azathioprine has been researched along with Experimental Hepatoma in 5 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azathioprine is a widely used anti-inflammatory, immunosuppressive, and anticancer agent." | 1.37 | Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway. ( Dinkova-Kostova, AT; Finlayson, S; Kalra, S; Knatko, EV; Yamamoto, M; Zhang, Y, 2011) |
| "In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment." | 1.27 | Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma. ( Sakata, T, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalra, S | 1 |
| Zhang, Y | 1 |
| Knatko, EV | 1 |
| Finlayson, S | 1 |
| Yamamoto, M | 1 |
| Dinkova-Kostova, AT | 1 |
| Rai, R | 1 |
| Flecknell, P | 1 |
| Richardson, C | 1 |
| Manas, DM | 1 |
| Sakata, T | 2 |
| Watanabe, A | 1 |
| Takei, N | 1 |
| Shiota, T | 1 |
| Nakatsukasa, H | 1 |
| Fujiwara, M | 1 |
| Kobayashi, M | 1 |
| Nagashima, H | 1 |
| Wolff, M | 1 |
| Jelkmann, W | 1 |
5 other studies available for azathioprine and Experimental Hepatoma
| Article | Year |
|---|---|
Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Azathioprine; Cells, Cultured; | 2011 |
Creation of porcine liver tumor using human hepatoma cell lines: experimental study.
Topics: Animals; Azathioprine; Cyclosporine; Drug Therapy, Combination; Graft Survival; Humans; Immunosuppre | 2005 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Effects of carbon tetrachloride and azathioprine on diethylnitrosamine and N-2-fluorenylacetamide-induced hyperplastic liver nodule and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1984 |
Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures.
Topics: Animals; Antineoplastic Agents; Azathioprine; Colchicine; Cyclophosphamide; Cyclosporine; Cytarabine | 1993 |