cortex Hormones; Antihypertensive Agents; Antirheumatic Agents; Azathioprine; Child; Cycloph

2014
Tumor Necrosis Factor-α Inhibitor Use and the Risk of Incident Hypertension in Patients with Rheumatoid Arthritis.
    Epidemiology (Cambridge, Mass.), 2016, Volume: 27, Issue:3

    Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine

2016
Con: The use of calcineurin inhibitors in the treatment of lupus nephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2016, Volume: 31, Issue:10

    Topics: Azathioprine; Calcineurin Inhibitors; Cyclophosphamide; Cyclosporine; Humans; Hyperglycemia; Hyperte

2016
Lupus nephritis among 624 cases of systemic lupus erythematosus in Riyadh, Saudi Arabia.
    Rheumatology international, 2009, Volume: 29, Issue:9

    Topics: Adolescent; Adult; Age of Onset; Azathioprine; Child; Cohort Studies; Cyclophosphamide; Drug Therapy

2009
[Epidemiology of pemphigus in the Hospital Universitario Virgen Macarena, Seville, Spain, 2005-2006].
    Actas dermo-sifiliograficas, 2009, Volume: 100, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Cushing Syndrome; Drug Therapy, Combination; Fem

2009
Pustular porokeratosis.
    Journal of cutaneous pathology, 2009, Volume: 36, Issue:11

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Human

2009
Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus.
    The Journal of rheumatology, 2012, Volume: 39, Issue:2

    Topics: Adult; Alanine Transaminase; Antibodies, Neutralizing; Antiphospholipid Syndrome; Aspartate Aminotra

2012
Long-term renal outcome and complications in South Africans with proliferative lupus nephritis.
    International urology and nephrology, 2013, Volume: 45, Issue:5

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Blood Pressure; Creatinine; Cyclophosphamide; Disease

2013
Prevalence of arterial hypertension and its morbidity in children and adolescents 3 years after renal transplantation with mycophenolate mofetil-based immunosuppression.
    Transplantation proceedings, 2002, Volume: 34, Issue:6

    Topics: Adolescent; Antihypertensive Agents; Azathioprine; Child; Cyclosporine; Graft Rejection; Humans; Hyp

2002
[Effect of cyclosporin and tacrolimus on lipoprotein oxidation after renal transplantation].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2002, Volume: 22, Issue:4

    Topics: Adult; Antihypertensive Agents; Apolipoproteins B; Arteriosclerosis; Azathioprine; Cholesterol; Cycl

2002
[FIRST EXPERIENCES IN RENAL TRANSPLANTATION IN HUMANS].
    Gaceta medica de Mexico, 1964, Volume: 94

    Topics: Acute Kidney Injury; Allergy and Immunology; Antineoplastic Agents; Azathioprine; Dactinomycin; Glom

1964
RENAL HOMOTRANSPLANTATION IN MAN; REPORT OF SIX CONSECUTIVE CASES.
    Annals of internal medicine, 1964, Volume: 61

    Topics: Adolescent; Anuria; Azathioprine; Blood Chemical Analysis; Dactinomycin; Drug Therapy; Hypertension;

1964
SIXTEEN CASES OF RENAL HOMOTRANSPLANTATION .
    Archives of internal medicine, 1964, Volume: 114

    Topics: Anuria; Azathioprine; Blood Group Incompatibility; Dactinomycin; Glomerulonephritis; Hypertension; I

1964
THE COURSE OF RENAL HYPERTENSION AFTER BILATERAL NEPHRECTOMY AND TRANSPLANTATION.
    Annals of the New York Academy of Sciences, 1964, Nov-30, Volume: 120

    Topics: Adolescent; Azathioprine; Fundus Oculi; Humans; Hypertension; Hypertension, Renal; Immunosuppressive

1964
CLINICAL EXPERIENCE WITH RENAL TRANSPLANTATION.
    British journal of urology, 1965, Volume: 37

    Topics: Azathioprine; Cadaver; Dactinomycin; Drug Therapy; Hemorrhage; Humans; Hypertension; Immunosuppressi

1965
Cyclosporine increases endothelin-1 plasma levels in renal transplant recipients.
    Transplantation proceedings, 2004, Volume: 36, Issue:4

    Topics: Adult; Azathioprine; Blood Pressure; Cyclosporine; Endothelin-1; Female; Follow-Up Studies; Humans;

2004
Predictors of improvement in renal function after calcineurin inhibitor withdrawal for post-liver transplant renal dysfunction.
    Clinical transplantation, 2005, Volume: 19, Issue:2

    Topics: Azathioprine; Calcineurin Inhibitors; Creatinine; Diabetes Complications; Enzyme Inhibitors; Female;

2005
Case 9: initiation of urate-lowering therapy for advanced gout complicated by chronic renal insufficiency.
    The American journal of medicine, 2006, Volume: 119, Issue:11 Suppl 1

    Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Contraindications; Drug Interact

2006
Nephrotic syndrome and pregnancy. Potential problems for mother and child.
    Postgraduate medicine, 1984, Nov-01, Volume: 76, Issue:6

    Topics: Adrenal Cortex Hormones; Antihypertensive Agents; Azathioprine; Cyclophosphamide; Female; Humans; Hy

1984
Hypertension in renal transplant recipients on cyclosporin A and corticosteroids and azathioprine.
    Transplantation proceedings, 1982, Volume: 14, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Cyclosporins; Dose-Response Relation

1982
Long-term nephrotoxicity of low doses of cyclosporine in heart transplant recipients.
    Transplantation proceedings, 1995, Volume: 27, Issue:5

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Creatinine; Cyclosporine; Female; Follow-Up Studies; Hear

1995
Immunosuppression switch in pediatric heart transplant recipients: cyclosporine to FK 506.
    Journal of the American College of Cardiology, 1995, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Antihypertensive Agents; Azathioprine; Cardiac Catheterization; Child; Cyclospori

1995
Late renal allograft failure secondary to thrombotic microangiopathy-human immunodeficiency virus nephropathy.
    Journal of the American Society of Nephrology : JASN, 1994, Volume: 4, Issue:9

    Topics: Adult; AIDS-Associated Nephropathy; Azathioprine; Cyclosporine; Graft Rejection; Humans; Hypertensio

1994
Nifedipine aggravates cyclosporine A-induced gingival hyperplasia.
    Pediatric nephrology (Berlin, Germany), 1994, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Gingival Hyperplas

1994
Anemia in renal transplant recipients caused by concomitant therapy with azathioprine and angiotensin-converting enzyme inhibitors.
    Transplantation, 1993, Volume: 56, Issue:3

    Topics: Adult; Anemia; Angiotensin-Converting Enzyme Inhibitors; Azathioprine; Enalapril; Female; Hematocrit

1993
De novo hypertension after liver transplantation.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:2

    Topics: Adult; Azathioprine; Cyclosporine; Humans; Hypertension; Immunosuppression Therapy; Labetalol; Liver

1993
Angiotensin converting enzyme inhibitor induced anemia in a kidney transplant recipient.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Adult; Anemia; Angiotensin-Converting Enzyme Inhibitors; Azathioprine; Drug Therapy, Combination; En

1996
Improvement in cyclosporine A associated gingival hyperplasia with azithromycin therapy.
    Transplantation proceedings, 1996, Volume: 28, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Azathioprine; Azithromycin; Calcium Channel Blockers; Cyclosporine; Fe

1996
Renal functional reserve in kidney and heart transplant recipients.
    Journal of the American Society of Nephrology : JASN, 1996, Volume: 7, Issue:8

    Topics: Adult; Aldosterone; Amino Acids; Azathioprine; Creatinine; Cyclosporine; Female; Glomerular Filtrati

1996
Five years' follow-up of renal glomerular and tubular functions in heart transplant recipients.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1996, Volume: 15, Issue:10

    Topics: Albuminuria; Antihypertensive Agents; Azathioprine; Cyclosporine; Female; Follow-Up Studies; Glomeru

1996
Dilemma: maintenance therapy enhances sclerogenic risk profile.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Adult; Age Factors; Aged; Antihypertensive Agents; Arteriosclerosis; Azathioprine; Cholesterol; Cort

1996
Kidney function in cyclosporine-treated pediatric heart transplant recipients.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1997, Volume: 16, Issue:12

    Topics: Adolescent; Azathioprine; Biopsy; Chelating Agents; Child; Child, Preschool; Chromium Radioisotopes;

1997
Forearm vasorelaxation in hypertensive renal transplant patients: the impact of withdrawal of cyclosporine.
    Journal of hypertension, 1998, Volume: 16, Issue:3

    Topics: Adult; Animals; Azathioprine; Blood Flow Velocity; Blood Pressure; Cyclosporine; Dinoprostone; Endot

1998
Risks and benefits of withdrawing cyclosporine from the long-term immunosuppression regimen of heart and heart-lung transplant recipients.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Adult; Aged; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Graft

1998
Improvement of nephrotoxicity, hypertension, and lipid metabolism after conversion of kidney transplant recipients from cyclosporine to tacrolimus.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Adult; Aged; Azathioprine; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cyclospo

1998
Outcome of twin pregnancy in a renal transplant recipient treated with tacrolimus.
    Transplantation, 1999, Feb-15, Volume: 67, Issue:3

    Topics: Azathioprine; Cesarean Section; Cyclosporine; Fatal Outcome; Female; Graft Rejection; Humans; Hypert

1999
Hypertension is associated with hyperlipidemia, coronary heart disease and chronic graft failure in kidney transplant recipients.
    Clinical nephrology, 1999, Volume: 51, Issue:5

    Topics: Azathioprine; Coronary Disease; Cyclosporine; Graft Rejection; Humans; Hyperlipidemias; Hypertension

1999
Hypertensive encephalopathy and nephrotic syndrome: a possible link?
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:7

    Topics: Anti-Inflammatory Agents; Antihypertensive Agents; Azathioprine; Brain Diseases; Calcium Channel Blo

1999
Risk factors of acute tacrolimus nephrotoxicity in renal allografts.
    Transplantation proceedings, 2000, Volume: 32, Issue:7

    Topics: ABO Blood-Group System; Adult; Age Factors; Azathioprine; Blood Group Incompatibility; Creatinine; D

2000
Reasons for long-term use of steroid in primary adult liver transplantation under tacrolimus.
    Transplantation, 2001, Apr-27, Volume: 71, Issue:8

    Topics: Adult; Azathioprine; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Hyperlipidemias; Hyperten

2001
Reduction of delayed renal allograft function using sequential immunosuppression.
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:8

    Topics: Antibodies; Azathioprine; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; Glucoco

2001
Long-term blood pressure changes in renal homotransplantation.
    Archives of internal medicine, 1978, Volume: 138, Issue:2

    Topics: Adult; Aged; Animals; Antilymphocyte Serum; Azathioprine; Blood Pressure; Cyclophosphamide; Dose-Res

1978
Donor-specific IgG antibody and the chronic rejection of human renal allografts.
    Surgery, 1975, Volume: 78, Issue:1

    Topics: Adult; Antibodies, Anti-Idiotypic; Antibody Specificity; Azathioprine; Basement Membrane; Child; Cyc

1975
Factor IX deficiency in the nephrotic syndrome: studies with prothrombin complex concentrate.
    The Journal of urology, 1975, Volume: 113, Issue:6

    Topics: Azathioprine; Coagulants; Factor X; Female; Hemophilia B; Humans; Hypertension; Middle Aged; Nephrot

1975
Crescentic glomerulonephritis in children.
    Pediatric nephrology (Berlin, Germany), 1992, Volume: 6, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Anticoagulants; Azathioprine; Child; Child, Preschool; Cyclopho

1992
[Pregnancy after renal transplantation. 27 patients and review of the literature].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1992, Volume: 21, Issue:6

    Topics: Adult; Azathioprine; Birth Weight; Cesarean Section; Cyclosporine; Drug Therapy, Combination; Female

1992
[Pregnancy after hepatic transplantation. 17 pregnancies].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1992, Volume: 21, Issue:6

    Topics: Abortion, Spontaneous; Abortion, Therapeutic; Adolescent; Adrenal Cortex Hormones; Adult; Azathiopri

1992
Long-term results of cyclosporin A therapy in children.
    Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:12 Suppl

    Topics: Adolescent; Antihypertensive Agents; Azathioprine; Child; Child, Preschool; Cyclosporine; Female; Fo

1992
Effect of steroid withdrawal on hypertension and cholesterol levels in living related recipients.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 2

    Topics: Azathioprine; Body Weight; Cholesterol; Creatinine; Cyclosporins; Humans; Hypertension; Immunosuppre

1991
Effect of cyclosporine on plasma endothelin levels in humans after cardiac transplantation.
    The American journal of cardiology, 1991, Apr-01, Volume: 67, Issue:8

    Topics: Adult; Azathioprine; Blood Pressure; Creatinine; Cyclosporins; Endothelins; Female; Heart Transplant

1991
Hypertensive exercise responses in ciclosporin-treated normotensive renal transplant recipients.
    Nephron, 1990, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Azathioprine; Blood Pressure; Cyclosporins; Exercise; Humans; Hypertension; Kidne

1990
Heart- and heart-lung transplantation in children.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 1989, Volume: 3, Issue:3

    Topics: Acute Kidney Injury; Azathioprine; Child; Child, Preschool; Cyclosporins; Drug Therapy, Combination;

1989
Prednisone withdrawal in HLA-identical living related donor transplant recipients.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 2

    Topics: Adult; Azathioprine; Female; Follow-Up Studies; Graft Rejection; Graft Survival; Histocompatibility

1989
Conversion from standard cyclosporine to low-dose cyclosporine in liver transplant recipients: effect on nephrotoxicity and hypertension beyond one year.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 2

    Topics: Azathioprine; Blood Pressure; Cyclosporins; Dose-Response Relationship, Drug; Drug Therapy, Combinat

1989
The effect of triple therapy on cyclosporine nephrotoxicity and hypertension in renal transplantation.
    Transplantation proceedings, 1989, Volume: 21, Issue:2

    Topics: Adult; Aged; Azathioprine; Creatinine; Cyclosporins; Drug Administration Schedule; Drug Therapy, Com

1989
Cyclosporine-associated hypertension.
    The American journal of medicine, 1989, Volume: 86, Issue:6 Pt 1

    Topics: Azathioprine; Cyclosporins; Humans; Hypertension; Kidney Transplantation; Renin-Angiotensin System

1989
Immunosuppression after heart transplantation: prednisone and cyclosporine with and without azathioprine.
    The Journal of thoracic and cardiovascular surgery, 1989, Volume: 98, Issue:5 Pt 2

    Topics: Actuarial Analysis; Adult; Azathioprine; Bacterial Infections; Cyclosporins; Drug Therapy, Combinati

1989
Hypertension in renal transplantation.
    Kidney international. Supplement, 1988, Volume: 25

    Topics: Angiography; Angioplasty, Balloon; Arterial Occlusive Diseases; Azathioprine; Blood Pressure; Constr

1988
Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent.
    The American journal of medicine, 1988, Volume: 85, Issue:2

    Topics: Adult; Azathioprine; Cyclosporins; Diet, Sodium-Restricted; Female; Humans; Hypertension; Kidney Tra

1988
Cyclosporine-associated posttransplant hypertension incidence and effect on renal transplant function.
    Transplantation proceedings, 1988, Volume: 20, Issue:3 Suppl 3

    Topics: Azathioprine; Cyclosporins; Diuretics; Dose-Response Relationship, Drug; Graft Survival; Humans; Hyp

1988
Influence of cyclosporine on posttransplant blood pressure response.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Antihypertensive Agents; Azathioprine; Blood Pressure; Cyclosporins; Drug Adminis

1987
Long-term hemodynamic results after cardiac transplantation.
    The Journal of thoracic and cardiovascular surgery, 1987, Volume: 94, Issue:5

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Cardiac Catheterization; Cyclosporins; Female; Follow-

1987
Exercise-induced hypertension in normotensive renal transplant recipients receiving cyclosporine A.
    Transplantation proceedings, 1987, Volume: 19, Issue:5

    Topics: Azathioprine; Cyclosporins; Exercise Test; Humans; Hypertension; Kidney Transplantation; Oxygen Cons

1987
Correlation of increased serum calcium fractions with the onset of cyclosporine-associated hypertension in renal transplant patients.
    Transplantation proceedings, 1987, Volume: 19, Issue:5

    Topics: Azathioprine; Calcium; Cyclosporins; Humans; Hypertension; Kidney Transplantation; Methylprednisolon

1987
Renal transplantation in the older recipient.
    The Journal of urology, 1985, Volume: 134, Issue:2

    Topics: Age Factors; Antilymphocyte Serum; Azathioprine; Cadaver; Cardiomyopathies; Coronary Disease; Diabet

1985
Cardiac transplantation--the London experience.
    Zeitschrift fur Kardiologie, 1985, Volume: 74 Suppl 6

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Cyclosporins; Drug Therapy, Combina

1985
Cyclosporine in renal transplantation: a single institutional experience.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1985, Volume: 5, Issue:6

    Topics: Azathioprine; Blood Pressure; Cadaver; Cost-Benefit Analysis; Cyclosporins; Drug Evaluation; Follow-

1985
Arteritis with impaired renal function.
    Perspectives in nephrology and hypertension, 1973, Volume: 1 Pt 2, Issue:0

    Topics: Adult; Aged; Anticoagulants; Azathioprine; Biopsy; Cyclophosphamide; Dipyridamole; Drug Therapy, Com

1973
Further observations on renal transplants in man from cadaveric donors.
    British medical journal, 1966, Dec-03, Volume: 2, Issue:5526

    Topics: Adult; Anti-Bacterial Agents; Azathioprine; Blood Pressure Determination; Cadaver; Calcium; Dactinom

1966
Human heart transplantation.
    Canadian Medical Association journal, 1969, Jan-18, Volume: 100, Issue:3

    Topics: Antibodies, Anti-Idiotypic; Azathioprine; Cardiac Catheterization; Cardiac Output; Cardiomegaly; Car

1969
[What is guaranteed in the therapy of chronic hepatitis?].
    Der Internist, 1973, Volume: 14, Issue:12

    Topics: Acne Vulgaris; Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Diabetes Mellitus; Gastrointe

1973
Systemic (allergic?) vasculitis.
    The Journal of allergy and clinical immunology, 1974, Volume: 54, Issue:1

    Topics: Antigen-Antibody Complex; Azathioprine; Complement System Proteins; Creatinine; Diphenhydramine; Ery

1974
Renal transplants in children.
    Transplantation proceedings, 1969, Volume: 1, Issue:1

    Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Azathioprine; Child; Epiphyses, Slipped; F

1969
Alternate-day single-dose prednisone therapy: a method of reducing steroid toxicity.
    Journal of pediatric surgery, 1972, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Azathioprine; Bacterial Infections; Bone Diseases; Cataract; Child; Child, Presch

1972
Rehabilitation of retransplant patients.
    Transplantation proceedings, 1972, Volume: 4, Issue:4

    Topics: Azathioprine; Bone Diseases; Creatinine; Fractures, Spontaneous; Graft Rejection; Humans; Hypertensi

1972
Evaluation of clearance studies in lupus nephritis.
    Clinical nephrology, 1974, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Aminohippuric Acids; Azathioprine; Biopsy; Blood Sedimentation; Creatinine; Femal

1974
The idiopathic nephrotic syndrome of childhood. A clinical reevaluation of 148 cases.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:6

    Topics: Adolescent; Antistreptolysin; Azathioprine; Bacteriuria; Blood Urea Nitrogen; Child; Child, Preschoo

1974
[Follow-up studies of Zurich clinical cases].
    Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie, 1967, Volume: 143, Issue:3

    Topics: Adult; Azathioprine; Cadaver; Chronic Disease; Follow-Up Studies; Glomerulonephritis; Hematologic Di

1967
A regional project in hemodialysis and transplantation.
    Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 100, Issue:4

    Topics: Anti-Glomerular Basement Membrane Disease; Antilymphocyte Serum; Azathioprine; Cadaver; Calcium Meta

1970
Kidney transplants in children.
    Journal of pediatric surgery, 1971, Volume: 6, Issue:3

    Topics: Adolescent; Antilymphocyte Serum; Azathioprine; Child; Child, Preschool; Female; Follow-Up Studies;

1971
Severe temporary deterioration of renal transplant function following meningococcemia.
    Transplantation proceedings, 1971, Volume: 3, Issue:2

    Topics: Adolescent; Antigens; Antigens, Bacterial; Azathioprine; Child; Cross Reactions; Female; Graft Rejec

1971
Clinicopathologic conference: hypertension and the lupus syndrome--revisited.
    The American journal of medicine, 1971, Volume: 51, Issue:6

    Topics: Allopurinol; Azathioprine; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Drug Interactions; H

1971
Myasthenia gravis. A clinical analysis of the total material from Finland with special reference to endocrinological and neurological disorders.
    Annals of clinical research, 1969, Volume: 1, Issue:2

    Topics: Age Factors; Ambenonium Chloride; Azathioprine; Cortisone; Diabetes Complications; Disability Evalua

1969