azathioprine has been researched along with Experimental Neoplasms in 28 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A current southeastern cancer study group protocol for the treatment of multiple myeloma involves induction with BCNU, cyclophosphamide, and prednisone (BCP) and maintenance with either melphalan and prednisone (MP), prednisone, Adriamycin, imuran, and vincristine (PAIV), or delayed treatment of relapsed cases following induction." | 7.66 | Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model. ( Cohen, HJ; Durant, JR; Ghanta, VK; Hiramoto, RN; Silberman, HR, 1981) |
| "A current southeastern cancer study group protocol for the treatment of multiple myeloma involves induction with BCNU, cyclophosphamide, and prednisone (BCP) and maintenance with either melphalan and prednisone (MP), prednisone, Adriamycin, imuran, and vincristine (PAIV), or delayed treatment of relapsed cases following induction." | 3.66 | Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model. ( Cohen, HJ; Durant, JR; Ghanta, VK; Hiramoto, RN; Silberman, HR, 1981) |
| " In 5 transplantable murine tumor models, including sc Sa180, sc Ca755, ip LL and ip leukemias; L1210 and P388 both drugs were found to be antitumor active in all the experiments carried out regardless of dosing regimen or the route of administration." | 1.28 | Experimental antitumor activity of new azathioprine analogues. ( Bałoniak, S; Gutsche, W; Hładoń, B; Sikorska, H, 1989) |
| "Treatment with azathioprine (a single injection 100-400 mg/kg or 5 daily doses of 10-80 mg/kg s." | 1.26 | Effect of chemotherapeutic agents on natural and BCG-stimulated macrophage cytotoxicity in mice. ( Candiani, GP; Luini, W; Mantovani, A; Spreafico, F, 1980) |
| "A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat." | 1.26 | Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response. ( Chang, YH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pirofsky, B | 1 |
| Dawson, PJ | 1 |
| Reid, RH | 1 |
| Mantovani, A | 1 |
| Luini, W | 1 |
| Candiani, GP | 1 |
| Spreafico, F | 1 |
| Ghanta, VK | 1 |
| Cohen, HJ | 1 |
| Silberman, HR | 1 |
| Durant, JR | 1 |
| Hiramoto, RN | 1 |
| Harvey, JJ | 1 |
| East, J | 1 |
| Katz, FE | 1 |
| Cohen, SM | 1 |
| Fukushima, S | 1 |
| Tsuda, H | 1 |
| Murasaki, G | 1 |
| Ito, N | 1 |
| Pot-Deprun, J | 1 |
| Chouroulinkov, I | 1 |
| Purves, EC | 1 |
| Chang, YH | 1 |
| Jacobs, SC | 1 |
| McLaughlin, AP | 1 |
| Gittes, RF | 1 |
| Zóltowska, A | 1 |
| Hładoń, B | 1 |
| Gutsche, W | 1 |
| Bałoniak, S | 1 |
| Sikorska, H | 1 |
| McEwan, A | 1 |
| Petty, LG | 1 |
| Gleichmann, H | 1 |
| Gleichmann, E | 1 |
| Krueger, GR | 3 |
| O'Conor, GT | 1 |
| Sussman, E | 1 |
| Tralka, TS | 1 |
| Allison, AC | 1 |
| Prejean, JD | 1 |
| Griswold, DP | 1 |
| Weisburger, JH | 2 |
| Vormittag, W | 1 |
| Cerilli, J | 1 |
| Hattan, D | 1 |
| Heine, UI | 1 |
| Dargent, M | 1 |
| Bourgoin, JJ | 1 |
| Noel, P | 1 |
| Weissbrod, R | 1 |
| Schlossberg, M | 1 |
| Hollander, VP | 1 |
| Krüger, GR | 1 |
| Nemoto, N | 1 |
| Kato, N | 1 |
| Mizuno, D | 1 |
| Takayama, S | 1 |
| Brambilla, G | 1 |
| Caraceni, CE | 1 |
| Cavanna, M | 1 |
| Parodi, S | 1 |
| Frankel, HH | 1 |
| Yamamoto, RS | 1 |
| Weisburger, EK | 1 |
| Malmgren, RA | 1 |
| Berard, CW | 1 |
| Vredevoe, DL | 1 |
| Hays, EF | 1 |
2 reviews available for azathioprine and Experimental Neoplasms
| Article | Year |
|---|---|
Immunosuppression and neoplasia. I. A critical review of experimental carcinogenesis and the immunesurveillance theory.
Topics: Animals; Antigens, Neoplasm; Antilymphocyte Serum; Autoantibodies; Azathioprine; Benz(a)Anthracenes; | 1973 |
Immunology in neoplasia relating to diagnosis, therapy and transplantation. Immunosuppression and oncogenesis.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinogens; Cortisone; Humans; Immunos | 1974 |
26 other studies available for azathioprine and Experimental Neoplasms
| Article | Year |
|---|---|
Azathioprine.
Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Carcinogens; Chemical Phenomena; Chemistry; Drug | 1981 |
Lack of oncogenicity with immunosuppressive therapy.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Female; Friend murine leukemia virus; Immunosuppression | 1980 |
Effect of chemotherapeutic agents on natural and BCG-stimulated macrophage cytotoxicity in mice.
Topics: Aminoimidazole Carboxamide; Animals; Azathioprine; Cyclophosphamide; Cytotoxicity, Immunologic; Dose | 1980 |
Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model.
Topics: Animals; Antineoplastic Agents; Azathioprine; Doxorubicin; Drug Therapy, Combination; Female; Humans | 1981 |
Azathioprine-induced lymphocytic neoplasms of NZB mice lack ecotropic murine leukaemia virus.
Topics: Animals; Azathioprine; Cell Line; Leukemia Virus, Murine; Leukemia, Experimental; Lymphoma, Non-Hodg | 1979 |
Effect of azathiopurine and OK-432 on urinary bladder carcinogenesis in rats.
Topics: Animals; Azathioprine; Biological Products; Butylhydroxybutylnitrosamine; Drug Synergism; Immunosupp | 1978 |
[Effect of immunostimulation by Corynebacterium parvum on evolution and metastatic dissemination of Lewis's tumor in mouse C57BL/6 mice].
Topics: Adjuvants, Immunologic; Animals; Azathioprine; Immunity, Cellular; Immunotherapy; L-Lactate Dehydrog | 1975 |
Mechanisms of specific and non-specific tumour immunity after azathioprine treatment of mice.
Topics: Animals; Antibodies, Neoplasm; Antibody Formation; Azathioprine; Cytotoxicity Tests, Immunologic; Do | 1975 |
Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response.
Topics: Animals; Arthritis; Arthritis, Experimental; Azathioprine; Cell Line; Cyclophosphamide; Edema; Freun | 1977 |
Effects of immunosuppression on the rejection of methylcholanthrene tumor isografts.
Topics: Animals; Antigens, Neoplasm; Azathioprine; Carcinoma, Squamous Cell; Graft Rejection; Immunosuppress | 1977 |
Lymphoreticular tissue lesions in mice after immunization with typhoid fever vaccine and immunosuppression with azathioprine.
Topics: Animals; Atrophy; Azathioprine; Female; Hyperplasia; Immunization Schedule; Immunosuppression Therap | 1975 |
Experimental antitumor activity of new azathioprine analogues.
Topics: Animals; Antineoplastic Agents; Azathioprine; Cell Survival; Culture Techniques; Humans; KB Cells; L | 1989 |
Oncogenicity of immunosuppressive drugs.
Topics: Animals; Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Mice; Neoplasms; Neoplasm | 1972 |
Ultrastructural and tissue culture studies of a thymic lymphoma induced by persistent antigenic stimulation and immunosuppression.
Topics: Animals; Antigens, Neoplasm; Azathioprine; Cells, Cultured; Cross Reactions; Immunosuppression Thera | 1973 |
Tumour development following immunosuppression.
Topics: Adult; Animals; Antilymphocyte Serum; Azathioprine; Child; Cricetinae; Female; Humans; Immunity, Cel | 1970 |
Transplantation of allogeneic tumors in rats and mice treated with azathioprine, prednisone and antilymphocyte serum.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinoma, Hepatocellular; Immunosuppre | 1972 |
[Cytostatic immunosuppressive therapy, chromosomal aberrations and carcinogenic effect (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Chromosomes, Human, 1-3; C | 1974 |
Morphogenesis of two immunologically induced mouse lymphomas.
Topics: Animals; Azathioprine; Cells, Cultured; Female; Hodgkin Disease; Liver; Lung; Lymph Nodes; Mice; Mic | 1972 |
The influence of azathioprine on tumorogenesis by 7-12 dimethylbenz (a) anthracene in rats.
Topics: Adenocarcinoma; Adenofibroma; Animals; Azathioprine; Benz(a)Anthracenes; Carcinoma; Female; Fibroma; | 1972 |
Imuran-induced regression of plasma cell tumor MOPC-315.
Topics: Animals; Azathioprine; Blood Proteins; Cyclophosphamide; Immunosuppressive Agents; Mercaptopurine; M | 1973 |
Host response during the latent period and the growth of an immunologically induced mouse lymphoma.
Topics: Animals; Antibody Formation; Antigens, Neoplasm; Azathioprine; Cross Reactions; Female; Freund's Adj | 1972 |
Progressive development of chemical carcinogen-induced skin tumor and of transplantable carcinoma with an immunosuppressor.
Topics: Animals; Azathioprine; Carcinoma, Ehrlich Tumor; Gold; Gold Isotopes; Methylcholanthrene; Mice; Mono | 1971 |
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil; | 1971 |
Chronic toxicity of azathioprine and the effect of this immunosuppressant on liver tumor induction by the carcinogen N-hydroxy-N-2-fluorenylacetamide.
Topics: Amides; Animals; Animals, Laboratory; Azathioprine; Body Weight; Carcinogens; Diet; Female; Liver; L | 1970 |
Malignant lymphomas and plasmacytosis in mice under prolonged immunosuppression and persistent antigenic stimulation.
Topics: Animals; Antigens; Antilymphocyte Serum; Atrophy; Azathioprine; Female; Freund's Adjuvant; Glomerulo | 1971 |
Effect of antilymphocytic and antithymocytic sera on the development of mouse lymphoma.
Topics: AKR murine leukemia virus; Animals; Antilymphocyte Serum; Azathioprine; Hemagglutination; Immune Ser | 1969 |