Page last updated: 2024-10-23

azathioprine and Diabetes Mellitus, Type 2

azathioprine has been researched along with Diabetes Mellitus, Type 2 in 16 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"To assess the risk of long-term cardiovascular and metabolic outcomes and all-cause mortality in patients with pemphigus managed by rituximab compared with those receiving treatment with first-line corticosteroid-sparing agents (azathioprine and mycophenolate mofetil [MMF])."4.31Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus. ( Kridin, K; Ludwig, RJ; Mruwat, N, 2023)
" In summary, mycophenolate mofetil is superior to azathioprine in maintaining remission and preventing relapse in lupus nephritis."3.78[Nephrology]. ( Martin, PY; Saudan, P, 2012)
" We describe a patient suffering from pancytopenia following a combination therapy of azathioprine and allopurinol because of lupus erythematodes and diabetic nephropathy with hyperuricemia."3.72[Panzytopenia from combination therapy with azathioprin and allopurinol]. ( Seidel, W, 2004)
"Diabetes mellitus (DM) has been considered a relative contraindication to heart transplantation (HTx) because of possible increased infection rates and worsening DM with prednisone immunosuppression."3.69Mid-term results of heart transplantation in diabetic patients. ( Bianco, R; Boffa, GM; Caforio, AL; Casarotto, D; Casula, R; Gambino, A; Grassi, G; Livi, U; Milano, A; Thiene, G, 1994)
" The autoimmune hepatitis was treated with prednisolone (initially 60 mg daily, then reduced to 10 mg daily) and azathioprine (initially 100 mg daily, reduced to 50 mg daily)."3.69[Autoimmune hepatitis, autoimmune gastritis, hypergastrinemia and stomach carcinoid]. ( Ormann, W, 1995)
"Type 2 diabetes mellitus is characterized by relative insulin deficiency and insulin resistance."1.48Antibody-Mediated Extreme Insulin Resistance: A Report of Three Cases. ( Anzaldi, L; Fesseha, B; Galiatsatos, P; Kim, HN; Sidhaye, A; Tsao, A, 2018)
"Azathioprine was started."1.42CIDP variants in diabetes: measuring treatment response with a small nerve fiber test. ( Névoret, ML; Vinik, AI, 2015)
"Delayed graft function was observed in 34."1.38Outcome of deceased donor renal transplantation in diabetic nephropathy: a single-center experience from a developing country. ( Engineer, DP; Godara, SM; Gumber, MR; Jain, SH; Kute, VB; Modi, PR; Munjappa, BC; Patel, HV; Sainaresh, VV; Shah, PR; Shah, VR; Trivedi, HL; Vanikar, AV, 2012)
"We report a case of disseminated superficial actinic porokeratosis (DSAP) with neutrophilic pustules within cornoid lamellae on histopathologic examination, corresponding to pustules along the elevated rim clinically as well."1.35Pustular porokeratosis. ( Miller, DD; Ruben, BS, 2009)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (37.50)18.2507
2000's3 (18.75)29.6817
2010's6 (37.50)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Kridin, K3
Mruwat, N3
Ludwig, RJ3
Kim, HN1
Fesseha, B1
Anzaldi, L1
Tsao, A1
Galiatsatos, P1
Sidhaye, A1
Palamuthusingam, D1
Mantha, M1
Dheda, S1
Névoret, ML1
Vinik, AI1
Wu, PH1
Lin, YT1
Yang, YH1
Lin, YC2
Miller, DD1
Ruben, BS1
Kute, VB1
Godara, SM1
Shah, PR1
Jain, SH1
Engineer, DP1
Patel, HV1
Gumber, MR1
Munjappa, BC1
Sainaresh, VV1
Vanikar, AV1
Modi, PR1
Shah, VR1
Trivedi, HL1
Saudan, P1
Martin, PY1
Seidel, W1
Numakura, K1
Satoh, S1
Tsuchiya, N1
Horikawa, Y1
Inoue, T1
Kakinuma, H1
Matsuura, S1
Saito, M1
Tada, H1
Suzuki, T1
Habuchi, T1
Krendel, DA1
Costigan, DA1
Hopkins, LC1
Livi, U1
Caforio, AL1
Grassi, G1
Boffa, GM1
Gambino, A1
Milano, A1
Bianco, R1
Casula, R1
Thiene, G1
Casarotto, D1
Ormann, W1
Paterson, AJ1
Lamey, PJ1
Lewis, MA1
Nolan, A1
Rademaker, M1
Fonseca, JA1
Ianhez, LE1
Sabbaga, E1
Arap, S1
Badellino, MM1
Cavarocchi, NC1
Narins, B1
Jessup, M1
Alpern, JB1
McClurken, JB1
Shuman, CR1

Trials

2 trials available for azathioprine and Diabetes Mellitus, Type 2

ArticleYear
Renal transplantation in diabetic patients: a survey of 100 cases.
    Transplantation proceedings, 1992, Volume: 24, Issue:5

    Topics: Adult; Azathioprine; Cyclosporine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Ne

1992
Cardiac transplantation in diabetic patients.
    Transplantation proceedings, 1990, Volume: 22, Issue:5

    Topics: Antilymphocyte Serum; Azathioprine; Blood Pressure; Cyclosporins; Diabetes Mellitus; Diabetes Mellit

1990

Other Studies

14 other studies available for azathioprine and Diabetes Mellitus, Type 2

ArticleYear
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Association of Rituximab With Risk of Long-term Cardiovascular and Metabolic Outcomes in Patients With Pemphigus.
    JAMA dermatology, 2023, 01-01, Volume: 159, Issue:1

    Topics: Azathioprine; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Immunosuppres

2023
Antibody-Mediated Extreme Insulin Resistance: A Report of Three Cases.
    The American journal of medicine, 2018, Volume: 131, Issue:1

    Topics: Antibodies; Azathioprine; Cyclophosphamide; Dexamethasone; Diabetes Mellitus, Type 2; Drug Therapy,

2018
HMG CoA reductase inhibitor associated myositis and autoimmune hepatitis.
    Internal medicine journal, 2017, Volume: 47, Issue:10

    Topics: Aged; Anti-Inflammatory Agents; Azathioprine; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Hepa

2017
CIDP variants in diabetes: measuring treatment response with a small nerve fiber test.
    Journal of diabetes and its complications, 2015, Volume: 29, Issue:2

    Topics: Autonomic Nervous System; Azathioprine; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabet

2015
The increased risk of active tuberculosis disease in patients with dermatomyositis - a nationwide retrospective cohort study.
    Scientific reports, 2015, Nov-17, Volume: 5

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Cohort Studies; Databases, Factual;

2015
Pustular porokeratosis.
    Journal of cutaneous pathology, 2009, Volume: 36, Issue:11

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Human

2009
Outcome of deceased donor renal transplantation in diabetic nephropathy: a single-center experience from a developing country.
    International urology and nephrology, 2012, Volume: 44, Issue:1

    Topics: Adult; Aged; Antilymphocyte Serum; Azathioprine; Cadaver; Calcineurin Inhibitors; Creatinine; Delaye

2012
[Nephrology].
    Revue medicale suisse, 2012, Jan-11, Volume: 8, Issue:323

    Topics: Anticholesteremic Agents; Azathioprine; Azetidines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Ty

2012
[Panzytopenia from combination therapy with azathioprin and allopurinol].
    Zeitschrift fur Rheumatologie, 2004, Volume: 63, Issue:5

    Topics: Aged; Allopurinol; Antirheumatic Agents; Autoantibodies; Azathioprine; Blood Cell Count; Diabetes Me

2004
Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus.
    Transplantation, 2005, Nov-27, Volume: 80, Issue:10

    Topics: Adiponectin; Adult; Azathioprine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes M

2005
Successful treatment of neuropathies in patients with diabetes mellitus.
    Archives of neurology, 1995, Volume: 52, Issue:11

    Topics: Aged; Azathioprine; Cyclophosphamide; Demyelinating Diseases; Diabetes Mellitus, Type 1; Diabetes Me

1995
Mid-term results of heart transplantation in diabetic patients.
    The Journal of cardiovascular surgery, 1994, Volume: 35, Issue:6 Suppl 1

    Topics: Actuarial Analysis; Adult; Azathioprine; Cardiac Catheterization; Coronary Angiography; Cyclosporins

1994
[Autoimmune hepatitis, autoimmune gastritis, hypergastrinemia and stomach carcinoid].
    Deutsche medizinische Wochenschrift (1946), 1995, Mar-17, Volume: 120, Issue:11

    Topics: Autoimmune Diseases; Azathioprine; Carcinoid Tumor; Cholangiopancreatography, Endoscopic Retrograde;

1995
Pemphigus vulgaris precipitated by glibenclamide therapy.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1993, Volume: 22, Issue:2

    Topics: Aged; Azathioprine; Candidiasis, Oral; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Fluconazole

1993