azathioprine has been researched along with Diffuse Large B-Cell Lymphoma in 34 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic immunosuppression is a known risk factor for various malignancies, and azathioprine in particular has been reported in association with solid and hematologic malignancies, including diffuse large B-cell lymphoma." | 8.31 | Primary hepatic Epstein-Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report. ( Marell, PS; Shi, M; Wingo, MT, 2023) |
| "A 52-year-old woman was treated for colorectal diffuse large B-cell lymphoma (DLBCL) after a prolonged treatment period of azathioprine (AZA) and infliximab (IFX) for Crohn's disease (CD)." | 7.96 | Diffuse large B-cell lymphoma of the colon and rectum in a patient with colonic Crohn's disease treated with infliximab and azathioprine. ( Daikuhara, S; Hirayama, A; Sato, K; Suga, T; Tanaka, E; Uehara, T, 2020) |
| "Azathioprine is used for immunosuppression in myasthenia gravis (MG)." | 7.81 | Brainstem lymphoma in a myasthenia gravis patient on azathioprine. ( Katirji, B; Termsarasab, P, 2015) |
| "Side effects of long-term use of azathioprine in myasthenia gravis are infrequently reported." | 7.71 | Prostatic involvement of a testicular lymphoma in a patient with myasthenia gravis on long-term azathioprine. ( Barthelmes, L; Seale, JR; Thomas, KJ, 2002) |
| " Chronic immunosuppression is a known risk factor for various malignancies, and azathioprine in particular has been reported in association with solid and hematologic malignancies, including diffuse large B-cell lymphoma." | 4.31 | Primary hepatic Epstein-Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report. ( Marell, PS; Shi, M; Wingo, MT, 2023) |
| "A 52-year-old woman was treated for colorectal diffuse large B-cell lymphoma (DLBCL) after a prolonged treatment period of azathioprine (AZA) and infliximab (IFX) for Crohn's disease (CD)." | 3.96 | Diffuse large B-cell lymphoma of the colon and rectum in a patient with colonic Crohn's disease treated with infliximab and azathioprine. ( Daikuhara, S; Hirayama, A; Sato, K; Suga, T; Tanaka, E; Uehara, T, 2020) |
| "We report a case of a 40 year old female who presented with a three month history of headaches with a background of Myasthenia Gravis (MG), treated with azathioprine." | 3.88 | An unusual presentation of cerebellar lymphoma. ( Astradsson, A; Harley, B; Muthurajah, V; Shivapathasundram, G; Wickremesekera, A, 2018) |
| "Azathioprine is used for immunosuppression in myasthenia gravis (MG)." | 3.81 | Brainstem lymphoma in a myasthenia gravis patient on azathioprine. ( Katirji, B; Termsarasab, P, 2015) |
| "Side effects of long-term use of azathioprine in myasthenia gravis are infrequently reported." | 3.71 | Prostatic involvement of a testicular lymphoma in a patient with myasthenia gravis on long-term azathioprine. ( Barthelmes, L; Seale, JR; Thomas, KJ, 2002) |
| "A 57-year old woman with perianal Crohn's disease receiving azathioprine and infliximab developed this type of lymphoma after a short period of time on the treatment." | 1.37 | Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection. ( Aldeguer, M; Arevalo, N; Benito, DM; de Fuenmayor, ML; Foncillas, MA; Plaza, R; Ponferrada, A, 2011) |
| "Multiple brain tumors were found and diagnosed as having B-cell, diffuse large cell type malignant lymphoma." | 1.30 | [A case of malignant lymphoma after renal transplantation]. ( Ikeda, K; Inoue, S; Matsuura, O; Murakami, S; Oyama, H; Sugiyama, T; Yamao, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (50.00) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 4 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Marell, PS | 1 |
| Shi, M | 1 |
| Wingo, MT | 1 |
| Christin, A | 1 |
| de Leval, L | 1 |
| Obeid, M | 1 |
| Suzuki, K | 1 |
| Ohe, R | 1 |
| Kabasawa, T | 1 |
| Aung, NY | 1 |
| Yano, M | 1 |
| Katsumi, S | 1 |
| Yanagiya, R | 1 |
| Yamamoto, M | 1 |
| Toubai, T | 1 |
| Ishizawa, K | 1 |
| Yamakawa, M | 1 |
| Quera, R | 1 |
| Flores, L | 1 |
| Simian, D | 1 |
| Kronberg, U | 1 |
| Vial, MT | 1 |
| de Guevara, DL | 1 |
| García-Rodríguez, MJ | 1 |
| Harley, B | 1 |
| Shivapathasundram, G | 1 |
| Astradsson, A | 1 |
| Muthurajah, V | 1 |
| Wickremesekera, A | 1 |
| Sato, K | 1 |
| Suga, T | 1 |
| Hirayama, A | 1 |
| Daikuhara, S | 1 |
| Uehara, T | 1 |
| Tanaka, E | 1 |
| Termsarasab, P | 1 |
| Katirji, B | 1 |
| Quesada, AE | 1 |
| Huh, YO | 1 |
| Wang, W | 1 |
| Medeiros, LJ | 1 |
| Thakral, B | 1 |
| Otto, F | 1 |
| Neuen-Jacob, E | 1 |
| Arendt, G | 1 |
| Stüve, O | 1 |
| Hartung, HP | 1 |
| McAleer, MA | 1 |
| D'Arcy, CA | 1 |
| Mulligan, NJ | 1 |
| Sheahan, K | 1 |
| Collins, P | 1 |
| Staufer, K | 1 |
| Sterneck, M | 1 |
| Schaefer, H | 1 |
| Nashan, B | 1 |
| Fischer, L | 1 |
| Plaza, R | 1 |
| Ponferrada, A | 1 |
| Benito, DM | 1 |
| Arevalo, N | 1 |
| Foncillas, MA | 1 |
| de Fuenmayor, ML | 1 |
| Aldeguer, M | 1 |
| Flynn, AD | 1 |
| Azar, JM | 1 |
| Chiorean, MV | 1 |
| Barthelmes, L | 1 |
| Thomas, KJ | 1 |
| Seale, JR | 1 |
| Gündüz, E | 1 |
| Korkmaz, C | 1 |
| Kaşifoğlu, T | 1 |
| Gülbaş, Z | 1 |
| Pirofsky, B | 1 |
| Dawson, PJ | 1 |
| Reid, RH | 1 |
| Geary, CG | 1 |
| Oyama, H | 1 |
| Yamao, K | 1 |
| Sugiyama, T | 1 |
| Matsuura, O | 1 |
| Murakami, S | 1 |
| Ikeda, K | 1 |
| Inoue, S | 1 |
| Tan, CW | 1 |
| Wilson, GE | 1 |
| Howat, JM | 1 |
| Shreeve, DR | 1 |
| Viteri, A | 1 |
| Vernace, SJ | 1 |
| Schaffner, F | 1 |
| Krueger, G | 1 |
| Schneck, SA | 1 |
| Penn, I | 2 |
| Pierce, JC | 1 |
| Madge, GE | 1 |
| Lee, HM | 1 |
| Hume, DM | 1 |
| Allison, AC | 1 |
| Birkeland, SA | 1 |
| Kemp, E | 1 |
| Miller, G | 1 |
| Coope, D | 1 |
| Sneddon, I | 1 |
| Wishart, JM | 1 |
| Imamura, N | 1 |
| Nakano, M | 1 |
| Kawase, A | 1 |
| Kawamura, Y | 1 |
| Yokoro, K | 1 |
| Myers, BD | 1 |
| Kessler, E | 1 |
| Levi, J | 1 |
| Pick, A | 1 |
| Rosenfeld, JB | 1 |
| Tikvah, P | 1 |
| Donohue, LR | 1 |
| Guisan, Y | 1 |
| Enderlin, F | 1 |
| Harder, F | 1 |
| Brunner, F | 1 |
| Thiel, G | 1 |
| Bernhardt, JP | 1 |
| Schädeli, J | 1 |
| Mihatsch, M | 1 |
| Moser, KD | 1 |
| Araoz, CA | 1 |
| Smith, PL | 1 |
| Deodhar, SD | 1 |
| Konomi, K | 1 |
| Nakamoto, S | 1 |
| Kuruvila, KC | 1 |
| Hammond, W | 1 |
| Brettschneider, L | 1 |
| Starzl, TE | 1 |
1 review available for azathioprine and Diffuse Large B-Cell Lymphoma
| Article | Year |
|---|---|
Colposcopic and cytologic evaluation of women undergoing immunosuppressive therapy.
Topics: Antigens, Neoplasm; Azathioprine; Carcinoma in Situ; Carcinoma, Squamous Cell; Colposcopy; Female; G | 1974 |
1 trial available for azathioprine and Diffuse Large B-Cell Lymphoma
| Article | Year |
|---|---|
Clinical experience with antilymphocyte globulin (ALG) in renal transplantation.
Topics: Anaphylaxis; Antilymphocyte Serum; Azathioprine; Clinical Trials as Topic; Drug Synergism; Graft Rej | 1971 |
32 other studies available for azathioprine and Diffuse Large B-Cell Lymphoma
| Article | Year |
|---|---|
Primary hepatic Epstein-Barr virus-positive diffuse large B-cell lymphoma associated with azathioprine immunosuppression: a case report.
Topics: Azathioprine; Epstein-Barr Virus Infections; Female; Hematologic Neoplasms; Herpesvirus 4, Human; Hu | 2023 |
A Diffuse Medullary Hypercaptation With No Bone Lesion.
Topics: Aged; Anti-Inflammatory Agents; Autoimmune Diseases; Azathioprine; Fatal Outcome; Humans; Immunosupp | 2020 |
A case of iatrogenic immunodeficiency-associated colonic lymphoma complicating ulcerative colitis.
Topics: Aged; Azathioprine; Colitis, Ulcerative; Colorectal Neoplasms; Humans; Iatrogenic Disease; Immunocom | 2020 |
[Rectal diffuse large B cell lymphoma appearing after immunosuppression for ulcerative colitis. Report of one case].
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Biopsy; Colitis, Ulcerative; Cyclophos | 2017 |
An unusual presentation of cerebellar lymphoma.
Topics: Adult; Azathioprine; Cerebellar Neoplasms; Epstein-Barr Virus Infections; Female; Humans; Immunocomp | 2018 |
Diffuse large B-cell lymphoma of the colon and rectum in a patient with colonic Crohn's disease treated with infliximab and azathioprine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antirheumatic Agents; Azathioprine; Colorectal Neopl | 2020 |
Brainstem lymphoma in a myasthenia gravis patient on azathioprine.
Topics: Aged, 80 and over; Azathioprine; Brain Stem Neoplasms; Disease Progression; Fatal Outcome; Humans; I | 2015 |
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma in a patient treated with azathioprine for ulcerative colitis.
Topics: Anaplastic Lymphoma Kinase; Azathioprine; Colitis, Ulcerative; Humans; Immunocompromised Host; Immun | 2016 |
A 69-year-old man with left hemispheric necrotizing mass lesion.
Topics: Aged; Azathioprine; Brain; Brain Stem; Encephalitis, Viral; Epstein-Barr Virus Infections; Humans; I | 2009 |
Primary cutaneous lymphoma associated with Epstein-Barr virus and azathioprine therapy.
Topics: Aged; Azathioprine; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, | 2010 |
Sirolimus addition to tacrolimus-based immunosuppression induces complete remission of post-transplant lymphoproliferative disorder in a liver transplant recipient.
Topics: Azathioprine; Female; Humans; Immunosuppression Therapy; Liver Transplantation; Lymphoma, Large B-Ce | 2010 |
Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Az | 2011 |
Spontaneous regression of colonic lymphoma following infliximab and azathioprine withdrawal in patients with Crohn's disease.
Topics: Adult; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Colonic | 2013 |
Prostatic involvement of a testicular lymphoma in a patient with myasthenia gravis on long-term azathioprine.
Topics: Azathioprine; Fatal Outcome; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Middle | 2002 |
Unusual presentation of non-Hodgkin lymphoma: polyarthritis and uveitis mimicking a rheumatologic disease.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middl | 2008 |
Lack of oncogenicity with immunosuppressive therapy.
Topics: Animals; Antilymphocyte Serum; Azathioprine; Female; Friend murine leukemia virus; Immunosuppression | 1980 |
Lymphoma and leukaemia due to drugs.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bone Marrow Diseases; Child; Female; Hodgkin Disease; | 1980 |
[A case of malignant lymphoma after renal transplantation].
Topics: Adult; Azathioprine; Brain Neoplasms; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immuno | 1997 |
Rectal lymphoma in ulcerative colitis treated with azathioprine.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, | 2001 |
Extrahepatic malignancy in chronic liver disease: report of six cases.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chronic Disease; Cystadenocarcinoma; Female; Hepatitis | 1976 |
The significance of immunosuppression and antigenic stimulation in the development of malignant lymphomas.
Topics: Animals; Antibody-Producing Cells; Antigen-Antibody Reactions; Antineoplastic Agents; Azathioprine; | 1975 |
De-novo brain tumours in renal-transplant recipients.
Topics: Adolescent; Adult; Azathioprine; Brain; Brain Neoplasms; Cadaver; Follow-Up Studies; Humans; Immunos | 1971 |
Lymphoma, a complication of renal allotransplantation in man.
Topics: Adolescent; Adult; Azathioprine; Dactinomycin; Histocompatibility Testing; Humans; Kidney Transplant | 1972 |
Tumour development following immunosuppression.
Topics: Adult; Animals; Antilymphocyte Serum; Azathioprine; Child; Cricetinae; Female; Humans; Immunity, Cel | 1970 |
Malignant tumours following immunosuppression in renal transplantation.
Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom | 1973 |
Epstein-Barr viral nuclear antigen (EBNA) in tumor cell imprints of experimental lymphoma of marmosets.
Topics: Animals; Antigens, Viral; Azathioprine; Burkitt Lymphoma; Cell Line; Cell Nucleus; Cell Transformati | 1974 |
Immunosuppression and malignancy.
Topics: Adult; Azathioprine; Dermatomyositis; Female; Humans; Immunosuppression Therapy; Lymphoma, Large B-C | 1972 |
Synergistic action of N-nitrosobutylurea and azathioprine in induction of leukemia in C57BL mice.
Topics: AKR murine leukemia virus; Animals; Antigens, Viral; Azathioprine; Drug Synergism; Female; Immune Se | 1973 |
Kaposi sarcoma in kidney transplant recipients.
Topics: Adult; Antilymphocyte Serum; Autopsy; Azathioprine; Brain Neoplasms; Cadaver; Female; Graft Rejectio | 1974 |
[Malignant tumors following transplantation. Case reports and review of the literature].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Graft Rejection; Humans; Kidney | 1973 |
Immunosuppressive therapy and reticulum cell sarcomas of the brain. A report of 2 cases.
Topics: Adult; Azathioprine; Brain Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male | 1972 |
Malignant lymphomas in transplantation patients.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Humans; Immunosuppre | 1969 |