azathioprine has been researched along with Heart Diseases in 21 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the study was to compare mitotic activity in the basal cell layer of normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth." | 7.71 | Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2001) |
| " Combined immunosuppressive therapy with prednisone and cyclophosphamide might be needed to treat recurrent thrombosis due to Behçet disease." | 3.80 | Recurrent right atrial thrombosis due to Behçet disease. ( Fukuda, K; Kuno, T; Kuwana, M; Murata, M; Ono, T; Satoh, T; Tamura, Y, 2014) |
| "Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health." | 3.75 | Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. ( Fauci, AS; Haynes, BF; Katz, P; Wolff, SM, 1983) |
| "The purpose of the study was to compare mitotic activity in the basal cell layer of normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth." | 3.71 | Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2001) |
| " However, optimal cyclosporine exposure can now be achieved through monitoring of cyclosporine levels 2 hours after dosing (C(2) monitoring)." | 2.42 | Optimizing the immunosuppressive regimen in heart transplantation. ( Eisen, H; Ross, H, 2004) |
| "The prevalence of hyperlipidemia in adolescents and young adults who are long-term survivors of pediatric renal transplantation with stable graft function has not previously been examined." | 1.29 | Hyperlipidemia in long-term survivors of pediatric renal transplantation. ( Hunninghake, DB; Kashtan, CE; Matas, AJ; Myers, TA; Sharma, AK, 1994) |
| " The ability to induce "shock protein" synthesis obviously seems to be restricted to toxic drugs." | 1.28 | A cell culture assay for the detection of cardiotoxicity. ( Löw-Friedrich, I; Schoeppe, W; von Bredow, F, 1991) |
| "Forty-nine patients with systemic lupus erythematosus (SLE) during childhood and adolescence presenting over a period of 17 years were followed during treatment with prednisone and azathioprine." | 1.26 | Systemic lupus erythematosus within the first two decades of life. ( Blau, EB; Burke, BA; Fish, AJ; Michael, AF; Vernier, RL; Westberg, NG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (47.62) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuno, T | 1 |
| Tamura, Y | 1 |
| Ono, T | 1 |
| Murata, M | 1 |
| Kuwana, M | 1 |
| Satoh, T | 1 |
| Fukuda, K | 1 |
| Lisitsyna, T | 1 |
| Alekberova, Z | 1 |
| Ovcharov, P | 1 |
| Volkov, A | 1 |
| Korsakova, J | 1 |
| Nasonov, E | 1 |
| Baumgart, DC | 1 |
| Eisen, H | 1 |
| Ross, H | 1 |
| David, KM | 1 |
| Morris, JA | 1 |
| Steffen, BJ | 1 |
| Chi-Burris, KS | 1 |
| Gotz, VP | 1 |
| Gordon, RD | 1 |
| Lawson, C | 1 |
| Holder, AL | 1 |
| Stanford, RE | 1 |
| Smith, J | 1 |
| Rose, ML | 1 |
| Fauci, AS | 2 |
| Haynes, BF | 1 |
| Katz, P | 1 |
| Wolff, SM | 2 |
| Wishnick, MM | 1 |
| Valensi, Q | 1 |
| Doyle, EF | 1 |
| Balian, A | 1 |
| Genieser, NB | 1 |
| Chrousos, G | 1 |
| Sharma, AK | 1 |
| Myers, TA | 1 |
| Hunninghake, DB | 1 |
| Matas, AJ | 1 |
| Kashtan, CE | 1 |
| Sartori, TM | 1 |
| Maurizio, PG | 1 |
| Sara, P | 1 |
| Ugolino, L | 1 |
| Annalisa, A | 1 |
| Panagiotis, T | 1 |
| Massimo, F | 1 |
| Antonio, G | 1 |
| Nurmenniemi, PK | 1 |
| Pernu, HE | 1 |
| Knuuttila, ML | 1 |
| Sgrosso, JL | 1 |
| Ferrer, J | 1 |
| Araujo, G | 1 |
| Romeo, L | 1 |
| Parisi, C | 1 |
| Vázquez, MC | 1 |
| McGeown, MG | 1 |
| Douglas, JF | 1 |
| Brown, WA | 1 |
| Donaldson, RA | 1 |
| Kennedy, JA | 1 |
| Loughridge, WG | 1 |
| Mehta, S | 1 |
| Hill, CM | 1 |
| Fish, AJ | 1 |
| Blau, EB | 1 |
| Westberg, NG | 1 |
| Burke, BA | 1 |
| Vernier, RL | 1 |
| Michael, AF | 1 |
| Barnard, CN | 1 |
| Löw-Friedrich, I | 1 |
| von Bredow, F | 1 |
| Schoeppe, W | 1 |
| Goetz, FC | 1 |
| Elick, B | 1 |
| Fryd, D | 1 |
| Sutherland, DE | 1 |
| Myers, BD | 1 |
| Horn, RG | 1 |
| Dale, DC | 1 |
| Schulz, HJ | 1 |
| Reitzig, P | 1 |
| Lisewski, G | 1 |
| Dietze, F | 1 |
| Cooley, DA | 1 |
| Bloodwell, RD | 1 |
| Hallman, GL | 1 |
| Leachman, RD | 1 |
| Nora, JJ | 1 |
| Milam, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II Trial of TNFR:Fc (Etanercept) in Patients With Wegener's Granulomatosis[NCT00001901] | Phase 2 | 60 participants | Interventional | 1999-02-28 | Completed | ||
| Randomized Conversion of Calcineurin-Inhibitors(Tacrolimus to Sirolimus),6-24 Months Post Transplant Prednisone-Free Immunosuppression Regimen: Impact of Incidence of Acute Cellular Rejection,Renal Allograft Function & Lymphocytes Function[NCT00866879] | Phase 4 | 275 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Genetic Predisposition of Chronic Nephrotoxicity From Calcineurin Inhibitors in Liver Transplant Recipients, Potential Correlation With Urinary Biomarkers[NCT00857844] | 207 participants (Actual) | Observational | 2007-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary purpose of this research study is to evaluate whether the use of mycophenolate mofetil/Cellcept ® and either tacrolimus/Prograf ® (Group #1) or mycophenolate mofetil/Cellcept ® and sirolimus/Rapamune® (Group #2) impacts the incidence of acute cellular rejection in post-kidney transplant patients. This study will examine whether switching from tacrolimus to sirolimus will better preserve long-term kidney function. (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 7 |
| Transition to Sirolimus Group | 31 |
"Specifically we reported here the percentage of regulatory T cells that were present in the two groups at 24 months post randomization.~With peripheral leukocytes taken at baseline (first visit) prior to randomization and at 6, 12 and 24 Months post-randomization, researchers will also review possible modifications of lymphocytes function and of the lymphocytes subpopulations that might have occurred as a consequence of the switch from tacrolimus to sirolimus (randomization)." (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
| Intervention | % of Treg Cells (Mean) |
|---|---|
| Control | 75 |
| Transition to Sirolimus Group | 98 |
Evaluate whether CI conversion (tacrolimus→sirolimus) contributes positively or negatively on the renal allograft function calculated with e-GFR and proteinuria (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
| Intervention | mL/min (Mean) |
|---|---|
| Control | 57.6 |
| Transition to Sirolimus Group | 58.4 |
In addition to monitoring renal allograft function, evaluation will be conducted on the incidence of acute rejection, patient and graft survival, the impact of CI conversion on the lipid profile, the incidence of hypertension, malignancies, opportunistic infections and post-transplant DM (de novo diabetes mellitus). (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
| Intervention | number of incidents (Number) | |||||||
|---|---|---|---|---|---|---|---|---|
| Infections | Malignancies | Proteinura | Hyperlipidemia | NODAT | BK viremia | BK nephropathy | Neutropenia | |
| Control | 33 | 4 | 12 | 9 | 3 | 15 | 1 | 22 |
| Transition to Sirolimus Group | 83 | 9 | 61 | 19 | 2 | 28 | 5 | 35 |
This study also reviews the impact of the immunosuppressive medications on patient and graft survival. (NCT00866879)
Timeframe: Assessed at 6 Months, 12 Months, 24 Months, months 24 reported
| Intervention | number of incidents (Number) | |
|---|---|---|
| Kidney transplant loss | Patient death | |
| Control | 4 | 3 |
| Transition to Sirolimus Group | 12 | 10 |
5 reviews available for azathioprine and Heart Diseases
| Article | Year |
|---|---|
Left ventricular intracardiac thrombus in a patient with Behçet disease successfully treated with immunosuppressive agents without anticoagulation: a case report and review of the literature.
Topics: Adrenal Cortex Hormones; Anticoagulants; Azathioprine; Behcet Syndrome; Drug Therapy, Combination; H | 2015 |
Optimizing the immunosuppressive regimen in heart transplantation.
Topics: Adrenal Cortex Hormones; Azathioprine; Calcineurin Inhibitors; Cyclosporine; Dose-Response Relations | 2004 |
Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.
Topics: Adolescent; Adult; Aged; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Administrati | 1983 |
Renal transplantation in diabetes.
Topics: Adolescent; Adult; Age Factors; Azathioprine; Child; Costs and Cost Analysis; Diabetes Mellitus; Dia | 1986 |
Cyclosporine nephrotoxicity.
Topics: Acute Kidney Injury; Adult; Azathioprine; Creatine; Cyclosporins; Glomerular Filtration Rate; Glomer | 1986 |
Cyclosporine nephrotoxicity.
Topics: Acute Kidney Injury; Adult; Azathioprine; Creatine; Cyclosporins; Glomerular Filtration Rate; Glomer | 1986 |
Cyclosporine nephrotoxicity.
Topics: Acute Kidney Injury; Adult; Azathioprine; Creatine; Cyclosporins; Glomerular Filtration Rate; Glomer | 1986 |
Cyclosporine nephrotoxicity.
Topics: Acute Kidney Injury; Adult; Azathioprine; Creatine; Cyclosporins; Glomerular Filtration Rate; Glomer | 1986 |
1 trial available for azathioprine and Heart Diseases
| Article | Year |
|---|---|
Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years.
Topics: Adolescent; Adult; Aged; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Administrati | 1983 |
16 other studies available for azathioprine and Heart Diseases
| Article | Year |
|---|---|
Recurrent right atrial thrombosis due to Behçet disease.
Topics: Anticoagulants; Azathioprine; Behcet Syndrome; Disease Progression; Heart Atria; Heart Diseases; Hum | 2014 |
How many lives does an ulcerative colitis patient have?
Topics: Abscess; Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Aortic Valve Insufficiency; Atriove | 2010 |
Mycophenolate mofetil vs. azathioprine is associated with decreased acute rejection, late acute rejection, and risk for cardiovascular death in renal transplant recipients with pre-transplant diabetes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Black People; Cause of Death; Diabetes Com | 2005 |
Anti-intercellular adhesion molecule-1 antibodies in sera of heart transplant recipients: a role in endothelial cell activation.
Topics: Adult; Animals; Antibody Formation; Azathioprine; Base Sequence; CHO Cells; Cricetinae; DNA Primers; | 2005 |
Churg-Strauss syndrome. Development of cardiomyopathy during corticosteroid treatment.
Topics: Adolescent; Asthma; Azathioprine; Cardiomyopathies; Cyclophosphamide; Granuloma; Heart Diseases; Hum | 1982 |
Hyperlipidemia in long-term survivors of pediatric renal transplantation.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Cohort Stud | 1994 |
Relation between long-term steroid treatment after heart transplantation, hypofibrinolysis and myocardial microthrombi generation.
Topics: Azathioprine; Biopsy; Coronary Artery Disease; Cyclosporine; Drug Therapy, Combination; Female; Fibr | 1999 |
Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth.
Topics: Adult; Aged; Azathioprine; Calcium Channel Blockers; Cell Count; Cyclosporine; Epithelial Cells; Epi | 2001 |
Histopathological findings in heart transplant patients under tacrolimus-mycophenolate mofetil versus cyclosporine microemulsion-azathioprine.
Topics: Adolescent; Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejection; H | 2002 |
Low dose steroid from the day following renal transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Central Nervous System Diseases; Child; Colonic Neoplasms; Do | 1979 |
Systemic lupus erythematosus within the first two decades of life.
Topics: Adolescent; Azathioprine; Central Nervous System Diseases; Child; Child, Preschool; Female; Follow-U | 1977 |
The present status of heart transplantation.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Coronary Disease; Echocardiography; Electrocardiography; | 1975 |
A cell culture assay for the detection of cardiotoxicity.
Topics: Animals; Autoradiography; Azathioprine; Cells, Cultured; Cyclosporins; Electrophoresis, Polyacrylami | 1991 |
Wegener's granulomatosis.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Diagnosis, Differe | 1974 |
[Malabsorption syndrome and intestinal pseudoobstruction in primary vascular and heart amyloidosis].
Topics: Adult; Amyloidosis; Antibody Formation; Antigen-Antibody Complex; Azathioprine; Chloramphenicol; Cys | 1973 |
Cardiac transplantation: general considerations and results.
Topics: Antilymphocyte Serum; Azathioprine; Brain Diseases; Child, Preschool; Electrocardiography; Female; H | 1969 |