azathioprine has been researched along with Cholestasis, Intrahepatic in 16 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy." | 9.41 | Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature. ( Akria, L; Carmiel Haggai, M; Frank Wolf, M; Lowenstein, L; Rimon, E; Sloma, R; Wiener, Y, 2023) |
| " Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case." | 7.70 | Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999) |
| "Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy." | 5.41 | Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature. ( Akria, L; Carmiel Haggai, M; Frank Wolf, M; Lowenstein, L; Rimon, E; Sloma, R; Wiener, Y, 2023) |
| "MODE OF ACTION OF URSODEOXYCHOLIC ACID: In cholestasis, the impaired biliary secretion of toxic bile acids causes their accumulation in the liver and a subsequent hepatic failure." | 4.81 | [Treatment of cholestatic liver diseases]. ( Gatzen, M; Pausch, J, 2002) |
| " Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case." | 3.70 | Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999) |
| "A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy." | 3.68 | Reversible cholestasis with bile duct injury following azathioprine therapy. A case report. ( Geubel, AP; Horsmans, Y; Rahier, J, 1991) |
| "Azathioprine is a drug commonly used for the treatment of inflammatory bowel disease, organ transplantation and various autoimmune diseases." | 2.40 | Cholestatic hepatocellular injury with azathioprine: a case report and review of the mechanisms of hepatotoxicity. ( Jewell, L; Lalor, E; Romagnuolo, J; Sadowski, DC; Thomson, AB, 1998) |
| "Azathioprine was withdrawn." | 1.36 | Azathioprine-induced severe cholestatic hepatitis in patient carrying TPMT*3C polymorphism. ( Belajouza, C; Ben Salah, L; Ben Salem, C; Bouraoui, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Frank Wolf, M | 1 |
| Sloma, R | 1 |
| Akria, L | 1 |
| Rimon, E | 1 |
| Wiener, Y | 1 |
| Carmiel Haggai, M | 1 |
| Lowenstein, L | 1 |
| Céruti, H | 1 |
| Kayem, G | 1 |
| Guilbaud, L | 1 |
| Dussaux, C | 1 |
| Gervais, A | 1 |
| Beaufrère, A | 1 |
| Coffin, B | 1 |
| Mandelbrot, L | 1 |
| Maisonneuve, E | 1 |
| Roda, G | 1 |
| Caponi, A | 1 |
| Belluzzi, A | 1 |
| Roda, E | 1 |
| Ben Salem, C | 1 |
| Ben Salah, L | 1 |
| Belajouza, C | 1 |
| Bouraoui, K | 1 |
| Eisenbach, C | 1 |
| Goeggelmann, C | 1 |
| Flechtenmacher, C | 1 |
| Stremmel, W | 1 |
| Encke, J | 1 |
| Teruel, JL | 1 |
| Marcén, R | 1 |
| Celma, ML | 1 |
| Bueno, R | 1 |
| Jiménez del Cerro, L | 1 |
| Matesanz, R | 1 |
| Quereda, C | 1 |
| Ortuño, J | 1 |
| Fasshauer, K | 1 |
| Rath, I | 1 |
| Hizawa, N | 1 |
| Kojima, J | 1 |
| Kojima, T | 1 |
| Sukoh, N | 1 |
| Yamaguchi, E | 1 |
| Kawakami, Y | 1 |
| Matsushima, T | 1 |
| Romagnuolo, J | 1 |
| Sadowski, DC | 1 |
| Lalor, E | 1 |
| Jewell, L | 1 |
| Thomson, AB | 1 |
| Delladetsima, JK | 1 |
| Boletis, JN | 1 |
| Makris, F | 1 |
| Psichogiou, M | 1 |
| Kostakis, A | 1 |
| Hatzakis, A | 1 |
| Delgado, J | 1 |
| Muñoz de Bustillo, E | 1 |
| Ibarrola, C | 1 |
| Colina, F | 1 |
| Morales, JM | 1 |
| Rodriguez, E | 1 |
| Aguado, JM | 1 |
| Fuertes, A | 1 |
| Gomez, MA | 1 |
| Gatzen, M | 1 |
| Pausch, J | 1 |
| Horsmans, Y | 1 |
| Rahier, J | 1 |
| Geubel, AP | 1 |
| Wakabayashi, T | 1 |
| Mori, S | 1 |
| Pastolero, J | 1 |
| Sugimura, H | 1 |
| Mendel, R | 1 |
| Hebestreit, HP | 1 |
| Droste, R | 1 |
| Bade, J | 1 |
| Georgi, M | 1 |
| Sparberg, M | 1 |
| Simon, N | 1 |
| del Greco, F | 1 |
3 reviews available for azathioprine and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature.
Topics: Azathioprine; Cholestasis, Intrahepatic; Female; Humans; Mercaptopurine; Pregnancy; Pregnancy Compli | 2023 |
Cholestatic hepatocellular injury with azathioprine: a case report and review of the mechanisms of hepatotoxicity.
Topics: Azathioprine; Cholestasis, Intrahepatic; Crohn Disease; Drug Hypersensitivity; Humans; Immunosuppres | 1998 |
[Treatment of cholestatic liver diseases].
Topics: Adult; Age Factors; Anti-Inflammatory Agents; Azathioprine; Bile; Child; Cholagogues and Choleretics | 2002 |
13 other studies available for azathioprine and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Intrahepatic cholestasis of pregnancy associated with azathioprine: A case series.
Topics: Adult; Azathioprine; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; C | 2021 |
Severe cholestatic acute hepatitis following azathioprine therapy in a patient with ulcerative pancolitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Cholestasis, Intrahepatic; Colitis, Ulcerativ | 2009 |
Azathioprine-induced severe cholestatic hepatitis in patient carrying TPMT*3C polymorphism.
Topics: Adult; Azathioprine; Cholestasis, Intrahepatic; Follow-Up Studies; Genetic Carrier Screening; Hetero | 2010 |
Severe cholestatic hepatitis caused by azathioprine.
Topics: Aged; Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Liver | 2005 |
[Hepatopathy in kidney transplant patients: incidence, etiology and clinical forms of presentation].
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytomegalovirus Inf | 1984 |
[Comments on the indication of immunosuppressive long-term therapy in myasthenia gravis (author's transl)].
Topics: Azathioprine; Bone Marrow Diseases; Cholestasis, Intrahepatic; Cholinesterase Inhibitors; Humans; Jo | 1981 |
A patient with chronic hepatitis C who simultaneously developed interstitial pneumonia, hemolytic anemia and cholestatic liver dysfunction after alpha-interferon administration.
Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Cholestasis, Intrahepatic; Female; Hepatitis C; Humans; | 1994 |
Fibrosing cholestatic hepatitis in renal transplant recipients with hepatitis C virus infection.
Topics: Adult; Alanine Transaminase; Azathioprine; Biopsy; Cholestasis, Intrahepatic; Cyclosporine; Fatal Ou | 1999 |
Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor?
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatal Outcome; Hear | 1999 |
Reversible cholestasis with bile duct injury following azathioprine therapy. A case report.
Topics: Azathioprine; Bile Ducts, Intrahepatic; Biopsy; Cholestasis, Intrahepatic; Humans; Male; Middle Aged | 1991 |
Bile ductal and ductular changes of the livers in the renal allografted patients.
Topics: Adult; Azathioprine; Bile Ducts, Intrahepatic; Biopsy, Needle; Chemical and Drug Induced Liver Injur | 1987 |
[2 cases of primary sclerosing cholangitis--the ERCP documentation of a 3-year course of immunosuppressive therapy].
Topics: Adult; Azathioprine; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis; Cholestasis, Intr | 1985 |
Intrahepatic cholestasis due to azathioprine.
Topics: Adult; Azathioprine; Cholestasis, Intrahepatic; Humans; Kidney Transplantation; Male; Postoperative | 1969 |