azathioprine has been researched along with Gaucher Disease in 2 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Indications for the procedure were (1) prevention of azathioprine-induced neutropenia (n = 20); (2) Type I Gaucher disease (n = 9); and (3) cholesteryl ester storage disease, chronic myelogenous leukemia, thalassemia major, and splenic cyst in one patient each." | 3.68 | Elective subtotal splenectomy. Indications and results in 33 patients. ( Barton, N; Guzzetta, PC; Merrick, HF; Ruley, EJ; Verderese, C, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guzzetta, PC | 1 |
| Ruley, EJ | 1 |
| Merrick, HF | 1 |
| Verderese, C | 1 |
| Barton, N | 1 |
| Patel, SC | 1 |
| Davis, GL | 1 |
| Barranger, JA | 1 |
2 other studies available for azathioprine and Gaucher Disease
| Article | Year |
|---|---|
Elective subtotal splenectomy. Indications and results in 33 patients.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Gaucher Disease; Humans; Infant; Neutropen | 1990 |
Gaucher's disease in a patient with chronic active hepatitis.
Topics: Adolescent; Azathioprine; Drug Therapy, Combination; Female; Gaucher Disease; Hepatitis, Chronic; Hu | 1986 |