Page last updated: 2024-10-23

azathioprine and Depression

azathioprine has been researched along with Depression in 8 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"A 14-year-old girl with systemic lupus erythematosus presented with a mixed overdose of paracetamol, ibuprofen and azathioprine (1500 mg) following a deliberate self-harm attempt."2.49Intentional overdose of azathioprine in a patient with systemic lupus erythematosus. ( Khan, AM; Mahmood, K; Martin, K; Ramanan, AV, 2013)
"Mixed connective tissue disorder (MCTD) with predominant polymyositis and neuropsychiatric manifestations was diagnosed as the patient had anti-RNP positive with significantly raised muscle enzymes."1.40Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder. ( Kiani, IG; Qureshi, SH; Shah, F, 2014)
"Medical therapy of Meniere's disease is geared not only toward the differential diagnosis that has led to Meniere's disease and the supportive therapy for the physical manifestations of the disease but also for the psychologic sequelae of the disease such as mild-to-moderate situational depression and even chronic depression."1.31Medical management of Meniere's disease. ( Sajjadi, H, 2002)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Sutton, SS1
Magagnoli, J1
Cummings, T1
Hardin, JW1
Love, BL1
Mahmood, K1
Khan, AM1
Ramanan, AV1
Martin, K1
Kiani, IG1
Qureshi, SH1
Shah, F1
Campos, S1
Portela, F1
Sousa, P1
Sofia, C1
Sajjadi, H1
Moons, P1
Vanrenterghem, Y1
Van Hooff, JP1
Squifflet, JP1
Margodt, D1
Mullens, M1
Thevissen, I1
De Geest, S1
Hommel, KA1
Davis, CM1
Baldassano, RN1
Baker, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of Information and Communication Technologies for Health Support in Inflammatory Bowel Diseases: The DAMASCO Trial (Stage I)[NCT04893928]351 participants (Anticipated)Observational2021-05-03Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for azathioprine and Depression

ArticleYear
Intentional overdose of azathioprine in a patient with systemic lupus erythematosus.
    Scottish medical journal, 2013, Volume: 58, Issue:4

    Topics: Acetaminophen; Adolescent; Affective Disorders, Psychotic; Anti-Inflammatory Agents, Non-Steroidal;

2013

Trials

1 trial available for azathioprine and Depression

ArticleYear
Psychopathology in systemic lupus erythematosus. I. Psychiatric observations.
    Seminars in arthritis and rheumatism, 1973, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Affective Symptoms; Aspirin; Azathioprine; Brain Diseases; Clinical Trials as Top

1973

Other Studies

6 other studies available for azathioprine and Depression

ArticleYear
Association between thiopurine exposure and depression in patients with inflammatory bowel disease and rheumatoid arthritis.
    Journal of psychopharmacology (Oxford, England), 2020, Volume: 34, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cohort St

2020
Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2014, Volume: 24 Suppl 2

    Topics: Adult; Antibodies, Antinuclear; Anticonvulsants; Antidepressive Agents, Second-Generation; Azathiopr

2014
Inflammatory bowel disease: adherence to immunomodulators in a biological therapy era.
    European journal of gastroenterology & hepatology, 2016, Volume: 28, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aged; Azathioprine; Depression; Drug Therapy, Combination; Female; H

2016
Medical management of Meniere's disease.
    Otolaryngologic clinics of North America, 2002, Volume: 35, Issue:3

    Topics: Adrenal Cortex Hormones; Amitriptyline; Antidepressive Agents, Tricyclic; Antiemetics; Azathioprine;

2002
Health-related quality of life and symptom experience in tacrolimus-based regimens after renal transplantation: a multicentre study.
    Transplant international : official journal of the European Society for Organ Transplantation, 2003, Volume: 16, Issue:9

    Topics: Adult; Aged; Azathioprine; Depression; Drug Therapy, Combination; Female; Health Status; Humans; Imm

2003
Medication adherence and quality of life in pediatric inflammatory bowel disease.
    Journal of pediatric psychology, 2008, Volume: 33, Issue:8

    Topics: Adolescent; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Depression;

2008