azathioprine has been researched along with Chronic Hepatitis C in 19 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The medical records of eight patients who developed severe pancytopenia following concomitant use of azathioprine and ribavirin were retrospectively reviewed." | 3.74 | Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression. ( Bigard, MA; Bronowicki, JP; Cadranel, JF; Canva, V; Cortot, A; Gueant, JL; Nousbaum, JB; Oussalah, A; Peyrin-Biroulet, L; Roblin, X; Seddik, M; Sogni, P, 2008) |
| "Factors associated with HCV recurrence were evaluated." | 2.79 | Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes. ( Burroughs, AK; Cholongitas, E; Corbani, A; Davidson, B; Davidson, J; Dhillon, AP; Hayes, P; Luong, T; Manousou, P; McCormick, PA; O'Beirne, J; Patch, D; Rodríguez-Perálvarez, M; Rolles, K; Samonakis, D; Thorburn, D; Tsochatzis, E, 2014) |
| " Patients were randomized to the non-RTX group (to receive conventional treatment, consisting of 1 of the following 3: glucocorticoids; azathioprine or cyclophosphamide; or plasmapheresis) or the RTX group (to receive 2 infusions of 1 gm each, with a lowering of the glucocorticoid dosage when possible, and with a second course of RTX at relapse)." | 2.77 | A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis. ( Bombardieri, S; Campanini, M; De Vita, S; Ferri, C; Filippini, D; Gabrielli, A; Galli, M; Isola, M; Lenzi, M; Mascia, MT; Maset, M; Masolini, P; Mazzaro, C; Migliaresi, S; Monti, G; Naclerio, C; Perrella, O; Pietrogrande, M; Pioltelli, P; Quartuccio, L; Roccatello, D; Scaini, P; Tavoni, A; Zabotti, A; Zignego, AL, 2012) |
| "A total of 79 patients with hepatitis C, B, or both, transplanted between 1973 and 1990, were grouped according to whether they had AZA either withdrawn from the immunosuppressive regimen [group (G) I, n=45] or a dosage reduction only (group II, n=34)." | 2.69 | The impact of azathioprine on chronic viral hepatitis in renal transplantation: a long-term, single-center, prospective study on azathioprine withdrawal. ( Americo da Fonseca, J; David-Neto, E; Ianhez, LE; Jota de Paula, F; Nahas, WC; Sabbaga, E, 1999) |
| "Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) was recognized as a new disease entity; however, IgG4-associated de novo AIH after the liver transplantation had not been reported yet." | 2.49 | Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review. ( Jia, JD; Rakhda, MI; Wang, TI; Zhao, XY, 2013) |
| "AST, ALT, HCV RNA, and liver fibrosis were determined, and results were compared with a control group of non-treated chronic hepatitis C patients." | 1.40 | Does low-dose prolonged steroid therapy affect the natural history of chronic hepatitis C? ( Artaza Varasa, T; Bárcena Marugán, R; del Campo Terrón, S; Moreno Zamora, A; Romero Gutiérrez, M; Sánchez Ruano, JJ, 2014) |
| "A 57-year old woman with perianal Crohn's disease receiving azathioprine and infliximab developed this type of lymphoma after a short period of time on the treatment." | 1.37 | Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection. ( Aldeguer, M; Arevalo, N; Benito, DM; de Fuenmayor, ML; Foncillas, MA; Plaza, R; Ponferrada, A, 2011) |
| "The chronic hepatitis C-autoimmune hepatitis (AIH) overlap syndrome has been described in the literature, but to date appropriate therapy remains controversial." | 1.32 | Differential efficacy of corticosteroids and interferon in a patient with chronic hepatitis C-autoimmune hepatitis overlap syndrome. ( Dries, V; Goeser, T; Kasper, HU; Petersen-Benz, C, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| López Couceiro, L | 1 |
| Gómez Domínguez, E | 1 |
| Muñoz Gómez, R | 1 |
| Castellano Tortajada, G | 1 |
| Ibarrola de Andrés, C | 1 |
| Fernández Vázquez, I | 1 |
| Zhao, XY | 1 |
| Rakhda, MI | 1 |
| Wang, TI | 1 |
| Jia, JD | 1 |
| González-Artacho, C | 1 |
| Rodríguez Sicilia, MJ | 1 |
| Alegría-Motte, C | 1 |
| Gómez García, M | 1 |
| Manousou, P | 1 |
| Cholongitas, E | 1 |
| Samonakis, D | 1 |
| Tsochatzis, E | 1 |
| Corbani, A | 1 |
| Dhillon, AP | 1 |
| Davidson, J | 1 |
| Rodríguez-Perálvarez, M | 1 |
| Patch, D | 1 |
| O'Beirne, J | 1 |
| Thorburn, D | 1 |
| Luong, T | 1 |
| Rolles, K | 1 |
| Davidson, B | 1 |
| McCormick, PA | 1 |
| Hayes, P | 1 |
| Burroughs, AK | 1 |
| Romero Gutiérrez, M | 1 |
| del Campo Terrón, S | 1 |
| Moreno Zamora, A | 1 |
| Sánchez Ruano, JJ | 1 |
| Artaza Varasa, T | 1 |
| Bárcena Marugán, R | 1 |
| Lin, KM | 1 |
| Cheng, TT | 1 |
| Lin, JC | 1 |
| Chen, CJ | 1 |
| Magalhães-Costa, P | 1 |
| Lebre, L | 1 |
| Machado, D | 1 |
| Chagas, C | 1 |
| Hsiao, CH | 1 |
| Tseng, KC | 1 |
| Tseng, CW | 1 |
| Tung, CH | 1 |
| Peyrin-Biroulet, L | 1 |
| Cadranel, JF | 1 |
| Nousbaum, JB | 1 |
| Oussalah, A | 1 |
| Seddik, M | 1 |
| Canva, V | 1 |
| Cortot, A | 1 |
| Sogni, P | 1 |
| Gueant, JL | 1 |
| Bigard, MA | 1 |
| Roblin, X | 1 |
| Bronowicki, JP | 1 |
| Chaparro, M | 1 |
| Trapero-Marugán, M | 1 |
| Moreno-Otero, R | 1 |
| Gisbert, JP | 1 |
| Plaza, R | 1 |
| Ponferrada, A | 1 |
| Benito, DM | 1 |
| Arevalo, N | 1 |
| Foncillas, MA | 1 |
| de Fuenmayor, ML | 1 |
| Aldeguer, M | 1 |
| De Vita, S | 1 |
| Quartuccio, L | 1 |
| Isola, M | 1 |
| Mazzaro, C | 1 |
| Scaini, P | 1 |
| Lenzi, M | 1 |
| Campanini, M | 1 |
| Naclerio, C | 1 |
| Tavoni, A | 1 |
| Pietrogrande, M | 1 |
| Ferri, C | 1 |
| Mascia, MT | 1 |
| Masolini, P | 1 |
| Zabotti, A | 1 |
| Maset, M | 1 |
| Roccatello, D | 1 |
| Zignego, AL | 1 |
| Pioltelli, P | 1 |
| Gabrielli, A | 1 |
| Filippini, D | 1 |
| Perrella, O | 1 |
| Migliaresi, S | 1 |
| Galli, M | 1 |
| Bombardieri, S | 1 |
| Monti, G | 1 |
| Petersen-Benz, C | 1 |
| Kasper, HU | 1 |
| Dries, V | 1 |
| Goeser, T | 1 |
| Canet, S | 1 |
| Garrigue, V | 1 |
| Bismuth, J | 1 |
| Chong, G | 1 |
| Lesnik, A | 1 |
| Taourel, P | 1 |
| Mourad, G | 1 |
| Hokari, A | 1 |
| Zeniya, M | 1 |
| Maier, KP | 1 |
| Berenguer, M | 1 |
| Prieto, M | 1 |
| Córdoba, J | 1 |
| Rayón, JM | 1 |
| Carrasco, D | 1 |
| Olaso, V | 1 |
| San-Juan, F | 1 |
| Gobernado, M | 1 |
| Mir, J | 1 |
| Berenguer, J | 1 |
| Nakamura, K | 1 |
| Makino, I | 1 |
| David-Neto, E | 1 |
| Americo da Fonseca, J | 1 |
| Jota de Paula, F | 1 |
| Nahas, WC | 1 |
| Sabbaga, E | 1 |
| Ianhez, LE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Maintenance Treatment by Ribavirin to a Placebo, After an Initial One-year Treatment With Pegylated Interferon-α2a - Ribavirin Association in Hepatitis C Viral Recurrence After Liver Transplantation[NCT00151580] | Phase 3 | 200 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for azathioprine and Chronic Hepatitis C
| Article | Year |
|---|---|
Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review.
Topics: Antiviral Agents; Azathioprine; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; H | 2013 |
[Nocardiosis--is it frequently observed after the introduction of new immunosuppressive agents in renal transplantation?].
Topics: Adrenal Cortex Hormones; Adult; Aged; Antilymphocyte Serum; Azathioprine; Cyclosporine; Diabetes Com | 2004 |
[Difference between autoimmune hepatitis (AIH) with and without hepatitis C virus (HCV)].
Topics: Adrenal Cortex Hormones; Antiviral Agents; Autoantibodies; Azathioprine; Disease Susceptibility; Dru | 2004 |
[Drug therapy in chronic liver disease].
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Antiviral Agents; Azathioprine; Cholangitis, Scleros | 2005 |
[Autoimmune hepatitis: progress in its treatment].
Topics: Azathioprine; Female; Hepatitis C, Chronic; Hepatitis, Autoimmune; Humans; Middle Aged; Prednisolone | 1999 |
3 trials available for azathioprine and Chronic Hepatitis C
| Article | Year |
|---|---|
Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes.
Topics: Anti-Inflammatory Agents; Azathioprine; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Hum | 2014 |
A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents | 2012 |
The impact of azathioprine on chronic viral hepatitis in renal transplantation: a long-term, single-center, prospective study on azathioprine withdrawal.
Topics: Adult; Alanine Transaminase; Azathioprine; Bilirubin; Disease Progression; Dose-Response Relationshi | 1999 |
11 other studies available for azathioprine and Chronic Hepatitis C
| Article | Year |
|---|---|
Healing of autoimmune hepatitis associated with hepatitis C virus infection treated with direct-acting antivirals.
Topics: Antiviral Agents; Azathioprine; Benzimidazoles; Female; Fluorenes; Hepatitis C, Chronic; Hepatitis, | 2019 |
[Outcome of chronic hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive drugs and anti-TNF agents].
Topics: Adalimumab; Adenine; Adult; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azathioprine; Crohn | 2014 |
Does low-dose prolonged steroid therapy affect the natural history of chronic hepatitis C?
Topics: Adult; Azathioprine; Cohort Studies; Enzymes; Female; Hepatitis C, Chronic; Humans; Immunosuppressiv | 2014 |
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study.
Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumato | 2015 |
Lack of impact of hepatitis C virus infection on graft survival after kidney transplantation--a Portuguese single-center experience.
Topics: Adult; Age Factors; Aged; Azathioprine; Cardiovascular Diseases; Case-Control Studies; Cyclosporine; | 2015 |
Late-Onset Immune Thrombocytopenic Purpura After Withdrawal of Interferon Treatment for Chronic Hepatitis C Infection: A Case Report.
Topics: Age of Onset; Antiviral Agents; Azathioprine; Glucocorticoids; Hepatitis C, Chronic; Humans; Immunos | 2015 |
Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression.
Topics: Adult; Antiviral Agents; Azathioprine; Drug Interactions; Female; Hepatitis C, Chronic; Humans; Immu | 2008 |
Azathioprine plus ribavirin treatment and pancytopenia.
Topics: Adult; Anti-Inflammatory Agents; Antiviral Agents; Azathioprine; Crohn Disease; Drug Interactions; H | 2009 |
Plasmablastic lymphoma associated to Crohn's disease and hepatitis C virus chronic infection.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Az | 2011 |
Differential efficacy of corticosteroids and interferon in a patient with chronic hepatitis C-autoimmune hepatitis overlap syndrome.
Topics: Adult; Antiviral Agents; Azathioprine; Drug Therapy, Combination; Female; Glucocorticoids; Haplotype | 2004 |
Early development of chronic active hepatitis in recurrent hepatitis C virus infection after liver transplantation: association with treatment of rejection.
Topics: Alanine Transaminase; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Genome, Viral; | 1998 |