azathioprine has been researched along with Gingival Overgrowth in 9 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Gingival Overgrowth: Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to determine the incidence and severity of gingival overgrowth (GO) induced by tacrolimus (Tcr) compared with ciclosporin A (CiA) in the absence of calcium channel blockers (CCB) in renal transplant recipients." | 7.74 | Incidence of tacrolimus-induced gingival overgrowth in the absence of calcium channel blockers: a short-term study. ( Lotufo, RF; Paixão, CG; Pannuti, CM; Romito, GA; Saraiva, L; Sekiguchi, RT, 2007) |
| "The study aims to determine the prevalence and severity of gingival overgrowth in a group of adult organ transplant recipients immunosuppressed with tacrolimus in comparison with ciclosporin, and to examine various risk factors for the development of gingival overgrowth." | 7.72 | Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus. ( Ellis, JS; Seymour, RA; Taylor, JJ; Thomason, JM, 2004) |
| "The purpose of the study was to compare mitotic activity in the basal cell layer of normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth." | 7.71 | Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2001) |
| "The purpose of this study was to compare the distribution of Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth by means of an immunohistochemical study." | 7.70 | Density of CD1a-labeled Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 1999) |
| "The factors associated with cyclosporin A (CsA)- and nifedipine (Nif)-induced gingival overgrowth were investigated in 113 renal transplant recipients receiving CsA alone (Group 1) [n = 61], CsA and Nif (Group 2) [n = 28], or azathioprine (Aza) (Control Group) [n = 24]." | 7.69 | Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. ( Barbaro, A; Margiotta, V; Pizzo, G; Pizzo, I, 1996) |
| "In the absence of calcium channel blockers, this study showed that pharmacologic variables, such as cyclosporin serum concentration, prednisolone and azathioprine dosages, and time since transplant, are strongly related to gingival overgrowth." | 3.74 | Demographic, pharmacologic, and periodontal variables for gingival overgrowth in subjects medicated with cyclosporin in the absence of calcium channel blockers. ( Costa, JE; Cota, LO; Ferreira, SD; Lages, EJ; Oliveira Costa, F; Oliveira, AM, 2007) |
| "The aim of this study was to determine the incidence and severity of gingival overgrowth (GO) induced by tacrolimus (Tcr) compared with ciclosporin A (CiA) in the absence of calcium channel blockers (CCB) in renal transplant recipients." | 3.74 | Incidence of tacrolimus-induced gingival overgrowth in the absence of calcium channel blockers: a short-term study. ( Lotufo, RF; Paixão, CG; Pannuti, CM; Romito, GA; Saraiva, L; Sekiguchi, RT, 2007) |
| "The study aims to determine the prevalence and severity of gingival overgrowth in a group of adult organ transplant recipients immunosuppressed with tacrolimus in comparison with ciclosporin, and to examine various risk factors for the development of gingival overgrowth." | 3.72 | Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus. ( Ellis, JS; Seymour, RA; Taylor, JJ; Thomason, JM, 2004) |
| "The purpose of the study was to compare mitotic activity in the basal cell layer of normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth." | 3.71 | Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 2001) |
| "The purpose of this study was to compare the distribution of Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth by means of an immunohistochemical study." | 3.70 | Density of CD1a-labeled Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth. ( Knuuttila, ML; Nurmenniemi, PK; Pernu, HE, 1999) |
| "The factors associated with cyclosporin A (CsA)- and nifedipine (Nif)-induced gingival overgrowth were investigated in 113 renal transplant recipients receiving CsA alone (Group 1) [n = 61], CsA and Nif (Group 2) [n = 28], or azathioprine (Aza) (Control Group) [n = 24]." | 3.69 | Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. ( Barbaro, A; Margiotta, V; Pizzo, G; Pizzo, I, 1996) |
| "Univariate analysis identified the duration of transplant, papilla bleeding index, creatinine serum concentration, azathioprine and prednisolone dosage as risk factors for overgrowth severity." | 1.33 | Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers. ( Ellis, JS; Seymour, RA; Thomason, JM, 2005) |
| " Duration of treatment, dosage of drugs per kg body weight and serum cyclosporin levels were recorded." | 1.30 | Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. ( Ashley, FP; Koffman, CG; Morel, A; Ogg, CS; Rigden, SP; Smith, D; Wilson, RF, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ellis, JS | 2 |
| Seymour, RA | 2 |
| Taylor, JJ | 1 |
| Thomason, JM | 2 |
| Vescovi, P | 1 |
| Meleti, M | 1 |
| Manfredi, M | 1 |
| Merigo, E | 1 |
| Pedrazzi, G | 1 |
| Oliveira Costa, F | 1 |
| Ferreira, SD | 1 |
| Lages, EJ | 1 |
| Costa, JE | 1 |
| Oliveira, AM | 1 |
| Cota, LO | 1 |
| Sekiguchi, RT | 1 |
| Paixão, CG | 1 |
| Saraiva, L | 1 |
| Romito, GA | 1 |
| Pannuti, CM | 1 |
| Lotufo, RF | 1 |
| Margiotta, V | 1 |
| Pizzo, I | 1 |
| Pizzo, G | 1 |
| Barbaro, A | 1 |
| Wilson, RF | 1 |
| Morel, A | 1 |
| Smith, D | 1 |
| Koffman, CG | 1 |
| Ogg, CS | 1 |
| Rigden, SP | 1 |
| Ashley, FP | 1 |
| Nurmenniemi, PK | 2 |
| Pernu, HE | 2 |
| Knuuttila, ML | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth[NCT00104026] | 45 participants (Actual) | Observational | 2005-02-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for azathioprine and Gingival Overgrowth
| Article | Year |
|---|---|
Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus.
Topics: Adolescent; Adult; Aged; Azathioprine; Calcium Channel Blockers; Chi-Square Distribution; Cyclospori | 2004 |
Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers.
Topics: Anti-Inflammatory Agents; Azathioprine; Body Weight; Creatinine; Cyclosporine; Dental Plaque Index; | 2005 |
Cyclosporin-induced gingival overgrowth: a clinical-epidemiological evaluation of 121 Italian renal transplant recipients.
Topics: Adult; Aged; Anticonvulsants; Azathioprine; Calcium Channel Blockers; Chi-Square Distribution; Cyclo | 2005 |
Demographic, pharmacologic, and periodontal variables for gingival overgrowth in subjects medicated with cyclosporin in the absence of calcium channel blockers.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Calcium Channel Blockers; Chi-Square Distribution; Cy | 2007 |
Incidence of tacrolimus-induced gingival overgrowth in the absence of calcium channel blockers: a short-term study.
Topics: Adult; Anti-Infective Agents; Azathioprine; Calcium Channel Blockers; Cyclosporine; Dental Plaque In | 2007 |
Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens.
Topics: Adolescent; Adult; Azathioprine; Calcium Channel Blockers; Child; Cyclosporine; Dental Calculus; Den | 1996 |
Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Azathioprine; Body We | 1998 |
Density of CD1a-labeled Langerhans' cells in normal human gingiva and in nifedipine- and immunosuppressive medication-induced gingival overgrowth.
Topics: Adult; Anti-Inflammatory Agents; Antigens, CD1; Azathioprine; Calcium Channel Blockers; Cell Count; | 1999 |
Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth.
Topics: Adult; Aged; Azathioprine; Calcium Channel Blockers; Cell Count; Cyclosporine; Epithelial Cells; Epi | 2001 |