azathioprine has been researched along with Dysmyelopoietic Syndromes in 26 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 7.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "Azathioprine (Aza) is a widely used immunosuppressive drug in multiple sclerosis (MS) treatment." | 7.73 | Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis. ( Diener, HC; Germing, U; Knipp, S; Limmroth, V; Putzki, N; Ramczykowski, T; Vago, S, 2006) |
| "A woman with relapsing-remitting multiple sclerosis (MS) was treated with oral azathioprine (AZA) for 4 years and subsequently switched to interferon-beta1a." | 7.73 | Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosis. ( Al-Ali, HK; Niederwieser, D; Niklas, A; Schwarz, J; Strauss, A; Then Bergh, F; von Ahsen, N; Wagner, A, 2006) |
| "Azathioprine is widely used in patients with autoimmune diseases and after organ allografting." | 4.86 | Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia. ( Kwong, YL, 2010) |
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 3.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "Azathioprine (Aza) is a widely used immunosuppressive drug in multiple sclerosis (MS) treatment." | 3.73 | Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis. ( Diener, HC; Germing, U; Knipp, S; Limmroth, V; Putzki, N; Ramczykowski, T; Vago, S, 2006) |
| "A woman with relapsing-remitting multiple sclerosis (MS) was treated with oral azathioprine (AZA) for 4 years and subsequently switched to interferon-beta1a." | 3.73 | Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosis. ( Al-Ali, HK; Niederwieser, D; Niklas, A; Schwarz, J; Strauss, A; Then Bergh, F; von Ahsen, N; Wagner, A, 2006) |
| "Treatment with azathioprine may - depending on its cumulative dosage - lead to pancytopenia and subsequent development of myelodysplasia or secondary leukaemia, respectively." | 3.72 | [Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations]. ( Kaiser, U; Schlegelberger, B; Wilkens, L; Willerding-Möllmann, S, 2004) |
| "We describe a case of spontaneously reversible refractory anaemia, a subtype of myelodysplastic syndrome (MDS), with monosomy 7 secondary to chronic treatment with azathioprine (AZA) in a young renal transplant recipient." | 3.69 | Spontaneous remission in a patient with therapy-related myelodysplastic syndrome (t-MDS) with monosomy 7. ( De Mulder, A; Ferster, A; Hansen, V; Heimann, P; Jannsen, F; Renneboog, B, 1996) |
| "A 71-year-old man developed ulcerative colitis (UC) at 48 years of age." | 1.72 | [A case of "colitis-like intestinal Behçet's disease" accompanied by ulcerative colitis after the development of myelodysplastic syndrome]. ( Hara, E; Kamakura, M; Kitabatake, H; Kondo, S; Kunimoto, H; Nakamura, A; Ochi, Y; Saito, H; Seki, A, 2022) |
| "that describes potential risk of acute myeloid leukemia or myeloproliferative disorder among thiopurine therapy." | 1.62 | The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits? ( Ha, C, 2021) |
| "Azathioprine sodium use was observed more frequently in cases (odds ratio [OR], 7." | 1.46 | Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia. ( Al-Kali, A; Castro, J; Dueck, A; Ertz-Archambault, N; Finn, L; Foran, J; Gauthier, S; Kelemen, K; Kosiorek, H; Marino, R; Mesa, RA; Palmer, J; Sproat, LZ; Taylor, GE; Tibes, R, 2017) |
| "Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality." | 1.38 | Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus. ( Besbas, N; Bilginer, Y; Bulus, D; Cetin, M; Gokce, M; Gumruk, F, 2012) |
| " The long-term use of immunodulating agents in patients with CD is not without risks, and early therapy related myelodysplasia might not be easily detected by blood count and morphology assessment alone." | 1.31 | Clonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: a cautionary tale. ( Au, WY; Lai, KC; Ma, SK; Wan, TS; Yuen, MF, 2002) |
| "Relapsing polychondritis is a rare disorder of uncertain origin characterized by recurrent inflammation of cartilage." | 1.28 | [Relapsing polychondritis in a patient with myelodysplastic syndrome]. ( Egami, K; Honda, J; Matsuo, K; Naitoh, K; Nakamura, E; Natori, H; Osabe, S; Tanaka, K; Utsunomiya, I; Yoshida, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Kondo, S | 1 |
| Kamakura, M | 1 |
| Nakamura, A | 1 |
| Saito, H | 1 |
| Kunimoto, H | 1 |
| Kitabatake, H | 1 |
| Seki, A | 1 |
| Ochi, Y | 1 |
| Hara, E | 1 |
| Ha, C | 1 |
| Tibes, R | 2 |
| Ertz-Archambault, N | 2 |
| Kosiorek, H | 2 |
| Meijer, B | 1 |
| de Boer, NKH | 1 |
| Ram, R | 1 |
| Swarnalatha, G | 1 |
| Rao, CS | 1 |
| Adiraju, KP | 1 |
| Dakshinamurty, KV | 1 |
| Lopez, A | 1 |
| Mounier, M | 1 |
| Bouvier, AM | 1 |
| Carrat, F | 1 |
| Maynadié, M | 1 |
| Beaugerie, L | 1 |
| Peyrin-Biroulet, L | 1 |
| Deepak, P | 1 |
| Stobaugh, DJ | 1 |
| Taylor, GE | 1 |
| Kelemen, K | 1 |
| Dueck, A | 1 |
| Castro, J | 1 |
| Marino, R | 1 |
| Gauthier, S | 1 |
| Finn, L | 1 |
| Sproat, LZ | 1 |
| Palmer, J | 1 |
| Mesa, RA | 1 |
| Al-Kali, A | 1 |
| Foran, J | 1 |
| Tabata, R | 1 |
| Tabata, C | 1 |
| Okamoto, T | 1 |
| Omori, K | 1 |
| Terada, M | 1 |
| Nagai, T | 1 |
| Kwong, YL | 2 |
| Heredia, F | 1 |
| Sousa, J | 1 |
| Magalhães, S | 1 |
| Pinheiro, R | 1 |
| Chihara, D | 1 |
| Takeoka, T | 1 |
| Shirase, T | 1 |
| Kishimoto, W | 1 |
| Arimoto-Miyamoto, K | 1 |
| Tsuji, M | 1 |
| Ohno, T | 1 |
| Gokce, M | 1 |
| Bulus, D | 1 |
| Bilginer, Y | 1 |
| Gumruk, F | 1 |
| Besbas, N | 1 |
| Cetin, M | 1 |
| Au, WY | 2 |
| Yuen, MF | 1 |
| Lai, KC | 1 |
| Wan, TS | 2 |
| Ma, SK | 1 |
| Roy-Peaud, F | 1 |
| Paccalin, M | 1 |
| Le Moal, G | 1 |
| Landron, C | 1 |
| Juhel, L | 1 |
| Roblot, P | 1 |
| Becq-Giraudon, B | 1 |
| Offman, J | 1 |
| Opelz, G | 1 |
| Doehler, B | 1 |
| Cummins, D | 1 |
| Halil, O | 1 |
| Banner, NR | 1 |
| Burke, MM | 1 |
| Sullivan, D | 1 |
| Macpherson, P | 1 |
| Karran, P | 1 |
| Willerding-Möllmann, S | 1 |
| Wilkens, L | 1 |
| Schlegelberger, B | 1 |
| Kaiser, U | 1 |
| Knipp, S | 2 |
| Hildebrandt, B | 1 |
| Richter, J | 1 |
| Haas, R | 1 |
| Germing, U | 2 |
| Gattermann, N | 1 |
| Pang, A | 1 |
| Ma, ES | 1 |
| Cheng, LC | 1 |
| Putzki, N | 1 |
| Ramczykowski, T | 1 |
| Vago, S | 1 |
| Diener, HC | 1 |
| Limmroth, V | 1 |
| Then Bergh, F | 1 |
| Niklas, A | 1 |
| Strauss, A | 1 |
| von Ahsen, N | 1 |
| Niederwieser, D | 1 |
| Schwarz, J | 1 |
| Wagner, A | 1 |
| Al-Ali, HK | 1 |
| Aoki, M | 1 |
| Miura, A | 1 |
| Sato, I | 1 |
| Suzuki, C | 1 |
| Renneboog, B | 1 |
| Hansen, V | 1 |
| Heimann, P | 1 |
| De Mulder, A | 1 |
| Jannsen, F | 1 |
| Ferster, A | 1 |
| Tanaka, K | 1 |
| Nakamura, E | 1 |
| Naitoh, K | 1 |
| Utsunomiya, I | 1 |
| Matsuo, K | 1 |
| Osabe, S | 1 |
| Honda, J | 1 |
| Yoshida, K | 1 |
| Egami, K | 1 |
| Natori, H | 1 |
| Vandenberghe, EA | 1 |
| Mecucci, C | 1 |
| Delannoy, A | 1 |
| Van den Berghe, H | 1 |
| Bammatter, F | 1 |
| Binswanger, U | 1 |
| Fehr, J | 1 |
2 reviews available for azathioprine and Dysmyelopoietic Syndromes
| Article | Year |
|---|---|
Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Topics: Adult; Aged; Autoimmune Diseases; Azathioprine; Female; Graft Rejection; Humans; Immunosuppressive A | 2010 |
[Association of systemic diseases and myelodysplastic syndromes. A retrospective study of 14 cases].
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Blood Transfusion; Cyclophosp | 2003 |
24 other studies available for azathioprine and Dysmyelopoietic Syndromes
| Article | Year |
|---|---|
[A case of "colitis-like intestinal Behçet's disease" accompanied by ulcerative colitis after the development of myelodysplastic syndrome].
Topics: Aged; Azathioprine; Behcet Syndrome; Colitis, Ulcerative; Humans; Male; Myelodysplastic Syndromes; U | 2022 |
The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits?
Topics: Azathioprine; Humans; Incidence; Inflammatory Bowel Diseases; Leukemia, Myeloid, Acute; Myelodysplas | 2021 |
All Thiopurines Are Equal But Some Thiopurines Are More Equal Than Others-Reply.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
All Thiopurines Are Equal but Some Thiopurines Are More Equal Than Others.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
Anaemia in a renal allograft recipient: an unusual cause.
Topics: Aged; Anemia; Azathioprine; Copper; Diet, Vegetarian; Humans; Immunosuppressive Agents; Kidney Trans | 2014 |
Increased risk of acute myeloid leukemias and myelodysplastic syndromes in patients who received thiopurine treatment for inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Cohort Studies; Female; France; Humans; Immunosuppressive Agents; I | 2014 |
Risk of Myeloid Neoplasms in Inflammatory Bowel Disease Patients Is Linked to Exposure to Thiopurines and Not With Tumor Necrosis Factor-alpha Inhibitors.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukemia, Myelo | 2015 |
Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Case-Control Stud | 2017 |
Autoimmune pancreatitis associated with myelodysplastic syndrome.
Topics: Aged; Amylases; Autoantibodies; Autoimmune Diseases; Azathioprine; Bile Ducts; Bilirubin; Blood Cell | 2010 |
Therapy-related myelodysplastic syndrome with 17p deletion following long-term azathioprine treatment.
Topics: Adult; Azathioprine; Chromosome Deletion; Chromosomes, Human, Pair 17; Female; Humans; Myasthenia Gr | 2010 |
Progressive multifocal leukoencephalopathy in myelodysplastic syndrome involving pure red cell aplasia.
Topics: Aged; Azathioprine; Female; Humans; Immunosuppressive Agents; Leukoencephalopathy, Progressive Multi | 2010 |
Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus.
Topics: Antimetabolites; Azathioprine; Child; Fatal Outcome; Female; Humans; Lupus Erythematosus, Systemic; | 2012 |
Clonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: a cautionary tale.
Topics: Adult; Azathioprine; Crohn Disease; Humans; Male; Myelodysplastic Syndromes; Neutrophils; Sulfasalaz | 2002 |
Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation.
Topics: Acute Disease; Azathioprine; Base Pair Mismatch; Bone Marrow; DNA Repair; Follow-Up Studies; Heart T | 2004 |
[Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations].
Topics: Anemia; Azathioprine; Bone Marrow; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Hum | 2004 |
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azathioprine; Cell Transformation, Neoplastic; | 2005 |
Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation.
Topics: Adult; Azathioprine; B-Lymphocytes; Biopsy; Bone Marrow; Causality; Female; Humans; Immunosuppressiv | 2006 |
Secondary myelodysplastic syndrome following long-term treatment with azathioprine in patients with multiple sclerosis.
Topics: Adolescent; Adult; Azathioprine; Female; Humans; Immunosuppressive Agents; Incidence; Male; Middle A | 2006 |
Rapid progression of Myelodysplastic syndrome to acute myeloid leukemia on sequential azathioprine, IFN-beta and copolymer-1 in a patient with multiple sclerosis.
Topics: Acute Disease; Azathioprine; Disease Progression; Fatal Outcome; Female; Glatiramer Acetate; Humans; | 2006 |
[A case of repeated pyoderma gangrenosum with myelodysplastic syndrome].
Topics: Adult; Azathioprine; Humans; Male; Myelodysplastic Syndromes; Prednisolone; Pyoderma Gangrenosum; Re | 1993 |
Spontaneous remission in a patient with therapy-related myelodysplastic syndrome (t-MDS) with monosomy 7.
Topics: Adult; Anemia, Refractory; Azathioprine; Chromosomes, Human, Pair 7; Female; Humans; Immunosuppressi | 1996 |
[Relapsing polychondritis in a patient with myelodysplastic syndrome].
Topics: Azathioprine; Dapsone; gamma-Globulins; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Optic | 1990 |
Deletion of 5q by t(5;17) in therapy-related myelodysplastic syndrome.
Topics: Adult; Azathioprine; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 17; Chromosom | 1990 |
[Reversible azathioprine associated dysmyeloproliferative syndrome after kidney allotransplantation].
Topics: Adult; Azathioprine; Bone Marrow; Cyclosporins; Follow-Up Studies; Graft Rejection; Humans; Kidney F | 1987 |