azathioprine has been researched along with Hepatocellular Carcinoma in 41 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 7.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 5.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis." | 5.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| "Reported herein is a case of hepatocellular carcinoma (HCC) occurring in a 25-year-old Japanese man who was diagnosed with Crohn's disease (CD) at 14 years of age; treatment included predonisolone, azathioprine, and infliximab." | 3.75 | Hepatocellular carcinoma occurring in a young Crohn's disease patient. ( Enaka, M; Kawachi, K; Kunisaki, R; Morimoto, M; Murakami, A; Nagano, Y; Nozawa, A; Sasaki, T; Tanabe, M; Tanaka, Y; Ueda, M, 2009) |
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 3.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| "Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) was recognized as a new disease entity; however, IgG4-associated de novo AIH after the liver transplantation had not been reported yet." | 2.49 | Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review. ( Jia, JD; Rakhda, MI; Wang, TI; Zhao, XY, 2013) |
| " Adequately dosed steroids are the mainstay of remission induction treatment, while remission maintenance is best achieved by azathioprine." | 2.47 | Autoimmune hepatitis. ( Lohse, AW; Mieli-Vergani, G, 2011) |
| "In fact, it is expected that cancer will surpass cardiovascular complications as the leading cause of death in transplant patients within the next 2 decades." | 2.43 | Malignancy after transplantation. ( Buell, JF; Gross, TG; Woodle, ES, 2005) |
| "Ascites, variceal bleeding, and hepatocellular carcinoma were found in 1." | 1.46 | Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. ( Choi, HY; Jang, ES; Jeong, SH; Ki, M; Kim, BH; Kim, KA, 2017) |
| "The development of hepatocellular carcinoma (HCC) is attributed to several factors, including chronic viral infection, alcohol consumption, exposure to aflatoxin B1 and metabolic disorders." | 1.37 | Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease. ( Cui, DJ; Ouyang, Q; Zheng, SM, 2011) |
| "Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 °C incubator with 5% CO₂." | 1.37 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma. ( Cuevas, EP; Díaz-Laviada, I; Fernández-Moreno, MD; Gisbert, JP; Guijarro, LG; Hernández-Breijo, B; Monserrat, J; Ramírez-Rubio, S; Román, ID; Vara, D, 2011) |
| "We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients." | 1.36 | Hepatocellular carcinoma occurring in a Crohn's disease patient. ( Andoh, A; Fujiyama, Y; Hotta, M; Ishida, M; Kojima, F; Kurumi, Y; Naka, S; Nakahara, T; Okabe, H; Saito, Y; Shiomi, H; Takikita-Suzuki, M; Tani, T; Tsujikawa, T, 2010) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 1.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis." | 1.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| "Although the prognosis of type 1 autoimmune hepatitis is generally good with immunosuppressive treatment, the disease progresses in some patients despite the treatment." | 1.33 | Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis. ( Ikeda, H; Iwasaki, Y; Kobashi, H; Makino, Y; Miyake, Y; Okamaoto, R; Sakaguchi, K; Shiratori, Y; Takaguchi, K; Terada, R, 2006) |
| "The occurrence of hepatocellular carcinoma (HCC) in renal transplant recipients has typically been associated with hepatitis B or C infection." | 1.30 | Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series. ( Adams, MB; Franco, J; Komorowski, RA; Saeian, K, 1999) |
| " There was no increase in concurrent immunosuppressives dosage after the conversion." | 1.29 | Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation. ( Kaplan, MM; Pedrosa, MC; Rohrer, RM, 1995) |
| "Later, primary hepatocellular carcinoma assumes increasing importance." | 1.25 | Viral hepatitis and cirrhosis. ( Sherlock, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (48.78) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 10 (24.39) | 29.6817 |
| 2010's | 8 (19.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, BH | 1 |
| Choi, HY | 1 |
| Ki, M | 1 |
| Kim, KA | 1 |
| Jang, ES | 1 |
| Jeong, SH | 1 |
| Zhao, XY | 1 |
| Rakhda, MI | 1 |
| Wang, TI | 1 |
| Jia, JD | 1 |
| Rodríguez-Perálvarez, M | 1 |
| De la Mata, M | 1 |
| Burroughs, AK | 1 |
| Apostolidis, L | 1 |
| Kahlert, C | 1 |
| Siegmund, A | 1 |
| Thom, R | 1 |
| Horstmann, S | 1 |
| Jäger, D | 1 |
| Lordick, F | 1 |
| Maggs, J | 1 |
| Cullen, S | 1 |
| Krok, KL | 1 |
| Munoz, SJ | 1 |
| Murakami, A | 1 |
| Tanaka, Y | 1 |
| Ueda, M | 1 |
| Nagano, Y | 1 |
| Kunisaki, R | 1 |
| Morimoto, M | 1 |
| Enaka, M | 1 |
| Tanabe, M | 1 |
| Kawachi, K | 1 |
| Sasaki, T | 1 |
| Nozawa, A | 1 |
| Ishida, M | 1 |
| Naka, S | 1 |
| Shiomi, H | 1 |
| Tsujikawa, T | 1 |
| Andoh, A | 1 |
| Nakahara, T | 1 |
| Saito, Y | 1 |
| Kurumi, Y | 1 |
| Takikita-Suzuki, M | 1 |
| Kojima, F | 1 |
| Hotta, M | 1 |
| Tani, T | 1 |
| Fujiyama, Y | 1 |
| Okabe, H | 1 |
| Lohse, AW | 1 |
| Mieli-Vergani, G | 1 |
| Zheng, SM | 1 |
| Cui, DJ | 1 |
| Ouyang, Q | 1 |
| Hernández-Breijo, B | 1 |
| Monserrat, J | 1 |
| Ramírez-Rubio, S | 1 |
| Cuevas, EP | 1 |
| Vara, D | 1 |
| Díaz-Laviada, I | 1 |
| Fernández-Moreno, MD | 1 |
| Román, ID | 1 |
| Gisbert, JP | 1 |
| Guijarro, LG | 1 |
| Hino-Arinaga, T | 1 |
| Ide, T | 1 |
| Kuromatsu, R | 1 |
| Miyajima, I | 1 |
| Ogata, K | 1 |
| Kuwahara, R | 1 |
| Hisamochi, A | 1 |
| Torimura, T | 1 |
| Sata, M | 1 |
| Buell, JF | 1 |
| Gross, TG | 1 |
| Woodle, ES | 1 |
| Chen, SC | 1 |
| Cummings, OW | 1 |
| Hartley, MP | 1 |
| Filomena, CA | 1 |
| Cho, WK | 1 |
| Miyake, Y | 1 |
| Iwasaki, Y | 1 |
| Terada, R | 1 |
| Okamaoto, R | 1 |
| Ikeda, H | 1 |
| Makino, Y | 1 |
| Kobashi, H | 1 |
| Takaguchi, K | 1 |
| Sakaguchi, K | 1 |
| Shiratori, Y | 1 |
| Samarasena, J | 1 |
| Borgaonkar, M | 1 |
| Calne, R | 1 |
| Lee, FL | 1 |
| Murray, SM | 1 |
| Prior, J | 1 |
| Shreeve, DR | 1 |
| Pedrosa, MC | 1 |
| Rohrer, RM | 1 |
| Kaplan, MM | 1 |
| Konstantinov, BA | 1 |
| Eramishantsev, AK | 1 |
| Goté, SV | 1 |
| Tsirulńikova, OM | 1 |
| Skipenko, OG | 1 |
| Lebezev, VM | 1 |
| Shertsinger, AG | 1 |
| Lokshin, LS | 1 |
| Saeian, K | 1 |
| Franco, J | 1 |
| Komorowski, RA | 1 |
| Adams, MB | 1 |
| Cattan, S | 1 |
| Wendum, D | 1 |
| Chazouilleres, O | 1 |
| Schmitz, J | 1 |
| Gendre, JP | 1 |
| Russmann, S | 1 |
| Zimmermann, A | 1 |
| Krähenbühl, S | 1 |
| Kern, B | 1 |
| Reichen, J | 1 |
| Sherlock, S | 1 |
| O'Grady, JG | 1 |
| Johnson, PJ | 1 |
| Zaman, S | 1 |
| Calne, RY | 2 |
| Williams, R | 3 |
| Gruber, S | 1 |
| Dehner, LP | 1 |
| Simmons, RL | 1 |
| Alpert, E | 1 |
| Starzl, TE | 3 |
| Schur, PH | 1 |
| Isselbacher, KJ | 1 |
| Smith, MG | 2 |
| Doniach, D | 1 |
| Porter, KA | 1 |
| Brettschneider, L | 3 |
| Penn, I | 3 |
| Bell, P | 2 |
| Putnam, CW | 3 |
| McGuire, RL | 1 |
| Gütgemann, A | 3 |
| Schriefers, KH | 2 |
| Esser, G | 2 |
| Lee, TS | 1 |
| Paquet, KJ | 2 |
| Käufer, C | 3 |
| Lie, TS | 2 |
| Fortner, JG | 1 |
| Shiu, MH | 1 |
| Balner, H | 1 |
| Wilson, CB | 1 |
| Sichuk, G | 1 |
| Kawano, N | 1 |
| Holmes, JT | 1 |
| Beattie, EJ | 1 |
| Groth, CG | 1 |
| Blanchard, H | 1 |
| Kashiwagi, N | 1 |
| Starzi, TE | 1 |
| Giles, G | 1 |
| Picache, R | 1 |
| Prejean, JD | 1 |
| Griswold, DP | 1 |
| Weisburger, JH | 1 |
| Birtch, AG | 1 |
| Moore, FD | 1 |
| Pagaltsos, AP | 1 |
| Eddleston, AL | 1 |
| Anthony, CW | 1 |
| Pritzker, K | 1 |
| Siedek, M | 1 |
| Prange, CH | 1 |
| Rommelsheim, K | 1 |
| Fillmann, B | 1 |
| Birkeland, SA | 1 |
| Kemp, E | 1 |
7 reviews available for azathioprine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review.
Topics: Antiviral Agents; Azathioprine; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; H | 2013 |
Liver transplantation: immunosuppression and oncology.
Topics: Antilymphocyte Serum; Azathioprine; Calcineurin Inhibitors; Carcinoma, Hepatocellular; Humans; Immun | 2014 |
Management of autoimmune liver disease.
Topics: Autoantibodies; Azathioprine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellul | 2009 |
Autoimmune hepatitis.
Topics: Algorithms; Azathioprine; Carcinoma, Hepatocellular; Clinical Trials as Topic; Female; Hepatitis, Au | 2011 |
Malignancy after transplantation.
Topics: Azathioprine; Calcineurin Inhibitors; Carcinoma, Hepatocellular; Cyclosporine; Hepatitis, Viral, Hum | 2005 |
Clinical liver transplantation.
Topics: Adenoma, Bile Duct; Adult; Angiography; Aortography; Azathioprine; Bacterial Infections; Biliary Tra | 1969 |
Experience in liver transplantation.
Topics: Adenocarcinoma; Adolescent; Adult; Alkalosis; Animals; Antilymphocyte Serum; Azathioprine; Blood Coa | 1969 |
34 other studies available for azathioprine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Carcinoma, Hepato | 2017 |
Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Benzenesulfonates; Carcinoma, Hepatoce | 2009 |
Management of autoimmune and cholestatic liver disorders.
Topics: Anti-Inflammatory Agents; Azathioprine; Carcinoma, Hepatocellular; Cholagogues and Choleretics; Chol | 2009 |
Hepatocellular carcinoma occurring in a young Crohn's disease patient.
Topics: Adolescent; Adult; Age of Onset; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Cr | 2009 |
Hepatocellular carcinoma occurring in a Crohn's disease patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liv | 2010 |
Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease.
Topics: Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liver Neop | 2011 |
Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azathioprine; Buthionine Sulfoximine; Carcinoma | 2011 |
Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1.
Topics: Aged; Alanine Transaminase; Azathioprine; Biomarkers; Carcinoma, Hepatocellular; Cholagogues and Cho | 2012 |
Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab.
Topics: Adult; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Gastr | 2006 |
Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anti-Inflammatory Agents; Azathioprine; Carcinoma, He | 2006 |
Development of hepatocellular carcinoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adult; Azathioprine; Biopsy; Carcinoma, Hepatocellular; Crohn Disease; Diagnosis, Differential; Fata | 2007 |
Hepatic transplantation.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Graft Rejection; Humans; Immunosuppression Th | 1980 |
Primary liver cell cancer occurring in association with Crohn's disease treated with prednisolone and azathioprine.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Humans; Liver Neoplasms; Pred | 1983 |
Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarc | 1995 |
[Orthotopic liver transplantation (first clinical experience)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Carcinoma, Hepatocellular; Child; Cyclospo | 1993 |
Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Humans; Immunosuppressive Agents; Kidney Transplantat | 1999 |
Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Glycogen; Humans; Immunosuppr | 2000 |
Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Colitis, Ulcerative; Hepatic Veno-Occlusive Disease; | 2001 |
Viral hepatitis and cirrhosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Azathioprine; Carcinoma, Hepatocellular; Chronic Disease; Di | 1975 |
Decreased rate of growth of hepatocellular carcinoma recurrence after liver transplantation in patients maintained on cyclosporine immunosuppression.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Humans; Liver Neoplasms; Liver Transplantatio | 1988 |
De novo hepatocellular carcinoma without chronic liver disease but with 17 years of azathioprine immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Humans; Kidney Transplantation; Liver Neoplasms; Mal | 1987 |
Serum -fetoprotein in hepatoma patients after liver transplantation.
Topics: Adolescent; Adult; Alanine Transaminase; Alpha-Globulins; Aspartate Aminotransferases; Autopsy; Azat | 1971 |
Effect of orthotopic liver transplantation on serum-autoantibodies.
Topics: Antibodies, Antinuclear; Aspartate Aminotransferases; Autoantibodies; Azathioprine; Bilirubin; Carci | 1971 |
Clinical and pathologic observations after orthotopic transplantation of the human liver.
Topics: Adolescent; Adult; Alkaline Phosphatase; Azathioprine; Bilirubin; Blood Proteins; Carcinoma, Hepatoc | 1969 |
[Report of experience with homologous liver transplantation].
Topics: Adult; Alkaline Phosphatase; Antibodies, Anti-Idiotypic; Azathioprine; Bilirubin; Blood Proteins; Bo | 1969 |
A case of homologous liver transplantation.
Topics: Adult; Aldosterone; Ampicillin; Azathioprine; Cadaver; Carcinoma, Hepatocellular; Heparin; Humans; L | 1969 |
Observations on prolonged immune suppression for human liver homografts.
Topics: Antilymphocyte Serum; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Fluorescent Anti | 1971 |
Orthotopic liver transplantation in man.
Topics: Adrenal Gland Diseases; Adult; Anticoagulants; Antilymphocyte Serum; Azathioprine; Blood Coagulation | 1969 |
Transplantation of allogeneic tumors in rats and mice treated with azathioprine, prednisone and antilymphocyte serum.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinoma, Hepatocellular; Immunosuppre | 1972 |
Total haemolytic complement after liver transplantation and in liver disease.
Topics: Acute Disease; Adult; Aspartate Aminotransferases; Azathioprine; Bilirubin; Carcinoma, Hepatocellula | 1972 |
Disseminated toxoplasmosis in a liver transplant patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Female; Humans; Immunosuppression Therapy; Liver Neo | 1972 |
Neoplasia in renal transplant recipients.
Topics: Adolescent; Azathioprine; Carcinoma, Hepatocellular; Hepatitis; Humans; Immunosuppressive Agents; Ki | 1972 |
[Prolonged ischemic tolerance time of the human liver with successful grafting (author's transl)].
Topics: Adolescent; Antilymphocyte Serum; Azathioprine; Blood Pressure; Carcinoma, Hepatocellular; Drug Ther | 1974 |
Malignant tumours following immunosuppression in renal transplantation.
Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom | 1973 |