Page last updated: 2024-10-23

azathioprine and Granuloma

azathioprine has been researched along with Granuloma in 35 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.

Research Excerpts

ExcerptRelevanceReference
"To report the authors' experience with azathioprine and prednisone combination for adult periocular and orbital xanthogranulomatous disease."7.77Azathioprine and prednisone combination treatment for adult periocular and orbital xanthogranulomatous disease. ( Bijlsma, WR; Paridaens, D; van Daele, PL; van den Bosch, WA, 2011)
"Azathioprine therapy in a patient with granulomatous ileocolitis was associated with an attack of acute pancreatitis, which was confirmed by laparotomy."7.65Azathioprine-associated acute pancreatitis. ( Levin, B; Paloyan, D; Simonowitz, D, 1977)
"To report the authors' experience with azathioprine and prednisone combination for adult periocular and orbital xanthogranulomatous disease."3.77Azathioprine and prednisone combination treatment for adult periocular and orbital xanthogranulomatous disease. ( Bijlsma, WR; Paridaens, D; van Daele, PL; van den Bosch, WA, 2011)
"Wet weight of cotton-pellet granuloma and 35SO4-uptake in the acid mucopolysaccharides (AMPS) of granulation tissue of rats and the number of plaque forming cells (PFC) of mice were investigated after the treatment with antilymphocyte globulin, prednisolone, cyclophosphamide and azathioprine."3.65Experimental results to immunomesenchymal suppression. ( Hauss, GM; Hauss, WH; Kramer, H; Müller, U; Wirth, W, 1975)
"Azathioprine therapy in a patient with granulomatous ileocolitis was associated with an attack of acute pancreatitis, which was confirmed by laparotomy."3.65Azathioprine-associated acute pancreatitis. ( Levin, B; Paloyan, D; Simonowitz, D, 1977)
"If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease."2.37Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986)
"Azathioprine was added to her regimen due to lack of response; however, despite 6 weeks of this therapy, the ulcerations did not heal thus infliximab was initiated."1.91Successful multidisciplinary treatment of the rare pathology of vulvar Crohn's disease. ( Al Yacoub, R; Brown, K; Ladna, M, 2023)
"There is a reported association with Crohn's disease."1.46Ano-genital Granulomatosis and Crohn's Disease: A Case Series of Males Presenting with Genital Lymphoedema. ( Alexakis, C; Chong, H; Gordon, K; Mellor, R; Mortimer, P; Pollok, R, 2017)
"Thirteen patients with Wegener's granulomatosis have been treated with cytotoxic agents."1.25Treatment of Wegener's granulomatosis of lung. ( Isreal, HL; Patchfsky, AS, 1975)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199023 (65.71)18.7374
1990's2 (5.71)18.2507
2000's1 (2.86)29.6817
2010's6 (17.14)24.3611
2020's3 (8.57)2.80

Authors

AuthorsStudies
Renoux, MC1
Dutronc, S1
Kollen, L1
Theret, S1
Moreau, J1
Al Yacoub, R1
Brown, K1
Ladna, M1
Bajgai, P1
Sharma, A1
Singh, R1
Whittaker, K1
Guggenberger, K1
Venhoff, N1
Doostkam, S1
Schaefer, HE1
Fritsch, B1
Baughman, RP1
Lower, EE1
Alexakis, C1
Gordon, K1
Mellor, R1
Chong, H1
Mortimer, P1
Pollok, R1
Vingerhoedt, NM1
Janssen, S1
Mravunac, M1
Wauters, CA1
Strobbe, LJ1
Bijlsma, WR1
van den Bosch, WA1
van Daele, PL1
Paridaens, D1
Stephenson, SR1
Campbell, SM1
Drew, GS1
Magro, CM1
Chase, NM1
Verbsky, JW1
Hintermeyer, MK1
Waukau, JK1
Tomita-Mitchell, A1
Casper, JT1
Singh, S1
Shahir, KS1
Tisol, WB1
Nugent, ML1
Rao, RN1
Mackinnon, AC1
Goodman, LR1
Simpson, PM1
Routes, JM1
Domingo, EO1
Cowan, RB1
Warren, KS1
Reder, AT1
Antel, JP1
Koyama, T2
Matsuo, N1
Watanabe, Y1
Ojima, M1
Wishnick, MM1
Valensi, Q1
Doyle, EF1
Balian, A1
Genieser, NB1
Chrousos, G1
Sacco, O1
Fregonese, B1
Picco, P1
Faraci, M1
Facchetti, P1
Pistoia, V1
Rossi, GA1
Cooper, BJ1
Bacal, E1
Patterson, R1
Müller, U1
Wirth, W3
Kramer, H1
Hauss, GM1
Hauss, WH4
Hillyer, GV1
Cangiano, JL1
Jauregui, HO1
van Furth, R1
Paloyan, D1
Levin, B1
Simonowitz, D1
Cruickshank, B1
Isreal, HL1
Patchfsky, AS1
Knoblauch, M1
Lämmli, J1
Funk, C1
Sharma, RK1
Elhence, R1
Kher, V1
Naik, SR1
Bhandari, M1
Leavitt, RY1
Fauci, AS1
Paulsen, ME1
Lavach, JD1
Snyder, SP1
Severin, GA1
Eichenbaum, JD1
Aizawa, Y1
Komeji, S1
Irimajiri, S1
Abe, T1
Honma, M1
Junge-Hülsing, G3
Müller, US3
Wagner, H1
Büchner, RT1
Oberwittler, W1
Thöne, F1
Convit, J1
Kerdel, F1
Goihman, M1
Rondon, AJ1
Soto, JM1
Arinoviche, R1
Loewi, G1
Krueger, GR1
Perings, E1
Reisert, PM1
Kraft, HG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Continuous Positive Airway Pressure for Fatigue Treatment in Patients With Multiple Sclerosis and Obstructive Sleep Apnea[NCT01563900]0 participants (Actual)Interventional2012-02-29Withdrawn (stopped due to Was unable to recruit subjects)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for azathioprine and Granuloma

ArticleYear
Treatment of Sarcoidosis.
    Clinical reviews in allergy & immunology, 2015, Volume: 49, Issue:1

    Topics: Anti-Inflammatory Agents; Azathioprine; Clinical Trials as Topic; Drug Administration Schedule; Gran

2015
Macrophage activity and clinical immunology. Origin and kinetics of mononuclear phagocytes.
    Annals of the New York Academy of Sciences, 1976, Volume: 278

    Topics: Animals; Azathioprine; Glucocorticoids; Granuloma; Humans; Hydrocortisone; Inflammation; Kinetics; M

1976
Pulmonary vasculitis.
    The American review of respiratory disease, 1986, Volume: 134, Issue:1

    Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy

1986

Trials

1 trial available for azathioprine and Granuloma

ArticleYear
Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID).
    Journal of clinical immunology, 2013, Volume: 33, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Antibodies, Monoclonal, Murine-Derived; Azathioprine; B-Lym

2013

Other Studies

31 other studies available for azathioprine and Granuloma

ArticleYear
A Case of Disseminated Tuberculosis in a Child with Crohn's Disease After Treatment with Azathioprine, Adalimumab and Ustekinumab.
    Archivos de bronconeumologia, 2021, Volume: 57, Issue:8

    Topics: Adalimumab; Azathioprine; Child; Crohn Disease; Granuloma; Humans; Immunosuppressive Agents; Treatme

2021
Successful multidisciplinary treatment of the rare pathology of vulvar Crohn's disease.
    BMJ case reports, 2023, Oct-16, Volume: 16, Issue:10

    Topics: Azathioprine; Crohn Disease; Dermatitis; Erythema; Female; Granuloma; Humans; Infliximab; Ulcer; Vul

2023
Disseminated Tubercular Granulomas Associated with the Use of Azathioprine.
    Ocular immunology and inflammation, 2021, Jul-04, Volume: 29, Issue:5

    Topics: Antitubercular Agents; Azathioprine; Choroid Diseases; Coloring Agents; Female; Fluorescein Angiogra

2021
Cerebral granulomatosis as a manifestation of Crohn's disease.
    BMC neurology, 2018, Oct-03, Volume: 18, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Brain Diseases; Crohn Disease; Disease Progression; Fe

2018
Ano-genital Granulomatosis and Crohn's Disease: A Case Series of Males Presenting with Genital Lymphoedema.
    Journal of Crohn's & colitis, 2017, Apr-01, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Aged; Anus Diseases; Azathioprine; Child; Crohn Disease; Genital Diseases, Male;

2017
[Granulomatous lobular mastitis: a benign abnormality that mimics malignancy].
    Nederlands tijdschrift voor geneeskunde, 2008, May-03, Volume: 152, Issue:18

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Breast Neoplasms; Cytodiagnosis; Diagnosis, Different

2008
Azathioprine and prednisone combination treatment for adult periocular and orbital xanthogranulomatous disease.
    Acta ophthalmologica, 2011, Volume: 89, Issue:3

    Topics: Adult; Aged; Azathioprine; Conjunctival Diseases; Drug Therapy, Combination; Eye Diseases; Eyelid Di

2011
Palisaded neutrophilic and granulomatous dermatitis presenting in a patient with rheumatoid arthritis on adalimumab.
    Journal of cutaneous pathology, 2011, Volume: 38, Issue:8

    Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthrit

2011
The inhibition of granuloma formation around Schistosoma mansoni eggs. I. Immunosuppressive drugs.
    The American journal of tropical medicine and hygiene, 1967, Volume: 16, Issue:3

    Topics: Animals; Azathioprine; Dactinomycin; Fluocinolone Acetonide; Granuloma; Methotrexate; Mice; Schistos

1967
Clinical spectrum of multiple sclerosis.
    Neurologic clinics, 1983, Volume: 1, Issue:3

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Age Factors; Azathioprine; Brain Diseas

1983
Wegener's granulomatosis with destructive ocular manifestations.
    American journal of ophthalmology, 1984, Dec-15, Volume: 98, Issue:6

    Topics: Adult; Azathioprine; Cyclophosphamide; Eye; Eye Movements; Granuloma; Granulomatosis with Polyangiit

1984
Churg-Strauss syndrome. Development of cardiomyopathy during corticosteroid treatment.
    American journal of diseases of children (1960), 1982, Volume: 136, Issue:4

    Topics: Adolescent; Asthma; Azathioprine; Cardiomyopathies; Cyclophosphamide; Granuloma; Heart Diseases; Hum

1982
Common variable immunodeficiency presenting in a girl as lung infiltrates and mediastinal adenopathies leading to severe "superior vena caval" syndrome.
    The European respiratory journal, 1996, Volume: 9, Issue:9

    Topics: Anti-Inflammatory Agents; Azathioprine; Child; Common Variable Immunodeficiency; Diagnosis, Differen

1996
Allergic angiitis and granulomatosis. Prolonged remission induced by combined prednisone--azathioprine therapy.
    Archives of internal medicine, 1978, Volume: 138, Issue:3

    Topics: Adolescent; Adult; Azathioprine; Drug Therapy, Combination; Female; Granuloma; Humans; Male; Polyart

1978
Experimental results to immunomesenchymal suppression.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Animals; Antibody Specificity; Antilymphocyte Serum; Azathioprine; Cell Count; Cyclophosphamide; Gly

1975
Schistosoma mansoni granuloma in immunosuppressed man. Report of a case.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979, Volume: 73, Issue:3

    Topics: Adult; Azathioprine; Colon; Granuloma; Humans; Immunosuppression Therapy; Liver; Male; Niridazole; P

1979
Lymphomatoid granulomatosis after immunosuppression for pemphigus.
    Archives of dermatology, 1978, Volume: 114, Issue:7

    Topics: Aged; Autopsy; Azathioprine; Granuloma; Humans; Immunosuppressive Agents; Lung; Lymphoma; Male; Pemp

1978
Azathioprine-associated acute pancreatitis.
    The American journal of digestive diseases, 1977, Volume: 22, Issue:9

    Topics: Acute Disease; Adult; Azathioprine; Crohn Disease; Granuloma; Humans; Male; Pancreatitis

1977
Pulmonary granulomatous pneumocystosis following renal transplantation. Report of a case.
    American journal of clinical pathology, 1975, Volume: 63, Issue:3

    Topics: Adult; Azathioprine; Biopsy; Female; Granuloma; Humans; Kidney Transplantation; Lung; Pneumonia, Pne

1975
Treatment of Wegener's granulomatosis of lung.
    The American journal of medicine, 1975, Volume: 58, Issue:5

    Topics: Azathioprine; Cyclophosphamide; Drug Evaluation; Granuloma; Granulomatosis with Polyangiitis; Hodgki

1975
[Drug-induced liver diseases].
    Gastroenterologische Fortbildungskurse fur die Praxis, 1975, Volume: 5

    Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C

1975
Liver disease in renal transplant recipients.
    Transplantation proceedings, 1992, Volume: 24, Issue:5

    Topics: Azathioprine; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; Granuloma; Hepatitis; Hepa

1992
Nodular granulomatous episclerokeratitis in dogs: 19 cases (1973-1985).
    Journal of the American Veterinary Medical Association, 1987, Jun-15, Volume: 190, Issue:12

    Topics: Adrenal Cortex Hormones; Age Factors; Animals; Azathioprine; Conjunctiva; Cornea; Dog Diseases; Dogs

1987
[Effective use of azathioprine in a case of polyarteritis nodosa with recurrent intestinal perforation: a distinction between polyarteritis nodosa and allergic granulomatous angiitis].
    Nihon rinsho. Japanese journal of clinical medicine, 1974, Dec-10, Volume: 32, Issue:12

    Topics: Adult; Arteritis; Azathioprine; Diagnosis, Differential; Granuloma; Humans; Intestinal Perforation;

1974
[Cytostatic agents and mesenchyma. 2. The effect of azathioprine and prednisolone on the growth of granuloma and on mucopolysaccharide metabolism in mesenchymal cells].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:6

    Topics: Animals; Antineoplastic Agents; Azathioprine; Connective Tissue; Connective Tissue Cells; Drug Syner

1971
[Animal experiments on the anti-inflammatory and immunosuppressive effect of cytostatic agents].
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Cyclic P-Oxides; Cyclophosphamide; Dose-Response Re

1973
[Suppressive effects in mesenchyme and immunosuppressive effects of cytostatica].
    International journal of clinical pharmacology, therapy and toxicology, 1973, Volume: 7, Issue:2

    Topics: Alkylating Agents; Animals; Azathioprine; Cyclophosphamide; Glycosaminoglycans; Granulation Tissue;

1973
Progressive, atrophying, chronic granulomatous dermohypodermitis. Autoimmune disease?
    Archives of dermatology, 1973, Volume: 107, Issue:2

    Topics: Adult; Atrophy; Autoimmune Diseases; Axilla; Azathioprine; BCG Vaccine; Chronic Disease; Cutis Laxa;

1973
Comparison of the effects of two cytotoxic drugs and of antilymphocytic serum on immune and non-immune inflammation in experimental animals.
    Annals of the rheumatic diseases, 1970, Volume: 29, Issue:1

    Topics: Animals; Antilymphocyte Serum; Arthritis; Azathioprine; Cyclophosphamide; DNA Replication; Exudates

1970
Effect of immunosuppression on the development of the adjuvant-induced granuloma in mice.
    Pathologia et microbiologia, 1971, Volume: 37, Issue:6

    Topics: Animals; Antibody Formation; Antilymphocyte Serum; Autopsy; Azathioprine; Female; Freund's Adjuvant;

1971
[Studies on the anti-inflammatory effect of azathioprine].
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1971, Volume: 5, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Exudates and Transudates; Granuloma; Hydrocortisone

1971