azathioprine has been researched along with Hyperplasia in 41 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three cases of nodular regenerative hyperplasia of the liver associated with azathioprine therapy are reported." | 8.78 | [Nodular regenerative hyperplasia of the liver associated with azathioprine therapy]. ( Dhumeaux, D; Duvoux, C; Kracht, M; Lang, P; Vernant, JP; Zafrani, ES, 1991) |
| "We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver." | 7.77 | [Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. ( Corbatón, P; de la Fuente-Fernández, E; Gisbert, JP; López-Martín, C; Sánchez, MC, 2011) |
| "We conclude that treatment of experimental vein grafts with azathioprine is associated with a reduction of neointimal hyperplasia and an increased apoptosis rate in the vascular wall." | 7.73 | Perivascular treatment with azathioprine reduces neointimal hyperplasia in experimental vein grafts. ( Bernecker, O; Bonatti, J; Heiss, S; Kroell, A; Laufer, G; Schachner, T; Tzankov, A; Zipponi, D, 2006) |
| " Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case." | 7.70 | Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999) |
| "Three cases of nodular regenerative hyperplasia of the liver associated with azathioprine therapy are reported." | 4.78 | [Nodular regenerative hyperplasia of the liver associated with azathioprine therapy]. ( Dhumeaux, D; Duvoux, C; Kracht, M; Lang, P; Vernant, JP; Zafrani, ES, 1991) |
| "We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver." | 3.77 | [Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. ( Corbatón, P; de la Fuente-Fernández, E; Gisbert, JP; López-Martín, C; Sánchez, MC, 2011) |
| " Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case." | 3.70 | Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999) |
| " There is a substantial decrease in intimal hyperplasia at anastomotic sites and a higher graft patency rate in dogs treated with low-dose azathioprine as compared with control of steroid-treated animals." | 3.66 | Steroids and immunosuppression. Effect on anastomotic intimal hyperplasia in femoral arterial dacron bypass grafts. ( Cohn, M; Dachelet, R; DeWeese, JA; Elbadawi, A; Hoepp, LM; Peterson, C, 1979) |
| "In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment." | 1.27 | Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma. ( Sakata, T, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (43.90) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 4 (9.76) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| Authors | Studies |
|---|---|
| Lanis, A | 1 |
| Volochayev, R | 1 |
| Kleiner, DE | 1 |
| Vittal, A | 1 |
| Heller, T | 1 |
| Rider, LG | 1 |
| Shenoi, S | 1 |
| Gilissen, LPL | 1 |
| Tajzai, R | 1 |
| Romberg, M | 1 |
| Pierik, M | 1 |
| Stronkhorst, A | 1 |
| Steenhuisen, K | 1 |
| Van Bodegraven, A | 1 |
| Daniels, A | 1 |
| Wong, D | 1 |
| Simsek, M | 1 |
| Meijer, B | 1 |
| Ramsoekh, D | 1 |
| Bouma, G | 1 |
| van der Wouden, EJ | 1 |
| den Hartog, B | 1 |
| de Vries, AC | 1 |
| Hoentjen, F | 1 |
| Dijkstra, G | 1 |
| de Boer, SY | 1 |
| Jansen, JM | 1 |
| van der Meulen, AE | 1 |
| Beukers, R | 1 |
| Brink, MA | 1 |
| Steinhauser, T | 1 |
| Oldenburg, B | 1 |
| Gilissen, LP | 1 |
| Naber, TH | 1 |
| Verhagen, MA | 1 |
| de Boer, NKH | 1 |
| Mulder, CJJ | 1 |
| Bryant, DL | 1 |
| Miles, CJ | 1 |
| Gearry, RB | 1 |
| Błogowski, W | 1 |
| Marlicz, W | 1 |
| Smereczyński, A | 1 |
| Lawniczak, M | 1 |
| Lewosiuk, A | 1 |
| Starzyńska, T | 1 |
| López-Martín, C | 1 |
| de la Fuente-Fernández, E | 1 |
| Corbatón, P | 1 |
| Sánchez, MC | 1 |
| Gisbert, JP | 1 |
| Arruda, JA | 1 |
| Costa, MA | 1 |
| Brito, FS | 1 |
| Tedesco, H | 1 |
| Barbosa, AH | 1 |
| Ribeiro, EP | 1 |
| Pestana, JO | 1 |
| Lima, VC | 1 |
| Pethig, K | 1 |
| Heublein, B | 1 |
| Wahlers, T | 1 |
| Dannenberg, O | 1 |
| Oppelt, P | 1 |
| Haverich, A | 1 |
| de Boer, NK | 2 |
| Mulder, CJ | 2 |
| van Bodegraven, AA | 2 |
| Schachner, T | 1 |
| Heiss, S | 1 |
| Zipponi, D | 1 |
| Tzankov, A | 1 |
| Bernecker, O | 1 |
| Kroell, A | 1 |
| Laufer, G | 1 |
| Bonatti, J | 1 |
| Li, HY | 1 |
| Tanaka, K | 1 |
| Oeser, B | 1 |
| Wertman, B | 1 |
| Kobashigawa, JA | 1 |
| Tobis, JM | 1 |
| Buster, EH | 1 |
| van Vuuren, HJ | 1 |
| Zondervan, PE | 1 |
| Metselaar, HJ | 1 |
| Tilanus, HW | 1 |
| de Man, RA | 1 |
| Tuynman, H | 1 |
| Bloemena, E | 1 |
| Westerga, J | 1 |
| Van Der Peet, DL | 1 |
| Cuesta, MA | 1 |
| Meuwissen, SG | 1 |
| Van Nieuwkerk, CM | 1 |
| Sakata, T | 1 |
| Elariny, HA | 1 |
| Mizrahi, SS | 1 |
| Hayes, DH | 1 |
| Boudreaux, JP | 1 |
| Hussey, JL | 1 |
| Farr, GH | 1 |
| Gane, E | 1 |
| Portmann, B | 1 |
| Saxena, R | 1 |
| Wong, P | 1 |
| Ramage, J | 1 |
| Williams, R | 1 |
| Veldman, W | 1 |
| van Beek, M | 1 |
| Keuning, JJ | 1 |
| Driessen, WM | 1 |
| Sacco, O | 1 |
| Fregonese, B | 1 |
| Picco, P | 1 |
| Faraci, M | 1 |
| Facchetti, P | 1 |
| Pistoia, V | 1 |
| Rossi, GA | 1 |
| Delgado, J | 1 |
| Muñoz de Bustillo, E | 1 |
| Ibarrola, C | 1 |
| Colina, F | 1 |
| Morales, JM | 1 |
| Rodriguez, E | 1 |
| Aguado, JM | 1 |
| Fuertes, A | 1 |
| Gomez, MA | 1 |
| Barr, ML | 1 |
| Baker, CJ | 1 |
| Schenkel, FA | 1 |
| McLaughlin, SN | 1 |
| Stouch, BC | 1 |
| Starnes, VA | 1 |
| Rose, EA | 1 |
| Russmann, S | 1 |
| Zimmermann, A | 1 |
| Krähenbühl, S | 1 |
| Kern, B | 1 |
| Reichen, J | 1 |
| Hoepp, LM | 1 |
| Elbadawi, A | 1 |
| Cohn, M | 1 |
| Dachelet, R | 1 |
| Peterson, C | 1 |
| DeWeese, JA | 1 |
| Mitrou, PS | 1 |
| Fischer, M | 1 |
| Mitrou, G | 1 |
| Röttger, P | 1 |
| Zóltowska, A | 1 |
| Duvoux, C | 1 |
| Kracht, M | 1 |
| Lang, P | 1 |
| Vernant, JP | 1 |
| Zafrani, ES | 1 |
| Dhumeaux, D | 1 |
| Mion, F | 1 |
| Napoleon, B | 1 |
| Berger, F | 1 |
| Chevallier, M | 1 |
| Bonvoisin, S | 1 |
| Descos, L | 1 |
| Glumov, VIa | 1 |
| Ivanova, GS | 1 |
| Bazhenov, EL | 1 |
| Xerri, L | 1 |
| Payan, MJ | 1 |
| Choux, R | 1 |
| Gros, N | 1 |
| Hassoun, J | 1 |
| Chamlian, A | 1 |
| Blin, D | 1 |
| Monties, JR | 1 |
| Chervu, A | 1 |
| Moore, WS | 1 |
| Quiñones-Baldrich, WJ | 1 |
| Henderson, T | 1 |
| Jones, MC | 1 |
| Best, PV | 1 |
| Catto, GR | 1 |
| Sekiya, S | 1 |
| Iwasaki, H | 1 |
| Takeda, B | 1 |
| Takamizawa, H | 1 |
| Gleichmann, H | 1 |
| Gleichmann, E | 1 |
| Tan, KN | 1 |
| Medak, H | 1 |
| Cohen, L | 1 |
| Burlakow, P | 1 |
| Miller, G | 1 |
| Coope, D | 1 |
| Westburg, SP | 1 |
| Stone, OJ | 1 |
| Striker, GE | 2 |
| Kelly, MR | 1 |
| Quadracci, LJ | 1 |
| Scribner, BH | 1 |
| Cutler, RE | 1 |
| Huang, TW | 1 |
| Benditt, EP | 1 |
| Van Vroonhoven, TJ | 2 |
| Malamud, DM | 1 |
| Malt, RA | 2 |
| Cobbe, SM | 1 |
| Herbertson, BM | 1 |
| Houghton, JB | 1 |
| Krueger, GR | 1 |
| Malmgren, RA | 1 |
| Berard, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Photopheresis in the Prevention of Acute Rejection in Highly Sensitized de Novo Kidney Transplant Recipients[NCT04414735] | 30 participants (Anticipated) | Interventional | 2022-08-17 | Recruiting | |||
| The Use of Extracorporeal Photopheresis as Immunomodulatory Therapy of Subclinical Antibody-mediated Rejection After Lung Transplantation: a Prospective RCT[NCT06112951] | 80 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for azathioprine and Hyperplasia
| Article | Year |
|---|---|
Nodular regenerative hyperplasia: a controversial indication for orthotopic liver transplantation.
Topics: Adult; Azathioprine; Female; Humans; Hyperplasia; Hypertension, Portal; Kidney Transplantation; Live | 1994 |
[Nodular regenerative hyperplasia of the liver associated with azathioprine therapy].
Topics: Adult; Azathioprine; Graft vs Host Disease; Humans; Hyperplasia; Hypertension, Portal; Immunosuppres | 1991 |
Immunosuppression and neoplasia. I. A critical review of experimental carcinogenesis and the immunesurveillance theory.
Topics: Animals; Antigens, Neoplasm; Antilymphocyte Serum; Autoantibodies; Azathioprine; Benz(a)Anthracenes; | 1973 |
3 trials available for azathioprine and Hyperplasia
| Article | Year |
|---|---|
Effect of systemic immunosuppression on coronary in-stent intimal hyperplasia in renal transplant patients.
Topics: Azathioprine; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Cyclosporine; Drug Therap | 2003 |
Mycophenolate mofetil for secondary prevention of cardiac allograft vasculopathy: influence on inflammation and progression of intimal hyperplasia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; C-Reactive Protein; Cyclosporine; Female; Hea | 2004 |
Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation.
Topics: Adolescent; Adult; Antibodies; Azathioprine; Chronic Disease; Coronary Disease; Coronary Vessels; Cy | 2000 |
Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation.
Topics: Adolescent; Adult; Antibodies; Azathioprine; Chronic Disease; Coronary Disease; Coronary Vessels; Cy | 2000 |
Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation.
Topics: Adolescent; Adult; Antibodies; Azathioprine; Chronic Disease; Coronary Disease; Coronary Vessels; Cy | 2000 |
Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation.
Topics: Adolescent; Adult; Antibodies; Azathioprine; Chronic Disease; Coronary Disease; Coronary Vessels; Cy | 2000 |
35 other studies available for azathioprine and Hyperplasia
| Article | Year |
|---|---|
Nodular Regenerative Hyperplasia of the liver in Juvenile Dermatomyositis.
Topics: Abatacept; Adolescent; Arthritis; Autoantibodies; Azathioprine; Calcinosis; Child; Cyclophosphamide; | 2022 |
The prevalence of nodular regenerative hyperplasia of the liver in long-term thiopurine-treated inflammatory bowel disease patients.
Topics: Azathioprine; Chronic Disease; Cross-Sectional Studies; Humans; Hyperplasia; Hypertension, Portal; I | 2021 |
Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients.
Topics: Adolescent; Adult; Aged; Azathioprine; Female; Humans; Hyperplasia; Inflammatory Bowel Diseases; Liv | 2019 |
Nodular regenerative hyperplasia of the liver secondary to azathioprine in a patient with inflammatory bowel disease.
Topics: Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Crohn Disease; Diagnosis, Differential | 2010 |
Nodular regenerative liver hyperplasia as a complication of azathioprine-containing immunosuppressive treatment for Crohn's disease.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Female; Humans; Hyperpla | 2011 |
[Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease].
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Humans; Hyperplasia; Hypertensi | 2011 |
Nodular regenerative hyperplasia and thiopurines: the case for level-dependent toxicity.
Topics: Azathioprine; Dose-Response Relationship, Drug; Humans; Hyperplasia; Immunosuppressive Agents; Liver | 2005 |
Perivascular treatment with azathioprine reduces neointimal hyperplasia in experimental vein grafts.
Topics: Animals; Apoptosis; Azathioprine; Carotid Artery, Common; Hyperplasia; Immunosuppressive Agents; In | 2006 |
Compensatory enlargement in transplant coronary artery disease: an intravascular ultrasound study.
Topics: Adult; Aged; Azathioprine; Coronary Disease; Coronary Vessels; Female; Heart Transplantation; Humans | 2006 |
Thiopurine-methyltransferase and inosine triphosphate pyrophosphatase polymorphism in a liver transplant recipient developing nodular regenerative hyperplasia on low-dose azathioprine.
Topics: Adult; Azathioprine; Esophageal and Gastric Varices; Female; Hepatitis B; Heterozygote; Humans; Hype | 2008 |
Histopathology of liver biopsies from a thiopurine-naïve inflammatory bowel disease cohort: prevalence of nodular regenerative hyperplasia.
Topics: Adolescent; Adult; Aged; Azathioprine; Biopsy, Needle; Female; Humans; Hyperplasia; Immunosuppressiv | 2008 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1984 |
Nodular regenerative hyperplasia of the liver graft after liver transplantation.
Topics: Adult; Azathioprine; Biopsy; Female; Humans; Hyperplasia; Hypertension, Portal; Liver; Liver Functio | 1994 |
Regional enteritis complicating malignant lymphoma.
Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti | 1996 |
Common variable immunodeficiency presenting in a girl as lung infiltrates and mediastinal adenopathies leading to severe "superior vena caval" syndrome.
Topics: Anti-Inflammatory Agents; Azathioprine; Child; Common Variable Immunodeficiency; Diagnosis, Differen | 1996 |
Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor?
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatal Outcome; Hear | 1999 |
Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Colitis, Ulcerative; Hepatic Veno-Occlusive Disease; | 2001 |
Steroids and immunosuppression. Effect on anastomotic intimal hyperplasia in femoral arterial dacron bypass grafts.
Topics: Animals; Azathioprine; Blood Vessel Prosthesis; Dogs; Femoral Artery; Hyperplasia; Immunosuppression | 1979 |
The oncogenic effect of immunosuppressive (cytotoxic) agents in (NZB x NZW) mice. II. Emergence of tumors in young animals treated with azathioprine and ifosfamide, including a histologic assessment of the neoplasms.
Topics: Animals; Azathioprine; Carcinogens; Carcinoma; Cyclophosphamide; Female; Hyperplasia; Ifosfamide; Ly | 1979 |
Lymphoreticular tissue lesions in mice after immunization with typhoid fever vaccine and immunosuppression with azathioprine.
Topics: Animals; Atrophy; Azathioprine; Female; Hyperplasia; Immunization Schedule; Immunosuppression Therap | 1975 |
Azathioprine induced liver disease: nodular regenerative hyperplasia of the liver and perivenous fibrosis in a patient treated for multiple sclerosis.
Topics: Adult; Azathioprine; Humans; Hyperplasia; Liver; Liver Cirrhosis; Male; Multiple Sclerosis | 1991 |
[Destructive and reparative processes in the liver in acute experimental peritonitis].
Topics: Acute Disease; Animals; Azathioprine; Hyperplasia; Levamisole; Liver; Liver Regeneration; Peritoniti | 1990 |
An exceptional 18-year follow-up after cardiac transplantation. How can malignancies occur during immunosuppressive therapy?
Topics: Adenocarcinoma, Papillary; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Follow-Up | 1989 |
Efficacy of corticosteroids in suppression of intimal hyperplasia.
Topics: Animals; Azathioprine; Carotid Arteries; Catheterization; Cyclophosphamide; Dexamethasone; Elastic T | 1989 |
Is nodular regenerative hyperplasia of the liver associated with azathioprine therapy after renal transplantation?
Topics: Adult; Azathioprine; Humans; Hyperplasia; Kidney Transplantation; Liver; Male; Postoperative Complic | 1988 |
Endometrial carcinoma following chronic anovulation in a premenopausal woman with systemic lupus erythematosus.
Topics: Adenocarcinoma; Adult; Anovulation; Azathioprine; Endometrium; Female; Humans; Hyperplasia; Lupus Er | 1988 |
Focal epithelial hyperplasia in a Mexican Indian.
Topics: Azathioprine; Child; Cyclophosphamide; Epithelium; Estrogens, Conjugated (USP); Glomerulonephritis; | 1969 |
Epstein-Barr viral nuclear antigen (EBNA) in tumor cell imprints of experimental lymphoma of marmosets.
Topics: Animals; Antigens, Viral; Azathioprine; Burkitt Lymphoma; Cell Line; Cell Nucleus; Cell Transformati | 1974 |
Multiple cutaneous squamous cell carcinomas during immunosuppressive therapy.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Fluorouracil; Humans; Hyperplasia; Immunosuppressive | 1973 |
The course of lupus nephritis: a clinical-pathological correlation of fifty patients.
Topics: Adolescent; Adult; Azathioprine; Basement Membrane; Biopsy; Chloroquine; Cyclophosphamide; Female; F | 1973 |
Renal failure, glomerulonephritis and glomerular epithelial cell hyperplasia.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Epithelial Cell | 1973 |
Reversal of azathioprine-induced inhibition of hyperplasia in regenerating liver.
Topics: Administration, Oral; Animals; Azathioprine; Body Weight; DNA; Hepatectomy; Hyperplasia; Liver; Live | 1972 |
Rebound hyperplasia of regenerating liver after cessation of azathioprine.
Topics: Animals; Azathioprine; DNA; Hyperplasia; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1971 |
Some effects of azathioprine on compensatory renal enlargement in mice.
Topics: Animals; Autoradiography; Azathioprine; DNA; Hyperplasia; Hypertrophy; Kidney; Male; Mice; Nephrecto | 1970 |
Malignant lymphomas and plasmacytosis in mice under prolonged immunosuppression and persistent antigenic stimulation.
Topics: Animals; Antigens; Antilymphocyte Serum; Atrophy; Azathioprine; Female; Freund's Adjuvant; Glomerulo | 1971 |