Page last updated: 2024-10-23

azathioprine and Demyelinative Myelitis

azathioprine has been researched along with Demyelinative Myelitis in 16 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"Longitudinally extensive transverse myelitis (LETM) is a frequently devastating clinical syndrome which has come into focus for its association with neuromyelitis optica (NMO)."2.50Longitudinally extensive transverse myelitis. ( Lucchinetti, CF; Tobin, WO; Weinshenker, BG, 2014)
"Azathioprine was the treatment prescribed in the four patients with NMOSD."1.51Inflammatory demyelinating diseases of the central nervous system in Niger. ( Adehossi Omar, É; Assadeck, H; Douma Maiga, D; Hassane Djibo, F; Mamadou, Z; Toudou Daouda, M, 2019)
"Background and objective Acute transverse myelitis (TM) is an infrequent neurological complication of systemic lupus erythematosus (SLE)."1.48Natural history of longitudinally extensive transverse myelitis in 35 Hispanic patients with systemic lupus erythematosus: good short-term functional outcome and paradoxical increase in long-term mortality. ( Aguirre-Villarreal, D; Cantú-Brito, C; Ceballos-Ceballos, J; Dávila-Maldonado, L; Díaz de León-Sánchez, E; Flores-Silva, FD; Fragoso-Loyo, H; González-Duarte, A; Guraieb-Chaín, P; Higuera-Calleja, J; Longoria-Lozano, O; Morales-Moreno, S; Murra-Antón, S; Quintanilla-González, L; Sentíes-Madrid, H; Treviño-Frenk, I; Valdés-Ferrer, SI; Vega-Boada, F, 2018)
"Acute transverse myelitis (ATM) is an inflammatory process involving a restricted area of the spinal cord."1.33A case of Sjögren's syndrome with acute transverse myelitis and polyneuropathy in a patient free of sicca symptoms. ( Tristano, AG, 2006)
"A 25-year-old Japanese woman with systemic lupus erythematosus (SLE) was admitted because of numbness of the face and left upper extremity, headache, and intermittent fever."1.31Systemic lupus erythematosus related transverse myelitis presenting longitudinal involvement of the spinal cord. ( Amano, H; Aramaki, T; Hirayama, Y; Kimura, KY; Seino, Y; Takano, T; Yamaguchi, H, 2002)
"We report an unusual case of MCTD with recurrent optic neuropathy and transverse myelopathy suggestive of a relapsing-remitting demyelinating disorder."1.29Mixed connective tissue disease: recurrent episodes of optic neuropathy and transverse myelopathy. Successful treatment with plasmapheresis. ( Baum, K; Flechtner, KM, 1994)
"A case of transverse myelitis in a 16-year-old woman with mixed connective tissue disease is described."1.27Transverse myelitis in mixed connective tissue disease. ( Boesen, F; Bonen, H; Pedersen, C, 1987)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's3 (18.75)18.2507
2000's5 (31.25)29.6817
2010's5 (31.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Ssemmanda, S1
Musubire, AK1
Thornley, K1
Canepa, C1
Flores-Silva, FD1
Longoria-Lozano, O1
Aguirre-Villarreal, D1
Sentíes-Madrid, H1
Vega-Boada, F1
Díaz de León-Sánchez, E1
Murra-Antón, S1
Morales-Moreno, S1
Quintanilla-González, L1
Fragoso-Loyo, H1
Guraieb-Chaín, P1
Higuera-Calleja, J1
Ceballos-Ceballos, J1
Treviño-Frenk, I1
González-Duarte, A1
Dávila-Maldonado, L1
Cantú-Brito, C1
Valdés-Ferrer, SI1
Assadeck, H1
Toudou Daouda, M1
Adehossi Omar, É1
Mamadou, Z1
Hassane Djibo, F1
Douma Maiga, D1
Tobin, WO1
Weinshenker, BG1
Lucchinetti, CF1
Austin, A1
Tincani, A1
Kivity, S1
Arango, MT1
Shoenfeld, Y1
Bolat, S1
Berding, G1
Dengler, R1
Stangel, M1
Trebst, C1
Zaidan, M1
Lidove, O1
Sacré, K1
Klein, I1
Papo, T1
Tristano, AG1
Bhinder, S1
Harbour, K1
Majithia, V1
Mok, CC1
Lau, CS1
Flechtner, KM1
Baum, K1
Chan, KF1
Boey, ML1
Itoyama, Y1
Fujihara, K1
Nakashima, I1
Misu, T1
Fujimori, T1
Sato, S1
Kimura, KY1
Seino, Y1
Hirayama, Y1
Aramaki, T1
Yamaguchi, H1
Amano, H1
Takano, T1
Pedersen, C1
Bonen, H1
Boesen, F1

Reviews

4 reviews available for azathioprine and Demyelinative Myelitis

ArticleYear
Longitudinally extensive transverse myelitis.
    Current opinion in neurology, 2014, Volume: 27, Issue:3

    Topics: Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Aquaporin 4; Autoantibodi

2014
Transverse myelitis, a rare neurological manifestation of mixed connective tissue disease--a case report and a review of literature.
    Clinical rheumatology, 2007, Volume: 26, Issue:3

    Topics: Aged; Azathioprine; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Magnetic

2007
Transverse myelopathy in SLE: clinical features and functional outcomes.
    Lupus, 1996, Volume: 5, Issue:4

    Topics: Adult; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Female; Humans; Immunosuppressive Agents

1996
[Multiple sclerosis--recent advances in pathogenesis and treatment].
    No to shinkei = Brain and nerve, 2002, Volume: 54, Issue:1

    Topics: Autoimmunity; Azathioprine; Cytokines; Glatiramer Acetate; Humans; Immunoglobulins, Intravenous; Imm

2002

Other Studies

12 other studies available for azathioprine and Demyelinative Myelitis

ArticleYear
Different clinical phenotypes of AQP4-IgG positive NMOSD in two first degree relatives.
    BMC neurology, 2023, Sep-04, Volume: 23, Issue:1

    Topics: Adult; Autoimmune Diseases; Azathioprine; Female; Gadolinium; HIV Infections; Humans; Immunoglobulin

2023
Neuromyelitis optica spectrum disorder (NMOSD) presenting as acute transverse myelitis with positive aquaporin 4 antibodies.
    BMJ case reports, 2021, Jan-27, Volume: 14, Issue:1

    Topics: Aged, 80 and over; Aquaporin 4; Autoantibodies; Azathioprine; Female; Glucocorticoids; Humans; Immun

2021
Natural history of longitudinally extensive transverse myelitis in 35 Hispanic patients with systemic lupus erythematosus: good short-term functional outcome and paradoxical increase in long-term mortality.
    Lupus, 2018, Volume: 27, Issue:8

    Topics: Adult; Azathioprine; Female; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Male

2018
Inflammatory demyelinating diseases of the central nervous system in Niger.
    Revue neurologique, 2019, Volume: 175, Issue:4

    Topics: Adult; Aged; Azathioprine; Central Nervous System Diseases; Demyelinating Diseases; Disability Evalu

2019
Transverse Myelitis Activation Post-H1N1 Immunization: A Case of Adjuvant Induction?
    The Israel Medical Association journal : IMAJ, 2015, Volume: 17, Issue:2

    Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Adult; Azathioprine; Cervical Vertebrae; Humans; Im

2015
Fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in the diagnosis of neurosarcoidosis.
    Journal of the neurological sciences, 2009, Dec-15, Volume: 287, Issue:1-2

    Topics: Anti-Inflammatory Agents; Azathioprine; Diagnosis, Differential; Encephalitis; Fluorodeoxyglucose F1

2009
"Fulminant" Behçet disease.
    Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11

    Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Antibodies, Monoclonal; Atrophy; Azathio

2011
A case of Sjögren's syndrome with acute transverse myelitis and polyneuropathy in a patient free of sicca symptoms.
    Clinical rheumatology, 2006, Volume: 25, Issue:1

    Topics: Acute Disease; Adult; Azathioprine; Biopsy; Cyclophosphamide; Drug Therapy, Combination; Female; Hum

2006
Transverse myelopathy complicating mixed connective tissue disease.
    Clinical neurology and neurosurgery, 1995, Volume: 97, Issue:3

    Topics: Azathioprine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucocorticoids;

1995
Mixed connective tissue disease: recurrent episodes of optic neuropathy and transverse myelopathy. Successful treatment with plasmapheresis.
    Journal of the neurological sciences, 1994, Volume: 126, Issue:2

    Topics: Adult; Azathioprine; Female; Humans; Magnetic Resonance Imaging; Mixed Connective Tissue Disease; My

1994
Systemic lupus erythematosus related transverse myelitis presenting longitudinal involvement of the spinal cord.
    Internal medicine (Tokyo, Japan), 2002, Volume: 41, Issue:2

    Topics: Adult; Autoimmune Diseases; Azathioprine; Brain; Cyclophosphamide; Drug Resistance; Facial Nerve Dis

2002
Transverse myelitis in mixed connective tissue disease.
    Clinical rheumatology, 1987, Volume: 6, Issue:2

    Topics: Adolescent; Azathioprine; Drug Therapy, Combination; Female; Humans; Mixed Connective Tissue Disease

1987