azathioprine has been researched along with Disease Models, Animal in 83 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI) phenotype, the hallmark of a defective MMR system." | 7.81 | Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model. ( Beaugerie, L; Bodo, S; Brousse, N; Buhard, O; Capel, C; Chalastanis, A; Collura, A; Cuillières-Dartigues, P; Dinard, L; Dumont, S; Duval, A; Fabiani, B; Fléjou, JF; Lafitte, P; Ledent, T; Muleris, M; Penard-Lacronique, V; Sourrouille, I; Svrcek, M; Wanherdrick, K, 2015) |
| "The author presents evidence from published papers of research done by numerous investigators that Multiple Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antigens involved, that the autoimmune reaction is effected by sensitized lymphocytes together with a specific antibody, that Experimental Allergic Encephalomyelitis (EAE) produced in animals can be used as a model for MS, and that the autoimmune reaction in MS can possibly be suppressed by the use of MBP given by an intravenous procedure together with an immunosuppressive drug and a corticosteroid." | 7.67 | Suppression of the immune reaction in multiple sclerosis might be achieved by intravenous injections of myelin basic protein, concomitant with the administration of an immunosuppressant and a corticosteroid. ( Eidinoff, H, 1988) |
| "Recent controlled clinical trials have documented the development of acute pancreatitis in 5% of patients receiving azathioprine for Crohn's disease, by far the highest incidence of drug-induced pancreatitis recorded to date." | 7.66 | Azathioprine and acute pancreatitis: studies with an isolated perfused canine pancreas. ( Broe, PJ; Cameron, JL, 1983) |
| "Progressive passive Heymann nephritis (group II) was induced in rats by i." | 5.28 | Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis. ( Aono, Y; Ito, M; Nagamatsu, T; Suzuki, A; Suzuki, Y, 1989) |
| " The immunomodulating capabilities of the agents tested are assessed by their effects on the allergic contact reaction to oxazolone, a cell-mediated delayed hypersensitivity reaction." | 4.77 | The effect of selected immunomodulating agents on experimental contact reactions. ( Anderson, C, 1985) |
| " Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI) phenotype, the hallmark of a defective MMR system." | 3.81 | Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model. ( Beaugerie, L; Bodo, S; Brousse, N; Buhard, O; Capel, C; Chalastanis, A; Collura, A; Cuillières-Dartigues, P; Dinard, L; Dumont, S; Duval, A; Fabiani, B; Fléjou, JF; Lafitte, P; Ledent, T; Muleris, M; Penard-Lacronique, V; Sourrouille, I; Svrcek, M; Wanherdrick, K, 2015) |
| "Most untreated Msh2(WT) and Msh2(+/)⁻ mice remained asymptomatic and alive at 250 days of age, whereas azathioprine-treated Msh2(WT) and Msh2(+/)⁻ mice developed lymphomas and died prematurely (median survival of 71 and 165 days of age, respectively)." | 3.76 | Azathioprine-induced carcinogenesis in mice according to Msh2 genotype. ( Antoine, N; Buhard, O; Chalastanis, A; Defaweux, V; Dumont, S; Duval, A; Fabiani, B; Fléjou, JF; Muleris, M; Penard-Lacronique, V; Renault, I; Svrcek, M; Te Riele, H; Tubacher, E, 2010) |
| " In addition, we suppressed the immune system with either azathioprine (Aza) or mycophenolate mofetil (MMF) during the second half of pregnancy to determine whether the these symptoms could be ameliorated." | 3.75 | Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension. ( Chiasson, VL; Mahajan, A; Mitchell, BM; South, S; Tinsley, JH, 2009) |
| "To evaluate the potential risk of dissemination or reactivation of toxoplasmosis following the administration of immunosuppressive therapy we examined the effect of corticoids, azathioprine, and cyclosporine given alone or in combination on the course of murine acute and chronic toxoplasmic infection." | 3.69 | Effect of immunosuppressive drug regimens on acute and chronic murine toxoplasmosis. ( Derouin, F; Garin, YJ; Sumyuen, MH, 1996) |
| "The author presents evidence from published papers of research done by numerous investigators that Multiple Sclerosis (MS) is an autoimmune disease, that the target tissue is the myelin sheath which covers the nerve fibers in the brain and spinal cord, that Myelin Basic Protein (MBP) is the antigen or one of the antigens involved, that the autoimmune reaction is effected by sensitized lymphocytes together with a specific antibody, that Experimental Allergic Encephalomyelitis (EAE) produced in animals can be used as a model for MS, and that the autoimmune reaction in MS can possibly be suppressed by the use of MBP given by an intravenous procedure together with an immunosuppressive drug and a corticosteroid." | 3.67 | Suppression of the immune reaction in multiple sclerosis might be achieved by intravenous injections of myelin basic protein, concomitant with the administration of an immunosuppressant and a corticosteroid. ( Eidinoff, H, 1988) |
| " Azathioprine in different doses, and cyclophosamide and methylprednisolone combinations did not result in predictable leukocytopenia without significant mortality." | 3.67 | Development of a leukocytopenic baby guinea pig model with azathioprine and cyclophosphamide. ( Cleveland, RP; Kumar, A; Leonard, MC, 1989) |
| "Recent controlled clinical trials have documented the development of acute pancreatitis in 5% of patients receiving azathioprine for Crohn's disease, by far the highest incidence of drug-induced pancreatitis recorded to date." | 3.66 | Azathioprine and acute pancreatitis: studies with an isolated perfused canine pancreas. ( Broe, PJ; Cameron, JL, 1983) |
| " Current immunosuppression protocols include a combination of calcineurin inhibitors, such as tacrolimus, and antiproliferative agents (most commonly mycophenolate mofetil), with or without different dosing regimens of corticosteroids." | 2.52 | Current State of Immunosuppression: Past, Present, and Future. ( Karam, S; Wali, RK, 2015) |
| "The optimal treatment of atopic dermatitis requires regular medical supervision." | 2.42 | [Systemic therapy of atopic dermatitis]. ( Breuer, K; Heratizadeh, A; Kapp, A; Werfel, T, 2003) |
| "Mucopolysaccharidoses (MPSs) are lysosomal storage diseases caused by a deficit in the enzymes needed for glycosaminoglycan (GAG) degradation." | 1.35 | Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I. ( Dickson, P; Jabagat, C; Kakkis, ED; Krieger, A; Le, S; Lester, T; Manuel, H; McEntee, M; Passage, M; Peinovich, M, 2008) |
| "Azathioprine (AZA) is a cytotoxic immunosuppressive drug used in the prevention of rejection in organ transplants and the treatment of auto-immune diseases." | 1.35 | The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse. ( Chen, CM; Gibson, FM; Marway, HK; McKeag, S; Mifsud, CV; Molyneux, G; Pilling, AM; Turton, JA; Whayman, MJ, 2008) |
| "Latent Trypanosoma cruzi infection may be reactivated in immunosuppressed individuals, with unusual clinical patterns, such as meningoencephalitis, pseudo neoplastic lesions in the central nervous system, and myocarditis with numerous parasites in the heart muscle." | 1.30 | Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi. ( Andrade, SG; Andrade, ZA; Carneiro Filho, A; de Lima, ES; de Souza, AJ, 1997) |
| "The objective of the present study was to evaluate the dosing regimen of immunosuppressants necessary to avoid the formation of anti-hGH antibodies in a pig model." | 1.30 | Plasma concentration of hGH and anti-hGH antibodies after subcutaneous administration of hGH for 3 weeks to immunosuppressed pigs. ( Agersø, H; Drustrup, J; Haahr, PM; Jørgensen, KD; Wilken, M, 1999) |
| "Drug treatment of late-stage human African Trypanosomiasis (HAT) in which the central nervous system (CNS) is involved may be complicated by a severe post-treatment reactive encephalopathy (PTRE) which can be fatal in up to 10% of cases." | 1.30 | The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of Human African Trypanosomiasis. ( Kennedy, PG, 1999) |
| "Azathioprine treatment alone did not alter ionized calcium, 1,25(OH)2VitD, or PTH levels." | 1.29 | Azathioprine alone is bone sparing and does not alter cyclosporin A-induced osteopenia in the rat. ( Armstrong, EC; Bryer, HP; Buchinsky, FJ; Epstein, S; Isserow, JA; Mann, GN; Romero, DF; Rucinski, B, 1995) |
| "The treatment of human African sleeping sickness is complicated by a post-treatment meningoencephalitis that may be fatal." | 1.28 | The use of azathioprine to ameliorate post-treatment encephalopathy associated with African trypanosomiasis. ( Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M, 1992) |
| "Progressive passive Heymann nephritis (group II) was induced in rats by i." | 1.28 | Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis. ( Aono, Y; Ito, M; Nagamatsu, T; Suzuki, A; Suzuki, Y, 1989) |
| "Thalidomide treatment was successful in the majority of animals (16 of 18)." | 1.28 | Therapy of chronic graft-v-host disease in a rat model. ( Friedman, KJ; Hess, AD; Santos, GW; Vogelsang, GB, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (49.40) | 18.7374 |
| 1990's | 11 (13.25) | 18.2507 |
| 2000's | 19 (22.89) | 29.6817 |
| 2010's | 11 (13.25) | 24.3611 |
| 2020's | 1 (1.20) | 2.80 |
| Authors | Studies |
|---|---|
| Krenitsky, TA | 1 |
| Hall, WW | 1 |
| Selph, JL | 1 |
| Truax, JF | 1 |
| Vinegar, R | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Weder, B | 1 |
| Mozaffari, M | 1 |
| Biedermann, L | 1 |
| Mamie, C | 1 |
| Moncsek, A | 1 |
| Wang, L | 1 |
| Clarke, SH | 1 |
| Rogler, G | 1 |
| McRae, BL | 1 |
| Graff, CL | 1 |
| Ruiz, PA | 1 |
| Hausmann, M | 1 |
| Reggio, A | 1 |
| Spada, F | 1 |
| Rosina, M | 1 |
| Massacci, G | 1 |
| Zuccotti, A | 1 |
| Fuoco, C | 1 |
| Gargioli, C | 1 |
| Castagnoli, L | 1 |
| Cesareni, G | 1 |
| Li, Y | 1 |
| Liu, Q | 1 |
| Tang, JH | 1 |
| Wen, JJ | 1 |
| Zhu, JQ | 1 |
| Marinkovic, G | 1 |
| Hibender, S | 1 |
| Hoogenboezem, M | 1 |
| van Broekhoven, A | 1 |
| Girigorie, AF | 1 |
| Bleeker, N | 1 |
| Hamers, AA | 1 |
| Stap, J | 1 |
| van Buul, JD | 1 |
| de Vries, CJ | 1 |
| de Waard, V | 1 |
| Myrelid, P | 1 |
| Salim, SY | 1 |
| Darby, T | 1 |
| Almer, S | 1 |
| Melgar, S | 1 |
| Andersson, P | 1 |
| Söderholm, JD | 1 |
| Karam, S | 1 |
| Wali, RK | 1 |
| Bodo, S | 1 |
| Svrcek, M | 2 |
| Sourrouille, I | 1 |
| Cuillières-Dartigues, P | 1 |
| Ledent, T | 1 |
| Dumont, S | 2 |
| Dinard, L | 1 |
| Lafitte, P | 1 |
| Capel, C | 1 |
| Collura, A | 1 |
| Buhard, O | 2 |
| Wanherdrick, K | 1 |
| Chalastanis, A | 2 |
| Penard-Lacronique, V | 2 |
| Fabiani, B | 2 |
| Fléjou, JF | 2 |
| Brousse, N | 1 |
| Beaugerie, L | 1 |
| Duval, A | 2 |
| Muleris, M | 2 |
| Huang, YF | 1 |
| Zhou, JT | 1 |
| Qu, C | 1 |
| Dou, YX | 1 |
| Huang, QH | 1 |
| Lin, ZX | 1 |
| Xian, YF | 1 |
| Xie, JH | 1 |
| Xie, YL | 1 |
| Lai, XP | 1 |
| Su, ZR | 1 |
| Takae, Y | 1 |
| Nishikawa, T | 1 |
| Amagai, M | 1 |
| Dickson, P | 1 |
| Peinovich, M | 2 |
| McEntee, M | 1 |
| Lester, T | 2 |
| Le, S | 1 |
| Krieger, A | 1 |
| Manuel, H | 1 |
| Jabagat, C | 1 |
| Passage, M | 2 |
| Kakkis, ED | 1 |
| Bozkurt, D | 1 |
| Sipahi, S | 1 |
| Cetin, P | 1 |
| Hur, E | 1 |
| Ozdemir, O | 1 |
| Ertilav, M | 1 |
| Sen, S | 1 |
| Duman, S | 1 |
| Tinsley, JH | 1 |
| Chiasson, VL | 1 |
| South, S | 1 |
| Mahajan, A | 1 |
| Mitchell, BM | 1 |
| Erwig, LP | 1 |
| Savage, CO | 1 |
| Defaweux, V | 1 |
| Antoine, N | 1 |
| Renault, I | 1 |
| Tubacher, E | 1 |
| Te Riele, H | 1 |
| De León, EJ | 1 |
| Olmedo, DA | 1 |
| Solís, PN | 1 |
| Gupta, MP | 1 |
| Terencio, MC | 1 |
| Askar, I | 1 |
| Bozkurt, M | 1 |
| Inkinen, K | 1 |
| Holma, K | 1 |
| Soots, A | 1 |
| Krogerus, L | 1 |
| Loginov, R | 1 |
| Bruggeman, C | 1 |
| Ahonen, J | 1 |
| Lautenschlager, I | 1 |
| Langford, CA | 1 |
| Balow, JE | 1 |
| Heratizadeh, A | 1 |
| Breuer, K | 1 |
| Kapp, A | 1 |
| Werfel, T | 1 |
| Nogal-Ruiz, JJ | 1 |
| Gómez-Barrio, A | 1 |
| Escario, JA | 1 |
| Martínez-Fernández, AR | 1 |
| Kakkis, E | 1 |
| Yang, R | 1 |
| Tanaka, C | 1 |
| Anand, V | 1 |
| Lemontt, J | 1 |
| Boehmer, LN | 1 |
| Wu, MF | 1 |
| John, J | 1 |
| Siegel, JM | 1 |
| Lamprecht, P | 1 |
| Päiväniemi, OE | 1 |
| Maasilta, PK | 2 |
| Alho, HS | 2 |
| Wolff, CH | 1 |
| Salminen, US | 3 |
| Wu, YT | 1 |
| Shen, C | 1 |
| Yin, J | 1 |
| Yu, JP | 1 |
| Meng, Q | 1 |
| Murray, KF | 1 |
| Stolzenburg, T | 1 |
| Ljungmann, K | 1 |
| Christensen, H | 1 |
| Molyneux, G | 1 |
| Gibson, FM | 1 |
| Chen, CM | 1 |
| Marway, HK | 1 |
| McKeag, S | 1 |
| Mifsud, CV | 1 |
| Pilling, AM | 1 |
| Whayman, MJ | 1 |
| Turton, JA | 1 |
| Broe, PJ | 1 |
| Cameron, JL | 1 |
| Roberts, JA | 1 |
| Domingue, GJ | 1 |
| Martin, LN | 1 |
| Kim, JC | 1 |
| Rangan, SR | 1 |
| Miller, ML | 1 |
| Steinberg, AD | 1 |
| Ginzler, EM | 1 |
| Bollet, AJ | 1 |
| Friedman, EA | 1 |
| Toledo-Pereyra, LH | 1 |
| Gordon, DA | 1 |
| MacKenzie, GH | 1 |
| Goldberg, VM | 1 |
| Porter, BB | 1 |
| Lance, EM | 1 |
| Bryer, HP | 1 |
| Isserow, JA | 1 |
| Armstrong, EC | 1 |
| Mann, GN | 1 |
| Rucinski, B | 1 |
| Buchinsky, FJ | 1 |
| Romero, DF | 1 |
| Epstein, S | 1 |
| Fujiwara, K | 1 |
| Yoshino, T | 1 |
| Akagi, T | 1 |
| Teramoto, N | 1 |
| Hayashi, K | 1 |
| Fouad, FM | 1 |
| Mamer, OA | 1 |
| Shahidi, F | 1 |
| Sumyuen, MH | 1 |
| Garin, YJ | 1 |
| Derouin, F | 1 |
| Andrade, SG | 1 |
| Carneiro Filho, A | 1 |
| de Souza, AJ | 1 |
| de Lima, ES | 1 |
| Andrade, ZA | 1 |
| Ikonen, T | 1 |
| Uusitalo, M | 1 |
| Taskinen, E | 1 |
| Korpela, A | 1 |
| Maasilta, P | 1 |
| Harjula, AL | 2 |
| Agersø, H | 1 |
| Wilken, M | 1 |
| Drustrup, J | 1 |
| Haahr, PM | 1 |
| Jørgensen, KD | 1 |
| Kennedy, PG | 2 |
| Taskinen, EI | 1 |
| Ikonen, TS | 1 |
| Corbel, MJ | 1 |
| Eades, SM | 1 |
| Kupor, LR | 1 |
| Lowance, DC | 1 |
| McPhaul, JJ | 1 |
| Steinke, H | 1 |
| Laufs, R | 1 |
| Perings, E | 1 |
| Junge, U | 1 |
| Nigida, SM | 1 |
| Falk, LA | 1 |
| Wolfe, LG | 1 |
| Deinhardt, F | 1 |
| Lakeman, A | 1 |
| Alford, CA | 1 |
| Peller, P | 1 |
| Goetz, O | 1 |
| Benfield, JR | 2 |
| Shors, E | 1 |
| Schick, P | 1 |
| Byfield, PE | 1 |
| Okita, M | 2 |
| Krueger, G | 1 |
| Zółtowska, A | 1 |
| Shors, EC | 1 |
| Matsumura, K | 1 |
| Cohen, AH | 1 |
| Davenport, HW | 1 |
| Bogossian, M | 1 |
| Huraux, JM | 1 |
| Nicolas, JC | 1 |
| Begué, P | 1 |
| Bricout, F | 1 |
| Hunter, CA | 1 |
| Jennings, FW | 1 |
| Murray, M | 1 |
| Hermánek, J | 2 |
| Mennander, A | 1 |
| Tiisala, S | 1 |
| Paavonen, T | 1 |
| Halttunen, J | 1 |
| Häyry, P | 1 |
| Eidinoff, H | 1 |
| Prokopic, J | 1 |
| Bruning, JH | 1 |
| Bruggeman, CA | 1 |
| van Breda Vriesman, PJ | 1 |
| Appleby, P | 1 |
| Webber, DG | 1 |
| Bowen, JG | 1 |
| Kumar, A | 1 |
| Leonard, MC | 1 |
| Cleveland, RP | 1 |
| Ito, M | 1 |
| Aono, Y | 1 |
| Suzuki, A | 1 |
| Nagamatsu, T | 1 |
| Suzuki, Y | 1 |
| Vogelsang, GB | 1 |
| Hess, AD | 1 |
| Friedman, KJ | 1 |
| Santos, GW | 1 |
| Anderson, C | 1 |
| Bell, PR | 1 |
| Briggs, JD | 1 |
| Calman, KC | 1 |
| Paton, AM | 1 |
| Wood, RF | 1 |
| Macpherson, SG | 1 |
| Kyle, K | 1 |
| Husberg, BS | 1 |
| Levitsky, S | 1 |
| Parks, LC | 1 |
| Williams, WH | 1 |
| Morrow, AG | 1 |
| Babington, RG | 1 |
| Wedeking, PW | 1 |
| Arustamova, RG | 1 |
| Serov, VV | 1 |
| Mukhin, NA | 1 |
| Drozd, TN | 1 |
| Berezina, TA | 1 |
| Beck, FJ | 1 |
| Whitehouse, MW | 1 |
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| Bradfield, JW | 1 |
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| Ranek, L | 1 |
| Bremmelgaard, A | 1 |
| Dupont, B | 1 |
| Jorgensen, M | 1 |
| Keiding, S | 1 |
| Thomsen, P | 1 |
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| Nowakowski, A | 1 |
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| Antonovych, TT | 1 |
| Fortner, RW | 1 |
| Knieser, MR | 1 |
| Carter, CB | 1 |
| Knepshield, JH | 1 |
| Baerg, DC | 1 |
| Young, MD | 1 |
| Tuchmann-Duplessis, H | 1 |
| Vogel, CL | 1 |
| De Vita, VT | 1 |
| Lisak, RP | 1 |
| Kies, MW | 1 |
8 reviews available for azathioprine and Disease Models, Animal
| Article | Year |
|---|---|
Current State of Immunosuppression: Past, Present, and Future.
Topics: Abatacept; Alemtuzumab; Animals; Antibodies, Monoclonal, Humanized; Azathioprine; Bone Marrow Transp | 2015 |
ANCA-associated vasculitides: advances in pathophysiology and treatment.
Topics: Animals; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cyto | 2010 |
New insights into the immunopathogenesis and treatment of small vessel vasculitis of the kidney.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal; Ant | 2003 |
[Systemic therapy of atopic dermatitis].
Topics: Adjuvants, Immunologic; Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Animals; Anti-Bacte | 2003 |
[New aspects in ANCA-associated vasculitides].
Topics: Animals; Antibodies, Antineutrophil Cytoplasmic; Autoantigens; Azathioprine; CD28 Antigens; Churg-St | 2004 |
The natural history and response to therapy of lupus nephritis.
Topics: Animals; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Disease Models, Animal; Fluoresce | 1980 |
The effect of selected immunomodulating agents on experimental contact reactions.
Topics: Animals; Azathioprine; Basophils; Cell Division; Croton Oil; Cyclophosphamide; Cyclosporins; Dermati | 1985 |
Immunosuppressive agents in protein-losing nephritis.
Topics: Animals; Azathioprine; Cyclophosphamide; Disease Models, Animal; Glomerulonephritis; Humans; Hyperse | 1970 |
2 trials available for azathioprine and Disease Models, Animal
| Article | Year |
|---|---|
Systemic lupus erythematosus--immunoregulatory therapies.
Topics: Animals; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Disease Models, Animal; Female; H | 1983 |
The natural history and response to therapy of lupus nephritis.
Topics: Animals; Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Disease Models, Animal; Fluoresce | 1980 |
74 other studies available for azathioprine and Disease Models, Animal
| Article | Year |
|---|---|
Nucleosides of azathioprine and thiamiprine as antiarthritics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Azathioprine; Cell Surviv | 1989 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice.
Topics: Animals; Apoptosis; Azathioprine; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Human | 2018 |
The immunosuppressant drug azathioprine restrains adipogenesis of muscle Fibro/Adipogenic Progenitors from dystrophic mice by affecting AKT signaling.
Topics: Adipogenesis; Animals; Azathioprine; Cell Differentiation; Cells, Cultured; Disease Models, Animal; | 2019 |
Regulatory mechanism of mesalazine on TLR4/MyD88-dependent pathway in mouse ulcerative colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Colon; Disease | 2019 |
Immunosuppressive drug azathioprine reduces aneurysm progression through inhibition of Rac1 and c-Jun-terminal-N-kinase in endothelial cells.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Aneurysm; Aortic Rupture; Apolipoproteins | 2013 |
Effects of anti-inflammatory therapy on bursting pressure of colonic anastomosis in murine dextran sulfate sodium induced colitis.
Topics: Anastomosis, Surgical; Animals; Anti-Inflammatory Agents; Azathioprine; Colitis; Dextran Sulfate; Di | 2015 |
Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model.
Topics: Adult; Aged; Animals; Azathioprine; Disease Models, Animal; DNA Mismatch Repair; Dose-Response Relat | 2015 |
Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-κB activation on dextran sulfate sodium-induced ulcerative colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Brucea; Colitis, Ulcerative; Cytokines; Dextran Sul | 2017 |
Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.
Topics: Animals; Azathioprine; Body Weight; Cyclophosphamide; Cyclosporine; Desmoglein 3; Dexamethasone; Dis | 2009 |
Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I.
Topics: Animals; Azathioprine; Cyclosporine; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; | 2008 |
Does immunosuppressive treatment ameliorate morphology changes in encapsulating peritoneal sclerosis?
Topics: Animals; Azathioprine; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Femal | 2009 |
Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.
Topics: Animals; Azathioprine; Blood Pressure; Cytokines; Desoxycorticosterone; Disease Models, Animal; Endo | 2009 |
Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Azathioprine; Carcinogens; Disease M | 2010 |
Diayangambin exerts immunosuppressive and anti-inflammatory effects in vitro and in vivo.
Topics: Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Dexamethasone; Dinoproston | 2002 |
Protective effects of immunosuppressants and steroids against ischemia-reperfusion injury in cremaster muscle flap at microcirculatory level.
Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Cyclosporine; Dexamethasone; Disease Models, Animal | 2002 |
Expression of TGF-beta and PDGF-AA antigens and corresponding mRNAs in cytomegalovirus-infected rat kidney allografts.
Topics: Animals; Azathioprine; Cyclosporine; Cytomegalovirus; Disease Models, Animal; Gene Expression Regula | 2003 |
Effect of Anapsos in a murine model of experimental trichomoniasis.
Topics: Adjuvants, Immunologic; Animals; Azathioprine; Cyclophosphamide; Disease Models, Animal; Disease Sus | 2003 |
Successful induction of immune tolerance to enzyme replacement therapy in canine mucopolysaccharidosis I.
Topics: Animals; Azathioprine; Cyclosporine; Disease Models, Animal; Dogs; Humans; Iduronidase; Immune Toler | 2004 |
Treatment with immunosuppressive and anti-inflammatory agents delays onset of canine genetic narcolepsy and reduces symptom severity.
Topics: Age of Onset; Animals; Anti-Inflammatory Agents; Azathioprine; Disease Models, Animal; Disease Progr | 2004 |
Cyclooxygenase-2 expression in experimental post-transplant obliterative bronchiolitis.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Chondrocytes; Cyclooxygenase 2; Cyclospori | 2004 |
Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid.
Topics: Acetylcysteine; Animals; Azathioprine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liv | 2006 |
Autoimmune hepatitis: are we using the right therapy?
Topics: Adolescent; Animals; Azathioprine; Child; Cyclosporine; Disease Models, Animal; Genetic Predispositi | 2007 |
The effect of azathioprine on anastomotic healing: an experimental study in rats.
Topics: Anastomosis, Surgical; Animals; Azathioprine; Colon; Disease Models, Animal; Female; Immunosuppressi | 2007 |
The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse.
Topics: Animals; Apoptosis; Azathioprine; Body Weight; Bone Marrow Cells; Colony-Forming Units Assay; Diseas | 2008 |
Azathioprine and acute pancreatitis: studies with an isolated perfused canine pancreas.
Topics: Acute Disease; Amylases; Animals; Azathioprine; Blood Glucose; Disease Models, Animal; Dogs; Pancrea | 1983 |
Immunology of pyelonephritis in the primate model. II. Effect on immunosuppression.
Topics: Animals; Antibodies, Viral; Antibody Formation; Azathioprine; Cyclophosphamide; Cytomegalovirus; Dis | 1981 |
Immunologic response to liver cell allografts.
Topics: Animals; Azathioprine; Disease Models, Animal; Dogs; Graft Rejection; Liver; Liver Diseases; Liver T | 1982 |
Transplantation of the canine knee joint on a vascular pedicle. A preliminary study.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Cartilage, Articular; Disease Models, Animal; Dogs; Eva | 1980 |
Azathioprine alone is bone sparing and does not alter cyclosporin A-induced osteopenia in the rat.
Topics: Animals; Azathioprine; Body Weight; Bone Diseases, Metabolic; Calcitriol; Calcium; Cyclosporine; Dis | 1995 |
Promotional effects of azathioprine on peripheral B cell lymphomas in BALB/c mice induced by administration of 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azathioprine; Carcinogens; Disease Models, Animal; Drug S | 1994 |
Acute-phase response in rat to carbon tetrachloride-azathioprine induced cirrhosis and partial hepatectomy of cirrhotic liver.
Topics: Acute-Phase Reaction; alpha 1-Antitrypsin; Animals; Antimetabolites; Azathioprine; Carbon Tetrachlor | 1996 |
Effect of immunosuppressive drug regimens on acute and chronic murine toxoplasmosis.
Topics: Acute Disease; Animals; Azathioprine; Chronic Disease; Cyclosporine; Disease Models, Animal; Female; | 1996 |
Influence of treatment with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi.
Topics: Animals; Antibodies, Helminth; Azathioprine; Betamethasone; Brain; Chagas Disease; Chronic Disease; | 1997 |
Obliterative lesions in small airways in an immunosuppressed porcine heterotopic bronchial allograft model.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Cyclosporine; Disease Models, Animal; Immu | 1998 |
Plasma concentration of hGH and anti-hGH antibodies after subcutaneous administration of hGH for 3 weeks to immunosuppressed pigs.
Topics: Animals; Antibody Formation; Area Under Curve; Autoantibodies; Azathioprine; Cyclosporine; Disease M | 1999 |
The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of Human African Trypanosomiasis.
Topics: Analgesics; Animals; Azathioprine; Disease Models, Animal; Eflornithine; Encephalitis; Hippocampus; | 1999 |
Prevention of small airway obliteration in a swine heterotopic lung allograft model.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Disease Models, Animal; Epithelium; Everol | 2000 |
Factors determining the susceptibility of mice to experimental phycomycosis.
Topics: Age Factors; Animals; Azathioprine; Brain; Cortisone; Cyclophosphamide; Disease Models, Animal; Fema | 1975 |
Single and multiple drug therapy in autologous immune complex nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azathioprine; Basement Membrane; Compleme | 1976 |
The effect of an immunosuppressive drug (azathioprine) on the latent infection of marmoset monkeys (Callithrix jacchus) with the oncogenic Herpesvirus saimiri.
Topics: Animals; Azathioprine; Callitrichinae; Disease Models, Animal; Haplorhini; Herpesviridae; Herpesviri | 1975 |
Experimental infection of marmosets with a cytomegalovirus of human origin.
Topics: Animals; Animals, Newborn; Antibody Formation; Azathioprine; Callitrichinae; Cells, Cultured; Cytome | 1975 |
[Immunosuppressive therapy and cytomegalovirus infection in the animal experiment].
Topics: Animals; Antilymphocyte Serum; Azathioprine; Cyclophosphamide; Cytomegalovirus Infections; Disease M | 1975 |
Monitoring of immunosuppression in beagles.
Topics: Animals; Antibodies; Azathioprine; Carcinoma, Bronchogenic; Dinitrochlorobenzene; Disease Models, An | 1977 |
The significance of immunosuppression and antigenic stimulation in the development of malignant lymphomas.
Topics: Animals; Antibody-Producing Cells; Antigen-Antibody Reactions; Antineoplastic Agents; Azathioprine; | 1975 |
[Changes in the lymphoreticular system of animals following long-term immunization with antityphoid vaccine].
Topics: Animals; Azathioprine; B-Lymphocytes; Cricetinae; Disease Models, Animal; Female; Guinea Pigs; Haplo | 1975 |
Effects of localized chemical carcinogenesis and immunosuppression upon bronchial preneoplasia in the dog.
Topics: Animals; Azathioprine; Benzopyrenes; Bronchial Neoplasms; Carcinogens; Disease Models, Animal; Dogs; | 1977 |
Prevention and suppression by azathioprine of venom-induced protein-losing gastropathy in dogs.
Topics: Animals; Azathioprine; Disease Models, Animal; Dogs; Protein-Losing Enteropathies; Snake Venoms; Sto | 1976 |
[Experimental herpetic infection in rabbits combined with immunodepression (author's transl)].
Topics: Animals; Antibodies, Viral; Antibody Formation; Azathioprine; Disease Models, Animal; Herpes Simplex | 1975 |
The use of azathioprine to ameliorate post-treatment encephalopathy associated with African trypanosomiasis.
Topics: Animals; Azathioprine; Brain Diseases; Diminazene; Disease Models, Animal; Female; Mice; Mice, Inbre | 1992 |
Nonspecific immunomodulation influences resistance of mice to experimental infection with Mesocestoides corti and Ascaris suum.
Topics: Adjuvants, Immunologic; Animals; Ascariasis; Ascaris; Azathioprine; Cestode Infections; Disease Mode | 1991 |
Chronic rejection of rat aortic allograft. II. Administration of cyclosporin induces accelerated allograft arteriosclerosis.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Azathioprine; Cyclosporine; Disease Models, Animal; Drug | 1991 |
Suppression of the immune reaction in multiple sclerosis might be achieved by intravenous injections of myelin basic protein, concomitant with the administration of an immunosuppressant and a corticosteroid.
Topics: Animals; Autoimmune Diseases; Azathioprine; Disease Models, Animal; Drug Therapy, Combination; Encep | 1988 |
Influence of thymic preparations on the result of experimental infection with Taenia crassiceps (Zeder, 1800) in ICR mice.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Helminth; Azathioprine; Disease Models, Animal; Enzyme- | 1989 |
Transfer of cytomegalovirus infection via renal allografts: role of immunosuppressive regimens on the transfer rate, and effect of cytomegalovirus infections on renal allograft rejection; study in a rat model.
Topics: Animals; Azathioprine; Cyclosporins; Cytomegalovirus Infections; Disease Models, Animal; Graft Rejec | 1989 |
Murine chronic graft-versus-host disease as a model of systemic lupus erythematosus: effect of immunosuppressive drugs on disease development.
Topics: Animals; Azathioprine; Cyclophosphamide; Cyclosporins; Deoxyguanosine; Dexamethasone; Disease Models | 1989 |
Development of a leukocytopenic baby guinea pig model with azathioprine and cyclophosphamide.
Topics: Animals; Azathioprine; Body Weight; Cyclophosphamide; Disease Models, Animal; Guinea Pigs; Leukocyte | 1989 |
Accelerated passive Heymann nephritis in rats as an experimental model for membranous glomerulonephritis and effects of azathioprine and prednisolone on the nephritis.
Topics: Animals; Azathioprine; Disease Models, Animal; Glomerulonephritis; Glomerulonephritis, Membranous; K | 1989 |
Therapy of chronic graft-v-host disease in a rat model.
Topics: Animals; Azathioprine; Cyclosporins; Disease Models, Animal; Drug Synergism; Graft vs Host Disease; | 1989 |
Reversal of acute clinical and experimental organ rejection using large doses of intravenous prednisolone.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Creatinine; Disease Models, Animal; Graft Rejection; He | 1971 |
In vitro studies of the cell-bound and antibody-mediated immunity evoked by murine renal allotransplants. Influence of presensitization, total body irradiation and immunosuppressive agents.
Topics: Animals; Antibody Formation; Antilymphocyte Serum; Azathioprine; Cells, Cultured; Dactinomycin; Dise | 1973 |
Inhibition of experimental cardiac hypertrophy by azathioprine.
Topics: Animals; Aortic Coarctation; Azathioprine; Cardiomegaly; Computers; Disease Models, Animal; DNA; Gui | 1970 |
The influence of cinanserin and selected pharmacologic agents on experimental allergic encephalomyelitis (EAE).
Topics: 5-Hydroxytryptophan; Amphetamine; Anilides; Animals; Azathioprine; Body Weight; Chlorpheniramine; Ci | 1971 |
Effect of imuran on the course of experimental amyloidosis.
Topics: Amyloid; Amyloidosis; Animals; Antigens; Azathioprine; Blood Protein Disorders; Caseins; Disease Mod | 1974 |
Impaired drug metabolism in rats associated with acute inflammation: a possible assay for anti-injury agents.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Azathioprine; Biological Assa | 1974 |
The effect of uraemia on organ graft survival in the rat.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Azathioprine; Disease Models, Animal; Graft Rejecti | 1973 |
Experimentally induced chronic pyelonephritis using bacterial antigen and its prevention with immunosuppression.
Topics: Animals; Antigens, Bacterial; Azathioprine; Chronic Disease; Disease Models, Animal; Escherichia col | 1974 |
[Administration of new therapeutic combinations on the model of hematogenous pyelonephritis in the rat. 1. The combination of OTC and imuran].
Topics: Animals; Azathioprine; Disease Models, Animal; Drug Combinations; Male; Oxytetracycline; Pyelonephri | 1973 |
The effects of azathioprine on CCl4 induced cirrhosis in the rat.
Topics: Adenosine Triphosphate; Animals; Azathioprine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; | 1974 |
Goodpasture's syndrome: recovery from severe pulmonary hemorrhage after bilateral nephrectomy.
Topics: Adult; Anti-Glomerular Basement Membrane Disease; Autoantibodies; Azathioprine; Complement System Pr | 1971 |
Plasmodium falciparum infection induced in the black spider monkey, Ateles Fusciceps, and black howler monkey, Alouatta villosa.
Topics: Animals; Azathioprine; Disease Models, Animal; Haplorhini; Malaria; Plasmodium falciparum; Splenecto | 1970 |
Teratogenic drug screening. Present procedures and requirements.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Animals, Laboratory; Azathioprine; Ca | 1972 |
Suppression of experimental allergic encephalomyelitis by NSC 82196, a new imidazole carboxamide derivative.
Topics: Amides; Animals; Azathioprine; Cyclophosphamide; Disease Models, Animal; Encephalomyelitis, Autoimmu | 1969 |