Page last updated: 2024-10-23

azathioprine and Graves Ophthalmopathy

azathioprine has been researched along with Graves Ophthalmopathy in 6 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Graves Ophthalmopathy: An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.

Research Excerpts

ExcerptRelevanceReference
"Graves orbitopathy is both disabling and disfiguring."3.30Factors Predicting Long-term Outcome and the Need for Surgery in Graves Orbitopathy: Extended Follow-up From the CIRTED Trial. ( Cook, A; Dayan, CM; French, R; Gattamaneni, R; Hanna, S; Hills, R; Jackson, S; Lee, RWJ; Li, C; Pell, J; Plowman, N; Rajendram, R; Taylor, P; Uddin, JM; Wilson, V, 2023)
"Azathioprine treatment was provided for 48 weeks at 100-200 mg per day (dispensed as 50 mg tablets), depending on bodyweight (100 mg for <50 kg, 150 mg 50-79 kg, 200 mg for ≥80 kg)."2.87Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial. ( Bremner, F; Bunce, C; Cook, A; Dayan, CM; Dick, AD; Drummond, SR; Ezra, DG; Garrott, H; Gattamaneni, R; Harris, N; Herbert, HM; Hills, R; Hurel, SJ; Jackson, S; Jain, R; Kemp, E; Lane, C; Lee, RWJ; Li, C; Morris, D; Morris, OC; Olver, J; Palaniappan, N; Pell, J; Plowman, N; Potts, MJ; Rajendram, R; Ritchie, DM; Rose, GE; Rumsey, N; Taylor, PN; Tomlinson, M; Uddin, JM; Wilson, VJ; Yarrow, S, 2018)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's3 (50.00)2.80

Authors

AuthorsStudies
Bartalena, L1
Tanda, ML1
Taylor, P1
Rajendram, R2
Hanna, S1
Wilson, V1
Pell, J2
Li, C2
Cook, A2
Gattamaneni, R2
Plowman, N2
Jackson, S2
Hills, R2
French, R1
Uddin, JM2
Lee, RWJ2
Dayan, CM2
Taylor, PN1
Wilson, VJ1
Harris, N1
Morris, OC1
Tomlinson, M1
Yarrow, S1
Garrott, H1
Herbert, HM1
Dick, AD1
Jain, R1
Olver, J1
Hurel, SJ1
Bremner, F1
Drummond, SR1
Kemp, E1
Ritchie, DM1
Rumsey, N1
Morris, D1
Lane, C1
Palaniappan, N1
Ezra, DG1
Potts, MJ1
Rose, GE1
Bunce, C1
Zhou, X1
Zhou, D1
Wang, J1
Chen, G1
Gonzales, M1
Fratianni, C1
Mamillapali, C1
Khardori, R1
Levy, SL1
Salvi, SM1

Reviews

3 reviews available for azathioprine and Graves Ophthalmopathy

ArticleYear
Current concepts regarding Graves' orbitopathy.
    Journal of internal medicine, 2022, Volume: 292, Issue:5

    Topics: Antithyroid Agents; Azathioprine; Biological Factors; Cyclosporine; Glucocorticoids; Graves Ophthalm

2022
Treatment strategies for Graves' ophthalmopathy: a network meta-analysis.
    The British journal of ophthalmology, 2020, Volume: 104, Issue:4

    Topics: Antibodies, Monoclonal, Humanized; Azathioprine; Combined Modality Therapy; Cyclosporine; Glucocorti

2020
Immunotherapy in miscellaneous medical disorders Graves ophthalmopathy, asthma, and regional painful syndrome.
    The Medical clinics of North America, 2012, Volume: 96, Issue:3

    Topics: Allergens; Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Ant

2012

Trials

2 trials available for azathioprine and Graves Ophthalmopathy

ArticleYear
Factors Predicting Long-term Outcome and the Need for Surgery in Graves Orbitopathy: Extended Follow-up From the CIRTED Trial.
    The Journal of clinical endocrinology and metabolism, 2023, 09-18, Volume: 108, Issue:10

    Topics: Azathioprine; Follow-Up Studies; Graves Ophthalmopathy; Humans; Inflammation; Quality of Life; Treat

2023
Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial.
    The lancet. Diabetes & endocrinology, 2018, Volume: 6, Issue:4

    Topics: Adult; Aged; Azathioprine; Chemoradiotherapy; Double-Blind Method; Female; Graves Ophthalmopathy; Hu

2018

Other Studies

1 other study available for azathioprine and Graves Ophthalmopathy

ArticleYear
Reactivation of Darier's disease following Azathioprine treatment for thyroid eye disease.
    Eye (London, England), 2013, Volume: 27, Issue:4

    Topics: Azathioprine; Darier Disease; Female; Graves Ophthalmopathy; Humans; Immunosuppressive Agents; Middl

2013