azathioprine has been researched along with Chromosomal Translocation in 7 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 7.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 3.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "A boy with microcephaly, unusual facial features, micropenis, and growth retardation was born to a 30-year-old woman who took azathioprine and prednisone before and during pregnancy for systemic lupus erythematosus." | 3.67 | Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone. ( Ostrer, H; Perinchief, P; Stamberg, J, 1984) |
| " The patient presented is a 22-year-old white male who, following two renal transplants and prolonged immunosuppressive therapy with azathioprine and methylprednisolone, developed chronic granulocytic leukemia." | 3.66 | Chronic granulocytic leukemia following successful renal transplantation. ( Adler, KR; Lempert, N; Scharfman, WB, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chin, LK | 1 |
| Cheah, CY | 1 |
| Michael, PM | 1 |
| MacKinnon, RN | 1 |
| Campbell, LJ | 1 |
| Knipp, S | 1 |
| Hildebrandt, B | 1 |
| Richter, J | 1 |
| Haas, R | 1 |
| Germing, U | 1 |
| Gattermann, N | 1 |
| Ostrer, H | 1 |
| Stamberg, J | 1 |
| Perinchief, P | 1 |
| Adler, KR | 1 |
| Lempert, N | 1 |
| Scharfman, WB | 1 |
| Vandenberghe, EA | 1 |
| Mecucci, C | 1 |
| Delannoy, A | 1 |
| Van den Berghe, H | 1 |
| Pikler, GM | 1 |
| Say, B | 1 |
| Stamper, S | 1 |
| Vormittag, W | 1 |
7 other studies available for azathioprine and Chromosomal Translocation
| Article | Year |
|---|---|
11q23 rearrangement and duplication of MLLT1-MLL gene fusion in therapy-related acute myeloid leukemia.
Topics: Azathioprine; Chromosome Banding; Chromosomes, Human, Pair 11; Cyclosporine; Female; Gene Duplicatio | 2012 |
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azathioprine; Cell Transformation, Neoplastic; | 2005 |
Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Azathioprine; Chromosome Aberrations; C | 1984 |
Chronic granulocytic leukemia following successful renal transplantation.
Topics: Adult; Azathioprine; Cadaver; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 6-12 and X; Human | 1978 |
Deletion of 5q by t(5;17) in therapy-related myelodysplastic syndrome.
Topics: Adult; Azathioprine; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 17; Chromosom | 1990 |
Cytogenetic findings in acute monocytic leukemia in a renal allograft recipient.
Topics: Azathioprine; Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Female; Humans; Immune Toleran | 1986 |
[Cytostatic immunosuppressive therapy, chromosomal aberrations and carcinogenic effect (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Chromosomes, Human, 1-3; C | 1974 |