azathioprine has been researched along with Connective Tissue Diseases in 21 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Owing to adverse pharmacokinetics, azathioprine treatment may fail to induce a satisfactory clinical response in systemic connective tissue diseases." | 7.68 | 6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment. ( Kriegbaum, NJ; Schmiegelow, K, 1993) |
| "Intensive immunosuppression (IIS) was compared with prednisolone alone over a 2-year period in the treatment of severe connective tissue diseases." | 7.66 | Intensive immunosuppression versus prednisolone in the treatment of connective tissue diseases. ( Ansell, BM; de Vere Tyndall, A; Denman, AM; Gumpel, JM; Hollingworth, P; Mertin, J; Platts-Mills, T; Smith, DS, 1982) |
| "Owing to adverse pharmacokinetics, azathioprine treatment may fail to induce a satisfactory clinical response in systemic connective tissue diseases." | 3.68 | 6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment. ( Kriegbaum, NJ; Schmiegelow, K, 1993) |
| "Intensive immunosuppression (IIS) was compared with prednisolone alone over a 2-year period in the treatment of severe connective tissue diseases." | 3.66 | Intensive immunosuppression versus prednisolone in the treatment of connective tissue diseases. ( Ansell, BM; de Vere Tyndall, A; Denman, AM; Gumpel, JM; Hollingworth, P; Mertin, J; Platts-Mills, T; Smith, DS, 1982) |
| "Sweet syndrome, also referred to as acute febrile neutrophilic dermatosis, is characterized by tender, red inflammatory nodules or papules that occur in association with infection, malignancy, connective tissue disease, or following exposure to certain drugs." | 2.46 | EPONYM. Sweet syndrome. ( Choe, YH; Kim, MJ, 2010) |
| "When unrecognized and therefore untreated, vasculitis of the nervous system leads to pervasive injury and disability making this a disorder of paramount importance to all clinicians." | 2.42 | Vasculitis of the nervous system. ( Younger, DS, 2004) |
| "Azathioprine is a valuable alternative to slow-acting antirheumatic drugs in older patients with rheumatoid arthritis." | 2.38 | Azathioprine, cyclophosphamide and chlorambucil. ( Bacon, PA; Luqmani, RA; Palmer, RG, 1990) |
| "If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease." | 2.37 | Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986) |
| "Azathioprine is a commonly prescribed therapy for connective tissue disease-associated interstitial lung disease (CTD-ILD)." | 1.43 | Azathioprine response in patients with fibrotic connective tissue disease-associated interstitial lung disease. ( Adegunsoye, A; Chen, L; Chung, JH; Hsu, S; Lee, C; Montner, S; Noth, I; Oldham, JM; Strek, ME; Valenzi, E; Vij, R; Witt, LJ, 2016) |
| "Hypogonadism has been established as a cause of osteoporosis in males, and in this case would explain the occurrence of fractures in the absence of other major risk factors." | 1.31 | Osteoporosis with underlying connective tissue disease: an unusual case. ( De Silva, M; Prasad, R, 2002) |
| "Five developed septic arthritis, including the site of a hip prosthesis in one patient." | 1.28 | Salmonella arizona arthritis and septicemia associated with rattlesnake ingestion by patients with connective tissue diseases. A dangerous complication of folk medicine. ( Alarcón-Segovia, D; Guerra-Bautista, G; Kraus, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, D | 1 |
| Adegunsoye, A | 2 |
| Oldham, JM | 2 |
| Kozlitina, J | 1 |
| Garcia, N | 1 |
| Poonawalla, M | 1 |
| Strykowski, R | 1 |
| Linderholm, AL | 1 |
| Ley, B | 1 |
| Ma, SF | 1 |
| Noth, I | 2 |
| Strek, ME | 2 |
| Wolters, PJ | 1 |
| Garcia, CK | 1 |
| Newton, CA | 1 |
| Tzilas, V | 1 |
| Kahn, N | 1 |
| Bouros, D | 1 |
| Siramolpiwat, S | 1 |
| Sakonlaya, D | 1 |
| Keyßer, G | 1 |
| Zierz, S | 1 |
| Kornhuber, M | 1 |
| Alqurashi, EH | 1 |
| Sayeed, A | 1 |
| Alsulami, HH | 1 |
| Al-Qurashi, HM | 1 |
| Lee, C | 1 |
| Valenzi, E | 1 |
| Witt, LJ | 1 |
| Hsu, S | 1 |
| Chen, L | 1 |
| Montner, S | 1 |
| Chung, JH | 1 |
| Vij, R | 1 |
| Kim, MJ | 1 |
| Choe, YH | 1 |
| Hartley, A | 1 |
| Pyne, D | 1 |
| Bickerstaff, M | 1 |
| Noaiseh, G | 1 |
| Bhangle, S | 1 |
| Vivino, F | 1 |
| Prasad, R | 1 |
| De Silva, M | 1 |
| Younger, DS | 1 |
| Lampropoulos, CE | 1 |
| Zain, M | 1 |
| Jan, W | 1 |
| Nader-Sepahi, A | 1 |
| Sabin, IH | 1 |
| D' Cruz, DP | 1 |
| Hollingworth, P | 1 |
| de Vere Tyndall, A | 1 |
| Ansell, BM | 1 |
| Platts-Mills, T | 1 |
| Gumpel, JM | 1 |
| Mertin, J | 1 |
| Smith, DS | 1 |
| Denman, AM | 2 |
| Bacon, BR | 1 |
| Treuhaft, WH | 1 |
| Goodman, AM | 1 |
| Schmiegelow, K | 1 |
| Kriegbaum, NJ | 1 |
| Bentes, C | 1 |
| de Carvalho, M | 1 |
| Valente, I | 1 |
| Sales Luis, ML | 1 |
| da Silva, JP | 1 |
| Kraus, A | 1 |
| Guerra-Bautista, G | 1 |
| Alarcón-Segovia, D | 1 |
| Luqmani, RA | 1 |
| Palmer, RG | 2 |
| Bacon, PA | 1 |
| Leavitt, RY | 1 |
| Fauci, AS | 1 |
| Smith-Burchnell, CA | 1 |
| Dore, CJ | 1 |
| Lovisetto, P | 1 |
| Manachino, D | 1 |
| Biarese, V | 1 |
| Marchi, L | 1 |
| Andrione, P | 1 |
5 reviews available for azathioprine and Connective Tissue Diseases
| Article | Year |
|---|---|
EPONYM. Sweet syndrome.
Topics: Adult; Azathioprine; Child; Connective Tissue Diseases; Erythema; Fever; Granulocyte Colony-Stimulat | 2010 |
Vasculitis of the nervous system.
Topics: Azathioprine; Connective Tissue Diseases; Cyclophosphamide; Diagnosis, Differential; Giant Cell Arte | 2004 |
Azathioprine, cyclophosphamide and chlorambucil.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Connective Tissue Diseases; Cyclophosphamide; Hum | 1990 |
Pulmonary vasculitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy | 1986 |
[Blood hypereosinophilias. IV. Symptomatic hypereosinophilias: connective tissue diseases, neoplasms, blood diseases, various causes].
Topics: Aged; Asthma; Azathioprine; Connective Tissue Diseases; Cortisone; Eosinophilia; Female; Hematologic | 1985 |
16 other studies available for azathioprine and Connective Tissue Diseases
| Article | Year |
|---|---|
Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease.
Topics: Azathioprine; Connective Tissue Diseases; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppression T | 2023 |
Azathioprine for Connective Tissue Disease-Associated Interstitial Lung Disease: In Search for Evidence-Based Medicine.
Topics: Azathioprine; Connective Tissue Diseases; Evidence-Based Medicine; Humans; Lung Diseases, Interstiti | 2020 |
Clinical and histologic features of Azathioprine-induced hepatotoxicity.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Azathioprine; Bilirubin; Chemical and Drug Induce | 2017 |
Treatment of adult idiopathic inflammatory myopathies with conventional immunosuppressive drugs : Results of a retrospective study.
Topics: Adult; Azathioprine; Connective Tissue Diseases; Dermatomyositis; Drug Therapy, Combination; Female; | 2019 |
Perplexing case of lung mass perfectly mimicking a malignancy.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Biopsy; Bronchiolitis; Connective Tissue Diseases; Dia | 2019 |
Azathioprine response in patients with fibrotic connective tissue disease-associated interstitial lung disease.
Topics: Adult; Aged; Azathioprine; Connective Tissue Diseases; Cross-Over Studies; Female; Hospitalization; | 2016 |
A near miss.
Topics: Abdominal Pain; Acyclovir; Adult; Antiviral Agents; Azathioprine; Connective Tissue Diseases; Female | 2011 |
Idiopathic mediastinal fibrosis presenting with antiphospholipid antibody syndrome and manifestations suggestive of connective tissue disease.
Topics: Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Antirheumatic Agents; Azathioprine; Connecti | 2012 |
Osteoporosis with underlying connective tissue disease: an unusual case.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Accidental Falls; Adult; Anti-Ulcer Agents; Antibodies, Ant | 2002 |
Hypertrophic pachymeningitis and undifferentiated connective tissue disease: a case report and review of the literature.
Topics: Azathioprine; Brain; Connective Tissue Diseases; Decompression, Surgical; Drug Therapy, Combination; | 2006 |
Intensive immunosuppression versus prednisolone in the treatment of connective tissue diseases.
Topics: Adolescent; Adult; Aged; Antilymphocyte Serum; Azathioprine; Connective Tissue Diseases; Dermatomyos | 1982 |
Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases.
Topics: Adult; Arthritis, Juvenile; Azathioprine; Blood Cell Count; Bone Marrow; Connective Tissue Diseases; | 1981 |
6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment.
Topics: Adult; Aged; Azathioprine; Connective Tissue Diseases; Erythrocytes; Evaluation Studies as Topic; Fe | 1993 |
Amyotrophic lateral sclerosis syndrome associated with connective tissue disease; improvement after immunosuppressive therapy. A long-term follow-up case.
Topics: Amyotrophic Lateral Sclerosis; Anti-Inflammatory Agents; Azathioprine; Connective Tissue Diseases; F | 1999 |
Salmonella arizona arthritis and septicemia associated with rattlesnake ingestion by patients with connective tissue diseases. A dangerous complication of folk medicine.
Topics: Adolescent; Adult; Animals; Arthritis, Infectious; Azathioprine; Connective Tissue Diseases; Drug Th | 1991 |
Thioguanine-resistant mutations induced by cytotoxic drugs in lymphocytes of patients with connective tissue diseases.
Topics: Azathioprine; Chlorambucil; Connective Tissue Diseases; Cyclophosphamide; Drug Resistance; Humans; H | 1986 |