azathioprine has been researched along with Collagen Diseases in 40 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that collagen was equivalent to connective tissue, but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term collagen diseases now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective study in the United Kingdom of 1,634 patients without transplants treated with immunosuppressive drugs (68 percent with azathioprine, 28 percent with cyclophosphamide) found an excess of non-Hodgkin's lymphoma and squamous cell skin cancer, suggesting that the excesses (although larger) of the same malignancies found among transplant recipients are not due solely to the foreign antigens of the graft." | 3.67 | Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. ( Kinlen, LJ, 1985) |
| "B-, T- and O-lymphocytes detected as EAC-, E- and non-rosette forming lymphocytes were investigated in venous blood in 49 patients with connective tissue diseases, psoriasis and chronic lymphogenous leukaemia (CLL) during treatment with either prednisone alone, prednisone and cytostatic agents or cytostatic agents alone." | 3.65 | Influence of prednisone and cytostatics on human blood B-, T- and O-lymphocytes in diseases. ( Jonsson, V, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (92.50) | 18.7374 |
| 1990's | 1 (2.50) | 18.2507 |
| 2000's | 1 (2.50) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mimori, T | 1 |
| Matsumoto, I | 1 |
| Goerz, G | 1 |
| Merk, H | 1 |
| Auzuki, A | 1 |
| Matsuoka, Y | 1 |
| Alexander, M | 1 |
| Kampf, D | 1 |
| Easty, DL | 1 |
| Madden, P | 1 |
| Jayson, MI | 1 |
| Carter, C | 1 |
| Noble, BA | 1 |
| Jerusalem, F | 1 |
| Denman, AM | 1 |
| Pelton, BK | 1 |
| Kinsley, M | 1 |
| Knight, S | 1 |
| Partridge, C | 1 |
| Walker, P | 1 |
| Bannister, B | 1 |
| Gumpel, M | 1 |
| Smith, DS | 1 |
| Loewi, E | 1 |
| Jonsson, V | 1 |
| Hallauer, W | 1 |
| Schirmeister, J | 1 |
| Keller, P | 1 |
| Krieger, G | 1 |
| Schirrmeister, H | 1 |
| Hryszko, S | 1 |
| Myśliwiec, M | 1 |
| Bielawiec, M | 1 |
| Kiersnowska-Rogowska, B | 1 |
| Bogdanikowa, B | 1 |
| Helmke, K | 1 |
| Becker, H | 1 |
| Nashel, DJ | 1 |
| Kinlen, LJ | 1 |
| Nasonova, VA | 1 |
| Lorenzen, I | 2 |
| Videbaek, A | 2 |
| Joseph, RR | 1 |
| Tourtellotte, CD | 1 |
| Barry, WE | 1 |
| Smalley, RV | 1 |
| Durant, JR | 1 |
| Robitaille, P | 1 |
| Leone, G | 1 |
| Pola, P | 1 |
| Guerrera, G | 1 |
| Bizzi, B | 1 |
| Chlud, K | 2 |
| Hazleman, BL | 1 |
| Deicher, H | 3 |
| Klatskin, G | 1 |
| Kantor, FS | 1 |
| Dierkesmann, R | 1 |
| Cegla, UH | 1 |
| Meier-Sydow, J | 1 |
| Kroidl, R | 1 |
| Herreman, G | 1 |
| Broquie, G | 1 |
| Metzger, JP | 1 |
| Godeau, P | 1 |
| Miti, L | 1 |
| Massei, V | 1 |
| Sanguinetti, CM | 1 |
| Fricke, R | 2 |
| Krull, P | 1 |
| Kruli, P | 1 |
| Alwall, N | 1 |
| Halldorson, T | 1 |
| Kjellstrand, CM | 1 |
| Lindholm, T | 1 |
| Ahlström, CG | 1 |
| Heidelmann, G | 1 |
| Fleischer, J | 1 |
| Schwenke, R | 1 |
| Zosin, C | 1 |
| Mănescu, N | 1 |
| Iacob, G | 1 |
| Schwarzkopf, A | 1 |
| Sabo, I | 1 |
| Gluhovschi, G | 1 |
| Kölle, G | 1 |
| Cruchaud, A | 1 |
| Katsuta, Y | 1 |
| Matsuo, H | 1 |
| Gerhartz, H | 1 |
| Schwenke, H | 1 |
| Helbig, W | 1 |
| Müldner, J | 1 |
| Szotowa, W | 1 |
| Ludwiczak, H | 1 |
| Oknińska, A | 1 |
| Zeligowska, J | 1 |
| Serejska, E | 1 |
| Jensen, MK | 1 |
| Soborg, M | 1 |
6 reviews available for azathioprine and Collagen Diseases
| Article | Year |
|---|---|
[Immunosuppressants].
Topics: Azathioprine; Calcineurin Inhibitors; Collagen Diseases; Cyclophosphamide; Cyclosporine; Humans; Imm | 2009 |
[Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 4. Azathioprine].
Topics: Azathioprine; Collagen Diseases; Humans; Immunosuppressive Agents; Rheumatic Diseases | 2011 |
[Current treatment of collagen diseases. 4. Immunosuppressive agents: key points in their application].
Topics: Azathioprine; Collagen Diseases; Cyclophosphamide; Cyclosporine; Humans; Immunosuppressive Agents; M | 1997 |
[Treatment of myopathies and spinal muscular atrophies (author's transl)].
Topics: Amyotrophic Lateral Sclerosis; Azathioprine; Collagen Diseases; Dermatomyositis; Glycogen Storage Di | 1978 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophos | 1985 |
[Treatment of chronic diseases of connective tissue by cytostatic drugs].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Female; Huma | 1970 |
1 trial available for azathioprine and Collagen Diseases
| Article | Year |
|---|---|
[The P phenomenon in progressive chronic polyarthritis (pcP) and collagen diseases].
Topics: Adult; Animals; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; C-Reactive Protein; Chro | 1969 |
33 other studies available for azathioprine and Collagen Diseases
| Article | Year |
|---|---|
[Medicamental immunosuppression in dermatology (author's transl)].
Topics: Autoimmune Diseases; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Glucocorticoid | 1981 |
[Hyperergic collagenoses. Clinical aspects, differential diagnosis and therapy (author's transl)].
Topics: Adolescent; Adult; Age Factors; Aged; Azathioprine; Child; Collagen Diseases; Cyclophosphamide; Derm | 1977 |
Systemic immunosuppression in marginal keratolysis.
Topics: Aged; Autoantibodies; Azathioprine; Collagen Diseases; Cornea; Corneal Diseases; Female; Humans; Imm | 1978 |
The treatment of connective tissue diseases with antilymphocyte globulin.
Topics: Aged; Antilymphocyte Serum; Azathioprine; Collagen Diseases; Dermatomyositis; Drug Therapy, Combinat | 1976 |
Influence of prednisone and cytostatics on human blood B-, T- and O-lymphocytes in diseases.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Azathioprine; B-Lymphocytes; Child; Chlorambucil; Co | 1975 |
[Collagen disease with pure red cell anemia and perimembraneous glomerulonephritis (author's transl)].
Topics: Adult; Anemia; Anemia, Hemolytic; Antibodies, Antinuclear; Azathioprine; Bone Marrow; Bone Marrow Ce | 1976 |
[Effect of immunosuppressive treatment on the blood's fibrinolytic activity].
Topics: Adult; Aged; Azathioprine; Collagen Diseases; Female; Fibrinogen; Fibrinolysis; Humans; Male; Middle | 1975 |
[Immunomodulating therapy of collagen diseases].
Topics: Adrenal Cortex Hormones; Azathioprine; Collagen Diseases; Cyclophosphamide; Cyclosporins; Drug Admin | 1986 |
Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squa | 1985 |
[Active pathogenetic therapy of systemic rheumatic diseases].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Azathioprine; Child; Collagen Diseases; Cyclophosphamid | 1985 |
Treatment of collagen diseases with cytostatics.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Asthma; | 1965 |
Prolonged immunological disorder terminating in hematological malignancy: A human analogue of animal disease?
Topics: Aged; Animal Diseases; Animals; Autoimmune Diseases; Azathioprine; Blood Protein Disorders; Blood Pr | 1970 |
[Detection of antibodies to soluble nucleoprotein and to deoxyribonucleic acid using a radioimmunologic method].
Topics: Antibodies; Antibodies, Antinuclear; Arthritis, Rheumatoid; Azathioprine; Collagen Diseases; Dermato | 1974 |
[Acquired von Willebrand's syndrome during collagen disorder (author's transl)].
Topics: Adult; Azathioprine; Blood Coagulation Tests; Collagen Diseases; Factor VIII; Female; Hemorrhagic Di | 1974 |
Drug treatment of connective tissue disease.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Aspirin; Azathioprine; Chloroquine; Collagen Dise | 1974 |
[Immunosuppressive therapy in systemic lupus erythematosus].
Topics: Antibodies, Antinuclear; Autoantibodies; Azathioprine; Child; Collagen Diseases; Cyclophosphamide; E | 1972 |
Mitochondrial antibody in primary biliary cirrhosis and other diseases.
Topics: Antibodies; Azathioprine; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Ch | 1972 |
[Therapy of diffuse pulmonary fibrosis (including prevention of development and progression)].
Topics: Adrenal Cortex Hormones; Azathioprine; Biopsy; Bronchitis; Collagen Diseases; Humans; Immunosuppress | 1974 |
[Treatment of systemic lupus and other collagenoses with antilymphocyte globulins. Apropos of 10 cases].
Topics: Adult; Angioedema; Antibodies; Antilymphocyte Serum; Azathioprine; Collagen Diseases; Epistaxis; Fem | 1972 |
[Immunosuppressive therapy of collagen diseases. Case report].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Collagen Diseases; Female; Humans; Immunosuppressi | 1974 |
[Treatment of chronic connective tissue diseases with cytostatics].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Chronic Disease; Collagen | 1970 |
On corticosteroid and azathioprine treatment of glomerular renal diseases. A study of 90 cases, treated 1964-1969.
Topics: Adolescent; Adult; Aged; Azathioprine; Biopsy; Child; Collagen Diseases; Female; Glomerulonephritis; | 1972 |
[Case report on the treatment with azathioprine of collagen diseases].
Topics: Adult; Arthritis; Autoimmune Diseases; Azathioprine; Chronic Disease; Collagen Diseases; Dermatomyos | 1971 |
[Immunodepressive therapy in nephropathies].
Topics: Azathioprine; Chlorambucil; Collagen Diseases; Diabetic Nephropathies; Glomerulonephritis; Humans; I | 1969 |
[Bone marrow damage following immunosuppressive therapy with azathioprine of juvenile rheumatoid arthritis and the Still syndrome].
Topics: Adolescent; Agranulocytosis; Arthritis, Juvenile; Azathioprine; Bone Marrow Diseases; Bone Marrow Ex | 1969 |
[Immunosuppressive treatment of collagen diseases].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1969 |
[Cytostatic and antimetabolite therapy in chronic inflammatory joint diseases and collagen diseases].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Biopsy; Collagen Diseases; Cyclophospham | 1969 |
[Collagen diseases].
Topics: Arthritis, Rheumatoid; Azathioprine; Collagen Diseases; Humans; Immunosuppressive Agents; Lupus Eryt | 1970 |
[Immunosuppressive effect of cytostatics in the clinic].
Topics: Azathioprine; Colitis, Ulcerative; Collagen Diseases; Granulomatosis with Polyangiitis; Hematologic | 1970 |
[Immunosuppressive therapy in autoimmune diseases].
Topics: Anemia, Hemolytic; Antineoplastic Agents; Autoimmune Diseases; Azathioprine; Collagen Diseases; Huma | 1971 |
[Use of immunosuppressive cytostatic agents in children's diseases in our experience].
Topics: Adolescent; Autoimmune Diseases; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Collage | 1969 |
[Treatment of connective tissue diseases with cytostatics. 6-mercaptopurine and azathioprine].
Topics: Aged; Azathioprine; Collagen Diseases; Female; Humans; Male; Mercaptopurine; Middle Aged | 1965 |
Chromosome aberrations in human cells following treatment with imuran. Preliminary report.
Topics: Azathioprine; Bone Marrow Examination; Carcinogens; Collagen Diseases; Female; Humans | 1966 |