azathioprine has been researched along with Gingival Hyperplasia in 12 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Gingival Hyperplasia: Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nifedipine is often used to control hypertension in kidney graft recipients." | 7.69 | Nifedipine aggravates cyclosporine A-induced gingival hyperplasia. ( Albers, N; Beier, C; Bohnhorst, B; Bökenkamp, A; Brodehl, J; Offner, G, 1994) |
| "To investigate the development of gingival hyperplasia in dogs after renal transplantation and administration of microemulsified cyclosporine A (MCsA)." | 3.74 | Gingival overgrowth in dogs associated with clinically relevant cyclosporine blood levels: observations in a canine renal transplantation model. ( Hyun, C; Kim, WH; Kwak, HH; McAnulty, JF; Nam, HS; Woo, HM; Yoon, BI, 2008) |
| "Severe gingival hyperplasia (GH) is one of the most frequent side-effects associated with the prescription of Cyclosporine-A (CsA)." | 3.71 | Cyclosporin A-induced gingival overgrowth is unrelated to allograft function in renal transplant recipients. ( Baboolal, K; Newcombe, RG; Subramanian, N; Thomas, DW, 2001) |
| " Nifedipine is often used to control hypertension in kidney graft recipients." | 3.69 | Nifedipine aggravates cyclosporine A-induced gingival hyperplasia. ( Albers, N; Beier, C; Bohnhorst, B; Bökenkamp, A; Brodehl, J; Offner, G, 1994) |
| "Gingival hyperplasia has been demonstrated in animal experiments and also during treatment of humans." | 1.27 | Gingival enlargement. A comparison between cyclosporine and azathioprine treated renal allograft recipients. ( Friskopp, J; Klintmalm, G, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Condé, SA | 1 |
| Aarestrup, FM | 1 |
| Vieira, BJ | 1 |
| Bastos, MG | 1 |
| Nam, HS | 1 |
| McAnulty, JF | 1 |
| Kwak, HH | 1 |
| Yoon, BI | 1 |
| Hyun, C | 1 |
| Kim, WH | 1 |
| Woo, HM | 1 |
| Bökenkamp, A | 1 |
| Bohnhorst, B | 1 |
| Beier, C | 1 |
| Albers, N | 1 |
| Offner, G | 1 |
| Brodehl, J | 1 |
| Somacarrera, ML | 1 |
| Lucas-Tomas, M | 1 |
| Boran, M | 1 |
| Güneş, Z | 1 |
| Doruk, F | 1 |
| Gönenç, F | 1 |
| Cetin, S | 1 |
| Payne, VM | 1 |
| Thomas, DW | 1 |
| Baboolal, K | 1 |
| Subramanian, N | 1 |
| Newcombe, RG | 1 |
| Pernu, HE | 1 |
| Pernu, LM | 1 |
| Huttunen, KR | 1 |
| Nieminen, PA | 1 |
| Knuuttila, ML | 1 |
| Bazzano, F | 1 |
| Nencioni, M | 1 |
| Tarello, F | 1 |
| Tejani, A | 1 |
| Butt, KM | 1 |
| Khawar, MR | 1 |
| Hong, JH | 1 |
| Fusi, M | 1 |
| Pomrantz, A | 1 |
| Seymour, RA | 1 |
| Smith, DG | 1 |
| Rogers, SR | 1 |
| Friskopp, J | 1 |
| Klintmalm, G | 1 |
1 trial available for azathioprine and Gingival Hyperplasia
| Article | Year |
|---|---|
Roxithromycin reduces cyclosporine-induced gingival hyperplasia in renal transplant patients.
Topics: Adult; Aged; Anti-Bacterial Agents; Azathioprine; Cyclosporine; Female; Gingival Hyperplasia; Humans | 2008 |
11 other studies available for azathioprine and Gingival Hyperplasia
| Article | Year |
|---|---|
Gingival overgrowth in dogs associated with clinically relevant cyclosporine blood levels: observations in a canine renal transplantation model.
Topics: Animals; Azathioprine; Cyclosporine; Dog Diseases; Dogs; Gingival Hyperplasia; Graft Rejection; Immu | 2008 |
Nifedipine aggravates cyclosporine A-induced gingival hyperplasia.
Topics: Adolescent; Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Gingival Hyperplas | 1994 |
Reversion of cyclosporine-induced overgrowth.
Topics: Azathioprine; Child; Cyclosporine; Gingival Hyperplasia; Heart Transplantation; Humans; Male | 1996 |
Improvement in cyclosporine A associated gingival hyperplasia with azithromycin therapy.
Topics: Adult; Anti-Bacterial Agents; Azathioprine; Azithromycin; Calcium Channel Blockers; Cyclosporine; Fe | 1996 |
Re: Periodontal management of gingival overgrowth in the heart transplant patient: a case report (1997;68:1140-1146)
Topics: Adult; Azathioprine; Calcium Channel Blockers; Candidiasis, Oral; Chlorhexidine; Cyclosporine; Gingi | 1998 |
Cyclosporin A-induced gingival overgrowth is unrelated to allograft function in renal transplant recipients.
Topics: Adolescent; Adult; Aged; Azathioprine; Calcium Channel Blockers; Child; Child, Preschool; Creatinine | 2001 |
Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors.
Topics: Adult; Aged; Azathioprine; Cyclosporine; Dental Plaque Index; Gingival Hyperplasia; Humans; Immunosu | 1992 |
[Hypertrophic hyperplastic gingivopathy in patients treated with immunosuppressive Cyclosporin-A therapy].
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Cyclosporins; Female; Gingival Hyperplasia; Gingival H | 1988 |
Cyclosporine experience in renal transplantation in children.
Topics: Adolescent; Anemia; Azathioprine; Child; Creatinine; Cyclosporins; Female; Gingival Hyperplasia; Gra | 1987 |
The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. A longitudinal study.
Topics: Adult; Azathioprine; Cyclosporins; Female; Gingiva; Gingival Hyperplasia; Humans; Kidney Transplanta | 1987 |
Gingival enlargement. A comparison between cyclosporine and azathioprine treated renal allograft recipients.
Topics: Adult; Azathioprine; Cyclosporins; Female; Gingival Hyperplasia; Gingival Hypertrophy; Humans; Kidne | 1986 |