azathioprine has been researched along with Hypertension, Portal in 29 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three cases of nodular regenerative hyperplasia of the liver associated with azathioprine therapy are reported." | 8.78 | [Nodular regenerative hyperplasia of the liver associated with azathioprine therapy]. ( Dhumeaux, D; Duvoux, C; Kracht, M; Lang, P; Vernant, JP; Zafrani, ES, 1991) |
| "We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver." | 7.77 | [Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. ( Corbatón, P; de la Fuente-Fernández, E; Gisbert, JP; López-Martín, C; Sánchez, MC, 2011) |
| "Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years." | 7.68 | Long term treatment of myasthenia gravis with azathioprine. ( Fonseca, V; Havard, CW, 1990) |
| "A 52 year old man with myasthenia gravis and normal liver function was treated with neostigmine, prednisolone and azathioprine." | 7.67 | Portal hypertension secondary to azathioprine in myasthenia gravis. ( Fonseca, V; Havard, CW, 1988) |
| "Three cases of nodular regenerative hyperplasia of the liver associated with azathioprine therapy are reported." | 4.78 | [Nodular regenerative hyperplasia of the liver associated with azathioprine therapy]. ( Dhumeaux, D; Duvoux, C; Kracht, M; Lang, P; Vernant, JP; Zafrani, ES, 1991) |
| "We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver." | 3.77 | [Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. ( Corbatón, P; de la Fuente-Fernández, E; Gisbert, JP; López-Martín, C; Sánchez, MC, 2011) |
| " Both patients had been treated with azathioprine and prednisolone for 6 years and 4 months and for 4 years and 7 months, respectively, and presented with splenomegaly and thrombocytopenia suggesting hypersplenism." | 3.69 | Idiopathic portal hypertension in renal transplant recipients: report of two cases. ( Kobashi, T; Kohnosu, H; Ohmori, Y; Oka, T; Yasumura, T; Yoshimura, N, 1994) |
| "Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years." | 3.68 | Long term treatment of myasthenia gravis with azathioprine. ( Fonseca, V; Havard, CW, 1990) |
| "A 52 year old man with myasthenia gravis and normal liver function was treated with neostigmine, prednisolone and azathioprine." | 3.67 | Portal hypertension secondary to azathioprine in myasthenia gravis. ( Fonseca, V; Havard, CW, 1988) |
| "Factors associated with HCV recurrence were evaluated." | 2.79 | Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes. ( Burroughs, AK; Cholongitas, E; Corbani, A; Davidson, B; Davidson, J; Dhillon, AP; Hayes, P; Luong, T; Manousou, P; McCormick, PA; O'Beirne, J; Patch, D; Rodríguez-Perálvarez, M; Rolles, K; Samonakis, D; Thorburn, D; Tsochatzis, E, 2014) |
| "The fibroscan data showed significant liver fibrosis (F2-F3)." | 1.43 | Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease. ( Abreu García, L; Calleja Panero, JL; Calvo Moya, M; González Lama, Y; González Partida, I; Llop Herrera, E; Matallana Royo, V; Suárez Ferrer, C; Vera Mendoza, MI, 2016) |
| "Azathioprine is a useful agent for the treatment of Crohn's disease but side effects occur in 10% of patients." | 1.31 | Portal hypertension in the presence of minimal liver damage in Crohn's disease on long-term azathioprine: possible endothelial cell injury. ( Arnott, ID; Ghosh, S, 2000) |
| "Treatment with azathioprine and prednisolone for immunosuppression had been discontinued 1 year before admission." | 1.28 | Idiopathic portal hypertension in a renal transplant patient after long-term azathioprine therapy. ( Becker, K; Brauer, M; Classen, M; Lorenz, R; Tornieporth, N, 1992) |
| "Azathioprine was discontinued." | 1.27 | Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. ( Adler, M; Cremer, M; De Pauw, L; Delhaye, M; Deprez, C; Gelin, M; Hardy, N; Toussaint, C; Vereerstraeten, P, 1987) |
| " These observations strongly suggest an association between chronic use of azathioprine and the development of venous congestion of the liver with sinusoidal dilatation, eventually resulting in chronic liver disease." | 1.27 | Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation. ( Assmann, KM; Deckers, PF; Driessen, WM; Gerlag, PG; Lobatto, S; Schröder, E; Van Haelst, UJ; Van Hooff, JP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (31.03) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 4 (13.79) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Lanis, A | 1 |
| Volochayev, R | 1 |
| Kleiner, DE | 1 |
| Vittal, A | 1 |
| Heller, T | 1 |
| Rider, LG | 1 |
| Shenoi, S | 1 |
| Gilissen, LPL | 1 |
| Tajzai, R | 1 |
| Romberg, M | 1 |
| Pierik, M | 1 |
| Stronkhorst, A | 1 |
| Steenhuisen, K | 1 |
| Van Bodegraven, A | 1 |
| Daniels, A | 1 |
| Wong, D | 1 |
| Manousou, P | 2 |
| Cholongitas, E | 2 |
| Samonakis, D | 2 |
| Tsochatzis, E | 1 |
| Corbani, A | 1 |
| Dhillon, AP | 2 |
| Davidson, J | 1 |
| Rodríguez-Perálvarez, M | 1 |
| Patch, D | 2 |
| O'Beirne, J | 2 |
| Thorburn, D | 1 |
| Luong, T | 1 |
| Rolles, K | 2 |
| Davidson, B | 1 |
| McCormick, PA | 1 |
| Hayes, P | 2 |
| Burroughs, AK | 2 |
| Dooremont, D | 1 |
| Decaestecker, J | 1 |
| De Wulf, D | 1 |
| Ghillebert, G | 1 |
| Van Vlierberghe, H | 1 |
| Van Dorpe, J | 1 |
| Baert, F | 1 |
| Suárez Ferrer, C | 1 |
| Llop Herrera, E | 1 |
| Calvo Moya, M | 1 |
| Vera Mendoza, MI | 1 |
| González Partida, I | 1 |
| González Lama, Y | 1 |
| Matallana Royo, V | 1 |
| Calleja Panero, JL | 1 |
| Abreu García, L | 1 |
| McCormick, A | 1 |
| López-Martín, C | 1 |
| de la Fuente-Fernández, E | 1 |
| Corbatón, P | 1 |
| Sánchez, MC | 1 |
| Gisbert, JP | 1 |
| Calabrese, E | 1 |
| Hanauer, SB | 1 |
| Vernier-Massouille, G | 1 |
| Cosnes, J | 1 |
| Lemann, M | 1 |
| Marteau, P | 1 |
| Reinisch, W | 1 |
| Laharie, D | 1 |
| Cadiot, G | 1 |
| Bouhnik, Y | 1 |
| De Vos, M | 1 |
| Boureille, A | 1 |
| Duclos, B | 1 |
| Seksik, P | 1 |
| Mary, JY | 1 |
| Colombel, JF | 1 |
| Ehmsen, L | 1 |
| Marko, C | 1 |
| Breidert, M | 1 |
| Noël, C | 1 |
| Hazzan, M | 1 |
| Coppin, MC | 1 |
| Bridoux, F | 1 |
| Codaccioni, MX | 1 |
| Pruvot, FR | 1 |
| Yoshimura, N | 1 |
| Oka, T | 1 |
| Ohmori, Y | 1 |
| Yasumura, T | 1 |
| Kohnosu, H | 1 |
| Kobashi, T | 1 |
| Elariny, HA | 1 |
| Mizrahi, SS | 1 |
| Hayes, DH | 1 |
| Boudreaux, JP | 1 |
| Hussey, JL | 1 |
| Farr, GH | 1 |
| Gane, E | 1 |
| Portmann, B | 1 |
| Saxena, R | 1 |
| Wong, P | 1 |
| Ramage, J | 1 |
| Williams, R | 2 |
| Roland, S | 1 |
| Delwaide, J | 1 |
| Cornet, G | 1 |
| Mahieu, P | 1 |
| Jacquet, N | 1 |
| Belaiche, J | 1 |
| Arnott, ID | 1 |
| Ghosh, S | 1 |
| Nataf, C | 1 |
| Feldmann, G | 1 |
| Lebrec, D | 1 |
| Degott, C | 1 |
| Descamps, JM | 1 |
| Rueff, B | 1 |
| Benhamou, JP | 1 |
| Cello, JP | 1 |
| Lorenz, R | 1 |
| Brauer, M | 1 |
| Classen, M | 1 |
| Tornieporth, N | 1 |
| Becker, K | 1 |
| Duvoux, C | 1 |
| Kracht, M | 1 |
| Lang, P | 1 |
| Vernant, JP | 1 |
| Zafrani, ES | 1 |
| Dhumeaux, D | 1 |
| Fonseca, V | 2 |
| Havard, CW | 2 |
| Yanagisawa, N | 1 |
| Sugaya, H | 1 |
| Yunomura, K | 1 |
| Harada, T | 1 |
| Hisauchi, T | 1 |
| Read, AE | 1 |
| Wiesner, RH | 1 |
| LaBrecque, DR | 1 |
| Tifft, JG | 1 |
| Mullen, KD | 1 |
| Sheer, RL | 1 |
| Petrelli, M | 1 |
| Ricanati, ES | 1 |
| McCullough, AJ | 1 |
| Adler, M | 1 |
| Delhaye, M | 1 |
| Deprez, C | 1 |
| Hardy, N | 1 |
| Gelin, M | 1 |
| De Pauw, L | 1 |
| Vereerstraeten, P | 1 |
| Cremer, M | 1 |
| Toussaint, C | 1 |
| Gerlag, PG | 2 |
| van Hooff, JP | 2 |
| Warnes, TW | 1 |
| Lobatto, S | 1 |
| Driessen, WM | 1 |
| Deckers, PF | 1 |
| Schröder, E | 1 |
| Assmann, KM | 1 |
| Van Haelst, UJ | 1 |
| Murray-Lyon, IM | 1 |
| Stern, RB | 1 |
5 reviews available for azathioprine and Hypertension, Portal
| Article | Year |
|---|---|
Azathioprine induced serious portal hypertension: a case series of three IBD patients and review of the literature.
Topics: Adult; Azathioprine; Humans; Hypertension, Portal; Immunosuppressive Agents; Inflammatory Bowel Dise | 2013 |
Assessment of non-cirrhotic portal hypertension associated with thiopurine therapy in inflammatory bowel disease.
Topics: Azathioprine; Crohn Disease; Humans; Hypertension, Portal; Immunosuppressive Agents; Liver; Male; Me | 2011 |
Nodular regenerative hyperplasia: a controversial indication for orthotopic liver transplantation.
Topics: Adult; Azathioprine; Female; Humans; Hyperplasia; Hypertension, Portal; Kidney Transplantation; Live | 1994 |
[Nodular regenerative hyperplasia of the liver associated with azathioprine therapy].
Topics: Adult; Azathioprine; Graft vs Host Disease; Humans; Hyperplasia; Hypertension, Portal; Immunosuppres | 1991 |
Treatment of primary biliary cirrhosis.
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cholelithiasis; Colchicine | 1985 |
3 trials available for azathioprine and Hypertension, Portal
| Article | Year |
|---|---|
Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes.
Topics: Anti-Inflammatory Agents; Azathioprine; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Hum | 2014 |
Outcome of recurrent hepatitis C virus after liver transplantation in a randomized trial of tacrolimus monotherapy versus triple therapy.
Topics: Adolescent; Adult; Aged; Azathioprine; Biopsy; Child; Drug Therapy, Combination; Female; Graft Rejec | 2009 |
Controlled trial of prednisone and azathioprine in active chronic hepatitis.
Topics: Adult; Alkaline Phosphatase; Antibodies; Antibodies, Antinuclear; Aspartate Aminotransferases; Azath | 1973 |
21 other studies available for azathioprine and Hypertension, Portal
| Article | Year |
|---|---|
Nodular Regenerative Hyperplasia of the liver in Juvenile Dermatomyositis.
Topics: Abatacept; Adolescent; Arthritis; Autoantibodies; Azathioprine; Calcinosis; Child; Cyclophosphamide; | 2022 |
The prevalence of nodular regenerative hyperplasia of the liver in long-term thiopurine-treated inflammatory bowel disease patients.
Topics: Azathioprine; Chronic Disease; Cross-Sectional Studies; Humans; Hyperplasia; Hypertension, Portal; I | 2021 |
Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease.
Topics: Adult; Aged; Azathioprine; Cross-Sectional Studies; Female; Humans; Hypertension, Portal; Idiopathic | 2016 |
[Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease].
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Humans; Hyperplasia; Hypertensi | 2011 |
Nodular regenerative hyperplasia in patients with inflammatory bowel disease treated with azathioprine.
Topics: Adolescent; Adult; Azathioprine; Child; Epidemiologic Methods; Europe; Female; Focal Nodular Hyperpl | 2007 |
[Portal vein hypertension during azathioprine therapy in patients with Crohn's disease--a frequent phenomenon?].
Topics: Azathioprine; Crohn Disease; Enbucrilate; Esophageal and Gastric Varices; Focal Nodular Hyperplasia; | 2008 |
Idiopathic portal hypertension: an infrequent complication of renal transplantation.
Topics: Adult; Azathioprine; Cytomegalovirus Infections; Esophageal and Gastric Varices; Follow-Up Studies; | 1995 |
Idiopathic portal hypertension in renal transplant recipients: report of two cases.
Topics: Adult; Angiography; Azathioprine; Catheterization; Celiac Artery; Endoscopy; Esophageal and Gastric | 1994 |
Nodular regenerative hyperplasia of the liver graft after liver transplantation.
Topics: Adult; Azathioprine; Biopsy; Female; Humans; Hyperplasia; Hypertension, Portal; Liver; Liver Functio | 1994 |
[Clinical case of the month. Hepatoportal sclerosis in a patient treated with azathioprine].
Topics: Adult; Ascites; Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differ | 1998 |
Portal hypertension in the presence of minimal liver damage in Crohn's disease on long-term azathioprine: possible endothelial cell injury.
Topics: Adult; Azathioprine; Crohn Disease; Female; Humans; Hypertension, Portal; Immunosuppressive Agents; | 2000 |
Idiopathic portal hypertension (perisinusoidal fibrosis) after renal transplantation.
Topics: Adult; Azathioprine; Humans; Hypertension, Portal; Kidney Transplantation; Liver; Male; Mercaptopuri | 1979 |
Cholestasis in ulcerative colitis. Long term complications and medical therapy.
Topics: Anti-Bacterial Agents; Azathioprine; Bacterial Infections; Bile Acids and Salts; Cholangitis; Cholel | 1977 |
Idiopathic portal hypertension in a renal transplant patient after long-term azathioprine therapy.
Topics: Angiography; Azathioprine; Biopsy; Esophageal and Gastric Varices; Graft Rejection; Humans; Hyperten | 1992 |
Long term treatment of myasthenia gravis with azathioprine.
Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Humans; Hypertension, Portal; Jaundice; Long | 1990 |
A case of idiopathic portal hypertension after renal transplantation.
Topics: Adult; Azathioprine; Biopsy; Humans; Hypertension, Portal; Immunosuppression Therapy; Kidney Transpl | 1990 |
Hepatic veno-occlusive disease associated with renal transplantation and azathioprine therapy.
Topics: Adult; Azathioprine; Cyclophosphamide; Cytomegalovirus Infections; Esophageal and Gastric Varices; F | 1986 |
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature.
Topics: Adult; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Hepatic Veins; Hepatic Veno-Occ | 1987 |
Portal hypertension secondary to azathioprine in myasthenia gravis.
Topics: Azathioprine; Humans; Hypertension, Portal; Liver; Male; Middle Aged; Myasthenia Gravis | 1988 |
Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment: a cause of chronic liver disease after kidney transplantation.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hypert | 1987 |
Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Esophagus; Female; Humans; Hypertension | 1985 |