azathioprine has been researched along with Cell Transformation, Neoplastic in 10 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 7.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders." | 3.73 | Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. ( Gattermann, N; Germing, U; Haas, R; Hildebrandt, B; Knipp, S; Richter, J, 2005) |
| "Responses to treatment and disease progression were determined by comparing scores with baseline scores." | 1.31 | Oral lichen planus: patient profile, disease progression and treatment responses. ( Chainani-Wu, N; Lozada-Nur, F; Mayer, P; Silverman, S; Watson, JJ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mascolo, MG | 1 |
| Perdichizzi, S | 1 |
| Rotondo, F | 1 |
| Morandi, E | 1 |
| Guerrini, A | 1 |
| Silingardi, P | 1 |
| Vaccari, M | 1 |
| Grilli, S | 1 |
| Colacci, A | 1 |
| Schöffel, N | 1 |
| Sahm, M | 1 |
| Groneberg, DA | 1 |
| Pross, M | 1 |
| Knipp, S | 1 |
| Hildebrandt, B | 1 |
| Richter, J | 1 |
| Haas, R | 1 |
| Germing, U | 1 |
| Gattermann, N | 1 |
| Matula, S | 1 |
| Croog, V | 1 |
| Itzkowitz, S | 1 |
| Harpaz, N | 1 |
| Bodian, C | 1 |
| Hossain, S | 1 |
| Ullman, T | 1 |
| de Graaf, YG | 1 |
| Rebel, H | 1 |
| Elghalbzouri, A | 1 |
| Cramers, P | 1 |
| Nellen, RG | 1 |
| Willemze, R | 1 |
| Bouwes Bavinck, JN | 1 |
| de Gruijl, FR | 1 |
| Chainani-Wu, N | 1 |
| Silverman, S | 1 |
| Lozada-Nur, F | 1 |
| Mayer, P | 1 |
| Watson, JJ | 1 |
| Wessel, G | 1 |
| Abendroth, K | 1 |
| Wisheit, M | 1 |
| Hartwich, G | 1 |
| Miller, G | 1 |
| Coope, D | 1 |
| Leb, DE | 1 |
| Howell, RS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus: A Randomized Controlled Clinical Trial With Immunohistochemical Analysis[NCT05882864] | Phase 4 | 28 participants (Anticipated) | Interventional | 2023-08-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for azathioprine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
[Small intestinal signet-ring cell carcinoma in Crohn's disease: case report and review of the literature].
Topics: Adult; Anastomosis, Surgical; Azathioprine; Carcinoma, Signet Ring Cell; Cell Transformation, Neopla | 2013 |
[Cancerogenicity of cytostatics].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Cell Transformation, Neoplastic; Da | 1971 |
8 other studies available for azathioprine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
BALB/c 3T3 cell transformation assay for the prediction of carcinogenic potential of chemicals and environmental mixtures.
Topics: Animals; Azathioprine; BALB 3T3 Cells; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neop | 2010 |
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azathioprine; Cell Transformation, Neoplastic; | 2005 |
Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine.
Topics: Adult; Azathioprine; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colorectal Neoplasms; Dis | 2005 |
More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine.
Topics: Adult; Aged; Animals; Azathioprine; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Clone | 2008 |
Oral lichen planus: patient profile, disease progression and treatment responses.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Carcinoma, Squamous Ce | 2001 |
Malignant transformation during immunosuppressive therapy (azathioprine) of rheumatoid arthritis and systemic lupus erythematosus. A retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Cell Transformation, Neoplastic | 1987 |
Epstein-Barr viral nuclear antigen (EBNA) in tumor cell imprints of experimental lymphoma of marmosets.
Topics: Animals; Antigens, Viral; Azathioprine; Burkitt Lymphoma; Cell Line; Cell Nucleus; Cell Transformati | 1974 |
Carcinoma of the testis in a renal transplant recipient.
Topics: Adult; Azathioprine; Cell Transformation, Neoplastic; Humans; Immunosuppressive Agents; Kidney Trans | 1971 |