azathioprine has been researched along with Heart Failure in 32 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Out of 652 biopsied patients, 112 had a histological diagnosis of active lymphocytic myocarditis; 41 of these 112 patients were characterized by progressive heart failure despite conventional therapy and were treated with prednisone and azathioprine for 6 months." | 3.72 | Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. ( Calabrese, F; Chimenti, C; Frustaci, A; Maseri, A; Pieroni, M; Thiene, G, 2003) |
| " Immunosuppressive therapy with prednisolone 2 mg/kg/d and azathioprine 2 mg/kg/d was added on the assumption of chronic myocarditis (n = 4) or endocardial fibrosis (n = 2)." | 3.67 | [Immunosuppressive treatment of chronic myocarditis]. ( Proll, E; Salzer-Muhar, U; Schlemmer, M; Strigl, E; Wimmer, M, 1988) |
| "Our results do not support routine treatment of myocarditis with immunosuppressive drugs." | 2.68 | A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. ( Billingham, ME; Herskowitz, A; Mason, JW; McManus, BM; Moon, TE; O'Connell, JB; Rose, NR, 1995) |
| "Heart failure is a rare but life-threatening manifestation of cardiac involvement in SLE." | 1.35 | Heart failure as presenting manifestation of cardiac involvement in systemic lupus erythematosus. ( Bax, JJ; Boumpas, DT; Huizinga, TW; Kritikos, H; Mollema, SA; Schoe, A; van der Laan-Baalbergen, NE; van Laar, JM, 2009) |
| "Biopsies then taken revealed recurrence of myocarditis in the transplanted heart." | 1.28 | Response of recurrent giant cell myocarditis in a transplanted heart to intensive immunosuppression. ( Kong, G; Madden, B; Mitchell, A; Pomerance, A; Spyrou, N; Yacoub, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (37.50) | 18.7374 |
| 1990's | 7 (21.88) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, MY | 1 |
| Li, D | 1 |
| Feldman, CH | 1 |
| Yoshida, K | 1 |
| Guan, H | 1 |
| Kim, SC | 1 |
| Everett, BM | 1 |
| Costenbader, KH | 1 |
| Fujiwara, K | 1 |
| Hamuro, M | 1 |
| Imai, K | 1 |
| Yoshizawa, K | 1 |
| Ohno, N | 1 |
| Sakazaki, H | 1 |
| Tsukuda, K | 1 |
| Lin, YC | 1 |
| Oliveira, GH | 1 |
| Villa-Forte, A | 1 |
| Kittleson, MM | 1 |
| Kobashigawa, JA | 1 |
| Pineton de Chambrun, M | 1 |
| Charron, P | 1 |
| Vauthier-Brouzes, D | 1 |
| Cluzel, P | 1 |
| Haroche, J | 1 |
| Kahn, JE | 1 |
| Amoura, Z | 1 |
| Aubart, FC | 1 |
| Weitsman, T | 1 |
| Weisz, G | 1 |
| Keren, A | 1 |
| Hasin, T | 1 |
| Latushko, A | 1 |
| Ghazi, LJ | 1 |
| Frustaci, A | 3 |
| Russo, MA | 1 |
| Chimenti, C | 3 |
| van der Laan-Baalbergen, NE | 1 |
| Mollema, SA | 1 |
| Kritikos, H | 1 |
| Schoe, A | 1 |
| Huizinga, TW | 1 |
| Bax, JJ | 1 |
| Boumpas, DT | 1 |
| van Laar, JM | 1 |
| Tarner, IH | 1 |
| Lange, U | 1 |
| Madlener, K | 1 |
| Classen, K | 1 |
| Kandolf, R | 2 |
| Sperzel, J | 1 |
| Müller-Ladner, U | 1 |
| Naniwa, T | 1 |
| Takeda, Y | 1 |
| Möller, K | 1 |
| Klingel, K | 1 |
| Kaiser, U | 1 |
| Thum, M | 1 |
| Bönig, A | 1 |
| Hasenfuss, G | 1 |
| Scholz, KH | 1 |
| Calabrese, F | 1 |
| Pieroni, M | 1 |
| Thiene, G | 1 |
| Maseri, A | 2 |
| Beitzke, A | 1 |
| Suppan, C | 1 |
| Trittenwein, G | 1 |
| Uberfuhr, P | 1 |
| Reichart, B | 1 |
| Welz, A | 1 |
| Kreuzer, E | 1 |
| Kemkes, BM | 1 |
| Klinner, W | 1 |
| Hammer, C | 1 |
| Ertel, W | 1 |
| Reichenspurner, H | 1 |
| Gokel, M | 1 |
| Land, W | 1 |
| Franke, N | 1 |
| Mathes, P | 1 |
| Mason, JW | 1 |
| O'Connell, JB | 1 |
| Herskowitz, A | 2 |
| Rose, NR | 1 |
| McManus, BM | 1 |
| Billingham, ME | 1 |
| Moon, TE | 1 |
| Gehrke, D | 1 |
| Herzum, M | 1 |
| Schönian, U | 1 |
| Klein, HH | 1 |
| Drude, L | 1 |
| Mennel, HD | 1 |
| Maisch, B | 1 |
| Veness, MJ | 1 |
| Khalaf, TH | 1 |
| Strober, S | 1 |
| Garrelts, G | 1 |
| Stinson, EB | 2 |
| Desjardins, V | 1 |
| Pelletier, G | 1 |
| Leung, TK | 1 |
| Waters, D | 1 |
| Jones, SR | 1 |
| Hutchins, GM | 1 |
| Baughman, KL | 1 |
| Kong, G | 1 |
| Madden, B | 1 |
| Spyrou, N | 1 |
| Pomerance, A | 1 |
| Mitchell, A | 1 |
| Yacoub, M | 1 |
| Bilińska, ZT | 1 |
| Ruzyłło, W | 1 |
| Lubiszewska, B | 1 |
| Gajewski, W | 1 |
| Wimmer, M | 1 |
| Proll, E | 1 |
| Salzer-Muhar, U | 1 |
| Schlemmer, M | 1 |
| Strigl, E | 1 |
| Nora, JJ | 1 |
| Cooley, DA | 1 |
| Fernbach, DJ | 1 |
| Rochelle, DG | 1 |
| Milam, JD | 1 |
| Montgomery, JR | 1 |
| Leachman, RD | 1 |
| Butler, WT | 1 |
| Rossen, RD | 1 |
| Bloodwell, RD | 1 |
| Hallman, GL | 1 |
| Trentin, JJ | 1 |
| Schroeder, JS | 1 |
| Popp, RL | 1 |
| Dong, E | 1 |
| Shumway, NE | 1 |
| Harrison, DC | 1 |
| Cagli, V | 1 |
| Eales, L | 1 |
| Grosser, Y | 1 |
| Levey, M | 1 |
| Dubost, C | 1 |
| Cachera, JP | 1 |
| Böttcher, D | 1 |
| Maas, D | 1 |
| Wendt, F | 1 |
| Schubothe, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| RANDOMIZED, MULTICENTRIC STUDY COMPARING THE EFFECT OF TWO REGIMENS OF COMBINED IMMUNOSUPPRESSIVE THERAPY IN THE TREATMENT OF INFLAMMATORY CARDIOMYOPATHY CZECH-ICIT (CZECH INFLAMMATORY CARDIOMYOPATHY IMMUNOSUPPRESSION TRIAL)[NCT01877746] | Phase 3 | 234 participants (Anticipated) | Interventional | 2013-01-31 | Recruiting | ||
| Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance[NCT03525639] | 80 participants (Anticipated) | Interventional | 2016-12-06 | Recruiting | |||
| Single-blind, Investigator-initiated, Randomized, Controlled Trial to Assess the Safety and Efficacy of Intravenous Corticosteroid Therapy to Treat Patients With Acute Myocarditis With Mildly Reduced Left Ventricular Ejection Fraction[NCT05974462] | Phase 3 | 174 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| [NCT00000524] | Phase 2 | 0 participants | Interventional | 1986-07-31 | Completed | ||
| Single Blind Randomized Controlled Trial to Assess the Safety and Efficacy of High Dose Pulse Intravenous Corticosteroid Therapy to Treat Patients With Complicated/Fulminant Acute Myocarditis[NCT05150704] | Phase 3 | 288 participants (Anticipated) | Interventional | 2021-10-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for azathioprine and Heart Failure
| Article | Year |
|---|---|
Management of the ACC/AHA Stage D patient: cardiac transplantation.
Topics: Allografts; Azathioprine; Cardiotonic Agents; Contraindications; Graft Occlusion, Vascular; Graft Re | 2014 |
[Course and prognosis of glomerulonephritis].
Topics: Acute Disease; Age Factors; Anti-Bacterial Agents; Anti-Glomerular Basement Membrane Disease; Antige | 1970 |
2 trials available for azathioprine and Heart Failure
| Article | Year |
|---|---|
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
28 other studies available for azathioprine and Heart Failure
| Article | Year |
|---|---|
Comparative risks of cardiovascular disease events among SLE patients receiving immunosuppressive medications.
Topics: Adult; Azathioprine; Cardiovascular Diseases; Cause of Death; Coronary Artery Bypass; Cyclophosphami | 2021 |
Severe aortic valve regurgitation due to Takayasu's aortoarteritis in a child.
Topics: Aneurysm, False; Aorta, Thoracic; Aortic Valve Insufficiency; Azathioprine; Cardiac Catheterization; | 2013 |
Churg-Strauss syndrome and persistent heart failure: active disease or damage?
Topics: Azathioprine; Churg-Strauss Syndrome; Cyclophosphamide; Drug Therapy, Combination; Female; Heart Fai | 2013 |
Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report.
Topics: Adult; Azathioprine; Endomyocardial Fibrosis; Female; Heart Failure; Humans; Hypereosinophilic Syndr | 2015 |
Prompt benefit of early immunosuppressive therapy in acute lymphocytic myocarditis with persistent heart failure.
Topics: Adult; Azathioprine; Biopsy; Drug Therapy, Combination; Female; Heart Failure; Humans; Immunosuppres | 2016 |
A Case of Thiopurine-Induced Acute Myocarditis in a Patient with Ulcerative Colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Azathioprine; Cardiac Imaging Techniqu | 2016 |
Heart failure as presenting manifestation of cardiac involvement in systemic lupus erythematosus.
Topics: Adult; Azathioprine; Cyclophosphamide; Female; Glucocorticoids; Heart Failure; Humans; Immunosuppres | 2009 |
[A wolf in sheep's clothing: atypical systemic lupus erythematosus (SLE) presenting as cardiovascular disease].
Topics: Antiphospholipid Syndrome; Azathioprine; Biopsy; Diagnosis, Differential; Female; Heart Failure; Hea | 2010 |
Long-term remission of pulmonary veno-occlusive disease associated with primary Sjögren's syndrome following immunosuppressive therapy.
Topics: Azathioprine; Female; Heart Failure; Humans; Hypertension, Pulmonary; Immunosuppressive Agents; Pred | 2011 |
[Immunsuppressive therapy in virus-negative eosinophilic inflammatory cardiomyopathy].
Topics: Azathioprine; Biopsy; Cardiac Output, Low; Defibrillators, Implantable; Electrocardiography; Eosinop | 2011 |
Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders.
Topics: Adolescent; Adult; Autoantibodies; Azathioprine; Biopsy; Cardiotonic Agents; Chronic Disease; Echoca | 2003 |
[Immunosuppressive therapy in congestive cardiomyopathy in childhood].
Topics: Adolescent; Autoantibodies; Autoimmune Diseases; Azathioprine; Cardiomyopathy, Dilated; Child; Elect | 1984 |
[Report on a successful orthotopic cardiac transplantation in Germany].
Topics: Adrenal Cortex Hormones; Adult; Antilymphocyte Serum; Azathioprine; Creatinine; Cyclosporins; Dipyri | 1982 |
[Eosinophilic endomyocarditis post partum or pregnancy-related cardiomyopathy].
Topics: Adult; Azathioprine; Biopsy; Combined Modality Therapy; Cytomegalovirus Infections; Diagnosis, Diffe | 1994 |
Cardiac transplant-related cutaneous malignancies in an Australian recipient: immunosuppression, friend or foe?
Topics: Adult; Australia; Azathioprine; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cy | 1998 |
Global biventricular dysfunction in patients with asymptomatic coronary artery disease may be caused by myocarditis.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Autoimmune Diseases; Azathioprine; Biopsy; Cardiomy | 1999 |
Alterations in T and B lymphocytes in heart transplant patients early and late postoperatively.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; B-Lymphocytes; Female; Graft Rejection; Heart | 1976 |
Successful treatment of severe heart failure caused by idiopathic giant cell myocarditis.
Topics: Autoimmune Diseases; Azathioprine; Biopsy; Cardiomyopathy, Dilated; Cyclosporine; Drug Therapy, Comb | 1992 |
Effects of immunosuppressive therapy in biopsy-proved myocarditis and borderline myocarditis on left ventricular function.
Topics: Adolescent; Adult; Aged; Azathioprine; Echocardiography; Female; Heart Failure; Hemodynamics; Humans | 1991 |
Response of recurrent giant cell myocarditis in a transplanted heart to intensive immunosuppression.
Topics: Adult; Azathioprine; Biopsy; Cyclosporins; Granuloma, Giant Cell; Heart Failure; Heart Transplantati | 1991 |
[Late results of immunosuppressive therapy in patients with heart failure and biopsy proven myocarditis].
Topics: Adult; Azathioprine; Female; Follow-Up Studies; Heart Failure; Humans; Immunosuppressive Agents; Mal | 1989 |
[Immunosuppressive treatment of chronic myocarditis].
Topics: Adolescent; Autoimmune Diseases; Azathioprine; Child; Child, Preschool; Chronic Disease; Drug Therap | 1988 |
Rejection of the transplanted human heart.
Topics: Antilymphocyte Serum; Azathioprine; Child, Preschool; Electrocardiography; Female; Heart Failure; He | 1969 |
Acute rejection following cardiac transplantation. Phonocardiographic and ultrasound observations.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Electrocardiography; Female; Heart Auscultation; Heart Fa | 1969 |
Coproporphyrinuria and heart transplantation: its significance.
Topics: Age Factors; Anemia, Hemolytic; Azathioprine; Chemical and Drug Induced Liver Injury; Electrocardiog | 1970 |
Surgical Grand Rounds from the University of Mississippi Medical Center. Renal transplantation.
Topics: Adult; Azathioprine; Consanguinity; Heart Failure; Humans; Hypertension, Malignant; Kidney Transplan | 1971 |
[3 cases of allogenic heart graft in man].
Topics: Adult; Angiocardiography; Azathioprine; Coronary Disease; Electrocardiography; Globulins; Heart Fail | 1969 |
[Anemia caused by erythroblastopenia in adult age].
Topics: Aged; Analgesics; Anemia, Aplastic; Azathioprine; Blood Transfusion; Female; Heart Failure; Hepatiti | 1970 |