azathioprine has been researched along with Enlarged Spleen in 19 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Both patients had been treated with azathioprine and prednisolone for 6 years and 4 months and for 4 years and 7 months, respectively, and presented with splenomegaly and thrombocytopenia suggesting hypersplenism." | 3.69 | Idiopathic portal hypertension in renal transplant recipients: report of two cases. ( Kobashi, T; Kohnosu, H; Ohmori, Y; Oka, T; Yasumura, T; Yoshimura, N, 1994) |
| " Indications for the procedure were (1) prevention of azathioprine-induced neutropenia (n = 20); (2) Type I Gaucher disease (n = 9); and (3) cholesteryl ester storage disease, chronic myelogenous leukemia, thalassemia major, and splenic cyst in one patient each." | 3.68 | Elective subtotal splenectomy. Indications and results in 33 patients. ( Barton, N; Guzzetta, PC; Merrick, HF; Ruley, EJ; Verderese, C, 1990) |
| "Pregnancy with liver cirrhosis is a rare and dangerous event that exposes mother and fetus to potentially lethal risks." | 1.43 | Successful pregnancy with autoimmune cirrhosis. ( Braga, A; Braga, J, 2016) |
| "The fibroscan data showed significant liver fibrosis (F2-F3)." | 1.43 | Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease. ( Abreu García, L; Calleja Panero, JL; Calvo Moya, M; González Lama, Y; González Partida, I; Llop Herrera, E; Matallana Royo, V; Suárez Ferrer, C; Vera Mendoza, MI, 2016) |
| "Treatment with prednisone, azathioprine, and ursodeoxycholic acid led to a good response." | 1.39 | Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy. ( Bahri, I; Boudawara, T; Gargouri, L; Maalej, B; Mahfoudh, A; Majdoub, I; Mnif, H; Mnif, L; Safi, F; Tahri, N; Turki, F, 2013) |
| "Treatment with prednisone and azathioprine, plus, in three children, cyclosporine, resulted in complete remission in eight, partial remission in six, and failure in two." | 1.37 | Giant cell hepatitis with autoimmune hemolytic anemia in early childhood: long-term outcome in 16 children. ( Bernard, O; Choulot, JJ; Fabre, M; Gori, L; Jacquemin, E; Maggiore, G; Pacifico, L; Resti, M; Sciveres, M, 2011) |
| "Common characteristics include: Crohn's disease (CD), thiopurine administration, fever lasting more than 5 days, lymphadenopathy, splenomegaly, anemia, lymphopenia, and elevated serum triglycerides and ferritin." | 1.37 | Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis. ( Biank, VF; Kugathasan, S; Margolis, D; Sheth, MK; Simpson, P; Stephens, M; Talano, J, 2011) |
| "Treatment with prednisolone and azathioprine was initiated." | 1.30 | [Pyoderma gangrenosum and portal vein thrombosis in a 33-year-old female patient]. ( Berr, F; Halm, U; Mössner, J; Paasch, U; Pönisch, W; Schiefke, I, 1999) |
| " These observations strongly suggest an association between chronic use of azathioprine and the development of venous congestion of the liver with sinusoidal dilatation, eventually resulting in chronic liver disease." | 1.27 | Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation. ( Assmann, KM; Deckers, PF; Driessen, WM; Gerlag, PG; Lobatto, S; Schröder, E; Van Haelst, UJ; Van Hooff, JP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (47.37) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Lanis, A | 1 |
| Volochayev, R | 1 |
| Kleiner, DE | 1 |
| Vittal, A | 1 |
| Heller, T | 1 |
| Rider, LG | 1 |
| Shenoi, S | 1 |
| Mavilia, M | 1 |
| McAuliffe, A | 1 |
| Hafeez, S | 1 |
| Vaziri, H | 1 |
| Gargouri, L | 1 |
| Mnif, L | 1 |
| Safi, F | 1 |
| Turki, F | 1 |
| Majdoub, I | 1 |
| Maalej, B | 1 |
| Bahri, I | 1 |
| Mnif, H | 1 |
| Boudawara, T | 1 |
| Tahri, N | 1 |
| Mahfoudh, A | 1 |
| Braga, A | 1 |
| Braga, J | 1 |
| Suárez Ferrer, C | 1 |
| Llop Herrera, E | 1 |
| Calvo Moya, M | 1 |
| Vera Mendoza, MI | 1 |
| González Partida, I | 1 |
| González Lama, Y | 1 |
| Matallana Royo, V | 1 |
| Calleja Panero, JL | 1 |
| Abreu García, L | 1 |
| Maggiore, G | 1 |
| Sciveres, M | 1 |
| Fabre, M | 1 |
| Gori, L | 1 |
| Pacifico, L | 1 |
| Resti, M | 1 |
| Choulot, JJ | 1 |
| Jacquemin, E | 1 |
| Bernard, O | 1 |
| Biank, VF | 1 |
| Sheth, MK | 1 |
| Talano, J | 1 |
| Margolis, D | 1 |
| Simpson, P | 1 |
| Kugathasan, S | 1 |
| Stephens, M | 1 |
| Caspi, D | 1 |
| Fishel, R | 1 |
| Varon, M | 1 |
| Yona, E | 1 |
| Baratz, M | 1 |
| Yaron, M | 1 |
| Yoshimura, N | 1 |
| Oka, T | 1 |
| Ohmori, Y | 1 |
| Yasumura, T | 1 |
| Kohnosu, H | 1 |
| Kobashi, T | 1 |
| Schiefke, I | 1 |
| Halm, U | 1 |
| Paasch, U | 1 |
| Pönisch, W | 1 |
| Berr, F | 1 |
| Mössner, J | 1 |
| Mozes, MF | 1 |
| Spigos, DS | 1 |
| Jonasson, O | 1 |
| Thomas, PA | 1 |
| Kauffman, HM | 1 |
| Lawson, RK | 1 |
| Adams, MB | 1 |
| Sampson, D | 1 |
| Sauerwein, HP | 1 |
| Guzzetta, PC | 1 |
| Ruley, EJ | 1 |
| Merrick, HF | 1 |
| Verderese, C | 1 |
| Barton, N | 1 |
| Gerlag, PG | 1 |
| Lobatto, S | 1 |
| Driessen, WM | 1 |
| Deckers, PF | 1 |
| Van Hooff, JP | 1 |
| Schröder, E | 1 |
| Assmann, KM | 1 |
| Van Haelst, UJ | 1 |
| Baumann, W | 1 |
| Levy, L | 1 |
| Leone, G | 1 |
| Pola, P | 1 |
| Guerrera, G | 1 |
| Bizzi, B | 1 |
| Schulz, K | 1 |
| Preussner, S | 1 |
| Frick, G | 1 |
19 other studies available for azathioprine and Enlarged Spleen
| Article | Year |
|---|---|
Nodular Regenerative Hyperplasia of the liver in Juvenile Dermatomyositis.
Topics: Abatacept; Adolescent; Arthritis; Autoantibodies; Azathioprine; Calcinosis; Child; Cyclophosphamide; | 2022 |
Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction.
Topics: Adult; Anemia, Hemolytic; Azathioprine; Biopsy; Chronic Disease; Colitis, Ulcerative; Fatal Outcome; | 2018 |
Type 2 autoimmune hepatitis overlapping with primary sclerosing cholangitis in a 10-year-old boy.
Topics: Alkaline Phosphatase; Azathioprine; Biomarkers; Child; Cholagogues and Choleretics; Cholangitis, Scl | 2013 |
Successful pregnancy with autoimmune cirrhosis.
Topics: Adrenal Cortex Hormones; Adult; Antihypertensive Agents; Azathioprine; Cesarean Section; Esophageal | 2016 |
Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease.
Topics: Adult; Aged; Azathioprine; Cross-Sectional Studies; Female; Humans; Hypertension, Portal; Idiopathic | 2016 |
Giant cell hepatitis with autoimmune hemolytic anemia in early childhood: long-term outcome in 16 children.
Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Bilirubin; Coom | 2011 |
Association of Crohn's disease, thiopurines, and primary epstein-barr virus infection with hemophagocytic lymphohistiocytosis.
Topics: Adolescent; Anemia; Azathioprine; Crohn Disease; Epstein-Barr Virus Infections; Ferritins; Fever; Hu | 2011 |
Multisystem presentation of eosinophilic fasciitis.
Topics: Adult; Ankle Joint; Azathioprine; Blood Sedimentation; Bone Marrow Examination; Elbow Joint; Eosinop | 1982 |
Idiopathic portal hypertension in renal transplant recipients: report of two cases.
Topics: Adult; Angiography; Azathioprine; Catheterization; Celiac Artery; Endoscopy; Esophageal and Gastric | 1994 |
[Pyoderma gangrenosum and portal vein thrombosis in a 33-year-old female patient].
Topics: Adult; Anti-Inflammatory Agents; Anticoagulants; Antineoplastic Agents; Ascites; Azathioprine; Bone | 1999 |
Transcatheteric partial splenic embolization (PSE) for azathioprine intolerance in renal transplant recipients.
Topics: Azathioprine; Bone Marrow Cells; Drug Tolerance; Embolization, Therapeutic; Humans; Kidney Transplan | 1979 |
Posttransplant hypersplenism.
Topics: Azathioprine; Drug Tolerance; Graft Survival; HLA Antigens; Humans; Immunosuppression Therapy; Kidne | 1979 |
[A patient with muscle weakness].
Topics: Aged; Arthritis, Rheumatoid; Autoantibodies; Azathioprine; Complement System Proteins; Cryoglobulins | 1977 |
Elective subtotal splenectomy. Indications and results in 33 patients.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Gaucher Disease; Humans; Infant; Neutropen | 1990 |
Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Esophagus; Female; Humans; Hypertension | 1985 |
[Diagnosis, therapy and clinical course in chronic active hepatitis in childhood with special reference to immunological findings (author's transl)].
Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Azathioprine; Chemical and Drug Induced Liver Inju | 1974 |
A contribution to the mechanism of drug inhibition of the graft vs host reaction.
Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Azathioprine; Cyclophosphamide; Cytarabine; D | 1973 |
[Acquired von Willebrand's syndrome during collagen disorder (author's transl)].
Topics: Adult; Azathioprine; Blood Coagulation Tests; Collagen Diseases; Factor VIII; Female; Hemorrhagic Di | 1974 |
[Thrombocyte survival time in thrombocytopenias].
Topics: Azathioprine; Blood Platelets; Chromium Isotopes; Diagnosis, Differential; Female; Humans; Hypersple | 1970 |