azathioprine has been researched along with Dermatitis Medicamentosa in 41 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a case of a 67-year-old man with multiple comorbidities including vitiligo, and a recent diagnosis of inflammatory bowel disease, who developed millimeter-size, circular, brown macules in photoexposed areas both affected and not affected by vitiligo while was taken azathioprine, which disappeared after drug withdrawal." | 7.83 | "Eruptive Lentiginosis" in a Patient With Vitiligo and Inflammatory Bowel Disease Treated With Azathioprine. ( Mendoza-Chaparro, C; Murillo-Lázaro, C; Ramos-Rodríguez, C, 2016) |
| "While being treated with azathioprine and dexamethasone, a 21-year old man with myasthenia gravis suddenly developed rapidly progressing brown macules, predominantly on the trunk, palms and soles." | 7.78 | [Eruptive melanocytic nevi during azathioprine therapy in myasthenia gravis]. ( Braun, SA; Frank, J; Hanneken, S; Helbig, D, 2012) |
| "Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third patient showed very high fever and severe chills." | 7.68 | Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis. ( Boerbooms, AM; Jeurissen, ME; Kruijsen, MW; van de Putte, LB, 1990) |
| "An acneiform eruption due to azathioprine was demonstrated through patch-tests and through elicitation on challenge." | 7.66 | [Acneiform exanthema caused by azathioprine]. ( Schmoeckel, C; von Liebe, V, 1983) |
| "2 women, 62 and 69 years old, both suffering from rheumatoid arthritis, were treated for 1 and 1 1/2 years, respectively, with penicillamine." | 7.66 | Two cases of penicillamine-induced pemphigus erythematosus. ( Thorvaldsen, J, 1979) |
| "Acute generalized exanthematous pustulosis (AGEP) is identified by several characteristic features." | 5.34 | Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. ( Elston, GE; Harman, KE; Johnston, GA; Mortimer, NJ, 2007) |
| " We report the case of a 50-year-old patient with indeterminate colitis, presenting with a febrile diffuse papulopustular and necrotizing skin eruption that healed with significant scarring and appeared 14 days after onset of treatment with azathioprine." | 4.91 | Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature. ( Contassot, E; Frei, P; French, LE; Imhof, L; Kamarachev, J; Kolios, A; Meier, B; Navarini, AA; Rogler, G, 2015) |
| " We report a case of a 67-year-old man with multiple comorbidities including vitiligo, and a recent diagnosis of inflammatory bowel disease, who developed millimeter-size, circular, brown macules in photoexposed areas both affected and not affected by vitiligo while was taken azathioprine, which disappeared after drug withdrawal." | 3.83 | "Eruptive Lentiginosis" in a Patient With Vitiligo and Inflammatory Bowel Disease Treated With Azathioprine. ( Mendoza-Chaparro, C; Murillo-Lázaro, C; Ramos-Rodríguez, C, 2016) |
| "An 81-year-old woman with Crohn disease presented with fever and an acute eruption of plaques on her extremities within 2 weeks of starting treatment with azathioprine." | 3.79 | Neutrophilic dermatosis after azathioprine exposure. ( Choi, JN; Cyrus, N; Ko, CJ; Mason, AR; Stavert, R, 2013) |
| "While being treated with azathioprine and dexamethasone, a 21-year old man with myasthenia gravis suddenly developed rapidly progressing brown macules, predominantly on the trunk, palms and soles." | 3.78 | [Eruptive melanocytic nevi during azathioprine therapy in myasthenia gravis]. ( Braun, SA; Frank, J; Hanneken, S; Helbig, D, 2012) |
| "Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third patient showed very high fever and severe chills." | 3.68 | Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis. ( Boerbooms, AM; Jeurissen, ME; Kruijsen, MW; van de Putte, LB, 1990) |
| "An acneiform eruption due to azathioprine was demonstrated through patch-tests and through elicitation on challenge." | 3.66 | [Acneiform exanthema caused by azathioprine]. ( Schmoeckel, C; von Liebe, V, 1983) |
| "2 women, 62 and 69 years old, both suffering from rheumatoid arthritis, were treated for 1 and 1 1/2 years, respectively, with penicillamine." | 3.66 | Two cases of penicillamine-induced pemphigus erythematosus. ( Thorvaldsen, J, 1979) |
| "Azathioprine (AZA) is an immunosuppressant commonly used for organ transplantation and autoimmune diseases." | 2.42 | Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis. ( Hakamada, A; Isoda, K; Kaketa, M; Mizutani, H; Mori, H; Tamada, K; Yamanaka, K; Yamanishi, K, 2004) |
| "A total of 500 patients (404 with Crohn's disease, 96 with ulcerative colitis) who received anti-TNF agents between June 2002 and July 2013 were identified and retrospectively investigated." | 1.42 | Concomitant use of azathioprine/6-mercaptopurine decreases the risk of anti-TNF-induced skin lesions. ( Byeon, JS; Kim, JH; Kim, KJ; Myung, SJ; Park, SH; Soh, JS; Won, CH; Yang, DH; Yang, SK; Ye, BD; Yun, WJ, 2015) |
| "We present the case of a woman with Crohn's disease who developed psoriasis after treatment with two anti-TNF- α drugs (infliximab and adalimumab)." | 1.37 | [Ustekinumab in a patient with Crohn's disease and anti-TNF-α-induced psoriasis]. ( Bosque López, MJ; Rocamora Durán, V; Royo Escosa, V; Sansó Sureda, A; Sapiña Camaró, A, 2011) |
| "Acute generalized exanthematous pustulosis (AGEP) is identified by several characteristic features." | 1.34 | Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. ( Elston, GE; Harman, KE; Johnston, GA; Mortimer, NJ, 2007) |
| "Azathioprine medication was stopped and the dermatologic features resolved completely after a period of 1 week." | 1.31 | [Erythema gyratum repens: drug reaction following azathioprine administration in a patient with type I autoimmune hepatitis]. ( Fölsch, UR; Günther, R; Hinrichsen, H; Nasser, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (29.27) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 16 (39.02) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, P | 1 |
| Silverberg, JI | 1 |
| Nishizawa, A | 1 |
| Ishikawa, T | 1 |
| Hirose, M | 1 |
| Satoh, H | 1 |
| Nishii, S | 1 |
| Tomita, K | 1 |
| Hokari, R | 1 |
| Satoh, T | 1 |
| Milanesi, N | 1 |
| Gola, M | 1 |
| Francalanci, S | 1 |
| Tarabar, D | 1 |
| Kandolf-Sekulović, L | 1 |
| Tatomirović, Ž | 1 |
| Mijušković, Ž | 1 |
| Milenković, Z | 1 |
| Tarabar, O | 1 |
| Pecelj-Broćić, T | 1 |
| Cyrus, N | 1 |
| Stavert, R | 1 |
| Mason, AR | 1 |
| Ko, CJ | 1 |
| Choi, JN | 1 |
| Yang, S | 1 |
| McHargue, C | 1 |
| Soh, JS | 1 |
| Yun, WJ | 1 |
| Kim, KJ | 1 |
| Won, CH | 1 |
| Park, SH | 1 |
| Yang, DH | 1 |
| Ye, BD | 1 |
| Byeon, JS | 1 |
| Myung, SJ | 1 |
| Yang, SK | 1 |
| Kim, JH | 1 |
| Imhof, L | 1 |
| Meier, B | 1 |
| Frei, P | 1 |
| Kamarachev, J | 1 |
| Rogler, G | 1 |
| Kolios, A | 1 |
| Navarini, AA | 1 |
| Contassot, E | 1 |
| French, LE | 1 |
| Ramos-Rodríguez, C | 1 |
| Murillo-Lázaro, C | 1 |
| Mendoza-Chaparro, C | 1 |
| Willis, DF | 1 |
| Chacko, B | 1 |
| Richard, M | 1 |
| Seneschal, J | 1 |
| Taïeb, A | 1 |
| Olaiwan, A | 1 |
| Wendling, J | 1 |
| Pouzoulet, J | 1 |
| Gaulier, A | 1 |
| Ingen-Housz-Oro, S | 1 |
| Sigal, M | 1 |
| Décisier, M | 1 |
| Duhalde, V | 1 |
| Faure, P | 1 |
| Ammoury, A | 1 |
| Gony, M | 1 |
| Moreau, J | 1 |
| Montastruc, JL | 1 |
| Bagheri, H | 1 |
| Bidinger, JJ | 1 |
| Sky, K | 1 |
| Battafarano, DF | 1 |
| Henning, JS | 1 |
| Richmond, BW | 1 |
| Cole, MB | 1 |
| Dash, A | 1 |
| Eyler, A | 1 |
| Boomershine, CS | 1 |
| Avgerinos, A | 1 |
| Giannikaki, E | 1 |
| Krüger-Krasagakis, S | 1 |
| Koutroubakis, IE | 1 |
| Sansó Sureda, A | 1 |
| Rocamora Durán, V | 1 |
| Sapiña Camaró, A | 1 |
| Royo Escosa, V | 1 |
| Bosque López, MJ | 1 |
| Hurtado-Garcia, R | 2 |
| Escribano-Stablé, JC | 1 |
| Pascual, Jc | 1 |
| Devesa, P | 1 |
| Matarredona, J | 1 |
| Braun, SA | 1 |
| Helbig, D | 1 |
| Frank, J | 1 |
| Hanneken, S | 1 |
| Günther, R | 1 |
| Nasser, S | 2 |
| Hinrichsen, H | 2 |
| Fölsch, UR | 2 |
| von Rainer Günther, ZB | 1 |
| Blasco, A | 1 |
| Enrique, E | 1 |
| de Mateo, JA | 1 |
| Castelló, JV | 1 |
| Ferriols, R | 1 |
| Malek, T | 1 |
| Mori, H | 1 |
| Yamanaka, K | 1 |
| Kaketa, M | 1 |
| Tamada, K | 1 |
| Hakamada, A | 1 |
| Isoda, K | 1 |
| Yamanishi, K | 1 |
| Mizutani, H | 1 |
| Merk, HF | 1 |
| Bovenschen, HJ | 1 |
| Tjioe, M | 1 |
| Vermaat, H | 1 |
| de Hoop, D | 1 |
| Witteman, BM | 1 |
| Janssens, RW | 1 |
| Stoof, TJ | 1 |
| van de Kerkhof, PC | 1 |
| Elston, GE | 1 |
| Johnston, GA | 1 |
| Mortimer, NJ | 1 |
| Harman, KE | 1 |
| Bailin, PL | 1 |
| Matkaluk, RM | 1 |
| Mosbech, H | 1 |
| Andersen, CW | 1 |
| Schmoeckel, C | 1 |
| von Liebe, V | 1 |
| Krel', AA | 1 |
| Kanevskaia, MZ | 1 |
| Rashchupkina, ZP | 1 |
| Bolotin, EV | 1 |
| Chichasova, NV | 1 |
| Adams, SJ | 1 |
| Davison, AM | 1 |
| Cunliffe, WJ | 1 |
| Giles, GR | 1 |
| Hermanns-Lê, T | 1 |
| Piérard, GE | 1 |
| Lavaud, F | 1 |
| Abdelli, N | 1 |
| Thiefin, G | 1 |
| Zimmerman, SW | 1 |
| Esch, J | 1 |
| Thorvaldsen, J | 1 |
| Delacrétaz, J | 1 |
| Jeurissen, ME | 1 |
| Boerbooms, AM | 1 |
| van de Putte, LB | 1 |
| Kruijsen, MW | 1 |
| Shuttleworth, D | 1 |
| Marks, R | 1 |
| Griffin, PJ | 1 |
| Salaman, JR | 1 |
| Bergman, SM | 1 |
| Krane, NK | 1 |
| Leonard, G | 1 |
| Soto-Aguilar, MC | 1 |
| Wallin, JD | 1 |
| Neumann, RA | 1 |
| Knobler, RM | 1 |
| Metze, D | 1 |
| Jurecka, W | 1 |
| Levantine, A | 1 |
| Almeyda, J | 1 |
8 reviews available for azathioprine and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature.
Topics: Anti-Inflammatory Agents; Azathioprine; Colitis; Drug Eruptions; Humans; Immunosuppressive Agents; I | 2015 |
The cutaneous and systemic manifestations of azathioprine hypersensitivity syndrome.
Topics: Adult; Aged; Azathioprine; Biopsy, Needle; Dose-Response Relationship, Drug; Drug Administration Sch | 2011 |
Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.
Topics: Azathioprine; Diagnosis, Differential; Drug Eruptions; Female; Humans; Immunosuppressive Agents; Lym | 2004 |
[Pharmacogenetics: Important aspects for dermatology].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Dapsone; Dermatology; Drug Eruptions; Fluorou | 2005 |
Induction of eruptive benign melanocytic naevi by immune suppressive agents, including biologicals.
Topics: Adult; Azathioprine; Drug Eruptions; Female; Humans; Immunocompromised Host; Immunologic Factors; Im | 2006 |
Cutaneous reactions to rheumatological drugs.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Azathioprine; Cushing Syndrome; Cy | 1982 |
Disseminated superficial porokeratosis and immunosuppression.
Topics: Aged; Azathioprine; Drug Eruptions; Humans; Immunosuppression Therapy; Keratosis; Male; Pemphigus; P | 1988 |
Drug reactions. XXIV. Cutaneous reactions to cytostatic agents.
Topics: Alopecia; Aminopterin; Antineoplastic Agents; Asparaginase; Azathioprine; Bleomycin; Busulfan; Chlor | 1974 |
33 other studies available for azathioprine and Dermatitis Medicamentosa
| Article | Year |
|---|---|
Adverse event monitoring in patients on oral systemic medications for inflammatory skin disease.
Topics: Azathioprine; Cross-Sectional Studies; Cyclosporine; Dermatitis, Atopic; Drug Eruptions; Drug Monito | 2020 |
Mogamulizumab-induced toxicoderma-like eruptions and autoimmune hepatitis successfully treated with azathioprine in adult T-cell leukaemia/lymphoma.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Azathioprine; Drug Eruptions; Female; Hepa | 2017 |
Photosensitivity in drug induced pellagra.
Topics: Adolescent; Azathioprine; Colitis, Ulcerative; Drug Eruptions; Female; Humans; Immunosuppressive Age | 2019 |
Cutaneous side effects caused by treatment for inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Cyclosporine; Drug E | 2016 |
Neutrophilic dermatosis after azathioprine exposure.
Topics: Aged, 80 and over; Azathioprine; Crohn Disease; Diagnosis, Differential; Drug Eruptions; Female; Hum | 2013 |
An asymptomatic papulopustular eruption in an immunosuppressed patient.
Topics: Azathioprine; Drug Eruptions; Drug Hypersensitivity; Female; Hepatitis, Autoimmune; Humans; Immunoco | 2014 |
Concomitant use of azathioprine/6-mercaptopurine decreases the risk of anti-TNF-induced skin lesions.
Topics: Adolescent; Adult; Aged; Azathioprine; Body Mass Index; Colitis, Ulcerative; Crohn Disease; Drug Eru | 2015 |
"Eruptive Lentiginosis" in a Patient With Vitiligo and Inflammatory Bowel Disease Treated With Azathioprine.
Topics: Aged; Anti-Inflammatory Agents; Apoptosis; Azathioprine; Biopsy; Drug Eruptions; Gastrointestinal Ag | 2016 |
Rash and fever in a man with granulomatosis with polyangiitis (Wegener's).
Topics: Azathioprine; Biopsy; Drug Eruptions; Exanthema; Fever; Glucocorticoids; Granulomatosis with Polyang | 2016 |
Azathioprine-induced rosacea.
Topics: Aged; Azathioprine; Drug Eruptions; Female; Humans; Rosacea | 2017 |
[Cutaneous manifestation of hypersensibility to azathioprine in a Crohn's disease patient].
Topics: Adolescent; Azathioprine; Crohn Disease; Drug Eruptions; Humans; Male | 2008 |
Rapid-onset febrile dermatosis.
Topics: Azathioprine; Colitis, Ulcerative; Drug Eruptions; Humans; Immunosuppressive Agents; Male; Middle Ag | 2009 |
A tale of two rashes.
Topics: Aged; Antihypertensive Agents; Azathioprine; Complement C4; Cryoglobulinemia; Diagnosis, Differentia | 2011 |
Acute generalized exanthematous pustulosis induced by azathioprine in a patient with ulcerative colitis.
Topics: Acute Generalized Exanthematous Pustulosis; Azathioprine; Colitis, Ulcerative; Drug Eruptions; Human | 2011 |
[Ustekinumab in a patient with Crohn's disease and anti-TNF-α-induced psoriasis].
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanize | 2011 |
Neutrophilic dermatosis caused by azathioprine hypersensitivity.
Topics: Adult; Azathioprine; Drug Eruptions; Female; Hand Dermatoses; Humans; Immunosuppressive Agents; Myas | 2012 |
[Eruptive melanocytic nevi during azathioprine therapy in myasthenia gravis].
Topics: Azathioprine; Drug Eruptions; Humans; Immunosuppressive Agents; Male; Myasthenia Gravis; Nevus, Pigm | 2012 |
[Erythema gyratum repens: drug reaction following azathioprine administration in a patient with type I autoimmune hepatitis].
Topics: Aged; Azathioprine; Diagnosis, Differential; Drug Eruptions; Drug Therapy, Combination; Female; Hepa | 2002 |
[Erythema gyratum repens. Drug hypersensitivity after azathioprine in a patient with type 1 autoimmune hepatitis].
Topics: Azathioprine; Diagnosis, Differential; Drug Eruptions; Female; Hepatitis, Autoimmune; Humans; Immuno | 2002 |
Positive patch test to azathioprine in inflammatory bowel disease.
Topics: Adult; Azathioprine; Drug Eruptions; Humans; Inflammatory Bowel Diseases; Male; Patch Tests | 2004 |
Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity.
Topics: Azathioprine; Drug Eruptions; Exanthema; Female; Humans; Immunosuppressive Agents; Middle Aged; Skin | 2007 |
[Azathioprine induced hypersensitivity].
Topics: Adult; Aged; Azathioprine; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Male | 1982 |
[Acneiform exanthema caused by azathioprine].
Topics: Acne Vulgaris; Adult; Azathioprine; Drug Eruptions; Exanthema; Humans; Male; Patch Tests | 1983 |
[Chlorbutin, azathioprine, D-penicillamine, and levamisole (Decaris) in the treatment of rheumatoid arthritis patients. I. Comparative analysis of side effects].
Topics: Arthritis, Rheumatoid; Azathioprine; Bronchial Spasm; Chlorambucil; Drug Eruptions; Dyspepsia; Human | 1981 |
Perioral dermatitis in renal transplant recipients maintained on corticosteroids and immunosuppressive therapy.
Topics: Adult; Azathioprine; Doxycycline; Drug Eruptions; Facial Dermatoses; Female; Humans; Kidney Transpla | 1982 |
Azathioprine-induced skin peeling syndrome.
Topics: Azathioprine; Cytoplasm; Desmosomes; Drug Eruptions; Female; Follow-Up Studies; Humans; Immunosuppre | 1997 |
Successful desensitization for azathioprine skin rash in a patient with severe Crohn's disease.
Topics: Adult; Azathioprine; Crohn Disease; Desensitization, Immunologic; Drug Eruptions; Female; Humans; Im | 1997 |
Skin lesions treated with azathioprine and prednisone. Comparison of nontransplant patients and renal transplant recipients.
Topics: Adult; Azathioprine; Drug Eruptions; Female; Humans; Kidney Transplantation; Male; Postoperative Com | 1978 |
Two cases of penicillamine-induced pemphigus erythematosus.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Drug Eruptions; Female; Humans; Middle Aged; Pemphigus; P | 1979 |
[Localized mucinous elastotic degeneration of the dermis after prednisone and azathioprine (author's transl)].
Topics: Aged; Azathioprine; Drug Eruptions; Epidermis; Female; Humans; Liver Cirrhosis; Prednisone | 1979 |
Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Eruptions; D | 1990 |
Epidermal dysplasia and cyclosporine therapy in renal transplant patients: a comparison with azathioprine.
Topics: Adolescent; Adult; Aged; Azathioprine; Cyclosporins; Drug Eruptions; Humans; Kidney Transplantation; | 1989 |
Azathioprine and hypersensitivity vasculitis.
Topics: Adult; Azathioprine; Drug Eruptions; Humans; Male; Middle Aged; Vasculitis, Leukocytoclastic, Cutane | 1988 |